metabolism. you must know… the key role of atp in energy coupling that enzymes work by lowering...
TRANSCRIPT
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METABOLISM
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YOU MUST KNOW…• THE KEY ROLE OF ATP IN ENERGY
COUPLING• THAT ENZYMES WORK BY LOWERING
THE ENERGY OF ACTIVATION• THE CATALYTIC CYCLE OF AN
ENZYME THAT RESULTS IN THE PRODUCTION OF A FINAL PRODUCT
• THE FACTORS THAT INFLUENCE THE EFFICIENCY OF ENZYMES
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CONCEPT 8.1• AN ORGANISM’S METABOLISM
TRANSFORMS MATTER AND ENERGY, SUBJECT TO THE LAWS OF THERMODYNAMICS
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METABOLISM• THE TOTALITY OF
AN ORGANISM’S CHEMICAL REACTIONS
• MANAGES THE MATERIAL AND ENERGY RESOURCES OF THE CELL
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CATABOLIC PATHWAY• LEADS TO THE RELEASE OF
ENERGY BY THE BREAKDOWN OF COMPLEX MOLECULES
TO SIMPLER
COMPOUNDS• EX. BREAKDOWN
OF FOOD
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ANABOLIC PATHWAY• CONSUME ENERGY TO BUILD
COMPLICATED MOLECULES FROM SIMPLER ONES
• EX. LINKING a.a. TO FORM MUSCLE PROTEIN IN RESPONSE TO PHYSICAL EXERCISE
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ENERGY• THE CAPACITY TO DO WORK• KINETIC ENERGY – ENERGY DURING
MOVEMENT• POTENTIAL ENERGY – STORED
ENERGY • CHEMICAL ENERGY – A FORM OF
POTENTIAL ENERGY WHERE ENERGY IS STORED IN MOLECULES AND THE AMOUNT DEPENDS ON ITS CHEMICAL BONDS
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THERMODYNAMICS• STUDY OF ENERGY
TRANSFORMATIONS THAT OCCUR IN MATTER
• FIRST LAW OF THERMODYNAMICS – THE ENERGY OF THE UNIVERSE IS CONSTANT AND THAT ENERGY CAN BE TRANSFERRED AND TRANSFORMED, BUT CANNOT BE CREATED OR DESTROYED
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THERMODYNAMICS• SECOND LAW OF THERMODYNAMICS
– EVERY ENERGY TRANSFER, OR TRANSFORMATION INCREASES THE ENTROPY OR THE AMOUNT OF DISORDER OR RANDOMNESS, IN THE UNIVERSE
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CONCEPT 8.2• THE FREE-ENERGY CHANGE OF A
REACTION TELLS US WHETHER THE REACTION OCCURS SPONTANEOUSLY
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FREE ENERGY• THE PART OF A SYSTEM’S ENERGY
THAT IS ABLE TO PERFORM WORK WHEN THE TEMPERATURE OF A SYSTEM IS UNIFORM
• INCLUDES EXERGONIC AND ENDERGONIC REACTIONS
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EXERGONIC REACTION• ENERGY IS RELEASED• OCCUR SPONTANEOUSLY (THAT
DOESN’T NECESSARILY MEAN QUICKLY) AND RELEASE FREE ENERGY TO THE SYSTEM
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ENDERGONIC REACION• REQUIRES ENERGY IN ORDER TO
PROCEED• ABSORB FREE ENERGY• THEY REQUIRE FREE ENERGY FROM
THE SYSTEM
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CONCEPT 8.3• ATP POWERS CELLULAR WORK
BY COUPLING EXERGONIC REACTIONS TO ENDERGONIC REACTIONS
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ENERGY COUPLING• THE WAY CELLS MANAGE THEIR
ENERGY RESOURCES TO DO CELL WORK
• THE USE OF AN EXERGONIC PROCESS TO DRIVE AN ENDERGONIC ONE
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ATP• THE PRIMARY SOURCE OF ENERGY
FOR CELL IN ENERGY COUPLING• MADE UP OF THE NITROGENOUS
BASE ADENINE, RIBOSE, AND A CHAIN OF 3 PHOSPHATE GROUPS
• WHEN A PHOSPHATE GROUP IS HYDROLYZED, ENERGY IS RELEASED IN AN EXERGONIC REACTION
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RELEASE OF ATP• WORK IN THE CELL IS DONE BY THE
RELEASE OF A PHOSPHATE GROUP FROM ATP
• THE EXERGONIC RELEASE OF THE PHOSPHATE GROUP IS USED TO DO THE ENDERGONIC WORK OF THE CELL
• WHEN ATP TRANSFERS ONE PHOSPHATE GROUP THROUGH HYDROLYSIS, IT BECOMES ADP
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CONCEPT 8.4• ENZYMES SPEED UP METABOLIC
REACTIONS BY LOWERING ENERGY BARRIERS
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CATALYSTS
• SUBSTANCES THAT CAN CHANGE THE RATE OF REACTION WITHOUT BEING ALTERED IN THE PROCESS
• ENZYMES ARE MACROMOLECULES THAT ARE BIOLOGICAL CATALYSTS
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ACTIVATION ENERGY• THE AMOUNT OF ENERGY IT TAKES
TO START A REACTION• THE AMOUNT OF ENERGY IT TAKES
TO BREAK THE BONDS OF THE REACTANT MOLECULES
• ENZYMES SPEED UP REACTIONS BY LOWERING THE ACTIVATION ENERGY OF THE REACTION BUT WITHOUT CHANGING THE FREE ENERGY CHANGE OF THE REACTION
• THE ENZYME ACTS ON A SUBSTRATE
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ACTIVE SITE• THE PART OF THE ENZYME
THAT BINDS TO THE SUBSTRATE
• FORMS AN ENZYME-SUBSTRATE COMPLEX THAT IS HELD TOGETHER BY WEAK INTERACTIONS
• SUBSTRATE IS THEN CONVERTED INTO PRODUCTS THAT ARE RELEASED FROM THE ENZYME
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WHAT AFFECTS ENZYME ACTIVITY?
• CHANGES IN pH AND TEMPERATURE
• 3-D SHAPE IS CHANGED SO THE ENZYME WILL NOT
BE AS EFFECTIVE (DENATURES)
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• MANY ENZYMES REQUIRE NONPROTEIN HELPERS CALLED COFACTORS TO FUNCTION PROPERLY
• ORGANIC COFACTORS ARE REFERRED TO AS COENZYMES
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COMPETITIVE INHIBITORS• REVERSIBLE INHIBITORS THAT
COMPETE WITH THE SUBSTRATE FOR THE ACTIVE SITE ON THE ENZYME
• SIMILAR CHEMICALLY TO THE SUBSTRATE
• REDUCE THE EFFICIENCY OF THE ENZYME AS IT COMPETES FOR THE ACTIVE SITE
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NONCOMPETITIVE INHIBITORS• DO NOT DIRECTLY COMPETE WITH
THE SUBSTRATE• IMPEDE ENZYME ACTIVITY BY
BINDING TO ANOTHER PART OF THE ENZYME
• CAUSES ENZYME TO CHANGE SHAPE MAKING THE ACTIVE SITE NONFUNCTIONAL
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CONCEPT 8.5• REGULATION OF ENZYME
ACTIVITY HELPS CONTROL METABOLISM
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ALLOSTERIC SITE• A SPECIFIC BINDING SITE BUT NOT
THE ACTIVE SITE• ONCE BOUND, THE SHAPE OF THE
ENZYME IS CHANGE AND IT CAN EITHER STIMULATE OR INHIBIT ENZYME ACTIVITY
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FEEDBACK INHIBITION• A TYPE OF
ALLOSTERIC
INHIBITION• IT INCREASES THE EFFICIENCY
OF THE PATHWAY BY TURNING IT OFF WHEN THE END PRODUCT ACCUMULATES IN THE CELL