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melbournehealthresearch week14 – 21 June 2007

RESEARCH WEEK14 – 21 JUNE 2007 PROGRAM

This publication contains the Research Week 2007 program and listing of abstracts accepted for publication, submitted by members of Melbourne Health and affiliated institutes.

The Research Week Committee was chaired by Associate Professor Geoffrey Hebbard and included the following members in 2007:

Dr James Beeson Ms Katrina Coulson Mr Gary Crosthwaite Mr Colin Dawson Dr Peter Hand Professor Stephen Jane Ms Carol Jewell Professor Andrew Kaye Ms Angela Kreso Professor Bruce Mann Ms Kerry May Ms Anne O’Sullivan Dr Jack Richards Ms Jan Sharrock Ms Kathleen Vincent Dr Angela Watt

The efforts of those involved in selecting suitable abstracts and in the adjudication of the Awards during Research Week are greatly appreciated.

Professor Ingrid Winship

Director of Research

Associate Professor Geoff Hebbard

Chairman, Research Week

With thanks to °Celsius Design who kindly designed and sponsored the cover of the Research Week 2007 Program

RESEARCH WEEK 14 – 21 JUNE 2007

1

Thursday, 14 June Session 1 First Plenary Session Venue: Charles LaTrobe Lecture

Theatre Chair: Professor Ingrid Winship

Schedule Event

12.30 pm - 1.00 pm Lunch Sponsored by Safety and Service Improvement

1.00 pm - 1.20 pm Guest Speaker Professor David de Kretser, AC Governor of Victoria

1.20 pm – 1.30 pm Presentation of Melbourne Boston Research Exchange

The Right Hon Lord Mayor John So Mayor, City of Melbourne

1.30 pm – 2.00 pm Free Papers

Abstract Numbers:

1. The Bcl-2 protein family controls platelet lifespan Mason KD, Carpinelli MR, Fletcher JI, Collinge JE, Hilton AA, Ellis S, Kelly PN, Ekert P, Metcalf D, Roberts AW, Kile BT, Huang DCS

With an introduction by: Associate Professor Andrew Grigg, Deputy Director of Clinical Haematology and Bone Marrow Transplantation, RMH

2. The protein methyltransferase PRMT5 links histone H4 methylation to Dnmt3a-dependent DNA methylation and transcriptional silencing Rank G, Zhao Q, Cerruti L, Cunningham J, Jane SM

With an introduction by: Dr Annabel Tuckfield, Haematologist, Diagnostic Haematology, RMH


2

Friday, 15 June Session 2 Molecular Medicine Informatics Model 2007 –

the Australian Cancer Grid: Current research and new trends in Molecular Medicine Informatics research

Venue: Charles LaTrobe Lecture Theatre Chair: Mr Robert Merriel

Schedule Event

12.30 pm - 1.00 pm Lunch Sponsored by MMIM

Introduction Mr Rob Merriel Director Business Development, MH

Epilepsy – the first seizure database and research Dr Raju Yerra

Colon cancer – the development of a chemotherapy prescribing model in colorectal cancer as part of the ACCORD database Dr Suzy Kosmider

Breast cancer – the Victorian Tissue Bank Initiative and the bias in stored specimens, focusing on potential implications and relevancy of research conducted on these samples Professor Bruce Mann

New linkages with PBS, MBS and death registries Mr Rob Merriel

1.00 pm - 2.00 pm

Conclusion Mr Rob Merriel


3

Saturday, 16 June Session 3 Surgical Research Forum Venue: Ewing Lecture Theatre Chair: Professor Andrew Kaye

Schedule Event

Free Papers

Abstract Numbers:

3. The role of lymphatic vessel location and calibre in cancer metastasis Shayan R, Karnezis T, Ashton MW, Varigos G, van Zyl N, Dunn R, Corlett RJ, Achen MG, Mann GB, Scolyer R, Taylor GI, Stacker SA

4. Preoperative imaging for DIEA perforator flaps: A comparative study of CT angiography and doppler ultrasound Rozen WM, Phillips TJ, Ashton MW, Stella DL, Gibson RN, Corlett RJ, Taylor GI

5. Aurora Kinase B is an independent protective factor in superficial bladder tumours with a dysfunctional G1 checkpoint Bruyere F, Corcoran NM, Berdjis N, Namdarian B, Pederson J, Ockram J, Voelzke B, Costello AJ, Hovens CM

6. Changes in the lymph structure of the upper limb following axillary dissection – Radiographic study in a human cadaver Suami H, Pan W-R, Ashton M, Corlett RJ, Taylor GI

7. Targeting angiogenesis in glioblastoma Wong MLH, Kaye A, Hovens C

8.30 am - 10.00 am

8. The effect of hospital and surgeon case volume on cancer mortality: a systematic review Gruen RL, Pitt V, Green S, Jolley D, Zavarsek S, Campbell D


4

Monday, 18 June Session 4 Research skills –

Funding and promoting your research Venue: Lovell Lecture Theatre Chair: Dr Angela Watt

Schedule Event

12.30 pm - 1.00 pm Lunch Sponsored by the Research Directorate

Funding from the NHMRC

Dr David Curtis NHMRC RD Wright Fellow, Rotary Bone Marrow Research Laboratories

Funding from international sources

Professor Stephen M Jane Director and Principal Research Fellow, Rotary Bone Marrow Research Laboratories

Funding from trusts and foundations

Mr David Jones Director Royal Melbourne Hospital Foundation

Funding from pharmaceutical companies

Professor Mark Rosenthal Director Medical Oncology

Funding from the medical and surgical colleges

Professor Peter Ebeling Chair of Medicine, Head of Endocrinology Department of Medicine (RMH/WH), University of Melbourne

Venture capital / private capital

Mr Rob Merriel Director Business Development, MH

1.00 pm - 2.00 pm

Promoting your research the right way

Ms Trudy Habner Executive Director, Communications and Community Relations, MH


5

Monday, 18 June Session 5 Nursing Forum Venue: Charles LaTrobe Lecture Theatre Chair: Mr Colin Dawson

Schedule Event

2.00 pm – 2.30 pm Guest Speaker Dr Trish Martin Director of Nursing Practice/Associate Professor Institute of Forensic Mental Health, Monash University

2.30 pm – 3.20 pm Free papers

Abstract Numbers:

9. Facilitating critical decision making in end stage lung disease - results of a questionnaire Wiles J

10. Nutrition assessment in the Melbourne Longitudinal COPD Cohort (MLCC) Thompson M, Hutchinson A, Bu XN, Anderson GP, Irving L

11. A randomised, controlled trial of conventional weaning versus an automated system (Smartcare™/PS) in mechanically ventilated critically-ill patients Rose L, Presneill JJ, Cade JF

12. A nurse-led rapid assessment service in the community decreases severity of exacerbations and readmission rates in the Melbourne Longitudinal COPD Cohort (MLCC) Hutchinson A, Thompson M, Brand C, Black J, Smallwood D, Vlahos R, Bozinovski S, Anderson GP, Irving L

3.20 pm – 3.40 pm Refreshments Sponsored by Nursing


6

Tuesday, 19 June Session 6 The Great Debate –

“The medical researcher who promotes their work to the media is a sell-out, not a superhero”

Venue: Charles LaTrobe Lecture Theatre

Chair: Associate Professor Geoffrey McColl

Schedule Event

10.00 am – 10.15 am Morning Tea Sponsored by the Research Directorate

PANELISTS

Judges

Ms Robynne Cooke Divisional Director Nursing – Medicine

Dr Donald Liew Director of Emergency Services

Ms Liz Cashill Director of Allied Health

Affirmative – He is a sell-out

Professor Jeff Szer Professor/Director Department of Clinical Haematology and Bone Marrow Transplant Service, RMH

Ms Sally Campbell Corporate Secretary and Executive Director Business Development, MH

Ms Trudy Habner Executive Director, Communications and Community Relations, MH

10.15 am – 12.00 pm

Negative – He is a superhero

Mr Tom Noble Media Consultant

Associate Professor Rodney Judson Divisional Director Surgery and Perioperative Services, Director of Trauma, Chairman Senior Medical Staff, MH

Professor Ingrid Winship Director of Research and Head of Adult Genetics, MH

12.00 pm – 12.30 pm Lunch Sponsored by the Research Directorate


7

Tuesday, 19 June Session 7 Clinical Research Venue: Charles LaTrobe

Lecture Theatre Chair: Associate Professor Peter Colman

Schedule Event

12.00 pm – 12.30 pm Lunch Sponsored by the Research Directorate


Abstract Numbers:

13. Prevalence of sleep disordered breathing in paroxysmal and persistent atrial fibrillation patients without structural heart disease Stevenson IH, Teichtahl H, Cunnington D, Ciavarella S, Gordon I, Kalman JM

14. Identifying severe community acquired pneumonia in the emergency department – a simple clinical prediction tool Buising KL, Thursky KA, Black JF MacGregor L, Street AC, Kennedy MP, Brown GV

15. Maternal age is associated with the decline in diastolic function in late pregnancy Zentner D, du Plessis M, Wong J, Brennecke S, Grigg L, Harrap S

16. CT predictors of hematoma growth in primary intracerebral hemorrhage: shape and density heterogeneity Barras CDJ, Christensen S, MacGregor L, Tress BM, Davis SM; for the Recombinant Activated Factor VII Intracerebral Hemorrhage Trial Investigators


8

Tuesday, 19 June Session 8 Allied Health, Continuing Care Medicine and

Rehabilitation Medicine Venue: Charles LaTrobe Lecture Theatre Chair: Dr Tony Snell

Schedule Event

1.30 pm – 1.35 pm Opening Address Dr Tony Snell Divisional Director Medicine, RMH

1.35 pm – 2.00 pm Keynote Speaker Pain in Dementia Dr Sam Scherer General Manager, Medical Services, Royal Freemasons' Homes of Victoria. Clinical Associate Professor, The University of Melbourne

Free Papers

Abstract Numbers:

17. A review of evidence of management of adults with spina bifida Hunter RA

18. Maximising outcomes for older people in the acute hospital setting: translating evidence into practice. The Functional Maintenance Program on General Medicine wards Wilson B, Bramley A, Clough L, Yiu C, English V

2.00 pm – 2.45 pm

19. Outcomes of the RMH Vestibular Rehabilitation Service McGann A, Hill, K, Louie J, Macdonell G

2.45 pm – 3.15 pm Afternoon Tea

20. Development of an Indigenous cognitive assessment tool and determination of prevalence of dementia and other aged care conditions in Indigenous elderly living in the Kimberley Smith K, Flicker L, Dwyer A, Almeida O, Lautenschlager N, Atkinson D, LoGiudice D

21. Carers’ perspective of the cognitive dementia and memory service Tan V

22. The experiences of allied health staff working in a sub-acute dementia-specific ward Barnett J

23. Effective communication with patients; developing a national tool to promote chronic disease self-management Davidson N, Jordan J, Osborne R

3.15 pm – 4.30 pm

24. Lower limb amputee phantom pain management - current status Hale, T

4.30 pm – 4.35 pm Closing Remarks Dr Tony Snell


9

Wednesday, 20 June Session 9 Research during your medical training –

How to find a project and a supervisor Venue: Lovell Lecture

Theatre Chair: Associate Professor Geoffrey Hebbard

Schedule Event

12.30 pm – 1.00 pm Lunch Sponsored by Medical Education Program

Professor Mark Rosenthal Director Medical Oncology, RMH

Dr Bob Anderson Ian Mackay Fellow in Translational Research, Autoimmunity and Transplantation Division, WEHI Consultant Gastroenterologist, RMH Chief Scientist and Medical Officer, Founder and Director, Nexpep Pty Ltd and Nexgrain Pty Ltd

1.00 pm – 1.30 pm Speakers

Dr Irani Ratnam Infectious Diseases PhD Fellow, University of Melbourne, Department of Medicine

Wednesday, 20 June Session 10 Public Lecture – Coeliac Disease: Progress

towards prevention and protection Venue: Charles LaTrobe Lecture Theatre Chair: Professor Ingrid Winship

Schedule Event

6.00 pm – 6.30 pm Refreshments

Professor Finlay Macrae Director Colorectal Medicine and Genetics, MH

Dr Bob Anderson Consultant Gastroenterologist, RMH Ian Mackay Fellow in Translational Research, Autoimmunity and Transplantation Division, WEHI Chief Scientist and Medical Officer, Founder and Director, Nexpep Pty Ltd and Nexgrain Pty Ltd

6.30 pm – 7.30 pm Speakers

Ms Sue Shepherd Advanced Accredited Practising Dietitian


10

Thursday, 21 June Session 11 Poster viewing Venue: Function and Convention Centre

Schedule Event

11.00 am – 1.00 pm Lunch and Poster Viewing

Lunch sponsored by Safety and Service Improvement


11

Thursday, 21 June Session 12 Second Plenary Session Venue: Charles LaTrobe

Lecture Theatre Chair: Associate Professor Geoffrey McColl

Schedule Event


Abstract Number:

25. Adverse drug reactions – re-prescription of offending medications! McDowall J, Dostal J, Etty-Leal M, Jones N, Robertson M, Steinborn R Arnold M, George C, Neilsen S, Zarth H

With an introduction by: Mr David Ford, Director of Pharmacy and General Manager Radiology, MH

26. The Melbourne first-episode of psychosis long term follow-up study: Decline in attentional set-shifting but not spatial working memory after the onset of psychosis Pantelis C, Proffitt TM, Wood SJ, O’Brien CL, Henry LP, Harris MG, Velakoulis D, Brewer WJ, McGorry PD

With an introduction by: Associate Professor Alex Cockram, Director NorthWestern Mental Health

27. Hedgehog signalling within the cell niche regulates B cell development Nguyen NN, McCormack MP, Siggins SL, Clarke AJ, Wainwright BJ, Curtis DJ

With an introduction by: Professor Jeffrey Szer, Professor/Director Department of Clinical Haematology and Bone Marrow Transplant Service, RMH

28. Neuronal firing patterns of higher order thalamocortical neurons during absence seizures: Potential implications for loss of consciousness O’Brien TJ, Pinault D

With an introduction by: Associate Professor Christine Kilpatrick, Executive Director, Clinical Governance, MH

1.55 pm – 2.00 pm Closing Remarks and Thanks

Professor Ingrid Winship, Director of Research and Head of Adult Genetics, MH


Thursday, 21 June Session 13 Informal and Community Poster Viewing Venue: Charles LaTrobe Lecture Theatre

Schedule Event

5.00 pm – 5.30 pm Poster Viewing

5.30 pm – 6.00 pm Award and Prize Presentations

Professor Ingrid Winship, Director of Research and Head of Adult Genetics, MH

12

RMH RESEARCH WEEK 14 – 21 JUNE 2007

Abstract Number:

29 Multi channel bio impedance meter Hebbard G, Afkari S, Fowler M

30 Electronic swallow detector Hebbard G, Afkari S, Junor P, Fowler M

31 Diffusion tensor imaging of the human optic nerve in optic neuritis Kolbe SC, Chapman C, Mitchell PJ, Kilpatrick TJ, Egan GF

32 ADAM22-4 a putative tumour suppressor in glioma, inhibits cellular proliferation via the cytoplasmic domain D’Abaco GM, Godde NJ, Paradiso L, Novak U

33 Applications of new molecular methodology for cytogenetically normal AML patients; FLT3-ITD and NPM1 Dean A, Bell AH, Anguillesi A, Tuckfield A

35 Detection of hippocampal and brain volume changes during epileptogenesis by manganese-enhanced MRI Shen Y, Fang K, Noordman I, Egan G, O'Brien TJ, Dedeurwaerdere S

36 Determination of voriconazole levels in vitreous and aqueous humour by HPLC Fullinfaw RO, Leong YC

37 Differential coding potential of ADAM22 mRNAs Gödde NJ, D’Abaco GM, Paradiso L, Novak U

38 The role of neutrophil serine proteases in resolving influenza infection after smoke exposureGualano RC, Jones JE, Langenbach S, Turner DJ, Laurent GJ, Sly PD, Anderson GP

39 Evidence Direct Harrison TM

40 Constituents of the coagulation cascade are spatially and functionally related to experimental tubulointerstitial fibrogenesis Winbanks C, Grimwood L, Darby IA, Hewitson TD, Becker GJ

41 Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination I STT, Straffon AFL, Schieb H, Hovens CM, Stylli SS, Lock P

42 Evidence for co-morbid psychotic-like behaviour in a genetic rat model of absence epilepsyJones N, van den Buuse M, Salzberg M, Morris M, O’Brien T

43 Increased depressive and anxiety-like behaviours are seen in the GAERS rat model of genetic absence epilepsy Jones N, Kumar G, Salzberg M, Morris M, Rees S, O’Brien T

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RMH RESEARCH WEEK 14 – 21 JUNE 2007 Abstract Number:

44 Early postnatal separation stress enhances vulnerability to later limbic epileptogenesis in young adult female but not male rats Kumar G, Supit L, Jones NC1, Morris MJ, Rees SM, Salzberg MR, O'Brien TJ

45 High sensitivity vs general purpose collimator SPECT imaging using 3D reconstruction algorithms Lichtenstein M, Barnden L, Westcott J

46 The Tks5 adaptor protein cooperates with TIP1/2 to promote ECM degradation by melanoma cells Stylli SS, I STT, Verhagen AM, Connolly L, Courtneidge SA, Roteno T, Pili M, Lock P

47 Overexpression of the EGFR mediates a Stat3-dependent desensitization of the TGF-β signalling pathway Luwor RB, Taylor LE, Wang B, Zhu H-J

48 Lmo2-driven T-ALL derives from a long-lived precursor and does not require Scl McCormack MP, Clarke AJ, Jane SM, Curtis DJ

49 In vivo quantification of benzodiazepine receptor density and affinity in rat brain using small animal PET with a multi-injection protocol Gregoire M-C, Dedeurwaerdere S, Vivash L, Binns D, Roselt P, Franklin M, Taylor P, Pham T, Katsifis A, Hicks RJ, O’Brien TJ, Myers DE

50 Evaluation of [18F] fluoroflumazenil for in vivo PET imaging of GABAA/cBZR density in small animal models of epilepsy Dedeurwaerdere S, Gregoire M-C, Roselt P, Binns D, Katsifis A, Hicks RJ, O’Brien TJ, Myers DE

51 The relevance of changes in HCN expression for epileptogenesis Ng C, Powell KL, O’Brien TJ, Xu SH, Williams DA, Foote SJ, Reid CA

52 Antibodies against Plasmodium falciparum invasion ligands have a strong association with protection against clinical malaria Richards JS, Stanisic DI, Wilson DW, Reiling L, Reeder JC, King CL, Michon P, Mueller I, Cowman AF, Beeson JG

53 The distinct N-terminal regions of SCL and Lyl-1 explain their functional differences Salmon JM, Slater NJ, McCormack MP, Curtis DJ

54 Adverse effects of valproate on bone disease: Defining a model to investigate pathophysiology Senn SM, Kantor S, Andrikopoulos S, O’Brien TJ, Morris MJ, Wark JD

55 Levosimendan increases contraction post-ischaemia in isloted guinea pig atria Soeding P, Royse C, Wright CE, Royse A, Angus JA

56 Evaluating the role of invadopodia in invasion and metastasis Stylli SS, I STT, Roteno T, Courtneidge SA, Kaye AH, Lock P

14


57 Glutathione peroxidase-1 primes TLR4-dependent innate immunity in vivo Vlahos R, Bozinovski S, Langenbach S, Crack P, Hertzog P, Anderson GP

58 Positive and negative cooperation of p38 MAPK with TGF-β in epithelial to mesenchymal transition (EMT) Wang B, Zhu HJ

59 A novel insight into the regulation of tumour suppressor pten: Phosphorylation switching it from a phosphatase to a kinase Xiao Y, Lio D, Stenseballe A, Simpson RJ, Cartimel B, Cheng HC, Zhu HJ

60 Retrospective and prospective study of “suspicious” fine-needle aspirate cytology of the thyroid in an urban, academic, Australian hospital Alexander K, Miller J, Judson R, Millar R, Lowe A

61 The arterial blood supply to the achilles tendon Chen T, Pan WR, Suami H, Ashton MW, Corlett RJC, Taylor GI

62 Prediction of obstructed breathing in the early post-operative period Chia PH, Blake DW, Donnan G, Williams D

63 The Global Evidence Mapping (GEM) initiative – The launch of a new concept in evidence-based practice Gruen RL, Collie A, Green S, Campbell D, Buchan H, Davies J, Tavender E, Harrison T, Zobel J, Kaye AH

64 A delay to theatre in patients with femoral neck fractures does not lead to adverse outcomeJohnston J

65 The ENIGMIA-II Trial: Nitrous oxide anaesthesia and cardiac morbidity after major surgery Leslie K

66 The distribution of superficial lymphatic vessels of the head and neck – An anatomical study and clinical application Pan WR, Suami H, Ashton M, Corlett R, Taylor GI

67 Spinal Dural Arteriovenous Fistulae: Radiological features of an uncommon cause of myelopathy. Fifteen-year experience at the Royal Melbourne Hospital Perchyonok Y, Phal P, Mitchell P

68 The branching pattern of the DIEA for perforator flaps: The importance of preoperative CT angiography Rozen WM, Palmer KP, Suami H, Pan WR, Ashton MW, Corlett RJ, Taylor GI

69 Dupuytren’s Disease in a patient with Marfan’s Syndrome: Manifestations of defective connective tissue remodeling and repair Snell BJ, Dowd M

70 Recurrent focal myositis: An novel cause of flexion contractures of the fingers Snell BJ, Dowd M

15


71 Bupivacaine in the Emergency Department: Under-utilised and scope for improved patient care Shen JJ, Taylor D, Knott J, MacBean C

72 Bicycle injuries in Victoria (2004-2005): Emergency Department and police presentations Dent M, Taylor D, Ashby K

73 Mobile telephone use among Melbourne drivers: The number of drivers at risk remains unchanged Taylor D, MacBean C, Das A, Mohd Rosli R

75 Randomised comparison of the Ambu® AuraOnce™ Disposable Laryngeal Mask with the Laryngeal Mask Airway UniqueTM during anaesthesia in spontaneously breathing adult patients Andrews DT, Alexander K, Zeng J

76 Omega-3 fatty acids reduce the risk of early transition to psychosis in ultra-high risk individuals: A double-blind randomized, placebo-controlled treatment study Amminger GP, Schaefer MR, Papageorgiou K, Becker J, Mossaheb N, Harrigan SM, McGorry PD, Berger GE

77 Olfactory identification deficits remain stable following a first episode of psychosis: Data from the EPPIC-medium term follow-up study Brewer WJ, O’Brien CL, Wood SJ, Henry LP, Harris MG, Pantelis C, McGorry PD

79 Met and unmet need in youth mental health Cosgrave E, Yung AR, Killackey E, Buckby J, Godfrey K, Stanford CA, Baksheev G

80 Resting heart rate and autonomic cardiac control in depressed adolescents Byrne M, Simmons J, Sheeber L, Davis B, Shortt JW, Katz LF, Allen N

81 Co-morbid borderline personality disorder and first episode psychosis: How many and what happens? Francey SM, Jovev M, Phassouliotis C, McDougall E, Cotton S, Chanen A

82 Last observation carried forward in psychiatric research – a flawed gold standard? Cotton SM, Yuen HP, Berger G, McGorry PD

83 Predictors of suicide attempt in treatment in first episode psychosis Cotton S, Robinson J, Conus P, Lambert M, McGorry PD

84 The SIMSEP-BD: A novel brief psychoeducation program for patients with bipolar affective disorder and carers that decreases relapse and medication non-adherence rates D’Souza R, Piskulic D, Sundram S

85 Estrogen prevents 5-HT1A receptor-induced disruptions of prepulse inhibition in healthy women Gogos A, Nathan PJ, Guille V, Croft RJ, van den Buuse M

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86 Early detection and optimal treatment may improve outcome in early-onset schizophrenia: Evidence from the EPPIC long-term follow-up study of first episode psychosis Harrigan SM, Amminger GP, Henry LP, Harris MG, Prosser A, Jackson H, McGorry PD

87 The EPPIC long term follow-up study of first episode psychosis: Clinical and functional outcomes at 7.5 years Henry LP, Harris MG, Amminger GP, Jackson HJ, Yuen HP, Harrigan SM, McGorry PD

88 The reliability and validity of the severity of dependence scale for detecting cannabis dependence in psychosis Hides L, Dawe S, Young R McD, Kavanagh DJ

89 Perceptual organisation in schizophrenia Joshua N, O’Regan A, Rossell S

90 Family history and cognitive functioning at intake predict short-term functional outcome in first-episode psychosis Kerr MJ, Proffitt TM, McConchie MA, Wood SJ, Markulev C, Yuen HP, Brewer WJ, McGorry PD, Pantelis C, Berger GE

91 Investigation of associations between Single Nucleotide Polymorphisms (SNP) of the Muscarinic1 Receptor (M1R) gene and cognitive deficits in schizophrenia Khademy-Deljo A, Sundram S, Dean B, Scarr E, Pantelis C

92 Results of the first Australian randomised controlled trial of individual placement and support in first episode psychosis Killackey E, Jackson H, McGorry PD

93 Anhedonia in opiate addiction: Psychophysiological predictors of relapse Lubman D, Allen N, Kettle J, Scaffidi A, MacKenzie T, Yucel M

94 Inhalent use in youth: What are the risks? Lubman DI, Hides L, Yucel M

95 Recovery of working memory functioning in first-episode psychosis: Relationship to family history of schizophrenia Markulev C, Proffitt TM, McConchie MA, Wood SJ, Kerr MJ, Yuen HP, Brewer WJ, McGorry PD, Pantelis C, Berger GE

97 A double blind, placebo-controlled randomized trial of low-dose risperidone, intensive psychological treatment and supportive therapy in young people with subthreshold symptoms at incipient risk of psychotic disorder: Baseline characteristics of the sample Nelson B, Phillips LJ, Yung AR, Francey SM, Leicester S, Baker K, Krstev H, Amminger P, Berger G, DiBella I, Thampi A, McGorry PD

98 Polymorphism of the Methionine Synthase gene associated with schizophrenia and cognitive symptoms O’Donnell C, Papas A, Foley D, McGorry P, Phassouliotis C, Moral J

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99 Building family skills together: Implementing an evidence based family intervention in the continuing care teams of an area mental health service O’Hanlon B, Harvey C, Perlesz A

100 Elevated homocysteine associated with poorer cognitive functioning in early psychosis Papas A, O’Donnell C, O’Regan MK, Proffitt T, Purcell R, McGorry PD

101 Clozapine transactivates the EGF receptor to stimulate ERK in cortical neurons. A therapeutic target for refractory schizophrenia? Pereira A, Fink G, Sundram S

102 Stability in intellectual, memory and attention deficits 5-10 years after the onset of psychosis: Data from the EPPIC long term follow-up study Proffitt TM, Wood SJ, O’Brien CL, Henry LP, Harris MG, Brewer WJ, Velakoulis D, McGorry PD, Pantelis C

103 An atypical intervention to improve psychosocial functioning of a community in a southern coastal town of Sri Lanka in the aftermath of the tsunami in 2004 Rajasuriya M

104 Assertive outreach in youth mental health: An audit of client characteristics and treatment effects in difficult to engage, 'high-risk' youth Schley C, Ryall V, Crothers L, Radovini S, Fletcher K, Marriage K, Nudds S, Groufsky C

105 Characterising white matter abnormalities in chronic schizophrenia: a TBSS voxel-wise analysis of diffusion images Seal ML, Yücel M, Fornito A, Wood SJ, Harrison BJ, Clarke K, Pell G, Soulsby B, Walterfang M, Velakoulis D, Pantelis C

106 A systematic evaluation of an expanded nurse practitioner role within a metropolitan psychiatric crisis assessment and treatment team Sundram S, Happell B, Johnstone H, Wortans J, Lakshmana R, Brown S, Jackson B, Gough K, Humphries R, Kelly T

107 The identification of co-morbid substance use disorders in in-patients with psychiatric illnessSundram S, Happell B, Gough K

109 An investigation into mood induction and the perception of social relationships in depressed stroke patients: A prerequisite for therapeutic change Turner M

110 The neuroanatomical basis of temperament in early adolescents Whittle SL, Barrett A, Allen NB, Wood SJ, Yucel M

111 Phospholipase-A2 (PLA2) activity predicts short-term outcome in first episode psychosis (FEP) Yun Y, Smesny S, Law M, Proffitt TM, Wood S, McConchie M, Kerr M, Markulev C, Cotton R, Cotton S, McGorry P, Berger G

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112 Lost in Translation? Transform your basic research into clinical application by utilizing the translational research laboratory at Cancer Trials Australia Campano L, Winstanley R, Rassell A, Clark M, Beckman I

113 Serum Amyloid Protein A is a predictive blood biomarker in acute exacerbations of COPD Bozinovski S, Hutchinson A, Thompson M, MacGregor L, Black J, Giannakis E, Smallwood D, Vlahos R, Irving LB, Anderson GP

114 The topographical relationship between the source localization of interictal and ictal EEG discharges recorded with sub-dural grid electrodes using low-resolution electromagnetic tomography (sLORETA) Cassidy D, Roten A, O’Brien T

115 Mycophenolate - beyond transplantation Dwyer J

116 Reflective preceptors: Students reap rewards Vienet M, Landau J, Galbraith K

117 In vivo quantification of lumbar intervertebral disc degeneration using axial T2 mapping Watanabe A, Benneker L, Boesch C, Watanabe T, Obata T, Anderson S

118 Ability of dGEMRIC and T2 mapping as measures for repair of cartilage after micro fracturing procedure Watanabe A, Boesch C, Mainil-Varlet P, Anderson S

119 Detection of subclinical left ventricular dysfunction by speckle tracking echocardiography in breast cancer patients receiving systemic therapy Chan W, DeBoer R, Rosenthal MA, Wong J

120 The evaluation of quantitative ultrasound in antiepileptic drug induced bone disease Chin LK, Kantor S, Petty S, O’Brien TJ, Wark JD

121 Immunophenotype of the splenic population following rituximab therapy Christie M, Macrae F

122 Inter-rater reliability of the Australasian Triage Scale for mental health patients Creaton A, Wright M, Liew D

123 The incidence and degree of recanalization depends on site of arterial occlusion in acute ischemic stroke De Silva DA, Christensen S, Butcher KS, Parsons MW, Levi CR, Bladin CF, Barber PA, Peeters A, Donnan GA, Davis SM: for the EPITHET investigators

124 Expediting MRI-based proof of concept stroke trials using an earlier primary endpoint Ebinger M, Christensen S, Butcher KS, Parsons MW, Levi CR, Bladin CF, Barber PA, Peeters A, Donnan GA, Davis SM: for the EPITHET investigators

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125 Low mannose-binding lectin complement activation function is associated with predisposition to Legionnaires’ disease Eisen D, Stubbs J, Spilsbury D, Carnie J, Leydon J, Howden B

126 Predictors of length of hospital stay and discharge destination in lower limb amputee rehabilitation Hale TA, Khan F, Seal E

127 Prolactinoma: the outcome of treatment using strict criteria of biochemical control Maartens NF, Imail NA

128 Pro-survival Bcl-2 is dispensable and Bcl-xL essential for the development of Myc-induced B cell leukaemia/lymphoma Kelly PN, Adams JM, Strasser A

129 The impact of the Emergency Department environment on patient satisfaction Walsh M, Knott J

130 Reasons for unexpected events during intra-hospital transfer of seriously ill patients from the Emergency Department Das A, Knott JC, Taylor DMcD, Papson J, Rosli R, MacBean C

131 Audit of deaths, palliative care referrals and diagnoses in a large Australian teaching hospital Le BH, Ashby MA

132 Analgesia from L-dopa in Parkinson patients with dyskinesia: A sensitization phenomenon?Lim SY, Farrell MJ, Helme RD, Gibson SJ, MacGregor L, Evans AH

133 A statistical methods for determining transmission characteristics of nosocomial pathogensMcBryde ES, Pettitt AN, McElwain DLS

134 Using samples to estimate the sensitivity and specificity of a surveillance process McBryde ES, Richards M, Russo P, Bull a, Marshall C, Eisen D, Kelly H

135 BK virus detection in renal transplant patients using SV-40 T Antigen immunostaining: A single-centre experience McKay D, Finlay M, Beaty A

136 Chronic anti-epileptic drug treatment is associated with lower balance function scores – a twin and matched sibling AED-discordant pair study Petty SJ, Paton LM, El Haber N, Berkovic SF, O’Brien TJ, Hill K, Wark JD

137 Pathogenesis of frozen shoulder Ramkumar S, Richardson M

138 Profile of frozen shoulder patients having arthroscopic surgery Ramkumar S, Richardson M

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139 The development of a randomised controlled trial designed to reduce suicide risk among young help-seekers: The ORYGEN Postcard Study Robinson J, Gook S, Evans R, Jorm T, McGorry P, Yung A

140 Randomized phase II study of Docetaxel with or without DMXAA (AS1404) in hormone-refractory metastatic prostate cancer (HRMPC) Rosenthal MA for the AS1404-203 Study Group Investigators

141 Atrial electrical remodelling occurs acutely in response to respiratory and metabolic acidoses – implications for atrial fibrillation susceptibility Stevenson IH, Edwards G, Spence S, Kistler P, Roberts-Thomson K, Kalman JM

142 Outcomes of aortic stenosis – a comparison of dialysis patients versus controls Zentner D, Chan W, Perkovic V, Grigg L, Hunt D

143 Osteoporosis education in elderly patients Abrahamson S, Khan F

144 Clinical outcomes after percutaneous coronary interventions in octogenarians Yan B, Ajani A, Gurvitch R, Duffy S, Clark D, Sebestian M, New G, Warren R, Lew R, Brennan A, Reid C. On behalf of the Melbourne Interventional Group (MIG) Investigators

145 Does female gender impact on contemporary Australian coronary interventional practice? Yan B, Ajani A, Ahmar W, New G, Duffy S, Walton A, Szto G, Warren R, Ponnuthurai L, Brennan A, Meehan A and Reid C. On behalf of the Melbourne Interventional Group (MIG) Investigators

146 A snapshot of current treatment of in-stent restenosis Yan B, Ajani A, Clark D, Duffy S, Warren R, Lew R, Sebastian M, Szto G, Eccleston D, Meehan A, Reid C. On behalf of the Melbourne Interventional Group (MIG) Investigators

147 Implementing evidence into practice: Results of the General Medical Indicator Program (GMIP) Brand C, Lam S, Smallwood D, Roberts C, Gorelik A, Russell D

148 The impact of a computerised decision support system to guide antibiotic prescribing for adults with community acquired pneumonia – a comparison with academic detailing KL Buising, KA Thursky, JF Black, L MacGregor, AC Street, MP Kennedy, GV Brown

149 A retrospective comparison of injection techniques used in breast lymphoscintigraphy over the last 6 years at The Royal Melbourne Hospital Callahan J, Mann B, Gunawardana D, Salehi N, Buechler M, Grinter E, Lichtenstein M, Collins J

150 Improvement in quality of life, functional status and mortality by four years of intervention of the Royal Melbourne Hospital Cardiomyopathy Service Kerlin ML, Chan W, Aggarwal A, Wong J, Grigg LE

151 Reduction in heart failure re-admission rates to all hospitals over 4 years by an outpatient multidisciplinary cardiomyopathy service Kerlin ML, Chan W, Aggarwal A, Wong J, Grigg LE

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152 Comparison of outcomes of primary and revision total hip arthroplasty in an in-patient rehabilitation unit Chu P, Khan F

154 Catheter ablation of scar-related ventricular tachycardia: Procedural results and long-term outcome in a single-centre series Haqqani HM, Vohra JK, Roberts-Thomson KC, Snowdon R, Medi C, Stevenson I, Sparks PB, Kalman JM, Morton JB

155 Capsule endoscopy, endoscopy, and barium studies in Peutz-Jeghers Syndrome and juvenile polyposis Macrae FA, Ibrahim M, Stella D, Gibson RN, Cameron D, Catto-Smitth A, Pizzey C, Brown G, Marion K, Alogaily S

156 Capsule endoscopy in orofacial granulomatosis Ibrahim M, Macrae FA, Cameron D, Brown G

157 CAPP2: A Trial of aspirin and/or resistant starch in people at risk of hereditary non polyposis colorectal cancer (HNPCC) Macrae FA, Ives PC, Winship I, Lipton L, Boussioutas A, Young M-A, Kentwell M, Leggett BA, Gattas M, White J, Geldard V, Scott RJ, Spigelman A, Groombridge C, Burgess B, Walpole I, Goldblatt J, George J, Burke J, Burn J, Jass JR

158 Antibiotic allergy among emergency department patients: prevalence and diagnostic accuracy Wong J, Knott JC, Taylor DMcD

159 A case series of African-born residents of Victoria Lemoh C, Hellard M, Street A, Biggs B

160 BRCA1 and BRCA2 founder mutations: a review of the literature and their potential clinical utility for genetic testing in Australia Hodgkin L, Lynch E, D'Souza R, Wang J, Bogwitz M, Winship I, Lindeman G

162 An audit of blood pressure control following stroke in the setting of a district rehabilitation service Ng L, Gibson J

163 Longitudinal brain MRI changes in young people at ultra-high risk for the development of psychosis and in first-episode schizophrenia Pantelis C, Sun D-Q, Phillips L, Velakoulis D, Yung A, Wood SJ, Thompson P, van Erp TGM, Toga AW, Cannon T, McGorry PD

164 Iron deficiency and anaemia in North Western Vietnam – A cross sectional survey Pasricha S, Caruana S, Trang Quang Phuc, Nong Thi Tien, Casey G, Murray S, Jolley D, Montressor A, Biggs B-A

165 Weekly iron supplementation and deworming rapidly improve haemoglobin and iron status in rural Vietnam Casey G, Trang Quang Phuc, Pasricha S, Nong Thi Tien, MacGregor L, Montressor A, Biggs B-A

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166 Clinical outcomes of frozen shoulder Ramkumar S, Richardson M

169 Implementation of osteoporosis screening and treatment guidelines in elderly patients in orthopaedic rehabilitation unit Tang K, Khan F

170 Efficacy of anticoagulation with Warfarin versus Aspirin for patients post biological aortic valve replacement Tatoulis J, Wynne R

171 Haemodynamic and electrocardiographic changes during off pump coronary artery bypass surgery. Tatoulis J, Rice S, Davis P, Goldblatt JC, Marasco S, Antippa P, Brown RP

172 Off pump coronary artery bypass graft surgery: results of the first 1000 operations Tatoulis J, Goldblatt JC, Brown RP, Royse AG, Antippa P, Atkinson V, Skillington PD, Jiang GC, Wynne R

173 Utility of MRI in adult first seizure patients – Development & validation of a clinical algorithmLowe AJ, Kilpatrick CJ, Yerra R, Ghougassian D, Matkovic D, O’Brien TJ

174 Fostering a research culture among pharmacists at the Royal Melbourne Hospital Galbraith K, Kay O, Jones N

175 Clinical handover – supporting safe transition back to the community Audehm R, Gilchrist J, Oates M

176 Implementation of an electronic approval system for restricted drugs Black J, Buising K, Richards M, Robertson M, Thursky K

177 Where does all our vancomycin go? Arnold M, George C, Neilsen S, Robertson M, Zarth H

178 Handover in the Emergency Department: Deficiencies and adverse effects Ye K, Taylor D, Knott JC, Dent A, MacBean CE

179 The development of clinical practice guidelines for the management of delirium in older people in Australia Tropea J, Slee J, Gray L, Snell T, Brand CA

180 The development of a music program for a dementia specific ward in a subacute hospital Barnett J

181 Are chronic joint symptoms a useful indicator of ‘possible arthritis’ in the Australian population Busija L, Buchbinder R, Osborne RH

182 A physiotherapy-led low back pain clinic Cary B, Frith C, Munro D, Turner P

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183 The frequency of risk factors for foot ulceration in individuals with nephropathy Freeman A, May K, Frescos N, Wraight P

184 Implementation of the Orthopaedic waiting list multi-attribute prioritisation tool and service delivery model Gordon B, Munro D, Cary B, Brand C, de Steiger R

185 The extent and breadth of benefits from participating in chronic disease self-management courses: a national patient-reported outcomes survey Nolte S, Elsworth GR, Springer AL, Sinclair AJ, Osborne OH

186 Improving timely and equitable referral for joint replacement surgery: results of a multi-site pilot implementation of the Hip and Knee Muti-Attribute Prioritsation Tool (MAPT) Osborne RH, Brand C, Jones C, Hawkins M, de Steiger R, Wicks I, Graves SE

188 Epicardial pacing practices in the Intensive Care Unit Bantick M, Nelson S

189 The challenges of holistic multidisciplinary care within the context of severe bilateral hand trauma Harper R, Anson L

190 Muscle wasting and dynamic hyperinflation in chronic obstructive pulmonary disease Bu XN, Thompson MA, Hutchinson AF, Pain MCF, Tee AKH, Anderson GP, Smallwood DM, Irving LB

191 Aetiology and clinical characteristaion of community exacerbations of COPD. The Melbourne Longitudinal COPD Cohort (MLCC) Hutchinson AF, Black J, Thompson MA, Bozinovski S, Anderson GP, Irving LB

192 Endotracheal cuff management: A survey of current practice Rose L, Redl L

193 Are staff secondments the way of the future? One example of inter-agency collaboration Allison M, Watt J

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research week2007

melbourne health research week - royal melbourne … · the research week committee was chaired by...

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