Melusine  Snake  Venoms  Collection  V-­‐9010/MLU_C134SN,  120118,  page  1/6  A  product  of  Atheris  Laboratories  exclusively  distributed  by  Bachem

Our ref.: V-9010 - Snake Venom Collection, 134 Venoms Re: Melusine pre-fractionated venoms ready-made for HTS lead discovery.

MELUSINE: LIBRARIES THAT DELIVER ! Discovery collections are offered on the fol lowing basis

• Standard 1x format, in 96- or 384-well plates for 1-3 screens; • Each sample is fractionated into 80 fractions that are dispensed in microplates; • A collection made of 10’720 snake venom fractions; • Each well typically contains 5-20 molecules for primary screens; • Library containing approximately 67’000 molecules; • Either in 96-well plates containing 80 fractions from one venom (134 plates total) with 16 empty wells (columns 11 & 12);

• Or in 384-well plates containing 320 fractions from 4 venoms (34 plates total) with 64 empty wells (columns 1, 2, 23 & 24);

• Designed to target nM & pM activities in primary screens; • Bioactives will be at an estimated concentration of 0.5-5 μM if dissolved in 50-100 μL; • Resupply from the same batch guaranteed.

A unique collection of 134 pre-fractionated snake venoms, including 32 rare venoms

• 1 atractaspidid; • 3 colubrids; • 59 crotalids; • 33 elapids; • 38 viperids.

Venoms can also be selected individually to build a custom collection. Each Melusine microplate is provided with

• A Material Safety Data Sheet (MSDS); • A Certificate of Analysis (CoA) that includes an RP-HPLC chromatographic profile and a matrix-assisted laser-desorption/ionisation time-of-flight (MALDI-TOF) mass spectrum of the crude venom with a list of detected molecular masses;

• An Excel spreadsheet for hit-follow-up.

A  branch  of  Atheris  Laboratories  

Melusine  Snake  Venoms  Collection  V-­‐9010/MLU_C134SN,  120118,  page  2/6  A  product  of  Atheris  Laboratories  exclusively  distributed  by  Bachem

V-9010 - Snake Venom Collection, 134 Venoms

MLU Code Family / Subfamily Species / Subspecies Common name Distribution

MLU_014001 Atractaspidinae Atractaspis bibronii* Southern bibron's burrowing asp or Stiletto snake Africa

MLU_013010 Colubridae Dispholidus typus ssp.* Boomslang Subsaharan Africa

MLU_013011 Colubridae Rhamphiophis rostratus* Rufous beaked snake Southeastern Africa

MLU_013012 Colubridae Toxicodryas blandingii Blanding's tree snake Central Africa

MLU_010034 Crotalinae Agkistrodon taylori Mexican moccasin, Taylor's or ornate cantil Northeastern Mexico

MLU_010041 Crotalinae Agkistrodon contortrix contortrix Southern copperhead USA

MLU_010042 Crotalinae Agkistrodon contortrix laticinctus

Broad-banded or Texas copperhead Southern USA

MLU_010043 Crotalinae Agkistrodon contortrix mokasen Northern copperhead Eastern USA

MLU_010044 Crotalinae Agkistrodon contortrix pictigaster Trans-Pecos copperhead Texas (USA) and

Northeastern Mexico

MLU_010003 Crotalinae Agkistrodon piscivorus conanti

Florida cottonmouth or green-tailed moccasin Southeastern USA

MLU_010051 Crotalinae Agkistrodon piscivorus leucostoma

Western cottonmouth or water moccasin Southern and Central USA

MLU_010052 Crotalinae Agkistrodon piscivorus piscivorus Eastern cottonmouth Eastern USA

MLU_010193 Crotalinae Atropoides mexicanus Central American jumping viper

Brazil, Paraguay and Argentina

MLU_010037 Crotalinae Atropoides nummifer Mexican jumping pit viper Mexico and Central America

MLU_010115 Crotalinae Bothriechis bicolor* Guatemala palm pit viper Southern Mexico and Guatemala

MLU_010194 Crotalinae Bothriechis schlegelii Eyelash or Schlegels pit viper Central and Southern America

MLU_010195 Crotalinae Bothrocophias hyoprora* Amazonian toadheaded pit viper Northern South America

MLU_010009 Crotalinae Bothropoides insularis* Golden lancehead Brazil

MLU_010080 Crotalinae Bothropoides jararaca Jararaca Brazil, Paraguay and Argentina

MLU_010100 Crotalinae Bothropoides neuwiedi Jararaca pintada Brazil, Praguay, Bolivia, Argentina and Peru

MLU_010062 Crotalinae Bothrops atrox Common lancehead Northern South America and Eastern Andes

MLU_010011 Crotalinae Bothrops jararacussu Jararacussu Brazil, Paraguay, Bolivia and Argentina

MLU_010088 Crotalinae Bothrops lanceolatus Martinique lancehead or Martinican pit viper Martinique Island

MLU_010013 Crotalinae Bothrops leucurus Whitetail lancehead Brazil

MLU_010093 Crotalinae Bothrops moojeni Brazilian lancehead Brazil, Paraguay and Argentina

MLU_010147 Crotalinae Calloselasma rhodostoma Malayan pit viper Southeastern Asia

MLU_010103 Crotalinae Crotalus adamanteus Eastern diamondback (rattlesnake) Southeastern USA

MLU_010107 Crotalinae Crotalus atrox Western diamondback (rattlesnake) Northern America

Melusine  Snake  Venoms  Collection  V-­‐9010/MLU_C134SN,  120118,  page  3/6  A  product  of  Atheris  Laboratories  exclusively  distributed  by  Bachem

MLU_010018 Crotalinae Crotalus basiliscus Mexican green rattler or Mexican west-coast rattlesnake

Western Mexico

MLU_010184 Crotalinae Crotalus cerastes cercobombus* Sonoran (desert) sidewinder Arizona (USA)

MLU_010112 Crotalinae Crotalus culminatus* Northwestern neotropical rattlesnake Mexico

MLU_010119 Crotalinae Crotalus enyo enyo* Lower California or Baja California rattlesnakes Baja California (Mexico)

MLU_010122 Crotalinae Crotalus horridus Timber, canebrake or banded rattlesnake

Northeastern USA and Canada

MLU_010124 Crotalinae Crotalus lepidus lepidus* Rock rattlesnake Southwestern USA and Northeastern Mexico

MLU_010125 Crotalinae Crotalus mitchellii mitchellii Speckled rattlesnake Baja California (Mexico)

MLU_010019 Crotalinae Crotalus mitchellii pyrrhus Southwestern speckled rattlesnake Southwestern USA and Northwestern Mexico

MLU_010129 Crotalinae Crotalus stephensi Panamint rattlesnake or rattler Southern Nevada and adjacent California (USA)

MLU_010134 Crotalinae Crotalus molossus molossus

Northern black tailed rattlesnake USA and Mexico

MLU_010138 Crotalinae Crotalus oreganus helleri Southern Pacific or black diamond rattlesnake

Southwestern California (USA) and Baja California (Mexico)

MLU_010155 Crotalinae Crotalus oreganus lutosus Great Basin rattlesnake Great Basin region (USA)

MLU_010140 Crotalinae Crotalus oreganus oreganus Northern Pacific rattlesnake Southwestern Canada and

Western USA

MLU_010187 Crotalinae Crotalus ravus ravus* Mexican or Central plateau pigmy rattlesnake Mexico

MLU_010020 Crotalinae Crotalus ruber ruber Red diamond rattlesnake Southwestern USA and Mexico

MLU_010143 Crotalinae Crotalus scutulatus scutulatus

Mohave rattlesnake or Mojave green

Southwestern USA and Central Mexico

MLU_010157 Crotalinae Crotalus viridis viridis Prairie, western or plains rattlesnake

Western USA, Southwestern Canada and Northern Mexico

MLU_010022 Crotalinae Deinagkistrodon acutus Hundred-pacer or sharp-nosed pit viper or Chinese moccasin

Southeastern Asia

MLU_010127 Crotalinae Gloydius brevicaudus ssp. Short tail mamushi or Korean slamosa snake Korea and China

MLU_010024 Crotalinae Gloydius halys halys Halys, Asiatic or Siberian pit viper Asia

MLU_010025 Crotalinae Lachesis muta South American bushmaster Northern of South America

MLU_010179 Crotalinae Ovophis okinavensis Okinawa or Ryukyu Islands pit viper Ryukyu Islands of Japan

MLU_010191 Crotalinae Porthidium ophryomegas* Slender hognose pit viper or western hog-nosed viper Central America

MLU_010192 Crotalinae Protobothrops flavoviridis ssp.

Habu, Okinawa habu, kume shima habu or yellow-green tree viper

Ryukyu Islands of Japan

MLU_010006 Crotalinae Rhinocerophis alternatus Crossed pit viper or Urutu Brazil, Uruguay, Paraguay and Argentina

MLU_010008 Crotalinae Rhinocerophis cotiara* Cotiara Brazil and Northeastern Argentina

MLU_010185 Crotalinae Sistrurus catenatus catenatus* Eastern or black massasauga USA

MLU_010186 Crotalinae Sistrurus miliarius barbouri

Dusky pigmy or Florida ground rattlesnake Southeastern USA

Melusine  Snake  Venoms  Collection  V-­‐9010/MLU_C134SN,  120118,  page  4/6  A  product  of  Atheris  Laboratories  exclusively  distributed  by  Bachem

MLU_010159 Crotalinae Trimeresurus albolabris White-lipped (tree) viper Southeastern Asia

MLU_010130 Crotalinae Trimeresurus mcgregori* Philippine pit viper Philippine Islands

MLU_010029 Crotalinae Trimeresurus puniceus* (female) Ashy or flat-nosed pit viper Indonesia

MLU_010030 Crotalinae Trimeresurus puniceus* (male) Ashy or flat-nosed pit viper Indonesia

MLU_010164 Crotalinae Trimeresurus purpureomaculatus* Shore or mangrove pit viper

Indonesia, Malaysia, Myanmar, Singapore and Thailand

MLU_010031 Crotalinae Trimeresurus schultzei* Schultze's pit viper Philippine Islands

MLU_010181 Crotalinae Tropidolaemus wagleri Wagler's (palm viper) or temple pit viper

Vietnam, Thailand, Malaysia, Indonesia and Singapore

MLU_012001 Elapidae Acanthophis antarcticus Common death adder Australia

MLU_012054 Elapidae Aspidelaps lubricus cowlesi* Angolan coral snake Southern Angola and

Northern Namibia

MLU_012208 Elapidae Aspidelaps scutatus ssp.* Shield-nosed snake Southern Africa

MLU_012003 Elapidae Austrelaps superbus Lowland copperhead Southeastern Australia and Tasmania

MLU_012043 Elapidae Bungarus fasciatus Banded krait Southern and Southeastern Asia

MLU_012004 Elapidae Bungarus multicinctus multicinctus

Taiwanese banded or many-banded krait

Taiwan, China, Vietnam, Thailand, Laos and Myanmar

MLU_012052 Elapidae Dendroaspis angusticeps Eastern green mamba Southeastern Africa

MLU_012057 Elapidae Dendroaspis jamesoni kaimosae Eastern Jameson's mamba Southern Africa

MLU_012069 Elapidae Dendroaspis polylepis polylepis Black mamba Africa

MLU_012080 Elapidae Dendroaspis viridis Western green mamba Western Africa

MLU_012209 Elapidae Elapsoidea boulengeri* Boulenger's garter snake Southern Africa

MLU_012207 Elapidae Elapsoidea sundewallii longicauda* Long-tailed garter snake Southern Africa

MLU_012082 Elapidae Hemachatus haemachatus

Ringhals or ring-necked spitting cobra Southern Africa

MLU_012196 Elapidae Laticauda colubrina* Colubrine, banded or yellow-lipped sea krait

Australia, Asia and Central America

MLU_012011 Elapidae Micropechis ikaheka Ikaheka or New Guinea small-eyed snake New Guinea

MLU_012087 Elapidae Micrurus fulvius Eastern or harlequin coral snake

Southeastern USA and Northeastern Mexico

MLU_012088 Elapidae Naja anchietae* Anchieta's cobra Southern Africa

MLU_012089 Elapidae Naja annulifera Snouted or banded cobra Southern Africa

MLU_012014 Elapidae Naja haje Egyptian cobra Africa and Arabian Peninsula

MLU_012115 Elapidae Naja katiensis Brown spitting or katian spitting or Mali cobra Western Africa

MLU_012116 Elapidae Naja legionis* Morocco cobra Northern Africa

MLU_012118 Elapidae Naja melanoleuca Black and white or forest cobra Africa

MLU_012121 Elapidae Naja mossambica Mozambique spitting cobra Africa

MLU_012210 Elapidae Naja nigricincta nigricincta Western barred spitting cobra Southern Africa

Melusine  Snake  Venoms  Collection  V-­‐9010/MLU_C134SN,  120118,  page  5/6  A  product  of  Atheris  Laboratories  exclusively  distributed  by  Bachem

MLU_012018 Elapidae Naja nigricollis Black-necked spitting cobra Subsaharan Africa

MLU_012145 Elapidae Naja nivea Cape cobra South Africa

MLU_012146 Elapidae Naja nubiae Nubian spitting cobra Northeastern Africa

MLU_012148 Elapidae Naja pallida African or red spitting cobra Africa

MLU_012162 Elapidae Notechis scutatus ssp. Mainland tiger snake Australia

MLU_012024 Elapidae Oxyuranus microlepidotus Inland taipan or fierce snake Australia

MLU_012176 Elapidae Pseudechis australis King brown or Mulga snake Australia

MLU_012026 Elapidae Pseudechis porphyriacus Red-bellied black snake Eastern Australia

MLU_012195 Elapidae Walterinnesia aegyptia Desert cobra Middle East

MLU_011032 Viperinae Atheris chlorechis Western bush or West African leaf viper Western Africa

MLU_011038 Viperinae Atheris nitschei Great lakes bush-viper Southeastern Africa

MLU_011053 Viperinae Atheris squamigera squamigera*

African or rough-scaled bush viper Central Africa

MLU_011004 Viperinae Bitis arietans arietans Puff adder Africa

MLU_011065 Viperinae Bitis caudalis Horned (puff) adder or viper Southwestern Africa

MLU_011066 Viperinae Bitis gabonica gabonica Gaboon adder Subsaharan Africa

MLU_011006 Viperinae Bitis gabonica rhinoceros Rhinoceros Gaboon adder Western Africa

MLU_011007 Viperinae Bitis nasicornis River jack or rhinoceros adder or viper Central and Western Africa

MLU_011076 Viperinae Bitis parviocula* Ethiopian (mountain) adder or viper Africa

MLU_011095 Viperinae Causus rhombeatus Common night adder Subsaharan Africa

MLU_011039 Viperinae Cerastes cerastes cerastes

Saharan or horned desert viper

Northern Africa and Middle East

MLU_011040 Viperinae Daboia palaestinae Palestine viper Syria, Jordan, Israel, Lebanon

MLU_011011 Viperinae Echis carinatus multisquamatus

Multiscale or Transcaspian saw-scaled viper

Uzbekistan, Pakistan and Turkmenistan

MLU_011137 Viperinae Echis carinatus sochureki Sochurek's or Eastern saw-scaled viper

India, Pakistan, Iran, Afghanistan, and parts of the Arabian Peninsula

MLU_011121 Viperinae Echis coloratus Palestine saw-scaled viper Middle East and Egypt

MLU_011125 Viperinae Echis ocellatus West African carpet viper or African saw-scaled viper Western Africa

MLU_011133 Viperinae Echis pyramidum pyramidum

Egyptian saw-scaled viper or North-East African carpet viper

Northeastern Africa and Arabian Peninsula

MLU_011013 Viperinae Eristicophis macmahoni Leaf-nosed or McMahons desert viper

Iran, Afghanistan and Pakistan

MLU_011141 Viperinae Macrovipera deserti Desert Levantine viper Northern Africa

MLU_011145 Viperinae Macrovipera lebetina obtusa Bluntnose viper Central Turkey to Kashmir

MLU_011147 Viperinae Macrovipera lebetina turanica Turan blunt nose viper

Turkmenistan, Uzbekistan, Tajikistan, Kazakhstan, Afghanistan and Pakistan

MLU_011031 Viperinae Macrovipera mauritanica Morocco or Moorish viper Northern Africa

Melusine  Snake  Venoms  Collection  V-­‐9010/MLU_C134SN,  120118,  page  6/6  A  product  of  Atheris  Laboratories  exclusively  distributed  by  Bachem

MLU_011016 Viperinae Macrovipera schweizeri Levantine viper Greece

MLU_011025 Viperinae Montivipera raddei raddei Caucasus viper Turkey, Iran, Armenia, Azerbaidjan and Iraq

MLU_011210 Viperinae Montivipera wagneri Wagner's viper Turkey and Iran

MLU_011036 Viperinae Montivipera xanthina Coastal or Ottoman viper Greece and Turkey

MLU_011155 Viperinae Proatheris superciliaris Lowland swamp or eyebrow viper

Tanzania, Malawi and Mozambique

MLU_011157 Viperinae Pseudocerastes fieldi Persian horned viper Middle East

MLU_011158 Viperinae Pseudocerastes persicus Persian horned viper From Middle East to Western Asia

MLU_011168 Viperinae Vipera ammodytes ammodytes

Western sand or nose-horned viper Middle East

MLU_011174 Viperinae Vipera ammodytes meridionalis* Eastern sand viper Greece and Turkey

MLU_011178 Viperinae Vipera ammodytes montandoni Transdanubian sand viper Bulgaria and Southern

Romania

MLU_011033 Viperinae Vipera aspis aspis Asp viper or European asp France, Switzerland and Germany

MLU_011187 Viperinae Vipera aspis atra* Black asp or viper France, Switzerland and Italy

MLU_011022 Viperinae Vipera aspis hugyi* Southern Italian asp Italy

MLU_011023 Viperinae Vipera aspis zinnikeri* Gascony asp or viper France and Spain

MLU_011207 Viperinae Vipera renardi renardi* Steppe viper

Romania, Ukraine, Russia, Kazakhstan, Kirgiziya, Uzbekistan, Tadzikistan, Mongolia and China

MLU_011209 Viperinae Vipera ursinii ursinii Meadow or Orsinis viper Italy

These venoms might be subject to availability that may induce minor changes.

* Considered as rare venoms, i.e. some venoms are more valuable because they originate from unique specimens, from species producing only tiny amounts of venoms or from samples requiring additional preparation efforts.

A product of:

Exclusively distr ibuted by: Atheris Laboratories Geneva ‒ Switzerland Tel +41 22 850 05 85 Fax +41 22 850 05 86 wonder@melusine.com www.atheris.com

Europe, Africa, Middle East and Asia Pacific: Bachem AG Bubendorf - Switzerland Tel +41 61 935 23 23 Fax +41 61 935 23 25 sales.ch@bachem.com www.bachem.com

Americas: Bachem Americas, Inc. Torrance CA - USA Tel +1 310 539 4171 Tel +1 888 422 2436 Fax +1 310 539 9428 sales.us@bachem.com www.bachem.com