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microsoft powerpoint - recurrent astrocytoma

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Recurrent Astrocytoma Prof. Nadia Mokhtar

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Page 1: Microsoft PowerPoint - Recurrent Astrocytoma

RecurrentAstrocytomaProf. Nadia Mokhtar

Page 2: Microsoft PowerPoint - Recurrent Astrocytoma

Classification & GRADING (WHO, 2000)

• Grade I: Pilocytic astrocytoma

• Grade II: Astrocytoma* Fibrillary* Protoplasmic* Gemistocytic

• Grade III: Anaplastic astrocytoma

• Grade IV: Glioblastoma multiforme & gliosarcoma

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Pilocytic astrocytoma

Page 4: Microsoft PowerPoint - Recurrent Astrocytoma
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Diffuse astrocytomasGrade IIHigh cellularity

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Anaplastic astrocytoma, grade III

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Glioblastoma multiformeGrade IV

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Molecular PathogenesisOf Astrocytomas

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Prognostic Factors

I: Tumor-related factors:• Histologic grade• Tumor size• Tumor site: pons tumors carry worse prog• Necrosis• Proliferation• Genetic alterations

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Ki-67

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Prognostic Factors (cont)

II Host-related Factors• Age: younger age • Pre-operative status: performance status

III Treatment-related Factors• Extent of resection• Adjuvant therapy


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