Merck & Co., Inc. Cowen 2015 Healthcare Conference March 3, 2015

Adam Schechter President, Global Human Health

Forward-Looking Statement

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This communication includes “forward-looking statements” within the meaning of the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of 1995. These statements are based upon the current beliefs and expectations of Merck’s management and are subject to significant risks and uncertainties. There can be no guarantees with respect to pipeline products that the products will receive the necessary regulatory approvals or that they will prove to be commercially successful. If underlying assumptions prove inaccurate or risks or uncertainties materialize, actual results may differ materially from those set forth in the forward-looking statements.

Risks and uncertainties include but are not limited to, general industry conditions and competition; general economic factors, including interest rate and currency exchange rate fluctuations; the impact of pharmaceutical industry regulation and health care legislation in the United States and internationally; global trends toward health care cost containment; technological advances, new products and patents attained by competitors; challenges inherent in new product development, including obtaining regulatory approval; Merck’s ability to accurately predict future market conditions; manufacturing difficulties or delays; financial instability of international economies and sovereign risk; dependence on the effectiveness of Merck’s patents and other protections for innovative products; and the exposure to litigation, including patent litigation, and/or regulatory actions.

Merck undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future events or otherwise. Additional factors that could cause results to differ materially from those described in the forward-looking statements can be found in Merck’s 2014 Annual Report on Form 10-K and the company’s other filings with the Securities and Exchange Commission (SEC) available at the SEC’s Internet site (www.sec.gov).

Merck is Positioned for Long-Term Growth through Innovation

Premier Research-Driven Biopharmaceutical Company

New Focused Model Suite of Opportunities

Improving Operating Model

Accelerating BD Strategy

Four Key Growth Platforms

Multiple New Product Launches

Programs in Areas with Large Unmet Needs

Advancing Innovative Pipeline

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Returned $13 Billion of cash to shareholders

Executed significant business development

Advanced the pipeline; obtained 6 new product registrations in the U.S.

Grew all 4 Commercial Focus Areas in Q4

Delivered Sales and EPS in-line with guidance

2014: A Year of Significant Execution for Merck

Strong momentum

entering 2015

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Total deaths from diabetes are projected to increase by 50% in the next 10 years

Antibiotic-resistant bacteria infects over 2 million Americans annually, resulting in 23,000 deaths

HOSPITAL ACUTE CARE

DIABETES

Prevention of disease through vaccination is cost effective

VACCINES

Every year, 8 million people die from cancer worldwide

ONCOLOGY

Focused Areas Give Us a Strong Platform for Growth

4 Sources: CDC, WHO

Focused Strategy supports Leadership in the DPP-4 Market

• Focusing resources on this important brand with ~$6 billion annual sales • Macro trends support a growing Diabetes market

JANUVIA Franchise 12-Wk Rolling TRx YoY Change %

1. Excludes impacts from foreign exchange. 2. Source: IMS (Jan 3, 2014 through Feb 13, 2015).

FY 2014 Sales Growth1 JANUVIA TRx Trend2

+4%

5

$4.0

$4.5

$5.0

$5.5

$6.0

$6.5

2013 2014

$ bi

llions

-4.0%

-2.0%

0.0%

2.0%

4.0%

6.0%

8.0%

Focused Strategy builds Leadership in the Global Vaccines Market

• A global leader in vaccines sales

• Broad portfolio

• GARDASIL market share leader at >90% globally

• GARDASIL 9, 9-valent HPV vaccine recently approved by FDA

• ZOSTAVAX single-dose shingles vaccine launching around the world

1. Excludes SPMSD joint venture sales. 6

+11% CAGR Merck Vaccine Sales1

2010 2014

$5.7B

$3.8B

Focused Strategy building Leadership in Hospital Acute Care An Area of Significant Unmet Need

• Merck’s Hospital Acute Care portfolio has annual sales ~$2.5 billion

• Key products include: − Antibiotics (INVANZ, PRIMAXIN) − Antifungals (NOXAFIL, CANCIDAS) − BRIDION

• Well-positioned longer term with several Phase 3 pipeline opportunities

1. Excludes impacts from foreign exchange.

FY 2014 Sales Growth1

>10%

$ bi

llions

7

$1.0

$1.5

$2.0

$2.5

2013 2014

Hospital Acute Care has an efficient customer base and positive momentum from regulatory and reimbursement trends.

Merck + Cubist: A Compelling Combination for the Long-Term

INVANZ (IV, Gram Negative) PRIMAXIN/TIENAM (IV, Broad Spectrum)

NOXAFIL & CANCIDAS (Antifungals) Relebactam/MK-7655 (IV, Gram Negative)

CUBICIN (IV, MRSA) SIVEXTRO (IV/Oral, MRSA)

ZERBAXA (IV, Gram Negative)

Prevention of Recurrence MK-3415a (IV mAb)

Treatment DIFICID (Oral); Surotomycin (Oral Ph III)

BRIDION GI Surgery

ENTEREG (US)

Merck Cubist

Complements position in Antibiotics / Antifungals High Growth Segment, Favorable Reimbursement

Building strength in C. difficile infections

Building strength and capabilities in surgery and post-operative care

Cubist strengthens Merck's Hospital Acute Care Pipeline and Portfolio

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Launching ZERBAXA in Gram-negative Infections

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• Rising resistance rates of traditional first-line agents • Approved for treatment of cUTI and cIAI caused by designated

susceptible Gram-negative bacteria • Ongoing Phase 3 programs in VABP and HABP

Launching BELSOMRA in Adults Who Have Insomnia

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• BELSOMRA now launching in the U.S. and Japan

− ~1000 U.S. TRx for the week ending February 13, 20151

• 2 billion insomnia medication doses administered per year in both the U.S. and Japan1

• 30% of patients are continuous treaters (~60% of Rx’s) and seeking new alternatives

1. Source: IMS

Strong KEYTRUDA Uptake in Advanced Melanoma

0

500

1000

1500

2000

2500

September October November December

Patients on KEYTRUDA Treatment1

1. Merck Internal Estimates 11

• $55mm in 2014 sales

• Vast majority of ipilimumab-refractory patients are receiving KEYTRUDA

• Strong access in labeled indication

– Launched KEYTRUDA for advanced melanoma

– Expected filing in mid-2015 for NSCLC

– Breakthrough designation in NSCLC

– Evidence of efficacy in 7 tumor types in 2014

– ~70 clinical trials ongoing or planned, more than 20 combinations, and in over 30 cancer types

– Expected filing in 1st Half 2015; Initial Phase 3 Data at EASL

• Phase 2: >90% efficacy at 12 weeks across patient types

– Phase 2 triplet program enrolling; Phase 3 expected to start in 2015

KEYTRUDA: anti-PD-1 for oncology

MK-5172A for hepatitis C virus

Merck has Multiple Clinical Programs in Areas with Large Unmet Need

12 EASL: European Association for the Study of the Liver

– Phase 3 fully enrolled

– Oral, once-daily, tablet being tested as additive therapy to statins

– Study completion targeted for early 2017

– 2 Phase 3 studies enrolling mild-to-moderate or prodromal patients

– BACE inhibitor prevents the formation of A-Beta peptides

– Passed interim safety analysis in December 2013

– First study completion targeted for early 2017

Anacetrapib: CETP Inhibitor for CV disease

BACE Inhibitor for Alzheimer’s Disease

Merck has Outcomes Studies in Large Markets with Unmet Need

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Growth from Core Commercial Areas and Launches

Diabetes Hospital Acute Care Oncology Vaccines

KEYTRUDA BELSOMRA BRIDION GARDASIL9 ZERBAXA ZONTIVITY

Core Focus Areas

Current and Near-term Launches

Potential Future Launches

Sales

Innovation MK-5172A (HCV)

Odanacatib (Osteoporosis)

Omarigliptin (Diabetes)

Anacetrapib (Dyslipidemia)

Doravirine (HIV)

MK-8931 (Alzheimer’s Disease)

Biosimilars Immunology Oncology Insulin

WAVE 1 WAVE 2

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Biosimilars Opportunity for Merck and Customers

Reference Product

Reference Product 2014 Sales2

Merck-Samsung Bioepis Product Expected Filing Timeline

Humira $8.0 B SB5 2015-2016(ex-EU/Russia/Turkey)

Remicade $6.0 B SB2 2015-2016(ex-EU/Russia/Turkey)

Enbrel $1.1 B SB4 2015-2016(ex-US/EU/Japan)

Lantus $8.4 B MK-1293 2015-2016

Herceptin $6.9 B SB3 2016

• Merck and Samsung Bioepis formed a partnership in 2013 where Samsung Bioepis conducts R&D and Manufacturing and Merck has Commercialization rights1

• Commercial opportunity offers customers alternatives to existing biologic therapies

• Addresses healthcare system needs while potentially creating cost capacity for new innovative treatments

• Strategic fit with global commercial capabilities; allows Merck R&D resources to focus on innovative therapeutics

• Five programs in Phase 3 development; others to follow

1. Merck and Samsung will collaborate on MK-1293. Merck will manufacture and commercialize the product 2. 2014 reference product sales In designated Merck markets. Sources: IMS, EvaluatePharma, February 2015 15

Merck’s BD Strategy is Adding Value and Increasing Focus

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Idenix (HCV) Cubist (Hospital Care) OncoEthix (Oncology) Multiple Oncology

collaborations NewLink (Ebola Vaccine) Bayer CV collaboration NGM collaboration1

Consumer Care Ophthalmology Saphris Diversified Brands (Aspen) Anti-IL-23

Acquiring

Divesting

1. Collaboration focused on Diabetes, Metabolic Dysregulation, and Oncology; consummation subject to satisfaction of closing conditions, including HSR waiting period.

Merck is on Track to Hit Savings Targets by the end of 2015 Reducing Costs by $2.5 billion

1. Non-GAAP SG&A + Non-GAAP R&D as a % of sales. 2. 2008 Operating expense ratio represents Merck standalone; 2009 represents 12 months of Merck + 2 months of Schering-Plough. 3. Peer group results based on Non-GAAP results reported by peers in Q4 earnings reports – group made up of 8 large pharmaceutical companies.

SG&A + R&D1

3 Peer Average Merck

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38%

40%

42%

44%

46%

48%

50%

52%

2008 2009 2010 2011 2012 2013 2014

Merck is Creating Value and Returning Cash to Shareholders

0

5

10

15

2014 2013 2012 2011 2010

Dividends Paid Share Repurchase

$ bi

llion

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Dividends and share repurchases > 90% of Free Cash Flow

2015: Merck Looking Forward to...

• Multiple product launches ongoing

• Future Launches: Near-term regulatory action for several additional programs

• Major filings in HCV, NSCLC, and Osteoporosis

• Targeting business development to drive long-term value

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