meeting rna virus persistence 2018 a5 ix · mechanisms and consequences of rna virus persistent...
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RNA VIRUS PERSISTENCE MEETING: MECHANISMS AND CONSEQUENCES
PROGRAM
AUGUST 23 - 25, 2018
Institute of Virology, Medical Center - University of Freiburg
WELCOME
Mechanisms and consequences of RNA virus persistent infections:
It is generally assumed that following acute infection RNA viruses are effectively cleared by the immune system. However, an increasing number of observations indicate that the majority of acute infections can result in the establishment of persistent infection. Many of these infections undergo undetected and the consequences for their animal and human hosts are not well understood. Furthermore, the emergence and re-emergence of in-fectious diseases may be determined by persistent infections in the human community as well as in wild and domestic animal populations, potentially increasing the zoonotic potential of some viruses. Establishing persistent infection likely involves a number of molecular, cellular and immunological determinants, including the genetics of the viruses, the genetics of their hosts and potential new host species, and many environmental factors, such as other microorganisms.
The purpose of this two-day conference is bringing together scientists working on many different viruses to address and extensively discuss underlying general and specific questions concerning the mechanisms and consequences of persistent RNA virus infections with an emphasis on zoonotic aspects.
Organizing committee:
Prof. Dr. Martin SchwemmleInstitute of VirologyMedical Center - University of Freiburg
Dr. Dennis Rubbenstroth, PhDFriedrich-Loeffler-InstitutFederal Research Institute for Animal Health
Prof. Raul AndinoMicrobiology and ImmunologyUniversity Clinic San Francisc
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DAY 1 - THURSDAY, AUGUST 23, 2018
12:00 Registration & snacks
13:00 Schwemmle/Andino
Opening remarks
Session I - Chairs: Conzelmann/Griffin
13:20 Bergmann CNS viral persistence: When T cells retire, B cells move in
13:55 Pinschewer Humoral immune defense and evasion in persistent viral infection
14:30 Snijder Arteriviruses: new names, old tricks
15:05 Reuther Visualization and characterization of non-cytolytic clearance of LCMV-infected cells during persistent viral infection
15:20 Coffee break
Session II - Chairs: Kochs/Weber
16:05 Becker Regulation of filovirus transcription/replication
16:40 Lee Emerging paramyxoviruses: diversity and danger?
17:15 Randall Phosphorylation of the P protein of PIV5 facilitates establishment of persistent infections
17:30 Rima Nucleotide sequence stability of measles virus in persistent infection and undiluted passage
17:45 Poster session (Snacks and drinks)
19:45 Freiburg tour by foot (optional)
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DAY 2 - FRIDAY, AUGUST 24, 2018
Session III - Chairs: Pietschmann/Stäheli
08:30 Cadwell Virust-Host Interactions and the Gut Microbiota
09:05 Baldridge Regulation of persistent enteric norovirus infection by the commensal microbiota
09:40 Lohmann Contribution innate immune responses to persistence versus clearance of hepatitis C virus and hepatitis A virus infections
09:55 Coffee break
Session IV - Chairs: Haller/Stertz
10:40 Carpentier Improved HCV infection of stem cell-derived hepatocytes allows analysis and modulation of the cellular antiviral innate immune response
10:55 Tautz Alternative protein interactions as switch between RNA replication and virion morphogenesis – lessons learned from a persisting RNA virus
11:30 Thiel Illuminating the coronavirus replicase: a platform for virus-host interactions
12:05 Lunch break (Networking with PIs)
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DAY 2 - FRIDAY, AUGUST 24, 2018
Session V - Chairs: Briese/Rubbenstroth
14:05 Tomonaga Roles of non-coding RNAs from endogenous bornavirus-like elements in Borna disease virus infection
14:40 Beer Zoonotic Bornaviruses: From Persistence to Lethal Infection
15:15 Ensser Severe encephalitis caused by Borna disease virus 1 (BoDV-1)
15:30 Bourgade Molecular and cellular mechanisms underlying the neuroprotective properties of Bornavirus X protein
15:45 Coffee break
Session VI - Chairs: Bergmann/Randall
16:30 Griffin Characterization of alpha virus persistence in the CNS
17:05 Conzelmann Protein kinase R is the key player in rabies virus cytotoxicity
17:40 Valarcher Gene signatures associated with foot-and-mouth disease virus infection and persistence. Part I: Model of Persistent FMDV infection in a three-dimensional model of the bovine soft palate
17:55 Eschbaumer Gene signatures associated with foot-and-mouth disease virus infection and persistence. Part II: Transcriptomic analysis
18:10 Poster session
20:00 Dinner (Barbeque at the Institute)
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DAY 3 - SATURDAY, AUGUST 25, 2018
Session VII - Chairs: Beer/Hengel
09:00 Andino Chronic infection as an evolutionary driving force determining lifespan setpoints
09:35 Schmidt-Chanasit
The role of viral persistance in human arbovirus infections
10:10 Kemming Characterization of the HEV-specific CD8+ T-cell response in acute and chronic Hepatitis E virus infection
10:25 Coffee break
10:55 Müller Exploring the role of viral persistence in context of reservoir host species
11:30 Palacios The Egyptian rousette genome reveals unexpected features of the bat innate and adaptive immune response
12:05 Schwemmle/Andino
Final Discussion
12:45 Schwemmle/Andino
Closing remarks
End of Meeting
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THANKS TO OUR SPONSORS:
GOLD SPONSOR: SILVER SPONSORS:
Stand nach Drucklegung: 08 | 2018Redaktion: Universitätsklinikum Freiburg | CCILayout: Universitätsklinikum Freiburg | Medienzentrum
CONGRESS INFORMATIONMartin SchwemmleInstitute of VirologyMedical CenterUniversity Freiburg
CONTACT CONVENERMelanie SpringmannStabsstelle UnternehmenskommunikationMedical CenterUniversity Freiburg
fon +49 761 [email protected]
WITH THE KIND SUPPORT OF:
All payments of our sponsors are disclosed on the following web:www.uniklinik-freiburg.de/rna-virus-persistence/sponsors.html
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