5605798

DNA DIAGNOSTIC BASED ON MASS S P E C T R O M E T R Y

Kuml oster Hubert Concord, MA, UNITED STATES assigned to Sequenom Inc

The invention provides fast and highly accurate mass spectrometer based processes for detecting a particular nucleic acid sequence in a biological sample. Depending on the sequence to be detected, the processes can be used, for example, to diagnose (e.g. prenatally or postnatally) a genetic disease or chromosomal abnormality; a predisposition to a disease or condition (e.g. obesity, artherosclerosis,cancer), or infection by a pathogenic organism (e.g. virus, bacteria, parasite or fungus).

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generalized distances. The calibration model may utilize principal component regression, partial least squares, multiple linear regression, or artificial neural networks, and reduction using principal component analysis or partial least squares scores. Unknown sample data is analyzed using data pretreatment followed by projection into the calibration model space, and identification and removal of outliers, with prediction of analyte concentration using the calibration model. The apparatus includes a pump which circulates a sample through tubing to fill a flowcell. Light from a NIR source is synchronized with a detector, facilitating light and dark measurements, and passes through a monochrometer and the flowcell and strikes the detector, whereby radiation transmitted through the sample is measured. Measurement data is stored in a general purpose programmable computer also controlling the pump, the detector, synchronization, and the monochrometer. The computer includes a general purpose microprocessor configured with computer program code employing the steps of the method.

METHOD AND APPARATUS FOR BIOLOGICAL FLUID ANALYTE

CONCENTRATION MEASUREMENT USING GENERALIZED DISTANCE

OUTLIER DETECTION

Price John; Long James McCordsville, IN, UNITED STATES assigned to Boehringer Mannheim Corporation

A method and apparatus for measuring the concentration of an analyte present in a biological fluid is disclosed. The method includes the steps of applying NIR radiation to calibration samples to produce calibration data, analyzing the calibration data to identify and remove outliers, constructing a calibration model, collecting and analyzing unknown samples to identify and remove outliers, and predicting analyte concentration of non-outliers from the calibration model. Analysis of the calibration data includes data pretreatment, data decomposition to remove redundant data, and identification and removal of outliers using

5606649

METHOD OF ENCODING A DOCUMENT WITH TEXT

CHARACTERS, AND METHOD OF SENDING A DOCUMENT W I T H T E X T

CHARACTERS FROM A T R A N S M I T T I N G C O M P U T E R

S Y S T E M T O A RECEIVING COMPUTER S Y S T E M

Tai Kuang-Cheng Taipei Hsien, CHINA (TAIWAN) assigned to Dynalab Inc

A method of encoding a document with text characters includes the steps of providing a font memory with a first memory region for storing a plurality of basic unit information and a second memory region for storing a