medulloblastoma
TRANSCRIPT
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Imaging Department
Feb 19th, 2013Reported by Dr. Giang
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Name: Nong Van Hieu Sex: Male Age: 5 years old. Dept: A13
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Clinical
Headache & vomiting for 1 month No fever No seizure
Family’s history: older sister die when 10 years old because of Epilepsy.
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CT Findings(From Ha Giang Hospital)
Hyperintense solid mass in 4th ventricle with edema surround
Hydrocephalus
NHP
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MRI Findings(T2WI, axial, Pre C+)
Hyper-signal & Heterogenous mass in posterior fossa (43x40x49 mm)
Fill up IV ventricle Hydrocephalus Some necrosis areas Vermis invasion.
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MRI Findings(Flair , Coronal, Pre C+)
Hyper-signal intensity. Spherical & well-defined
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MRI Findings(T1WI, Sagital, Pre C+)
Hypointense to gray matter No hemorrhage intra mass
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MRI Findings(Diffusion & ADC)
Diffusion: Decrease diffusion ADC : Hypo signal High density of cells
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MRI Findings(T1WI, Axial, Post C+)
Strong enhancement Heterogenous (necrosis areas)
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MRI Findings(T1WI, Sagital, Post C+)
Strong enhancement Heterogenous
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MRI Findings(T1WI, Coronal, Post C+)
Strong enhancement Heterogenous
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Diagnosis
Medulloblastoma
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Background of MB Medulloblastoma: is a highly malignant primary brain tumor that
originates in the cerebellum or posterior fossa. ( PNET-MB)
Epidemilogy: 15- 20% of all Pediatric brain tumor
30-40% of posterior fossa tumor in children
Rare in adult. Location: - 4th ventricle, arises from roof.
- Cerebellar hemisphere : older children & adult. Age: 75% < 10 years. Most diagnosed by 5 year. Gender: M > F = 2-4 : 1 Classification: 4 major PNET-MB subtype
- Classic
- Desmoplastic
- Extensive nodular with advanced neuronal differentiation
- Large cell
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Background of MB Presentation: - Ataxia , signs of increased intracranial
pressure.
(tumor rapid grow)
- Macrocephaly
- Cranial nerve palsies.
Treatment: Surgical excision , adjyvant chemotherapy Craniospinal irradiation if > 3 years
Top differential diagnosis: Ependymoma Atypical teratoid / rabdoid tumor
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Thank you for attention!