metalloporphyrins- hemoglobin and myoglobin.ppt
DESCRIPTION
Inorganic BiochemistryTRANSCRIPT
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SAMBA (J&K)SAMBA (J&K)(NAAC Accredited B)(NAAC Accredited B)
Recognized by J&K Govt. and Affiliated to the University of Jammu
Name: Ajay Name: Ajay KumarKumar
Class: B.Sc.-IIIClass: B.Sc.-III
Sec: MedicalSec: Medical
Roll No: 3Roll No: 3
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DISCUSSIONDISCUSSION
METALLOPORPHYRINSMETALLOPORPHYRINS
• HEMOGLOBINHEMOGLOBIN
• MYOGLOBINMYOGLOBIN
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• Porphines are macrocyclic tetradentate ligands made up of 4 pyrrole rings (C4H4NH) linked together through methene bridges(-CH=).
• This tetradentate ligand has a conjugated double bonded system with 4 nitrogen donor sites.
• 2 of the 4 Nitrogen are tertiary Nitrogen while the remaining 2 Nitrogen are secondary.
• The tert. Nitrogens donate pair of electrons form Coordinate bond(→)
• The Sec. Nitrogens loses proton and forms Covalent bond.
STRUCTURE OF PORPHIN LIGANDSTRUCTURE OF PORPHIN LIGAND
Porphin LigandPorphin Ligand
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STRUCTURE OF HEMOGLOBINSTRUCTURE OF HEMOGLOBIN
Occurs in the protein complex Occurs in the protein complex HemoglobinHemoglobin
Schematic view of Oxygenated Schematic view of Oxygenated Heme in HemoglobinHeme in Hemoglobin
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STRUCTURE OF MYOGLOBINSTRUCTURE OF MYOGLOBIN
An outline of the Structure of Myoglobin. The An outline of the Structure of Myoglobin. The tubular structure represents the Polypeptide.tubular structure represents the Polypeptide.
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HEMOGLOBIN AND MYOGLOBINHEMOGLOBIN AND MYOGLOBINBasic Function:• Hemoglobin and Myoglobin, carry and bind
O2..
• Hb is found in the blood and Mb is found in muscle tissue.
• They both metalloproteins, containing iron at the center of a heme group.
• Hb can bind 4 molecules of O2 and Mb can bind only 1 molecule of O2.
• Mb has much higher oxygen affinity at the low pO2(partial pressure of O2).
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HEMOGLOBIN AND MYOGLOBINHEMOGLOBIN AND MYOGLOBIN
Basic Function:• Hb is pH-sensitive while Mb is not.
• Hemoglobin picks up O2 in the lungs and transports it to the rest of the body.
• Myoglobin accepts O2 from the hemoglobin in the muscles and stores it until needed for energetic process.
• Deoxygenated hemoglobin uses some of its amino acids to fix up CO2 and then transport CO2 back to the lungs.
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ROLE OF HEMOGLOBIN AND ROLE OF HEMOGLOBIN AND MYOGLOBINMYOGLOBIN
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Ph Scale for BloodPh Scale for Blood
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Molecular Shift at the Heme Molecular Shift at the Heme Group after Oxygen BindingGroup after Oxygen Binding
Blue: deoxyRed: oxy
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