Publications on the use of MicroSys (1999 – DEC 2018) 2018 Non-fouling polymeric surface modification and signal amplification method for biomolecular detection. Inventor: Ashutosh Chilkoti United States Patent: US 9890420 B2, Publication Date: 13 February 2018. (MicroSys 5100) https://patents.google.com/patent/US9890420B2/en Cloning, purification and structure determination of the HIV integrase-binding domain of lens epithelium-derived growth factor. Clare Hannon, Abimael Cruz-Migoni, Olga Platonova, Robin L. Owen, Joanne E. Nettleship, Ami Miller, Stephen B. Carr, Gemma Harris, Terence H. Rabbitts, and Simon EV Phillips. Acta Crystallographica Sect. F: Struct. Biol. Communs, 1 March 2018; 74(3): 143-149. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5947699/ Thermal reaction device and method for using the same Inventors: Marc Unger, Ian D. Manger, Michael Lucero, Yong Yi, Emily Miyashita-lin, Anja Wienecke, and Geoffrey Facer. U.S. Patent Application: 2018/0073051 A1, Publication Date: 15 March 2018; (MicroSys 5100) http://www.freepatentsonline.com/y2018/0073051.html Analysis of Multiplexed Nanosensor Arrays Based on Near Infrared Fluorescent Single Walled Carbon Nanotubes. Juyao Dong, Daniel P. Salem, Jessica H. Sun, and Michael S. Strano. ACS Nano, 24 April 2018; 12(4): 3769-3779 Chip platforms for microarray 3D bioprinting. Inventor: Moo-Yeal Lee U.S. Patent Application: 2018/0142195 A1, Publication Date: 24 May 2018. https://patents.google.com/patent/US20180142195A1/en Inkjet-Printed Sensors on Flexible Substrates. Poonam Sundriyal, and Shantanu Bhattacharya. In: Environmental, Chemical & Medical Sensors, Spring 2018; Shantanu Bhattacharya, Avinash Kumar Agarwal, Nripen Chanda, Ashok Pandey, Ashis Kumar Sen (Eds), Springer, Singapore, pp. 89-113. Non-fouling polymeric surface modification and signal amplification method for biomolecular detection. Inventor: Ashutosh Chilkoti U.S. Patent Application: 2018/0155763 A1, Publication Date: 7 June 2018. (MicroSys 5100) http://www.freepatentsonline.com/y2018/0155763.html

Identification, Characterization, and X-ray Crystallographic Analysis of a Novel Type of Lectin AJLec from the Sea Anemone Anthopleura japonica. Hideaki Unno, Azusa Nakamura, Shingo Mori, Shuichiro Goda, Kenichi Yamaguchi, Keiko Hiemori, Hiroaki Tateno, and Tomomitsu Hatakeyama. Scientific Reports, 1 August 2018; 8(1): 11516, 12 pp. (MicroSys SQ4000) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070535/pdf/41598_2018_Article_29498.pdf Thermal reaction device and method for using the same. Inventors: Marc A. Unger, Lincoln McBride, and Geoffrey Facer. U.S. Patent Application: 2018/0243741 A1, Publication Date: 30 August 2018. (MicroSys 5100) https://patents.google.com/patent/US20180243741A1/en High-throughput identification of factors promoting neuronal differentiation of human neural progenitor cells in microscale 3D cell culture. Gregory J. Nierode, Sneha Gopal, Paul Kwon, Douglas S. Clark, David V. Schaffer, and Jonathan S. Dordick. Biotechnology and Bioengineering, 19 September 2018; ahead of print. (MicroSys 5100-4SQ) Crystallization of ectonucleotide phosphodiesterase/pyrophosphatase-3 and orientation of the SMB domains in the full-length ectodomain. Christoph Döhler, Matthias Zebisch, Dana Krinke, Andrea Robitzki, and Norbert Sträter. Acta Crystallographica Section F: Structural Biology Communications, 1 November 2018; 74(11): 696-703. (MicroSys 4000 XL) Advancing in vitro–in vivo toxicity correlations via high-throughput three-dimensional primary hepatocyte culture. Dylan M. Bruckner, Jeannette J. Connerney, and Jonathan S. Dordick. AIChE Journal, December 2018; 64(12): 4331-4340. (MicroSys SQ4000) Three-Dimensional Cell-Based Microarrays: Printing Pluripotent Stem Cells into 3D Microenvironments. Jorge F. Pascoal, Tiago G. Fernandes, Gregory J. Nierode, Maria Margarida Diogo, Jonathan S. Dordick, and Joaquim MS Cabral. Methods in Molecular Biology, 2018; 1771(Cell-Based Microarrays): 69-81 (MicroSys 4100 XL) 2017 Preface Moo-Yeal Lee In: Microarray Bioprinting Technology: Fundamentals and Practices, 17 January 2017; Moo-Yeal Lee ed., Springer, pp. v-vii Microarray Spotter and Printing Technologies Akshata Datar, Dong Woo Lee, Sang Youl jeon, Moo-Yeal Lee

In: Microarray Bioprinting Technology: Fundamentals and Practices, 17 January 2017; Moo-Yeal Lee ed., Springer, pp. 19-52 Dimensional accuracy and surface finish of biomedical implant fabricated as rapid investment casting for small to medium quantity production. Jaspreet Singh, Rupinder Singh, and Harwinder Singh. Journal of Manufacturing Processes, January 2017; 25: 201-211. Druppels maken samen het verschil (The history of inkjet printing) Herman M. A. Wijshoff Inaugural Lecture, 10 February 2017; Eindhoven University of Technology, 35 pp. https://pure.tue.nl/ws/files/55128189/Wijshoff_2017.pdf Ligand-induced conformational change of Insulin-regulated aminopeptidase: insights on catalytic mechanism and active site plasticity. Anastasia Mpakali, Emmanuel Saridakis, Karl Harlos, Yuguang Zhao, Paraskevi Kokkala, Dimitris Georgiadis, Petros Giastas, Athanasios Papakyriakou, and Efstratios Stratikos. Journal of Medicinal Chemistry, 13 April 2017; 60(7): 2963-2972. Biotransformations from and to methylated flavonoids. Herrn Diplom-Biochemiker Benjamin Weigel PhD Theses, 3 May 2017; der Martin-Luther-Universität, Halle-Wittenberg, 197 pp. https://d-nb.info/1139253840/34 Microfluidic device with reaction sites configured for blind filling. Inventors: Marc Unger, Ian D. Manger, Michael Lucero, Yong Yi, Emily Miyashita-Lin, Anja Wienecke, and Geoffrey Facer. United States Patent: US 9643178 B2, Publication Date: 9 May 2017; (MicroSys 5100) https://patents.google.com/patent/US9643178B2/en Dendritic Cell Immune Receptor Activator, Method for Activating Dendritic Cell Immune Receptor, Osteoclast Formation Inhibitor, Method for Inhibiting Osteoclast Formation, Dendritic Cell Differentiation/Proliferation Inhibitor, Method for Inhibiting Dendritic Cell Differentiation/Proliferation, Cytokine Production Inhibitor, Method for Inhibiting Cytokine Production, Therapeutic Method and Screening Method. Inventors: Yoichiro Iwakura, Tomonori Kaifu, and Rikio Yabe. U.S. Patent Application: 2017/0143754 A1, Publication Date: 25 May 2017. (MicroSys 4000) http://www.freepatentsonline.com/y2017/0143754.html The interaction between the Marek’s Disease Virus (MDV) neurovirulence factor pp14 and the host transcription factor, CREB3. Keshalini Sabaratnam PhD Theses, Spring 2017; University of Oxford, 238 pp; (MicroSys MIC4000) https://ora.ox.ac.uk/objects/uuid:d2fc6bd4-bc3a-4a37-924b-86881096a9b5/download_file?file_format=pdf&safe_filename=Thesis%2BK%2BSabaratnam%2BBODLEIAN.pdf&type_of_work=Thesis Solid substrate comprising array of dendrons and methods for using the same. Inventors: Joon Won Park, and Bong Jin Hong. United States Patent: US 9671396 B2, Publication Date: 6 June 2017; (MicroSys 5100)

https://patents.google.com/patent/US9671396B2/en Structural Insight into the Core of CAD, the Multifunctional Protein Leading de novo Pyrimidine Biosynthesis. María Moreno-Morcillo, Araceli Grande-García, Alba Ruiz-Ramos, Francisco del Caño-Ochoa, Jasminka Boskovic, and Santiago Ramón-Maiques. Structure, 6 June 2017; 25(6): 912–923 https://www.sciencedirect.com/science/article/pii/S0969212617301302 A structure-derived snap-trap mechanism of a multispecific serpin from the dysbiotic human oral microbiome. Theodoros Goulas, Miroslaw Ksiazek, Irene Garcia-Ferrer, Alicja M. Sochaj-Gregorczyk, Irena Waligorska, Marcin Wasylewski, Jan Potempa, and F. Xavier Gomis-Rüth. Journal of Biological Chemistry, 30 June 2017; 292(26): 10883-10898 (MicroSys 4000 XL) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491774/ The multidrug-resistance transporter MdfA from Escherichia coli: crystallization and X-ray diffraction analysis. Kumar Nagarathinam, Frank Jaenecke, Yoshiko Nakada-Nakura, Yunhon Hotta, Kehong Liu, So Iwata, Milton T. Stubbs, Norimichi Nomura, and Mikio Tanabe. Acta Crystallographica Sect. F: Struct. Biol. Communs, 1 July 2017; 73(7) 423-430 (MicroSys NQ). https://www.researchgate.net/profile/Kumar_Nagarathinam/publication/317783242_The_multidrug-resistance_transporter_MdfA_from_Escherichia_coli_Crystallization_and_X-ray_diffraction_analysis/links/595919beaca272c78abf078e/The-multidrug-resistance-transporter-MdfA-from-Escherichia-coli-Crystallization-and-X-ray-diffraction-analysis.pdf Structural characterization of the Rabphilin-3A–SNAP25 interaction. Cristina Ferrer-Orta, María Dolores Pérez-Sánchez, Teresa Coronado-Parra, Cristina Silva, David López-Martínez, Jesús Baltanás-Copado, Juan Carmelo Gómez-Fernández, Senena Corbalán-García, and Núria Verdaguer. Proceedings National Academy of Sciences, 3 July 2017; 114(27): E5343-E5351 (MicroSys 4000XL) https://pdfs.semanticscholar.org/eb06/6d15a8d167c110e13534d000f62ff60892a3.pdf 3D-printed miniature biological constructs. Inventor: Moo-Yeal Lee U.S. Patent Application: 2017/0198275 A1, Publication Date: 13 July 2017; https://www.google.com/patents/US20170198275 A comparison of nanoparticle-antibody conjugation strategies in sandwich immunoassays. Justina O. Tam, Helena de Puig, Chun-wan Yen, Irene Bosch, Jose Gómez-Márquez, Charles Clavet, Kimberly Hamad-Schifferli, and Lee Gehrke. Journal of Immunoassay and Immunochemistry, July-August 2017; 38(4): 355-377. Optimization of DNA microarray biosensors enables rapid and sensitive detection. Byeong Hee Hwang, Hwa Hui Shin, and Hyung Joon Cha. Biotechnology and Bioprocess Engineering, August 2017; 22(4): 469-473. (MicroSys 5100) High-throughput microarray for antimicrobial susceptibility testing. Anand Srinivasan, Grace C. Lee, Nelson S. Torres, Kevin Hernandez, Steven D. Dallas, Jose Lopez-Ribot, Christopher R. Frei, and Anand K. Ramasubramanian.

Biotechnology Reports, 8 November 2017; 16: 44-47. (MicroSys, OG Micro) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686425/ Development of a Sensitive Microarray Platform for the Ranking of Galectin Inhibitors: Identification of a Selective Galectin-3 Inhibitor. Johann Dion, Tamara Advedissian, Nataliya Storozhylova, Samir Dahbi, Annie Lambert, Frédérique Deshayes, Mireille Viguier, Charles Tellier, Françoise Poirier, Stéphane Téletchéa, Christophe Dussouy, Hiroaki Tateno, Jun Hirabayashi and Cyrille Grandjean. ChemBioChem, 14 December 2017; 18(24): 2428-2440. High-throughput microarray for antimicrobial susceptibility testing. Anand Srinivasan, Grace C. Lee, Nelson S. Torres, Kevin Hernandez, Steven D. Dallas, Jose Lopez-Ribot, Christopher R. Frei, and Anand K. Ramasubramanian. Biotechnology Reports, December 2017; 16: 44-47. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686425/ 2016 Screening of Pre-miRNA-155 Binding Peptides for Apoptosis Inducing Activity Using Peptide Microarrays. Jaeyoung Pai, Soonsil Hyun, Ji Young Hyun, Seong-Hyun Park, Won-Je Kim, Sung-Hun Bae, Nak-Kyoon Kim, Jaehoon Yu, and Injae Shin. Journal of the American Chemical Society, 27 January 2016; 138(3): 857-867. (MicroSys 5100) Enzymatic and Structural Characterization of the Major Endopeptidase in the Venus Flytrap Digestion Fluid. Michael W. Risør, Line R. Thomsen, Kristian W. Sanggaard, Tania A. Nielsen, Ida B. Thøgersen, Marie V. Lukassen, Litten Rossen, Irene Garcia-Ferrer, Tibisay Guevara, Carsten Scavenius, Ernst Meinjohanns, F. Xavier Gomis-Rüth and Jan J. Enghild Journal of Biological Chemistry, 29 January 2016; 291(5): 2271-2287. Development and Implementation of Methods for Electrocatalysis, Electroanalytical Chemistry and Energy Storage Applications. Zhange Feng PhD Theses, January 2016; Case Western Reserve University, 96 pp. https://etd.ohiolink.edu/!etd.send_file?accession=case1449154825&disposition=inline Carbohydrate microarrays for screening functional glycans. Jaeyoung Pai, Ji Young Hyun, Jieun Jeong, Sohee Loh, Eun-Hee Cho, Young-Sun Kang, Injae Shin. Chemical Science, 1 March 2016; 7(3): 2084-2093. (MicroSys 5100) http://pubs.rsc.org/en/content/articlepdf/2016/sc/c5sc03789a?page=search Lectin microarray technology identifies specific lectins related to lymph node metastasis of advanced gastric cancer. Keishi Yamashita, Atsushi Kuno, Atsushi Matsuda, Yuzuru Ikehata, Natsuya Katada, Jun Hirabayashi, Hisashi Narimatsu, and Masahiko Watanabe. Gastric Cancer, April 2016; 19(2): 531-542. (MicroSys 4000)

https://www.researchgate.net/profile/Atsushi_Matsuda/publication/274458952_Lectin_microarray_technology_identifies_specific_lectins_related_to_lymph_node_metastasis_of_advanced_gastric_cancer/links/56133c2408aedee13b5c1d87.pdf Development of Novel Technologies for Direct Cellular Patterning for the Establishment of Well Controlled Microenvironments to Facilitate Studies on Cellular Signaling, Sensing, and Other Diffusion-Based Phenomena William Hynes PhD Theses, 7 May 2016; SUNY Polytechnic Institute, 133 pp (MicroSys 5100 4SQ) https://dspace.sunyconnect.suny.edu/bitstream/handle/1951/66926/Hynes-Dissertation.pdf?sequence=1&isAllowed=y Hybrid microarray based on double biomolecular markers of DNA and carbohydrate for simultaneous genotypic and phenotypic detection of cholera toxin-producing Vibrio cholerae. Hwa Hui Shin, Jeong Hyun Seo, Chang Sup Kim, Byeong Hee Hwang, and Hyung Joon Cha. Biosensors and Bioelectronics, 15 May 2016; 79: 398-405. (MicroSys 5100) Structure of the I-SceI nuclease complexed with its dsDNA target and three catalytic metal ions. Jesús Prieto, Pilar Redondo, Nekane Merino, Maider Villate, Guillermo Montoya, Francisco J. Blanco, and Rafael Molina. Acta Crystallographica Sec. F: Structural Biology Communications, 1 June 2016; 72(6): 473-479. https://www.researchgate.net/profile/Rafael_Molina4/publication/303502251_Structure_of_the_I-SceI_nuclease_complexed_with_its_dsDNA_target_and_three_catalytic_metal_ions/links/5746f6ad08ae9f741b452a11.pdf Estudos das enzimas adenosina kinase isoforma 1, hipoxantina-guanina fosforibosiltransferase isoformas 1, 2 e 3, adenilsuccinato liase, adenilsuccinato sintetase de Schistosoma mansoni. Larissa Romanello PhD Theses, 3 June 2016; Universidade de São Paulo, São Carlos, 162 pp. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-27102016-102455/en.php Structural mimicry of receptor interaction by antagonistic IL-6 antibodies. Christophe Blanchetot, Natalie De Jonge, Aline Desmyter, Nico Ongenae, Erik Hofman, Alex Klarenbeek, Ava Sadi, Anna Hultberg, Anke Kretz-Rommel, Silvia Spinelli, Remy Loris, Christian Cambillau and Hans de Haard Journal of Biological Chemistry, 24 June 2016; 291(26): 13846-13854 (MicroSys SQ) http://www.jbc.org/content/291/26/13846.full.pdf Noninvasive disease diagnostics using engineered synthetic urinary biomarkers. Andrew David Warren PhD Theses, June 2016; MIT, 166 pp. https://dspace.mit.edu/handle/1721.1/104609 Identification, Characterization, and X-ray Crystallographic Analysis of a Novel Type of Mannose-Specific Lectin CGL1 from the Pacific Oyster Crassostrea gigas. Hideaki Unno, Kazuki Matsuyama, Yoshiteru Tsuji, Shuichiro Goda, Keiko Hiemori, Hiroaki Tateno, Jun Hirabayashi, and Tomomitsu Hatakeyama. Scientific Reports, 5 July 2016; 6: 29135, 13 pp. (MicroSys 4000) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932603/

Solid substrate comprising array of dendrons and methods for using the same. Inventors: Joon Won Park, and Bong Jin Hong. United States Patent: US 9389227 B2, Publication Date: 12 July 2016; (MicroSys 5100) https://www.google.com/patents/US9389227 High-throughput recombinant protein expression in Escherichia coli: current status and future perspectives. Baolei Jia, and Che Ok Jeon. Open Biology, 31 August 2016; 6(8): 160196, 17 pp. http://rsob.royalsocietypublishing.org/content/6/8/160196 Schwefel-Oxygenasen/-Reduktasen aus Acidianus ambivalens und Halothiobacillus neapolitanus. Uwe Pöll PhD Theses, 31 August 2017; Technischen Universität Darmstadt, 188 pp (MicroSys 4000) http://tuprints.ulb.tu-darmstadt.de/6578/1/Diss_U.Poell.pdf S-nitrosylation of Inhibitor-κB kinase: Identifying Novel Targets of Curcumin. Ning-Jo Kao, Chien-Sheng Wu, Jia-Yuan Hu, and Zwe-Ling Kong. Journal of Food and Nutrition Research, September 2016; 4(9): 600-609. http://pubs.sciepub.com/jfnr/4/9/7/ High-Throughput Toxicity and Phenotypic Screening of 3D Human Neural Progenitor Cell Cultures on a Microarray Chip Platform. Gregory J. Nierode, Brian C. Perea, Sean K. McFarland, Jorge F. Pascoal, Douglas S. Clark, David V. Schaffer, and Jonathan S. Dordick. Stem Cell Reports, 8 November 2016; 7(5): 970-982 (MicroSys 5100 4SQ) http://www.sciencedirect.com/science/article/pii/S221367111630220X High frequency performance characterization of super-fine inkjet printed silver traces. Ying Ying Lim, Masahiro Aoyagi, Yee Mey Goh, and Changqing Liu. In: CPMT Symposium Japan (ICSJ), 7-9 November 2016, IEEE, pp. 239-242. Non-fouling polymeric surface modification and signal amplification method for biomolecular detection. Inventor: Ashutosh Chilkoti United States Patent: US 9493823 B2, Publication Date: 15 November 2016; (MicroSys 5100) https://www.google.com/patents/US9493823 Non-fouling polymeric surface modification and signal amplification method for biomolecular detection. Inventor: Ashutosh Chilkoti U.S. Patent Application: 2016/0333392 A1, Publication Date: 17 November 2016; (MicroSys 5100) https://www.google.com/patents/US20160333392 Structural and functional probing of PorZ, an essential bacterial surface component of the type-IX secretion system of human oral-microbiomic Porphyromonas gingivalis. Anna M. Lasica, Theodoros Goulas, Danuta Mizgalska, Xiaoyan Zhou, Iñaki de Diego, Mirosław Ksiazek, Mariusz Madej et al. Yonghua Guo, Tibisay Guevara, Magdalena Nowak, Barbara Potempa, Apoorv Goel, Maryta Sztukowska, Apurva T. Prabhakar, Monika Bzowska, Magdalena Widziolek, Ida B. Thøgersen, Jan

J. Enghild, Mary Simonian, Arkadiusz W. Kulczyk, Ky-Anh Nguyen, Jan Potempa & F. Xavier Gomis-Rüth Scientific Reports, 24 November 2016; 6: 37708 (MicroSys 4000XL) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121618/pdf/srep37708.pdf Multiplex 16S rRNA-derived geno-biochip for detection of 16 bacterial pathogens from contaminated foods. Hwa Hui Shin, Byeong Hee Hwang, and Hyung Joon Cha. Biotechnology Journal, November 2016; 11(11): 1405-1414 (MicroSys 5100) http://onlinelibrary.wiley.com/doi/10.1002/biot.201600043/full Microarray Spotter and Printing Technologies. Akshata Datar, Dong Woo Lee, Sang Youl Jeon, and Moo-Yeal Lee. In: Microarray Bioprinting Technology, 20 December 2016; Springer International Publishing, pp. 19-51. Structure of RagB, a major immunodominant outer-membrane surface receptor antigen of Porphyromonas gingivalis. Theodoros Goulas, Irene Garcia Ferrer, Justin A. Hutcherson, Barbara A. Potempa, Jan Potempa, David A. Scott, and F. Xavier Gomis-Rüth. Molecular Oral Microbiology, December 2016; 31(6): 472-485. (MicroSys 4000XL) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823178/ A Comparison of Nanoparticle-Antibody Conjugation Strategies in Sandwich Immunoassays Justina O. Tam, Helena de Puig, Chun-wan Yen, Irene Bosch, Jose Gómez-Márquez, Charles Clavet, Kimberly Hamad-Schifferli & Lee Gehrke Journal of Immunoassay and Immunochemistry, 2016 2015 Method of making a hydrogel. Inventors: Catherine Louise Ruby Merry, Alberto Saiani, Kate Alexandra Meade, Emma Tranquility Lowe, Aline Fiona Saiani, and Jean-Baptiste Guilbaud. U.S. Patent Application: 2015/0030681 A1, Publication Date: 29 January 2015 (MicroSys 5100 4SQ) https://www.google.com/patents/US20150030681 A novel mechanism of latency in matrix metalloproteinases. Mar López-Pelegrín, Miroslaw Ksiazek, Abdulkarim Y. Karim, Tibisay Guevara, Joan L. Arolas, Jan Potempa, and F. Xavier Gomis-Rüth. Journal of Biological Chemistry, 20 February 2015; 290(8): 4728-4740. (MicroSys 4000XL) http://www.jbc.org/content/290/8/4728.full Development of a high-throughput screen for the identification of novel antifungal drug candidates. Inventors: Anand K. Ramasubramanian, Jose L. Lopez-Ribot, Anand Srinivasan, and Priya Uppuluri. United States Patent: US 8962531 B2, Publication Date: 24 February 2015. https://www.google.com/patents/US8962531

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses. Chun-Wan Yen, Helena de Puig, Justina O. Tam, José Gómez-Márquez, Irene Bosch, Kimberly Hamad-Schifferli, and Lee Gehrke. Lab on a Chip, 7 April 2015; 15(7): 1638-1641. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375736/ IL-6 binding molecules. Inventors: Christophe Blanchetot, Johannes De Haard, Torsten Dreier, Natalie De Jonge, Woning Paul Sebastian Van Der, and Nicolas Ongenae. U.S. Patent Application: 2015/0140011 A1, Publication Date: 21 May 2015; (MicroSys SQ) http://www.freepatentsonline.com/y2015/0140011.html Validation of a Combinatorial Approach Toward the Discovery of Electrolyte Formulations for Lithium-Ion Batteries Zhange Feng, Charles A. Cartier, and Daniel Scherson. In: The Electrochemical Society, Meeting Abstracts, 26 May 2015; 2: 413. http://ma.ecsdl.org/content/MA2015-01/2/413.short A C-type lectin isolated from the skin of Japanese bullhead shark (Heterodontus japonicus) binds a remarkably broad range of sugars and induces blood coagulation. Shigeyuki Tsutsui, Yuma Dotsuta, Ayaka Ono, Masanari Suzuki, Hiroaki Tateno, Jun Hirabayashi, and Osamu Nakamura. Journal of Biochemistry, May 2015; 157(5): 345-356. (MicroSys4000) Microbial testing devices, methods of making microbial testing devices and methods of identifying novel antimicrobial drug candidates. Inventors: Anand K. Ramasubramanian, Jose L. Lopez-Ribot, and Anand Srinivasan. U.S. Patent Application: 2015/0167046 A1, Publication Date: 18 June 2015; https://www.google.com/patents/US20150167046 Thermal Reaction Device and Method for Using the Same. Inventors: Marc A. Unger, Lincoln McBride, and Geoffrey Facer. U.S. Patent Application: 20150174575 A1, Publication Date: 25 June 2015; (MicroSys5100) https://www.google.com/patents/US20150174575 Structure and mechanism of a bacterial host-protein citrullinating virulence factor, Porphyromonas gingivalis peptidylarginine deiminase. Theodoros Goulas, Danuta Mizgalska, Irene Garcia-Ferrer, Tomasz Kantyka, Tibisay Guevara, Borys Szmigielski, Aneta Sroka, Claudia Millán, Isabel Usón, Florian Veillard, Barbara Potempa, Piotr Mydel, Maria Solà, Jan Potempa & F. Xavier Gomis-Rüth Scientific Reports, 1 July 2015; 5: 11969, 17 pp. (MicroSys4000XL) http://www.nature.com/articles/srep11969?WT.ec_id=SREP-631-20150707&spMailingID=49041640&spUserID=ODkwMTM2NjQzMAS2&spJobID=720800260&spReportId=NzIwODAwMjYwS0 A Combinatorial Approach toward the Discovery of Electrolyte Formulations for Non-Aqueous Electrochemical Energy Storage Devices. Charles Cartier, Zhange Feng, Jim Faulk, and Daniel Scherson. ECS Electrochemistry Letters, 16 July 2015; 4(9): A110-A114.

http://eel.ecsdl.org/content/4/9/A110.full.pdf+html Camelid Ig V genes reveal significant human homology not seen in therapeutic target genes, providing for a powerful therapeutic antibody platform. Alex Klarenbeek, Khalil El Mazouari, Aline Desmyter, Christophe Blanchetot, Anna Hultberg, Natalie de Jonge, Rob C. Roovers, Christian Cambillau, Sylvia Spinelli, Jurgen Del-Favero, Theo Verrips, Hans J de Haard, and Ikbel Achour MAbs, July-August 2015; 7(4): 693-706. (MicroSys SQ) http://europepmc.org/articles/pmc4622956 Crystal structure of human platelet phosphofructokinase-1 locked in an activated conformation. Marco Kloos, Antje Brüser, Jürgen Kirchberger, Torsten Schöneberg, and Norbert Sträter. Biochemical Journal, 1 August 2015; 469(3): 421-432. Microfluidic assay devices and methods. Inventors: Hany Ramez Nassef, Hou-Pu Chou, Michael Lucero, Andrew May, and Kathy Yokobata. United States Patent: US 9103825 B2, Publication Date: 11 August 2015. (MicroSys 5100) https://www.google.com/patents/US9103825 Crystal structure of insulin-regulated aminopeptidase with bound substrate analogue provides insight on antigenic epitope precursor recognition and processing. Anastasia Mpakali, Emmanuel Saridakis, Karl Harlos, Yuguang Zhao, Athanasios Papakyriakou, Paraskevi Kokkala, Dimitris Georgiadis, and Efstratios Stratikos. The Journal of Immunology, 15 September 2015; 195(6): 2842-2851. (MicroSys4000) A Combinatorial Approach toward the Discovery of Electrolyte Formulations for Non-Aqueous Electrochemical Energy Storage Devices. Charles Cartier, Zhange Feng, Jim Faulk, and Daniel Scherson. ECS Electrochemistry Letters, September 2015; 4(9): A110-A114. http://eel.ecsdl.org/content/4/9/A110.full Structure of RagB, a major immunodominant outer-membrane surface receptor antigen of Porphyromonas gingivalis. T. Goulas, I. Garcia-Ferrer, J. A. Hutcherson, B. A. Potempa, J. Potempa, D. A. Scott, and F. Xavier Gomis-Rüth. Molecular Oral Microbiology, 6 October 2015; published ahead of print (MicroSys 4000XL) Development and Implementation of Methods for Electrocatalysis, Electroanalytical Chemistry and Energy Storage Applications. Zhange Feng PhD Theses, 26 October 2015; Case Western Reserve University, 96 pp. Structure and binding properties of a cameloid nanobody raised against KDM5B. Anders Wiuf, Line Hyltoft Kristensen, Ole Kristensen, Jerzy Dorosz, Jonas Jensen, and Michael Gajhede. Acta Crystallographica Sec. F: Structural Biology Commns, October 2015; 71(10): 1235-1241. Biomolecule interaction using atomic force microscope. Inventors: Joon Won Park, Yu Jin Jung, Bong Jin Hong, Saul Tendler, and Stephanie Allen. United States Patent: US 9175335 B2, Publication Date: 3 November 2015; (MicroSys 5100) https://www.google.com/patents/US9175335

Mechanisms of proteolytic activity regulation exerted via a unique propeptide in matrix metalloproteinases and intra/intermolecular interactions in a novel family of minimal gluzincins. Maria del Mar López Pelegrín PhD Theses, 13 November 2015; Universitat de Barcelona, 171 pp. (MicroSys 4000XL) http://www.tdx.cesca.cat/handle/10803/347212 Size-controlled macromolecule. Inventors: Joon Won Park, Bong Jin Hong, Young Seo Choi, Soon Jin Oh, and Kwan Yong Choi. United States Patent: US 9201067 B2, Publication Date: 1 December 2015 (MicroSys 5100). https://www.google.com/patents/US9201067 A Hard Pill to Swallow: Viable Regulation of 3-D Printed Pharmaceuticals Victoria R. Graf Albany Law Journal of Science and Technology, 2015; 25: 593-623. http://www.albanylawjournal.org/Documents/Articles/25.3.593-Graf.pdf Structural and functional studies on Escherichia coli α2 macroglobulin: a snap-trap peptidase. Irene Garcia Ferrer PhD Theses, 2015; Universitat de Barcelona, Spain, 105 pp. (MicroSys 4000XL) 2014 Expression, purification, crystallization and preliminary X-ray diffraction analysis of the novel modular DNA-binding protein BurrH in its apo form and in complex with its target DNA. Stefano Stella, Rafael Molina, Claudia Bertonatti, Alexandre Juillerrat, and Guillermo Montoya. Acta Crystallographica Section F: Structural Biology Communications, January 2014; 70(1): 87-91. http://journals.iucr.org/f/issues/2014/01/00/bo5131/index.html Estructura cristalográfica de la β-lactamasa OXA-24: bases estructurales que determinan su actividad carbapenemasa Santillana Heras, Elena. PhD Theses, January 2014; Universidad Autónoma de Madrid, 149 pp. Polynucleotide synthesis on a modified surface. Inventors: Joon-Won Park, and Bong-Jin Hong. United States Patent: US 8647823 B2, Publication Date: 11 February 2014; (MicroSys 5100) https://www.google.com/patents/US8647823 Drug susceptibility of matrix-encapsulated Candida albicans nano-biofilms. Anand Srinivasan, Celia Macias Gupta, C. Agrawal, Kai P. Leung, Jose L. Lopez-Ribot, and Anand K. Ramasubramanian. Biotechnology and Bioengineering, February 2014; 111(2): 418-424 http://www.researchgate.net/profile/Anand_Ramasubramanian/publication/257648438_Drug_susceptibility_of_matrix-encapsulated_Candida_albicans_nano-biofilms/links/02e7e537288cdc95eb000000.pdf Crystallization and preliminary X-ray diffraction analysis of the homing endonuclease I-CvuI from Chlorella vulgaris in complex with its target DNA.

Pilar Redondo, Nekane Merino, Maider Villate, Francisco J. Blanco, Guillermo Montoya, and Rafael Molina. Acta Crystallographica Sect. F: Structural Biology Communications, February 2014; 70(2): 256-259. http://www.researchgate.net/profile/Rafael_Molina4/publication/259752645_Crystallization_and_preliminary_X-ray_diffraction_analysis_on_the_homing_endonuclease_of_Chlorella_vulgaris_I-CvuI_in_complex_with_its_target_DNA/links/0f31752ea2ecf01d73000000.pdf Printing and encapsulation of electrical conductors on polylactic acid (PLA) for sensing applications. Andres Vasquez Quintero, Nathalie Frolet, Daniel Marki, Alexis Marette, Giorgio Mattana, Danick Briand, and Nico F. de Rooij. In: Micro Electro Mechanical Systems (MEMS), 2014 IEEE 27th International Conference, February 2014; pp. 532-535. Biomolecule interaction using atomic force microscope. Inventors: Joon Won Park, Yu Jin Jung, Bong Jin Hong, Saul Tendler, and Stephanie Allen. United States Patent: US 8673621 B2, Publication Date: 18 March 2014; (MicroSys 5100) https://www.google.com/patents/US8673621 A Rapid, Direct, Quantitative, and Label-Free Detector of Cardiac Biomarker Troponin T Using Near-Infrared Fluorescent Single-Walled Carbon Nanotube Sensors. Jingqing Zhang, Sebastian Kruss, Andrew J. Hilmer, Steven Shimizu, Zeke Schmois, Flor De La Cruz, Paul W. Barone, Nigel F. Reuel, Daniel A. Heller, and Michael S. Strano. Advanced Healthcare Materials, March 2014; 3(3): 412-423 Purification, crystallization and preliminary X-ray diffraction analysis of the kinase domain of human tousled-like kinase 2. Ana M. Garrote, Pilar Redondo, Guillermo Montoya, and Inés G. Munoz. Acta Crystallographica Section F: Structural Biology Communications, March 2014; 70(3): 354-357. http://journals.iucr.org/f/issues/2014/03/00/rl5059/index.html Crystallization and preliminary crystallographic analysis of human muscle phosphofructokinase, the main regulator of glycolysis. Marco Kloos, A. Bruser, Juergen Kirchberger, T. Schoneberg, and N. Strater. Acta Crystallographica Section F: Structural Biology Communications, May 2014; 70(5): 578-582. Purification, crystallization and preliminary X-ray diffraction analysis of GatD, a glutamine amidotransferase-like protein from Staphylococcus aureus peptidoglycan. Diana Vieira, Teresa A. Figueiredo, Anil Verma, Rita G. Sobral, Ana M. Ludovice, Herminia de Lencastre, and Jose Trincao. Acta Crystallographica Section F: Structural Biology Communications, May 2014; 70(5): 632-635 Structure of the epimerization domain of tyrocidine synthetase A. Stefan A. Samel, Paul Czodrowski, and L-O. Essen. Acta Crystallographica Section D: Biological Crystallography, May 2014; 70(5): 1442-1452. (MicroSys 4004) The crystal structure of a Cardiovirus RNA-dependent RNA polymerase reveals an unusual conformation of the polymerase active site.

Laia Vives-Adrian, Celia Lujan, Baldo Oliva, Lonneke van der Linden, Barbara Selisko, Bruno Coutard, Bruno Canard, Frank JM van Kuppeveld, Cristina Ferrer-Orta, and Núria Verdaguer. Journal of Virology, May 2014; 88(10): 5595-5607. (MicroSys 4000 XL) http://jvi.asm.org/content/88/10/5595.full Microfluidic Devices And Methods Of Using Same Inventors: Lincoln Mcbride, Michael Lucero, Marc Unger, Hany Ramez Nassef, Geoffrey Facer European Patent: EP 1 615 721 B1, Publication Date: 18 June 2014; (MicroSys 5100) http://www.google.com/patents/EP1615721B1?cl=deFl Expression and purification of integral membrane metallopeptidase HtpX. Joan L. Arolas, Raquel García-Castellanos, Theodoros Goulas, Yoshinori Akiyama, and F. Xavier Gomis-Rüth. Protein Expression and Purification, July 2014; 99: 113-118. (MicroSys 4000 XL) http://digital.csic.es/bitstream/10261/101844/1/Arolas_PEP_2014_corrMs.pdf Lectin-Microarray Technique for Glycomic Profiling of Fungal Cell Surfaces. Azusa Shibazaki, and Tohru Gonoi. Methods in Molecular Biology, July 2014; 1200 (Lectins): 287-294. (MicroSys 4000) Directed Evolution of Lectins by an Improved Error-Prone PCR and Ribosome Display Method. Dan Hu, Hiroaki Tateno, and Jun Hirabayashi. Methods in Molecular Biology, July 2014; 1200 (Lectins): 527-538. (MicroSys 4000) Multiple stable conformations account for reversible concentration-dependent oligomerization and autoinhibition of a metamorphic metallopeptidase Mar López-Pelegrín, Núria Cerdà-Costa, Anna Cintas-Pedrola, Fátima Herranz-Trillo, Pau Bernadó, Juan R. Peinado, Joan L. Arolas, and F. Xavier Gomis-Rüth Angewandte Chemie Int Ed Engl., 26 September 2014; 53(40): 10624-10630 (MicroSys 4000XL) http://digital.csic.es/bitstream/10261/124304/4/LopezPelegrin_ACIE_manus%2Bsuppl_rev3.pdf Structure and Mechanism of Cysteine Peptidase Gingipain K (Kgp), a Major Virulence Factor of Porphyromonas gingivalis in Periodontitis. Iñaki de Diego, Florian Veillard, Maryta N. Sztukowska, Tibisay Guevara, Barbara Potempa, Anja Pomowski, James A. Huntington, Jan Potempa, and F. Xavier Gomis-Rüth. Journal of Biological Chemistry, 29 September 2014; 289(46): 32291-32302. (MicroSys 4000 XL) Biomolecule Interaction Using Atomic Force Microscope. Inventors: Joon Won Park, Yu Jin Jung, Bong Jin Hong, Saul Tendler, and Stephanie Allen. US Patent Application: 2014/0315319 A1, Publication Date: 23 October 2014. (MicroSys 5100) http://www.freepatentsonline.com/y2014/0315319.html A C-type lectin isolated from the skin of Japanese bullhead shark (Heterodontus japonicus) binds a remarkably broad range of sugars and induces blood coagulation. Shigeyuki Tsutsui, Yuma Dotsuta, Ayaka Ono, Masanari Suzuki, Hiroaki Tateno, Jun Hirabayashi, and Osamu Nakamura. Journal of Biochemistry, 29 November 2014; 10-1093/jb/mvu080. (MicroSys 4000) Structure-function Relationships in Wax Producing Enzymes. Steffen Justus Kawelke

PhD Theses, 3 December 2014; Georg-August-Universität Göttingen, 180 pp. https://d-nb.info/1102535524/34 2013 Microfluidic device and methods of using same. Inventors: Marc A. Unger, Ian David Manger, Michael Lucero, Yong Yi, Emily Miyashita-Lin, Anja Wienecke, Geoffrey Facer European Patent: EP1463796 B1, Publication Date: 9 January 2013 http://www.freepatentsonline.com/EP1463796.html Size-controlled macromolecule. Inventors: Joon Won Park, Bong Jin Hong, Young Seo Choi, Soon Jin Oh, Kwan Yong Choi European Patent: EP1664341 B1, Publication Date: 30 January 2013 http://www.freepatentsonline.com/EP1664341.html Non-fouling polymeric surface modification and signal amplification method for biomolecular detection. Inventor: Ashutosh Chilkoti United States Patent: US 8367314 B2, Publication Date: 5 February 5 2013; (MicroSys 5100) https://www.google.com/patents/US8367314 Development of a high-throughput screen for the identification of novel antifungal drug candidates Inventors: Anand K. Ramasubramanian, Jose L. Lopez-Ribot, Anand Srinivasan, Priya Uppuluri, US Patent Application: 20130040854 A1, Publication Date: 14 February 2013 http://www.freepatentsonline.com/y2013/0040854.html Crystallization and preliminary X-ray analysis of membrane-bound pyrophosphatases. Juho Kellosalo, Tommi Kajander, Riina Honkanen, and Adrian Goldman. Molecular Membrane Biology, February 2013; 30(1): 64-74. Structural analysis of coniferyl alcohol 9-O-methyltransferase from Linum nodiflorum reveals a novel active-site environment. Stefan Wolters, Manuel Neeb, Anna Berim, J. Schulze Wischeler, M. Petersen, and A. Heine. Acta Crystallographica Sec D: Biol. Crystallogr., May 2013; 69(5): 888-900. (MicroSys SQ 4000) Low dead volume extraction column device. Inventors: Douglas T. Gjerde, and Christopher P. Hanna. United States Patent: US 8501116 B2, Publication Date: 6 August 2013; https://www.google.com/patents/US8501116 Biochemical characterization of the Nup62·58·54 nucleoporin complex and mutational analysis of the exportin CRM1. Hema Chug PhD Theses, September 2013; Georg August University Göttingen, 119 pp.

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http://patent.ipexl.com/U2S/20120149600ZZDASHZZA1.html Structure of the regulatory domain of the LysR family regulator NMB2055 (MetR-like protein) from Neisseria meningitidis . Sarah Sainsbury, Jingshan Ren, Nigel J. Saunders, David I. Stuart, and Raymond J. Owens. Acta Crystallographica, Sect F Struct Biol Cryst Commun., 1 July 2012; 68(7): 730-737. http://bura.brunel.ac.uk/bitstream/2438/6672/2/Fulltext.pdf High-Throughput Transfection of Interfering RNA into a 3D Cell-Culture Chip. Haiyuan Zhang, Moo-Yeal Lee, Michael G. Hogg, Jonathan S. Dordick, and Susan T. Sharfstein. Small, 9 July 2012; 8(13): 2091-2098. Two crucial early steps in RNA synthesis by the hepatitis C virus polymerase involve a dual role of residue 405. Nathalie Scrima, Célia Caillet-Saguy, Michel Ventura, Déborah Harrus, Thérèse Astier-Gin, and Stéphane Bressanelli. Journal of Virology, July 2012; 86(13): 7107-7117. http://jvi.asm.org/content/86/13/7107.full.pdf+html Functional interaction analysis of GM1-related carbohydrates and Vibrio cholerae toxins using carbohydrate microarray. Chang Sup Kim, Jeong Hyun Seo, and Hyung Joon Cha. Analytical Chemistry, 7 August 2012; 84(15): 6884-6890. Bioactive cyclometalated phthalimides: design, synthesis and kinase inhibition. Sebastian Blanck, Yann Geisselbrecht, Katja Kräling, Stephen Middel, Thomas Mietke, Klaus Harms, Lars-Oliver Essen, and Eric Meggers. Dalton Transactions, 21 August 2012; 41(31): 9337-9348. Comparison of signal enhancement techniques for screening GM crops. Atsushi Ito, Tomoyuki Taguchi, Takeyuki Mogi, Hitoshi Wake, Takeo Tanaami, Hiroshi Akiyama, ReikoTeshima, Nobuhiro Sasaki, Akiyo Yamada, Yoshihiro Ozeki Japanese J. Food Chemistry and Safety, 24 August 2012; 19(2): 141-148 (MycroSys4100) http://ci.nii.ac.jp/els/110009489101.pdf?id=ART0009957224&type=pdf&lang=en&host=cinii&order_no=&ppv_type=0&lang_sw=&no=1446059313&cp= Crystallization and preliminary crystallographic studies of FoxE from Rhodobacter ferrooxidans SW2, an Fe(II) oxidoreductase involved in photoferrotrophy. L. Pereira, I. H. Saraiva, R. Coelho, D. K. Newman, R. O. Louro, and C. Frazao Acta Crystallographica, Sect F Struct Biol Cryst Commun., 1 September 2012; 68(9): 1106-1108. http://authors.library.caltech.edu/34983/1/fw5375.pdf Structure-based characterization of the multimodular Developmentally Regulated GTPase in complex with the DRG family regulatory protein. Sandrea Maureen Francis PhD Theses, 10 September 2012; Universidad Autónoma de Madrid, 145 pp. (MicroSys Honeybee) http://digital.csic.es/bitstream/10261/63149/1/THESIS%20SandreaMF.pdf

Analysis of density-dependent binding of glycans by lectins using carbohydrate microarrays. Xizhe Tian, Jaeyoung Pai, and Injae Shin. Chemistry, an Asian Journal, September 2012; 7(9): 2052-2060. Modeling of Piezo-Actuated Stick-Slip Micro-drives: An Overview. Ha Xuan Nguyen, Christoph Edeler, and Sergej Fatikow. Advances in Science and Technology, September 2012 (on-line); 81(Next Generation Micro/Nano Systems): 39-48. Method for detection of mutant alleles. Inventors: Geoffrey Facer, Marc A. Unger, Lincoln Mcbride EU Patent Application: EP2518161 A1, Publication Date: 31 October 2012 http://www.freepatentsonline.com/EP2518161.html Expression, purification, crystallization and preliminary X-ray diffraction analysis of the dihydroorotase domain of human CAD. Nada Lallous, Araceli Grande-Garcia, Rafael Molina, and Santiago Ramon-Maiques. Acta Crystallographica, Sect F Struct Biol Cryst Commun., 1 November 2012; 68(11):1341-5. High-Throughput Profiling of Peptide–RNA Interactions Using Peptide Microarrays. Jaeyoung Pai, Taejin Yoon, Nam Doo Kim, Im-Soon Lee, Jaehoon Yu, and Injae Shin. Journal of the American Chemical Society, 21 November 2012; 134(46): 19287-19296. Crystallization and preliminary X-ray analysis of the open form of human ecto-5'-nucleotidase (CD73). Karen Maree Knapp, Matthias Zebisch, and Norbert Strater. Acta Crystallographica, Sect F Struct Biol Cryst Commun., 1 December 2012; 68(12): 1545-1549 Influence of a three-dimensional, microarray environment on human cell culture in drug screening systems. Luciana Meli, Eric T. Jordan, Douglas S. Clark, Robert J. Linhardt, Jonathan S. Dordick Biomaterials, December 2012; 33(35): 9087-9096. Carbohydrate Microarrays for Enzymatic Reactions and Quantification of Binding Affinities for Glycan–Protein Interactions. Myung-Ryul Lee, Sungjin Park, and Injae Shin. Methods Mol Biology, Carbohydrate Microarrays, 2012; 808: 103-116. 2011 Rapid simultaneous screening of seven clinically important enteric pathogens using a magnetic bead based DNA microarray. Hong Sun, Qiu-Hua Mo, Ji-Can Lin, Ze Yang, Cheng-Ning Tu, Da-Yong Gu, Lei Shi, Wei-Ping Lu. World Journal of Microbiology and Biotechnology, January 2011; 27(1): 163-169. Single domain intracellular antibodies from diverse libraries emphasizing dual functions of LMO2 protein interactions using a single VH domain.

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Takao Fujii, Hiroyuki Sugino, Joseph D. Rouse, Kenji Furukawa Journal of Bioscience and Bioengineering, 2002; 94(5): 412-418 2001 Automated simultaneous detection of low levels of Listeriae and Salmonellae in foods Hui Peng, Leora A. Shelef International Journal of Food Microbiology, 15 February 2001; 63(3): 225-233 2000 A new rapid automated method for the detection of Listeria from environmental swabs and sponges. R. Firstenberg-Eden, L.A. Shelef International Journal of Food Microbiology, 1 June 2000; 56(2-3): 231-7. Rapid detection of low levels of Listeria in foods and next-day confirmation of L. monocytogenes. Hui Peng and Leora A. Shelef J Microbiol Methods, July 2000; 41(2):113-20. The application of ViewLux for the imaging of a GPCR melanophore assay in miniaturised plate formats Nicola Bevan, Stuart Baddeley, Karen Amaratunga, Yvonne Clements, Steve Rees SBS Conference, September 2000; (Melanophore cells) 1999 Automated detection of Salmonella spp. in foods. Wei Tan and Leora A. Shelef. J Microbiol Methods, 1 July 1999; 37(1): 87-91.