microsoft power point tm overview sept 15
DESCRIPTION
Time Medical_MRITRANSCRIPT
1
TJ RobertsonChief Operating OfficerTIME MEDICAL Systems
September 15, 2010
TIME MEDICALSYSTEMS
A brief introductionA brief introduction
2
TIME MEDICALSYSTEMS
Professor Q.Y. Ma, PhDProfessor Q.Y. Ma, PhD
Founder,Founder,Chairman & CEOChairman & CEO
3
Professor Q.Y. Ma, PhDProfessor Q.Y. Ma, PhD
Founder,Founder,Chairman & CEOChairman & CEO
Founded on core technologyFounded on core technologydeveloped in the USA atdeveloped in the USA atColumbia University’sColumbia University’s
Translational Research Lab.Translational Research Lab.and later validated & refinedand later validated & refinedat Harvard Medical Schoolat Harvard Medical Schooland Hong Kong Universityand Hong Kong University
TIME MEDICALSYSTEMS
OurOur USAUSA--basedbased Team of Clinical AdvisorsTeam of Clinical Advisors
4
Professor William Bradley, M.D., PhDChairman of RadiologyUCSD Medical CenterUniversity of California, San Diego
Prof. Bradley has authored more than 160articles and 17 books on Radiology & MRI.
He is one of the world’s foremostauthorities in MRI & Radiology - and hasprovided 3 decades of critical leadershipacross clinical, technical, research andpolicy-making initiatives.
Professor Ferenc Jolesz, M.D.Director of the MRI DivisionBrigham & Women’s HospitalHarvard Medical School
Prof. Jolesz has published over 300articles and book chapters on Surgery,Computer Science, Neurology,Neurosurgery, Radiology and MRI.
He is widely recognized for his pioneeringinnovations in Radiology and MRIResearch.
TIME MEDICALSYSTEMS
Our ChinaOur China--based Partnersbased Partners
5
Taizhou, Jiangsu May 31, 2010
TIME MEDICAL SYSTEMSproudly hosts Mr. Li Yuan Chao,
Chairman of theOrganization Department of the
Chinese Communist Party& former Secretary General of Jiangsuprovince. He is a strong supporter of
China Medical City
TIME MEDICALSYSTEMS
Our FacilitiesOur Facilities
TIME MEDICALSYSTEMS
6
TIME MEDICALSYSTEMS
TIME MEDICALSYSTEMS
R&D FacilityR&D Facility
HongHong KongKong
HK ScienceHK Science ParkPark
7
R&D FacilityR&D Facility
HongHong KongKong
HK ScienceHK Science ParkPark
TIME MEDICALSYSTEMS
R&D FacilityR&D Facility
SingaporeSingapore
Int’l Business ParkInt’l Business Park
8
R&D FacilityR&D Facility
SingaporeSingapore
Int’l Business ParkInt’l Business Park
TIME MEDICALSYSTEMS
R&D FacilityR&D Facility
ShanghaiShanghai
ZhangjiangZhangjiangHiHi--tech Parktech Park
9
R&D FacilityR&D Facility
ShanghaiShanghai
ZhangjiangZhangjiangHiHi--tech Parktech Park
TIME MEDICALSYSTEMS
R&D FacilityR&D Facility
San DiegoSan Diego
UCSD Medical CenterUCSD Medical Center
10
R&D FacilityR&D Facility
San DiegoSan Diego
UCSD Medical CenterUCSD Medical Center
TIME MEDICALSYSTEMS
Production FacilityProduction Facility
TaizhouTaizhou
China Medical CityChina Medical City
11
Production FacilityProduction Facility
TaizhouTaizhou
China Medical CityChina Medical City
TIME MEDICALSYSTEMS
A brief historyA brief history
MRI Innovations
12
MRI Innovations
Higher B0 = higher SNR
The trend of using higherfield strengths to improveSNR is coming to an end,driven mainly by the need forcost-containment andregulatory constraintsplaced on clinical MRI < 4T.
TIME MEDICALSYSTEMS
Magnetic Fields (B0)
13
Higher B0 = higher SNR
The trend of using higherfield strengths to improveSNR is coming to an end,driven mainly by the need forcost-containment andregulatory constraintsplaced on clinical MRI < 4T.
In spite of RF Array Coil improvements,copper RF coils are the dominant sourceof noise in the MR image.
HTS materials are now considered thebest solution for improving SNR.
TIME MEDICALSYSTEMS
Radio Frequency (RF) Coils
14
In spite of RF Array Coil improvements,copper RF coils are the dominant sourceof noise in the MR image.
HTS materials are now considered thebest solution for improving SNR.
Phantom image comparison:
(a) signal intensity plot and(b) corresponding cropped images
Room temperature copper
Cooled copper
HTS coil
TIME MEDICAL SYSTEMSbrings HTS RF Technology
to the MRI market.
On June 1, 2010 Professor Ma andhis team received Patent approval
for the development of the 1st“INTEGRATED SUPERCONDUCTOR
MR IMAGING SYSTEM”
According to Prof. Ma“This marks the beginning of the
SUPER MRI era!”
TIME MEDICALSYSTEMS High Temperature
Superconductors (HTS)
15
TIME MEDICAL SYSTEMSbrings HTS RF Technology
to the MRI market.
On June 1, 2010 Professor Ma andhis team received Patent approval
for the development of the 1st“INTEGRATED SUPERCONDUCTOR
MR IMAGING SYSTEM”
According to Prof. Ma“This marks the beginning of the
SUPER MRI era!”
TIME MEDICAL SYSTEMSbrings HTS RF Technology
to the MRI market.
On June 1, 2010 Professor Ma andhis team received Patent approval
for the development of the 1st“INTEGRATED SUPERCONDUCTOR
MR IMAGING SYSTEM”
According to Prof. Ma“This marks the beginning of the
SUPER MRI era!”
TIME MEDICALSYSTEMS
High TemperatureSuperconductors (HTS)
16
TIME MEDICAL SYSTEMSbrings HTS RF Technology
to the MRI market.
On June 1, 2010 Professor Ma andhis team received Patent approval
for the development of the 1st“INTEGRATED SUPERCONDUCTOR
MR IMAGING SYSTEM”
According to Prof. Ma“This marks the beginning of the
SUPER MRI era!”
TIME MEDICALSYSTEMS
The beginning of a new era:The beginning of a new era:
HTS MRI
17
HTS MRI
TIME MEDICALSYSTEMS
18
Hybridthe HTS System
TIME MEDICALSYSTEMS
Hybrid MONA
19
Hybrid MONAthe HTS System
TIME MEDICALSYSTEMS
The HTS breakthroughled to the new era of
low-cost, high-performanceMRI scanners.
Hybrid PICA (whole body) and Hybrid MONA(dedicated orthopedic) MRI scanners are the
first MRI scanners to take advantage ofHTS RF Coil Technology.
Operating in conventional or HTS mode,the Hybrid PICA and Hybrid MONA MRI scanners
enable a full range of clinical applications,with competitive IQ and scan time.
20
The HTS breakthroughled to the new era of
low-cost, high-performanceMRI scanners.
Hybrid PICA (whole body) and Hybrid MONA(dedicated orthopedic) MRI scanners are the
first MRI scanners to take advantage ofHTS RF Coil Technology.
Operating in conventional or HTS mode,the Hybrid PICA and Hybrid MONA MRI scanners
enable a full range of clinical applications,with competitive IQ and scan time.
TIME MEDICALSYSTEMS
The news of HTS is getting out.And the recognition is coming in.
On June 24, 2010 Professor Ma and histeam accepted the award for
2010 Medical Imaging ProductInnovation of the Year!
21
The news of HTS is getting out.And the recognition is coming in.
On June 24, 2010 Professor Ma and histeam accepted the award for
2010 Medical Imaging ProductInnovation of the Year!
TIME MEDICALSYSTEMS
A brief summaryA brief summary
MRI Markets,Opportunities
& Trends
22
MRI Markets,Opportunities
& Trends
TIME MEDICALSYSTEMS
2,000 MRI systems sold annually / USD $5 Billion annual market
16% annual growth rate
22,000 MRI systems installed globally
30 MRI units per 1M population (USA/Japan)
1.5 MRI units per 1M population (China)
< 1 MRI unit per 1M population (Developing markets)
Approximate Customer Realized Price in Developed Markets (in USD) $3M - Ultra High-field (3T) $1.5M - High-field (1.5T) $500K - Low-field (0.35T)
Global MRI Market and TM opportunityGlobal MRI Market and TM opportunity
0
1000
2000
3000
4000
5000
6000
7000
8000
9000
2008 2009 2010 2011 2012 2013 2014 2015
GlobalMRI forecast in Mio. USD
2,000 MRI systems sold annually / USD $5 Billion annual market
16% annual growth rate
22,000 MRI systems installed globally
30 MRI units per 1M population (USA/Japan)
1.5 MRI units per 1M population (China)
< 1 MRI unit per 1M population (Developing markets)
Approximate Customer Realized Price in Developed Markets (in USD) $3M - Ultra High-field (3T) $1.5M - High-field (1.5T) $500K - Low-field (0.35T)
0
1000
2000
3000
4000
5000
6000
7000
8000
9000
2008 2009 2010 2011 2012 2013 2014 2015
TIME MEDICALSYSTEMS
Value!
24
Value!
TIME MEDICALSYSTEMS
Performance!
25
Performance!
TIME MEDICALSYSTEMS
Innovation!
26
Innovation!
TIME MEDICALSYSTEMS
Lowest cost of ownershipLowest cost of ownership
Value
27
Value
TIME MEDICALSYSTEMS
Fixed costs
Equipment Lease
$ / month
Service Contract
$ / month
Revenue per patient
$ / patient
28
Lowest break-even fixed costs in the MR industry!Based on xyz market figures
Breakeven
< x Patient per day
(y days / week)
TIME MEDICALSYSTEMS
29
TIME MEDICALSYSTEMS
Fixed costs
Equipment Lease
USD $8,800 / month
Service Contract
USD $4,100 / month
Revenue per patient
USD $360
30
Lowest break-even fixed costs in the MR industry!Based on Hong Kong market figures
Breakeven
< 2 Patient per day
(6 days / week)
TIME MEDICALSYSTEMS
Hardware, Software & Clinical ApplicationsHardware, Software & Clinical Applications
Performance
31
Performance
TIME MEDICALSYSTEMS
MONA / PICA Specs: Brains and Muscle
• 0.2T / 0.35T• Vertical Field, Open• 30 cm / 42cm opening• 5,500 kg / 17,000 kg• Auto Shimming
Magnet• SE, GE, FSE, FLAIR, STIR, IR-FSE,
Single Shot , 2D/3D TOF MRA• Single, multi-slice, radial, 3D volume
PulseSequences
32
• 25 mT/m / 33 mT/m (Amplitude)• 50 T/m/s / 90T/m/s (Slew Rate)• 0.5 ms / 0.37 ms (Rise Time)
Gradients
• CP: Head, C-Spine, Shoulder, Knee,Extremity, Wrist/Hand, Foot /Ankle –For both MONA & PICA
• CP: Breast, Flex Body (3 sizes) – ForPICA only
• Multi-Array L/S Spine
RF Coils
• FOV: 5cm – 42 cm• TR: 6 ms – 18 sec• TE: 4 ms (minimum)• Slice Thickness: 2D 2mm (min)• Slice Thickness: 3D 0.25m (min)
ImagingParameters
TIME MEDICALSYSTEMS
Easy-to-Operate Graphic User Interface
33
TIME MEDICALSYSTEMS
Efficient Siting
34
TIME MEDICALSYSTEMS
35
Site Planning Support
TIME MEDICALSYSTEMS
A brief look at the proofA brief look at the proof
MRI Images
36
MRI Images
TIME MEDICALSYSTEMS
37
TIME MEDICALSYSTEMS
38
TIME MEDICALSYSTEMS
HTS Head Coil
HTS Helmholtz Coil HTS Wrist Coil
Quad C-Spine Array CoilQuad Head Array Coil
Quad Body Array Coil
39
HTS Knee Coil
Quad Wrist Array Coil
Quad Ankle Array CoilQuad Knee Array Coil
Quad Shoulder Array Coil
Large FOV Spine Coil
TIME MEDICALSYSTEMS
Patient Comfort + Fast Scan Times =Patient Comfort + Fast Scan Times =
MRI for All…
40
MRI for All…
TIME MEDICALSYSTEMS
Hybrid MONA and PICA’s Open-design offerspatient comfort and fast acquisition times.
This ensures that scans are successfullycompleted on the most challenging patients.
Especially important for children, elderly &sedated patients, as well as those sufferingfrom claustrophobia.
41
Hybrid MONA and PICA’s Open-design offerspatient comfort and fast acquisition times.
This ensures that scans are successfullycompleted on the most challenging patients.
Especially important for children, elderly &sedated patients, as well as those sufferingfrom claustrophobia.
TIME MEDICALSYSTEMS
Patient Comfort
42
TIME MEDICALSYSTEMS
Fast Acquisition TimesThe 20 minute BRAIN MRI Scan
43
TIME MEDICALSYSTEMS
NonNon--obsolescence through HTSobsolescence through HTS
Innovation
44
Innovation
TIME MEDICALSYSTEMS
Copper RF coilsremain the dominant source of noise
in MR image.
HTS RF Coilsovercome this problem!
45
Copper RF coilsremain the dominant source of noise
in MR image.
HTS RF Coilsovercome this problem!
TIME MEDICALSYSTEMS
46
Phantom image comparison:
(a) signal intensity plot and(b) corresponding cropped images
Room temperature copper
Cooled copper
HTS coil
TIME MEDICALSYSTEMS
47
TIME MEDICALSYSTEMS
A brief comparisonA brief comparison
HTS Results
48
HTS Results
TIME MEDICALSYSTEMS
HTS vs. CopperHTS Coil Technology
0.35T
49
Copper Coil
SNR = 57
HTS Coil
SNR = 192
TIME MEDICALSYSTEMS
HTS Coil TechnologyHTS vs. Copper
0.2T
50
Copper Coil
SNR = 25
HTS Coil
SNR = 51
TIME MEDICALSYSTEMS
HTS vs. Cu RF Coil at 2THTS Coil Technology
51
HTS coil Cu surface coil Cu volume coil
2T Rat Brain in-vivo images using HTS surface coil.
The SNR ratio for is 8:4:1 respectively
TIME MEDICALSYSTEMS
1. LN / out Tubes
2. Vacuum Port
High Resolution InHigh Resolution In--Vivo MR MicroscopyVivo MR Microscopy
52
3. DC connector
4. Seal Screws
Rat brain images obtained in vivo with an HTS coil at 2.0T
25 µm resolution
Images courtesy of the NIH Center for In vivo Microscopy at Duke University
TIME MEDICALSYSTEMS
HTS White Paper
The Hybrid MRI systemscan be run
in the traditional,or HTS mode…
53
The Hybrid MRI systemscan be run
in the traditional,or HTS mode…
TIME MEDICALSYSTEMS
HTS Poster fromISMRM 2010
54
HTS Poster fromISMRM 2010
TIME MEDICALSYSTEMS
HTS:Peer Review
Journal Articles
55
HTS:Peer Review
Journal Articles
TIME MEDICALSYSTEMS
56
TIME MEDICALSYSTEMS
57
TIME MEDICALSYSTEMS
58
TIME MEDICALSYSTEMS
59
TIME MEDICALSYSTEMS
60
TIME MEDICALSYSTEMS
61
TIME MEDICALSYSTEMS
62
TIME MEDICALSYSTEMS
63
Hybrid MONA & Hybrid PICAbring a new dimension to MR Imaging.
HTS Technologymake high performance MRI available to all.
TIME MEDICAL SYSTEMSVision Beyond Imagination.
64
TIME MEDICALSYSTEMS
65
TIME MEDICALSYSTEMS
66
TIME MEDICALSYSTEMS
67
TIME MEDICALSYSTEMS
68
TIME MEDICALSYSTEMS
69
TIME MEDICALSYSTEMS
70
TIME MEDICALSYSTEMS
71
TIME MEDICALSYSTEMS
72
TIME MEDICALSYSTEMS
73
TIME MEDICALSYSTEMS
74
TIME MEDICALSYSTEMS
75
TIME MEDICALSYSTEMS
76
TIME MEDICALSYSTEMS
77
TIME MEDICALSYSTEMS
78
TIME MEDICALSYSTEMS
79
TIME MEDICALSYSTEMS
80
TIME MEDICALSYSTEMS
81
TIME MEDICALSYSTEMS
82
TIME MEDICALSYSTEMS
83
TIME MEDICALSYSTEMS
84
TIME MEDICALSYSTEMS
85
TIME MEDICALSYSTEMS
863 mm slice thickness
TIME MEDICALSYSTEMS
873 mm slice thickness
TIME MEDICALSYSTEMS
Thank You.
88
Thank You.
This information is furnished without warranty, representation, or license of any kind, except that it is accurate to the best of Time Medical’s knowledge or obtained from sources believed to be accurate. TimeMedical does not assume any legal responsibility for use or reliance upon same. Customers are encouraged to conduct their own evaluation. Before using any product, read the product manuals and labels. Forproducts/features under development the information is provided to assist you. Until Time Medical releases this product for general sale, Time Medical reserves the right to alter prices, specifications, features,capabilities, function, manufacturing release dates, and even general availability of the product at any time.