Michael Chang | Ashok Ilankovan | Stephanie Pan | Patric Prado | Alyssa Rios

Faculty Advisor: Professor Konofagou

December 2, 2008

Design Problem:Spinal Muscular Atrophy (SMA) : a genetic disease that

attacks the motor neurons and leads to muscle weakness and atrophy.

Current evaluations are subjective, inaccurate, and insensitive.

Clinicians need a robust, quantitative motion analysis system Design Brief:

Our device will: work for different patient body types quantify intentional movements of the patient not place excessive weight on the patient’s arms maintain natural movement paths reduce friction maintain support of the patient’s arm

Design Problem and Brief

Our MissionDesign a clinical tool to quantitatively

evaluate the motions of SMA patients

Our Innovative ProductAn intuitive and consistently

accurate, yet affordable 2D motion tracking system coupled with a frictionless platform

Our Strategic Advantage Synergistic integration of currently

available technologiesPotentially rapid entry into untapped

market

Executive Summary& Company Overview

Prototype Design: OptEval 2D

Figure 1. Forearm Model

Figure 2. Full Arm Model

Optical Mini MouseKinimax$ 10

Polyurethane/Polyethylene Foam4" Thick, 24" X 24" Sheet$ 60

Porous Air MediumGlasgowAwaiting Quotation

Ball TransferMcMaster$ 5

Distance Sensor: 3-30cmSharp$ 10

Prototype Design: OptEval 2D

Dec Jan Feb March April May

Frictionless Platform

2-point Motion Capture

1st Proto:Integrated

System

2nd Proto:Independe

ntSystem

Optimization / Output

/ Clinical Trials

Prototype Plan

Testing

Parts for Alternativ

e

1st Proto:Integrated

SystemOutput

Software Clinical Trials

Development Plan: Short Term

Contingency:

Selling to SMA Clinics / Clinical Trials / Feedback

First Product

Custom Components

Home ProductProtocols, Data

Transfer

Selling to SMA Clinics

2010 2011 2012Mid-2009

Development Plan: Long Term

The Market Approximately 25,000 to 55,000 SMA patients in the

U.S., Europe, and JapanThe Customer

Clinics that treat SMA

SMA patients go to clinics for regular checkups at least once a month

During these checkups, a battery of tests is performed to thoroughly evaluate the patient’s condition, including many tests of patient mobility and strength.

The Market

Impact Doctors will have the ability to monitor

more patients with higher accuracy than ever before.

Patients and their families will have more meaningful feedback in terms of their progress and condition.

Researchers will have the ability to acquire objective, reproducible data.

Future At-home testing Expanded application for patients with

other neuromuscular diseases and stroke-related

The Market (cont.)

complications.

Marketing In-hospital demonstrations and statistical data to show

reliability and robustness Requires personnel to make appointments and travel to

SMA clinics Limited advertising Possibly through SMA websites and related diseases Referral Advertising

Offer of incentive, 10% off next purchase if referred other customers

Business Model

Device Sale Cost: $1000 Includes: Installation

Service Contract 1 Year: $150

2.5% Discount on Additional Service/Parts 2 Years: $250

5% Discount on Additional Service/Parts 3 Years: $350

10% Discount on Additional Service/Parts

Business Model (cont.)

Continuous Revenue Disposable foam arm support Software: $20/month Online Storage Database

Monthly Subscription Fee

Fixed Expenditure Fixed Server Maintenance

Business Model (cont.)

Financial Plan

Years 2 - 4•Sell to Clinics•Clinical Trials

Years 0 - 2•Research & Development

Years 4 & Beyond•Continue to sell to clinics•Expand to home market

Break Even

Pri

ce (

103

Do

llar

s)

Break Even Analysis

y = 100000x - 200000

y = 50000x

0

100

200

300

400

500

600

700

0 1 2 3 4 5 6 7 8

Total Cost

Total Revenue

Time (Years)

Motivation: Clinicians need a robust and quantitative motion capture and analysis system

Proposed Solution: OptEval 2D

Market: SMA Patients Customers: Clinicians

Development Plan: 1st Prototype by mid-2009 1st Product by end of 2009 Further expansion: Optimized

for home use

Summary

AcknowledgementsElisa Konofagou,

PhDAssistant Professor of Biomed. Eng.Columbia University

Petra Kaufmann, MD

Assistant Professor of NeurologyAssociate Director, Pediatric MDA

Neuromuscular Clinic

Elizabeth Hillman, PhDAssistant Professor of Biomed. Eng.Columbia University

Keith YeagerSenior Staff Associate, Lab ManagerColumbia University

Jacqueline MontesClinical Coordinator, Physical TherapistPediatric MDA Neuromuscular Clinic

Viktor GamarnikColumbia University Alumnus

Benjamin KooColumbia University Alumnus

Barclay Morrison, PhDAssociate Professor of Biomed. Eng.Columbia University

Questions?