METABOLIC DISEASES.

CALCIFICATION.

PIGMENTATION.

III. practical training

3rd year General Medicine

Atherosclerosis

dystrophic calcification

fibrosis

Atherosclerosis Crystals of cholesterol in an atheromatous plaque in an arterial wall

(optically free spaces of washed up crystals)

Metastatic calcification of the lung

Gall bladder concrement

-cholecystolithiasis

Prostatic conctements –

prostatolithiasis

Melanocytic nevus

Melanocytic nevus

Malignant melanoma

Nodular melanoma

Malignant melanoma

Malignant melanoma

Melanin in tumour cells

(lentigo maligna melanoma)

1

1

2

1 Melanin in tumour cells

2 Melanin fagocyted in

histiocytes (released from

tumour cells)

3 layer of keratinization in

epidermis

3

Malignant melanoma

Pathologic depigmentation of skin,

vitiligo

1 normal distribution of melanin

in basal layer

2 defect of melanin in basal layer

2

1

Vitiligo, impregnation of melanin by silver according to

Masson

1 normal distribution of melanin

in basal layer

2 defect of melanin in basal layer

1 2

Brown atrophy of the myocardium

(accumulation of lipofuscin)

Liver hemosiderosis

special staining of iron according Perls

Hemachromatosis (liver)

special staining of iron according Perls

Billiary cirrhosis

Billiary cirrhosis (special staining of bile according Fouchet)

Billiary nephrosis

Antracosis of the lung

1 antracotic pigment in

interalveolar septa indurated lung

2 clusters of siderophages

3 lumen of artery

1

2

2

3

Antracosis of the lung

1 capsule of lymph node

2 lymphatic follicles

3 medullar sinus

4 antracophages in medulla of lymph node

5 lung tissue

1

2

2

3

4

5

Silicosis of the lung

kopie

1

1 fibrous centre of nodul

2 blending of alveoli (perifocal

emphysema)

2

2

2

Silicosis of the lung

1

1

1

1 fibrous centre of nodul

Silicosis of the lung

copy

Silicosis of the lung– early stage (mostly in macrophages) silica crystals in polarized light

copy

Asbestosis of the lung

copy