Georgetown University g~( Hospital i MedStar Health

August 102010

Licensing Assistance Team Division ofNuclear Materials Safety US Nuclear Regulatory Commission Region 1 475 Allendale Road King of Prussia P A 19406-1415

~

Reference License 08-30577-01 License Amendment OJOJsL01 Dear SirMadam

The MedStar Georgetown Medical Center Inc (MGMC) requests a license amendment to n~e a new Radiation Safety Officer (RSO) for our radioactive material license Due to our current staffing challenges we also request an exemption to 10 CFR 3524(c)

In recent years there has been significant turnover in the RSO position at MGMC In February 2007 the position was transferred from John Glenn to Jason Dunavant In March 2009 the position was transferred from Jason Dunavant to an Interim RSO Auroba AI-Samaraee Ms AIshySamaraee served as the Interim RSO for 6 months until responsibility for the radiation safety program was transferred to Dennis Clum in September 2009 In May 2009 after serving in the role ofRSO for only 8 months Dennis Clum resigned his position with our facility

The departure of Dennis Clum left MGMC without a RSO MGMC took extensive measures to bring Auroba Al-Samaraee back to the US to serve as the Interim RSO until a qualified individual could be hired to manage this radiation safety program On June 162010 Ms AlshySamaraee was named the Interim RSO which was approved by the NRC for 60 days In addition MGMC contracted the services of Dade Moeller amp Associates staff of Certified Health Physicists and Health Physicists to assist with managing this program

MGMC has initiated another search for a qualified experienced RSO for this facility Rather than rush to fill the position and risk another departure MGMC would like to name one of our physicians Dr Giuseppe Esposito MD as the replacement RSO for this license Dr Esposito is board certified in Nuclear Medicine and has served as an Associate Professor and the Director of Nuclear Medicine Department of Radiology at MGMC since August 2007 Dr Esposito has also served on the MGMC Radiation Safety Committee since 2007 His resume is attached for your reVIew

It is our plan for Dr Esposito to serve as the RSO with continued contract support from Dade Moeller amp Associates during the search process which could take a significant amount of time

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1

For this reason we request the exemption to 10 CFR 3524(c) which currently limits the time period for a temporary RSO to 60 days

Due to the unexpected departure of Dennis Clum after only 8 months Dr Esposito is unable to obtain a signature on the Preceptor Attestation form In addition the Interim RSO is not deemed appropriate to sign the Preceptor Attestation form At this time there is no one qualified within MGMC to sign the form even though Dr Esposito has been intimately involved in the Radiation Safety Program since 2007 as a member ofthe RSO the head ofNuclear Medicine and as an active Authorized User for Nuclear Medicine and as an Authorized User for Y-90 Sirsphere Brachytherapy

Attached is a copy of Dr Espositos transcript from the Society of Nuclear Medicine documenting his continuing education from 2003-2009 Dr Esposito is scheduled to take the 40shyhour Medical Radiation Safety Officer course at the Dade Moeller Radiation Safety Academy in Gaithersburg MD September 13-172010 Copies of his Medical RSO training and DOT training certificates will be forwarded to your office once training is completed

Dr Esposito has previous research experience as indicated by his positions as Visiting Fellow and Visiting Associate at the National Institute on Mental Health NIH from 1992-1998 He is currently the Principle Investigator in research protocols at MGMC

Due to the fact that Dr Esposito has limited experience in the HDR and Cs-137 Brachytherapy Program as well with the Blood Bank Irradiator Dr Esposito has received additional training from those individuals managing these programs

Dr Esposito met with Dalong Pang PhD Radiation Physics Department The following was reviewed

bull Basic principles of radiation biology bull Occupational radiation dose limits bull Radiation dose limits to the adult pUblic embryofetus bull Principles of external beam radiation treatment including radiation safety training of staff

principles of shielding design control of access to high dose radiation areas caution signs and postings in high radiation areas

bull Tour of Cyberknife and treatment planning suite bull Brachytherapy overview including concepts of treatment and patient admission radiation

safety training of staff control of access to high dose radiation areas caution signs and posting in high radiation areas

bull Concepts ofHigh Dose Rate treatments with Iridium-92 training of staff control of access to high dose radiation areas caution signs and postings in high radiation areas Toured a room for high dose rate treatment reviewed secure storing of radiation sources and emergency procedures

bull Overview of Hot Lab including policies and procedures receiving radioactive material logs of radioactive material in Hot Lab disposal process of radioactive material access control and toured the Hot Lab

2

An overview of the Blood Bank was provided by Albert Langeberg including the following

bull Definition of radiation dose and radioactivity bull Dose an average person in the US receives a year from nature bull Allowable dose the public may receive bull Nuclear Regulatory Commissions (NRC) occupational annual limit for workers whole body

exposure and your likely exposure working with medical radioactive materials bull Health effects and risks of ionizing radiation bull Purpose of radiation detectors monitors used to make surveys bull Three (3) major safety principles for keeping exposure As Low As Reasonably Achievable

(ALARA) bull Where to use and store medical materials containing radioactive material bull Rights and responsibilities for radiation safety bull Requirements for the safe use of the blood irradiator bull Required checks for the use of the blood irradiator bull Tour of the Blood Irradiator

The orientation sessions were approximately two (2) hours in length

Thank you for your prompt attention regarding this amendment request Please contact me if additional information is needed If you have any questions I may be reached at 202-444-2903

Sincerely

camp~oo Executive Admimstration Representative to the Radiation Safety Committee Assistant Vice-President Safety Management amp Environmental Quality

Enclosure Board Certificate in Nuclear Medicine Resume of Dr Giuseppe Esposito Society of Nuclear Medicine Continuing Education

3

~un 25 10 0259p Radiation Safet~ 202 444 0069 p2

CE History - PhysiciansPreview Page 1 of 12

SNVI Advancing Moletular Imaging and Therapy

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CE History - Physicians

CE History - Physicians

The Society is pleased to offer Select Date Range physician members on-line access to Start Date 11012003 their history ofparticipation in

activities approved for AMA PRAEnd Date i62112010 Category 1 Credit(spM You may

search for your participation in activities from October 2003 to the

present

Select the View button to see a preview on screen or select the Print button for a print-ready copy

Please direct technical questions tosysm~uager~Jlm~Qrg or contentshyrelated questions to edqcationsnmorg

Preview of Transcript Below is a preview of your transcript To obtain a printable version check the date range you used above and click the Print button

1850 Samuel Morse Drive Reston VA 20190middot5316

Tel 7037089000SNVI Fax 7037089013 Advancing Molecular Imaging and Thec~IlY wwwsnmorg

June 21 2010 CME TRANSCRIPT

Giuseppe Esposito MD The SNM confirms you have participated in the Nuclear Medicine Georgetown following continuing education activities between the University Hospital dates of October 12003 and June 21 2010 The total of

34200 MA PRA Category 1 Credit(s)TM has been earned toward the AMA Physicians Recognition Award

I-A_c_middotc_r_ed_i_t8_ti_middoto_n_S_t_a_te_m_en_t_____--I c(LfVY 3~

httpslinteractivesnmorgiindexcfinPageID=3030 62112010

For this reason we request the exemption to 10 CFR 3524(c) which currently limits the time period for a temporary RSO to 60 days

Due to the unexpected departure of Dennis Clum after only 8 months Dr Esposito is unable to obtain a signature on the Preceptor Attestation form In addition the Interim RSO is not deemed appropriate to sign the Preceptor Attestation form At this time there is no one qualified within MGMC to sign the form even though Dr Esposito has been intimately involved in the Radiation Safety Program since 2007 as a member ofthe RSO the head ofNuclear Medicine and as an active Authorized User for Nuclear Medicine and as an Authorized User for Y-90 Sirsphere Brachytherapy

Attached is a copy of Dr Espositos transcript from the Society of Nuclear Medicine documenting his continuing education from 2003-2009 Dr Esposito is scheduled to take the 40shyhour Medical Radiation Safety Officer course at the Dade Moeller Radiation Safety Academy in Gaithersburg MD September 13-172010 Copies of his Medical RSO training and DOT training certificates will be forwarded to your office once training is completed

Dr Esposito has previous research experience as indicated by his positions as Visiting Fellow and Visiting Associate at the National Institute on Mental Health NIH from 1992-1998 He is currently the Principle Investigator in research protocols at MGMC

Due to the fact that Dr Esposito has limited experience in the HDR and Cs-137 Brachytherapy Program as well with the Blood Bank Irradiator Dr Esposito has received additional training from those individuals managing these programs

Dr Esposito met with Dalong Pang PhD Radiation Physics Department The following was reviewed

bull Basic principles of radiation biology bull Occupational radiation dose limits bull Radiation dose limits to the adult pUblic embryofetus bull Principles of external beam radiation treatment including radiation safety training of staff

principles of shielding design control of access to high dose radiation areas caution signs and postings in high radiation areas

bull Tour of Cyberknife and treatment planning suite bull Brachytherapy overview including concepts of treatment and patient admission radiation

safety training of staff control of access to high dose radiation areas caution signs and posting in high radiation areas

bull Concepts ofHigh Dose Rate treatments with Iridium-92 training of staff control of access to high dose radiation areas caution signs and postings in high radiation areas Toured a room for high dose rate treatment reviewed secure storing of radiation sources and emergency procedures

bull Overview of Hot Lab including policies and procedures receiving radioactive material logs of radioactive material in Hot Lab disposal process of radioactive material access control and toured the Hot Lab

2

An overview of the Blood Bank was provided by Albert Langeberg including the following

bull Definition of radiation dose and radioactivity bull Dose an average person in the US receives a year from nature bull Allowable dose the public may receive bull Nuclear Regulatory Commissions (NRC) occupational annual limit for workers whole body

exposure and your likely exposure working with medical radioactive materials bull Health effects and risks of ionizing radiation bull Purpose of radiation detectors monitors used to make surveys bull Three (3) major safety principles for keeping exposure As Low As Reasonably Achievable

(ALARA) bull Where to use and store medical materials containing radioactive material bull Rights and responsibilities for radiation safety bull Requirements for the safe use of the blood irradiator bull Required checks for the use of the blood irradiator bull Tour of the Blood Irradiator

The orientation sessions were approximately two (2) hours in length

Thank you for your prompt attention regarding this amendment request Please contact me if additional information is needed If you have any questions I may be reached at 202-444-2903

Sincerely

camp~oo Executive Admimstration Representative to the Radiation Safety Committee Assistant Vice-President Safety Management amp Environmental Quality

Enclosure Board Certificate in Nuclear Medicine Resume of Dr Giuseppe Esposito Society of Nuclear Medicine Continuing Education

3

~un 25 10 0259p Radiation Safet~ 202 444 0069 p2

CE History - PhysiciansPreview Page 1 of 12

SNVI Advancing Moletular Imaging and Therapy

PHILIPS Click here to learn more _ d IlmfillicitySystem Pages

CE History - Physicians

CE History - Physicians

The Society is pleased to offer Select Date Range physician members on-line access to Start Date 11012003 their history ofparticipation in

activities approved for AMA PRAEnd Date i62112010 Category 1 Credit(spM You may

search for your participation in activities from October 2003 to the

present

Select the View button to see a preview on screen or select the Print button for a print-ready copy

Please direct technical questions tosysm~uager~Jlm~Qrg or contentshyrelated questions to edqcationsnmorg

Preview of Transcript Below is a preview of your transcript To obtain a printable version check the date range you used above and click the Print button

1850 Samuel Morse Drive Reston VA 20190middot5316

Tel 7037089000SNVI Fax 7037089013 Advancing Molecular Imaging and Thec~IlY wwwsnmorg

June 21 2010 CME TRANSCRIPT

Giuseppe Esposito MD The SNM confirms you have participated in the Nuclear Medicine Georgetown following continuing education activities between the University Hospital dates of October 12003 and June 21 2010 The total of

34200 MA PRA Category 1 Credit(s)TM has been earned toward the AMA Physicians Recognition Award

I-A_c_middotc_r_ed_i_t8_ti_middoto_n_S_t_a_te_m_en_t_____--I c(LfVY 3~

httpslinteractivesnmorgiindexcfinPageID=3030 62112010

An overview of the Blood Bank was provided by Albert Langeberg including the following

bull Definition of radiation dose and radioactivity bull Dose an average person in the US receives a year from nature bull Allowable dose the public may receive bull Nuclear Regulatory Commissions (NRC) occupational annual limit for workers whole body

exposure and your likely exposure working with medical radioactive materials bull Health effects and risks of ionizing radiation bull Purpose of radiation detectors monitors used to make surveys bull Three (3) major safety principles for keeping exposure As Low As Reasonably Achievable

(ALARA) bull Where to use and store medical materials containing radioactive material bull Rights and responsibilities for radiation safety bull Requirements for the safe use of the blood irradiator bull Required checks for the use of the blood irradiator bull Tour of the Blood Irradiator

The orientation sessions were approximately two (2) hours in length

Thank you for your prompt attention regarding this amendment request Please contact me if additional information is needed If you have any questions I may be reached at 202-444-2903

Sincerely

camp~oo Executive Admimstration Representative to the Radiation Safety Committee Assistant Vice-President Safety Management amp Environmental Quality

Enclosure Board Certificate in Nuclear Medicine Resume of Dr Giuseppe Esposito Society of Nuclear Medicine Continuing Education

3

~un 25 10 0259p Radiation Safet~ 202 444 0069 p2

CE History - PhysiciansPreview Page 1 of 12

SNVI Advancing Moletular Imaging and Therapy

PHILIPS Click here to learn more _ d IlmfillicitySystem Pages

CE History - Physicians

CE History - Physicians

The Society is pleased to offer Select Date Range physician members on-line access to Start Date 11012003 their history ofparticipation in

activities approved for AMA PRAEnd Date i62112010 Category 1 Credit(spM You may

search for your participation in activities from October 2003 to the

present

Select the View button to see a preview on screen or select the Print button for a print-ready copy

Please direct technical questions tosysm~uager~Jlm~Qrg or contentshyrelated questions to edqcationsnmorg

Preview of Transcript Below is a preview of your transcript To obtain a printable version check the date range you used above and click the Print button

1850 Samuel Morse Drive Reston VA 20190middot5316

Tel 7037089000SNVI Fax 7037089013 Advancing Molecular Imaging and Thec~IlY wwwsnmorg

June 21 2010 CME TRANSCRIPT

Giuseppe Esposito MD The SNM confirms you have participated in the Nuclear Medicine Georgetown following continuing education activities between the University Hospital dates of October 12003 and June 21 2010 The total of

34200 MA PRA Category 1 Credit(s)TM has been earned toward the AMA Physicians Recognition Award

I-A_c_middotc_r_ed_i_t8_ti_middoto_n_S_t_a_te_m_en_t_____--I c(LfVY 3~

httpslinteractivesnmorgiindexcfinPageID=3030 62112010

~un 25 10 0259p Radiation Safet~ 202 444 0069 p2

CE History - PhysiciansPreview Page 1 of 12

SNVI Advancing Moletular Imaging and Therapy

PHILIPS Click here to learn more _ d IlmfillicitySystem Pages

CE History - Physicians

CE History - Physicians

The Society is pleased to offer Select Date Range physician members on-line access to Start Date 11012003 their history ofparticipation in

activities approved for AMA PRAEnd Date i62112010 Category 1 Credit(spM You may

search for your participation in activities from October 2003 to the

present

Select the View button to see a preview on screen or select the Print button for a print-ready copy

Please direct technical questions tosysm~uager~Jlm~Qrg or contentshyrelated questions to edqcationsnmorg

Preview of Transcript Below is a preview of your transcript To obtain a printable version check the date range you used above and click the Print button

1850 Samuel Morse Drive Reston VA 20190middot5316

Tel 7037089000SNVI Fax 7037089013 Advancing Molecular Imaging and Thec~IlY wwwsnmorg

June 21 2010 CME TRANSCRIPT

Giuseppe Esposito MD The SNM confirms you have participated in the Nuclear Medicine Georgetown following continuing education activities between the University Hospital dates of October 12003 and June 21 2010 The total of

34200 MA PRA Category 1 Credit(s)TM has been earned toward the AMA Physicians Recognition Award

I-A_c_middotc_r_ed_i_t8_ti_middoto_n_S_t_a_te_m_en_t_____--I c(LfVY 3~

httpslinteractivesnmorgiindexcfinPageID=3030 62112010

Jun 25 10 0300p Radiation Safet~ 202 0069 p3

CE History - PhysiciansPreview Page 2 of12

The SNM is accredited by the N Lynn Barnes MEd Accreditation Council for Continuing Director ofEducation Medical Education (ACCME) to sponsor continuing continuing medical education If you have any questions regarding this transcript please for physicians caB the SNM Education Department at (703) 708-9000 or

email ~gJ)cationsnmorg

AMA PRA Category 1 Cledit(s)IM Participation Detail ID 152445

Session Title I Date ICredit Code ~ts PET and PETCT Imaging Evaluation of Patients with 12312009 LL-A365 250 Urological Tumors

Investigational and Clinical Applications of PET and 123012009 LL-A366 250 SPECT Brain Imaging in Movement Disorders Psychiatric Disorders and Traumatic Brain Injury

Clinical Applications of SPECT and PET in the 122912009 LL-A359 250 Evaluation ofDementia

An Introduction to Nuclear Brain Imaging 12292009 LL-A358 250

CT Case Review for Nuclear Medicine Physicians 611612009 snm3460 2 175 Head amp Neck (Cases 1-12)

CT Case Review for Nuclear Medicine Physicians 61162009 snm3461 2 150 Head amp Neck (Cases 13-25)

fDA Clinical and Preclinical Regulatory Topics 61152009 snm3062 2 150

GI-Colon and Liver Cancers 6152009 snm3390 2 025

Image Guided Therapy 611512009 snm3404 2 075

Jadiopharmaceutical Therapy II 61152009 snm3408 2 025

Dementia I Healthy AginglDiagnosis of Dementia 6152009 snm3411 2 125

Dementia Brain PET ISPECT RWE (SAM) 61142009 snm3043 2 150

Plenary Session and Formal Opening 6142009 snm3104 2 075

Specialties in Magnetic Resonance Imaging 6142009 snm3116 2 125

Brain Imaging Council Young Investigator Award 6142009 snm3343 2 050 Symposium

Molecular Imaging Facilitating Development of New 6132009 snm2912 2 275 Cancer Therapeutic Agents - Cost-effective Solution for Clinical Trials - Morning Session

Thyroid Therapy in Children and Adolescents 611312009 snm3021 2 100

Molecular Imaging of Hypoxia Biology - Afternoon 6132009 snm3463 2 250 Session

Contrast Reactions 41192009 snm3264 2 100

Radioimmunotherapy ofNon-Hodgkins Lymphoma 411912009 snm3265 2 100

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CE History - PhysiciansPreview

Imaging Strategies for Neuroendocrine Tumors

What an Oncologist Wants from a PETCT Lymphoscintigraphyand Sentinal Node Imaging in Breast Cancer

How is Molecular Imaging Relevant to Your Clinical Practice

Evolving Role of Imaging in Oncology Drug Development

The Government and You

Panel Discussion The Future of Nuclear Medicine Where do you want to go

Update on the National PET Database Project

How Low Can You Go To Reduce the Radiation Dgtse of Pediatric PETCT and SPECTCT

Now that you Have It What do you Do PETICT Installation Acceptance and Getting Started

Cardiac Imaging in the Patient with Chest Pain

Cardiovascular Molecular Imaging

New Challenges in Heart Failure

Abdominal Pelvic CTIMR with PET Correlation

Audience Case Challenge

Leadership Not Just for the Few

Cardiovascular Case Presentations

Session III SNM Clinical Trials Network Introduction

Session IV 2009 FLT Demonstration Project Participation Qualification and Responsibilities

Session V Fundamentals of Clinical Trials Participation Workshops

Monitoring Cancer Therapy Response to Toxicity-Potential for Personalizing Patient Management shyEvaluating Cardiac Toxicity of Cancer Chemotherapy

Monitoring Cancer Therapy Response to Toxicity bull Potential for Personalizing Patient Management shyEvaluating Response to Cancer Therapy

Keynote Address Imaging in Clinical Trials Choo~ing the Right Imaging Application for Therapy Response Assessment

Session I The Role of Imaging Biomarkers in Drug

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Development and Multicenter Trials

Session II Areas of Need for Imaging Biomarkers in 282009 A023047 150 Drug Development

CT Review for Nuclear Medicine Physicians - CT 2172009 A023031 200 Chest (Cases 51-63)

CT Review for Nuclear Medicine Physicians - CT 2172009 A023031-2 200 Abdomen (Cases 64-75)

Cardiovascular Molecular Imaging 21712009 A023032 300

CT Review for Nuclear Medicine Physicians CT of the 2172009 A023034 400 Pelvis (Cases 76-100)

Current Topics in Pediatric Nuclear Medicine - Part II 2172009 A023038 200

CT Review for Nuclear Medicine Physicians - Neuro 2162009 A023029 200 Radiology (Cases 1-12)

CT Review for Nuclear Medicine Physicians - Neuro 2612009 A023029-2 200 Radiology (Cases 13-25)

CT Review for Nuclear Medicine Physicians CT Chest 262009 A023030 200 (Cases 26-37)

CT Review for Nuclear Medicine Physicians CT 262009 A023030middot2 200 Abdomen (Cases 38-50)

ACNP ACNM Medical Practice Seminar 2512009 A023028 350

Image Artifacts and Normal Variants in PET and 12302008 LL-A354 250 PETCT for Oncological Applications

Melanoma-Sarcoma-Neuroendocrine Malignancies 12302008 LL-A327 400

Oncology PET and PET ICT Gastrointestinal 1111412008 LL-A324 250 Malignancies

CT Case Review for Nuclear Medicine Physician 61172008 2588CME2008AM 800

Nuclear Medicine in Radiation Therapy Planning bull 61162008 2390CME2008AM 050 Challenges and Opportunities

CT of the Neck A Guide for Nuclear Medicine 61162008 2430CME2008AM 050 Physicians Reading PETCTI Read With the Experts Session

PETCT of the Head amp Neck Uses amp Abuses Pitfalls amp 61162008 2431CME2008AM 150 Problem Cases - Read With the Experts Session

Abdominal and Pelvic CT and PETCT Anatomy for 61152008 2317CME2008AM 150 Nuclear Medicine Read with the Experts Session - Part I

Brain PET and SPECT for Dementia Read with the 61152008 2374CME2008AM 150 Experts Session

SNM Plenary Session and Formal Opening 6152008 2405CME2008AM 025

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Development and Multicenter Trials

Session II Areas of Need for Imaging Biomarkers in 282009 A023047 150 Drug Development

CT Review for Nuclear Medicine Physicians - CT 2172009 A023031 200 Chest (Cases 51-63)

CT Review for Nuclear Medicine Physicians - CT 2172009 A023031-2 200 Abdomen (Cases 64-75)

Cardiovascular Molecular Imaging 21712009 A023032 300

CT Review for Nuclear Medicine Physicians CT of the 2172009 A023034 400 Pelvis (Cases 76-100)

Current Topics in Pediatric Nuclear Medicine - Part II 2172009 A023038 200

CT Review for Nuclear Medicine Physicians - Neuro 2162009 A023029 200 Radiology (Cases 1-12)

CT Review for Nuclear Medicine Physicians - Neuro 2612009 A023029-2 200 Radiology (Cases 13-25)

CT Review for Nuclear Medicine Physicians CT Chest 262009 A023030 200 (Cases 26-37)

CT Review for Nuclear Medicine Physicians CT 262009 A023030middot2 200 Abdomen (Cases 38-50)

ACNP ACNM Medical Practice Seminar 2512009 A023028 350

Image Artifacts and Normal Variants in PET and 12302008 LL-A354 250 PETCT for Oncological Applications

Melanoma-Sarcoma-Neuroendocrine Malignancies 12302008 LL-A327 400

Oncology PET and PET ICT Gastrointestinal 1111412008 LL-A324 250 Malignancies

CT Case Review for Nuclear Medicine Physician 61172008 2588CME2008AM 800

Nuclear Medicine in Radiation Therapy Planning bull 61162008 2390CME2008AM 050 Challenges and Opportunities

CT of the Neck A Guide for Nuclear Medicine 61162008 2430CME2008AM 050 Physicians Reading PETCTI Read With the Experts Session

PETCT of the Head amp Neck Uses amp Abuses Pitfalls amp 61162008 2431CME2008AM 150 Problem Cases - Read With the Experts Session

Abdominal and Pelvic CT and PETCT Anatomy for 61152008 2317CME2008AM 150 Nuclear Medicine Read with the Experts Session - Part I

Brain PET and SPECT for Dementia Read with the 61152008 2374CME2008AM 150 Experts Session

SNM Plenary Session and Formal Opening 6152008 2405CME2008AM 025

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Best Practices in PETCT (SAM Session) 61142008 2402CME2008AM 550

Decision Making in Pediatric Urinary Tract Disease 61142008 2439CME2008AM 050

Advances in PET Instrumentation and Methodology 4132008 A022837 100

Cardiovascular Molecular Imaging 411312008 A022838 LOO Case Presentations in PET and Nuclear Medicine 4132008 A022839 l00 Blood Volume 4132008 A022840 100

Heart Failure and Myocardial Viability 41122008 A022830 100 Detection of CAD and Risk Stratification 41122008 A022831 l00 Metabolic Imaging 41122008 A022832 100

Assessment of Cardiac Pain in ER 4122008 A022833 100

PETCT and Monitoring Response to Therapy 411212008 A022834 100

SPECTCT Clinical Applications 4122008 A022835 100

Parathyroid Imaging - Planar SPECT and SPECTCT 41112008 A022823 100

Pediatric Renal Imaging 4112008 A022824 100

Molecular Imaging Initiatives at NCr 41112008 A022825 100

Molecular Imaging as a Decision Making Aid in Cancer 41112008 A022826 050 Diagnosis and Therapy

Response to Radiation Terrorism in Maryland 41112008 A022827 100 CT Neck Anatomy 4112008 A022828 100 Thyroid Cancer Uptake 41112008 A022829 100

Oncology PET and PETCT Hematologic 12152007 LL-A325 250 Malignancies

Breast and Gynecologic Cancers 121102007 LL-A355 250

PETICT Imaging Evaluation of Patients with Head and 1292007 LL-A373 250 Neck Cancer and Brain Tumors

Solitary Pu1monary Nodules and Lung Cancer 111222007 LL-A326 250 CT of the Neck Part III (Cases 51-56) 1072007 A022563 100 CT of the Neck Part IV (Cases 57-62) 1072007 A022564 100 CT of the Thorax Part III (Cases 63-68) 1072007 A022565 l00 CT of the Thorax Part IV (Cases 69-74) 1072007 A022566 l00 CT of the Abdomen Part III (Cases 75-80) 1072007 A022567 100 CT of the Abdomen Part IV (Cases 81-86) 1072007 A022568 100 CT of the Pelvis Part III (Cases 87-93) 1072007 A022569 LOO CT of the Pelvis Part IV (Cases 94-100) 1072007 A022570 100 CT of the Neck Part 1 (Cases 1-6) 1062007 A022555 100 CT of the Neck Part II (Cases 7-12) 1062007 A022556 100

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CE History - PhysiciansPreview

CT of the Thorax Part I (Cases 13~18)

CT of the Thorax Part II (Cases 19~24)

CT of the Abdomen Part I (Cases 25-30)

CT of the Abdomen Part n (Cases 31-36)

CT of the Pelvis Part I (Cases 37-43)

CT of the Pelvis Part II (Cases 44-50)

Controversial Topics in the Management of Well-Differentiated Thyroid Cancer

How to Avoid PitfallsArtifacts in PETICT

CT 101 The Abdomen

Esophageal Colorectal Pancreas Read with the Experts Session

Response-adapted Therapy in Lymphoma Using PETICT as a Biologic Marker

Plenary Session and Formal OpenIng

Updates in Head and Neck Imaging in the Post-therapy Setting Where do We Stand

Hot Topics and Best Practices in PETCT

Molecular Imaging and Cancer Therapy Opportunities and Challenges for Nuclear Medicine

Combined Assessment ofMyocardial Perfusion amp CT Coronary Angiography

PET in the Evaluation of Alzheimers Disease amp Related Disorders

Brain PET Case Presentation Epilepsy Tumors amp Cognitive Impairment

Myocardial Perfusion PET Using Stand-alone and Hybrid Devices

Transition from SPECT to SPECT ICT amp PETICT Is it Time to Switch

Monitoring Therapeutic Intervention with PET

Head amp Neck PETICT Anatomy

Maintenance of Competency for Nuclear Medicine Physicians amp Technologists

Terrorism Using Radioactive Materials Perceptions amp Reality

The Role of PET amp PETCT in Colorectal amp Other GI Malignancies

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PETICT Instrumentation

Gastric Emptying Standardization and Simplification

Clinical Applications ofRadio nuclide Renal Scintigraphy A Case-Based Approach

Medical Events amp Other Radiation Safety-Related Incidents in a Nuclear Medicine Department

Giving VQ Scanning a Future in the post-PIOPED II Era Nuclear Medicine Imaging in Thyroid Cancer

Myocardial Viability Advances in Perfusion amp Metabolic Imaging

Radiation Planning

Conventional and New Imaging Approaches to Track Cell Therapies for Cardiac Disease

Molecular Therapies of Cancer

Serial vs Hybrid Imaging in CV Patients

PETCT Literature Evidence of its Clinical Value

Standardization ofPETCT Imaging Protocols for Cancer

Standardization of PETICT Imaging Protocols for Cardiology

FDG Imaging of InfectionInflammation

Role of Imaging and Approaches to the Patient with Heart Failure

Treatment Monitoring with PETCT When How and Why

Treatment Monitoring for CAD Who and How

Detecting Recurrent Cancer with PETCT

Multi-modality Imaging of CAD

SUV 101

Advanced Image Processing Techniques for Cardiac Imaging (AC absolute MBF)

NOPR - National Oncological PET Registry Updatt

Novel Agents for Cardiac Imaging (BMIPP MIBG and F-18 Flow Agent)

Multi-modality Imaging of Prostate Cancer

Multi-modality Approach to the Evaluation of Patie1ts Post Myocardial Infraction

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Advanced Image Processing Techniques for Oncology Imaging

Monitoring the Effects ofCytostatic Cancer Treatment

Imaging of Atherosclerosis The Next Frontier

Clinical Applications ofPETCT Focus on Oncology-Esophageal

Molecular Imaging in the Clinical Arena In Vivo Cellular and Molecular Imaging of Cancer

Oncology - Clinical Diagnosis Lung Cancer shyPredicting Response to Therapy

Oncology - Clinical Diagnosis Lung Cancer - Solitary Pulmonary Nodules

Oncology - Clinical Diagnosis Lymphoma

Special Plenary Session Cas sen Lectureship

Endocrinology Management of Thyroid Cancer Whats New

Musculoskeletal Musculo-skeletal Diseases of the Foot amp Hybrid Bone and Bone Marrow Imaging

Neurosciences - Neurology NeuTo-Oncology

Plenary Session and Fonnal Opening

Endocrinology Diagnosis of Benign Endocrine Diseases

Infectious Disease Infection Imaging FDG-PET

Musculoskeletal Spinal Disease Marrow and Hybrid Imaging

PETCT in Oncology- Focus on the Referring Physician What Does Your Referring Physician Want From PETCT

New PETCT Indications and PET Registry Update on PETleT Credentialing for NM Technologists

PETICT Applications amp Technical Considerations for Cardiology

PET and SPECT Imaging in the Diagnosis of Dementia

CT Anatomy Review Oncology PETCT

Case Studies - Read with the Experts PETCT Interesting Cases and Artifacts

Nuclear Cardiac Basics Radiophannaceuticals Stressors amp Protocols

httpsllinteractivesnmorgiindexcfinPageID=3030

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Gated Cardiac SPECT Additative Value of Dectection and Prognosis

Nuclear Cardiology Transition from SPECT to PETCT and SPECTCT

Clinical Experience with SPECT ICT Protocols and Applications

FDG~PET In Imaging Primary Breast Cancer

FDG-PET Imaging in Infection and Inflammation

Nuclear Medicine in the Prosthetic Joint

NIH Grant Process-Applications Funding Opportunities

Update on ACGME Changes to NM Residency Program Content amp ABNM Requirements

CT for Nuclear Medicine

Cancers of the GU System

Neuroimaging in Evaluation of Brain Tumors

Translational Research in Oncology

Brain PET - Clinical Case Presentations

Plenary Session MR and Optical Molecular Imaging Advancesin Clinical Oncology and Role of Imaging

Cross-Sectional Anatomy

Plenary Session - March 26th

Cardiac TranslationIFuture Direct of Cardiac Molecular Imaging

InstrumentationQuantification

PET and Non-Malignant Pulmonary Diseases

Neurology

Administrative Track QA National Oncologic PET RegistrylClinical Applications for NOPR

Clinical Indications

PET Physics

PET Instrumentation

Patient Preparation and Protocols

Radiation Safety

Imaging ofNeuroendocrine Tumors Read With the Experts

Special Plenary Session Cassen Lectureship

httpsinteractivesnmorgindexcfinPageID=3030

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Endocrinology Management ofThyroid Cancer II

Neurosciences - Neurology Dementia

Oncology - Basic Science Therapy Monitoring

Clinical Applications ofPETCT Focus on Oncology shyThyroid

CT MR and PET Evaluation of Brain Tumors - Read With the Experts

Lung and Head amp Neck Cancer Impact of PET in Radiation Therapy Planning - Read With the Experts

Special Plenary Session

Hematology PET Lymphoma and Multiple Myeloma

Performing and Interpreting Cardiac PET and PETleT hnaging - Interactive Read With the Experts Session

Plenary Session and Formal Opening

Oncology - Basic Science Visualization of Tumor Hypoxia

Oncology - Clinical Diagnosis Breast Cancer

Dementia Imaging Metabolism Blood Flow and Beyond

CT Anatomy of the Brain 1HampN Part I

CT Anatomy of the Brain I HampN Part II

ATS Staging ofLymph Nodes

CT of Pulmonary Nodules and Evaluating Primary Tumors

Cardiac CT

CT Instrumentation Part III

PETCT Case Review

CT Anatomy of the Abdomen and Pelvis

CT of Abdominal Malignancies

PETCT Case Review

CT Instrumentation Part I

Chest CT Basics Part I

PETICT Case Review

Chest CT Basics Part II

CT Instrumentation Part II

CT Protocols

PETICT Case Review

httpslinteractivesnmorglindexcfinPageID=3030

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CEmiddotHistory - PhysiciansPreview

Endocrinology Management ofThyroid Cancer II

Neurosciences - Neurology Dementia

Oncology - Basic Science Therapy Monitoring

Clinical Applications ofPETCT Focus on Oncology shyThyroid

CT MR and PET Evaluation of Brain Tumors - Read With the Experts

Lung and Head amp Neck Cancer Impact of PET in Radiation Therapy Planning - Read With the Experts

Special Plenary Session

Hematology PET Lymphoma and Multiple Myeloma

Performing and Interpreting Cardiac PET and PETleT hnaging - Interactive Read With the Experts Session

Plenary Session and Formal Opening

Oncology - Basic Science Visualization of Tumor Hypoxia

Oncology - Clinical Diagnosis Breast Cancer

Dementia Imaging Metabolism Blood Flow and Beyond

CT Anatomy of the Brain 1HampN Part I

CT Anatomy of the Brain I HampN Part II

ATS Staging ofLymph Nodes

CT of Pulmonary Nodules and Evaluating Primary Tumors

Cardiac CT

CT Instrumentation Part III

PETCT Case Review

CT Anatomy of the Abdomen and Pelvis

CT of Abdominal Malignancies

PETCT Case Review

CT Instrumentation Part I

Chest CT Basics Part I

PETICT Case Review

Chest CT Basics Part II

CT Instrumentation Part II

CT Protocols

PETICT Case Review

httpslinteractivesnmorglindexcfinPageID=3030

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CE History - PhysiciansPreview Page 11 of12

Site Planning 3252005 A021330 075

Oncology Therapy General 6222004 A020447 150

Management of Thyroid Cancer Controversies and 6222004 A020483 150 Advancements

Neurosciences - Neurology Parkinsons Disease and 62112004 A020414 150 Related Disorders

Functional Brain Imaging EvidencemiddotBased Practice 62112004 A020472 150

Fundamentals of Cardiac PET Imaging 62112004 A020474 150

Looking at the Future ofNeuroreceptor Imaging 62112004 A020530 150

Special Plenary Session New Directions in Coronary 62112004 A020546 150 Artery Disease and Cancer

Plenary Session and Formal Opening 61202004 A020368 075

Neurosciences - Neurology Mild Cognitive 6202004 A020413 150 Impairment and Early Diagnosis of Alzheimers Disease

Neurosciences Young Investigator Award Symposium- 6202004 A020415 150 Brain Imaging Council

Meet the Author] 6202004 A020457 075

Metabolic PET Imaging and Radiation Therapy 62012004 A020484 150 Perspectives for a Fruitful Collaboration

Brain Imaging Parkinsons Disease 6192004 A020355 525 Read With the Expert Everyday Cases with Impact on 5312004 A019539 100 Clinical Management

PET -CT Fusion Scans-Does it Make a Difference 532004 A019540 100 PET What the Oncologist Wants to Know 532004 A019541 100 PET Artifacts and Normal Variants 532004 A019542 100 Regulatory Issues Important to Our Profession 532004 A019545 100 Pattern ofNormal VarianceAcquisition amp 411712004 A02033 I 075 Interpretati on

Neuroimaging in Epilepsy 41172004 A020332 075 Functional and Metabolic Imaging of Brain Tumors 4172004 A020333 075 PET in Evaluation of Alzheimers Disease and Related 4172004 A020334 075 Dementia

Metabolic Crisis Following Traumatic Brain Injury An 411712004 A020335 100 Introduction to Metabolic Therapy

Predicting and Preventing Stroke with PET 411712004 A020336 075 Movement Disorders 41712004 A020337 075 Application of PET in Psychiatric Research 41712004 A020338 075

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PET Learning Center - Physicians

lNM-Dobutamine Stress Myocardial in Coronary Artery Disease

2222004

Perfusion Imaging 12152003

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Total Credits

1400

100

34200 Advertising SQ9nsorshm 1HeIQ ILegal Disclaimer 1 Site MJn 1850 Samuel Morse Drive IReston

Virginia 2019017037089000 copy 2010 SNM All rights reserved

httpslinteractivesnmorgindexcfmPageID=3030 6212010

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Home Address

Office Address

Date of Birth Place of Birth Citizenship

Licensure

CURRICULUM VITAE

Giuseppe Esposito MD

Department ofNuclear Medicine Georgetown University Hospital 3800 Reservoir Road NW 2005 Gonnan Washington DC 20007-2113 Phone 202-444-3360 Fax 202-444-4667 e-mail exgllguhgeorgetownedu

District of Columbia Maryland New York

Board Certification American Board ofNuclear Medicine

Date of Certification September 2001

Education (In Italy)

Undergraduate

Liceo Scientifico (Scientific High School) TLCaro Via Manzoni 53 80123 Naples Italy 1978 - 1983

Medical School

Medical School of the University Federico II Via Pansini 5 80131 Naples Italy 1984 -1990

Jyn 16 10 0952a Radiation Safet~ 202 444 0069 p2

Home Address

Office Address

Date of Birth Place of Birth Citizenship

Licensure

CURRICULUM VITAE

Giuseppe Esposito MD

Department ofNuclear Medicine Georgetown University Hospital 3800 Reservoir Road NW 2005 Gonnan Washington DC 20007-2113 Phone 202-444-3360 Fax 202-444-4667 e-mail exgllguhgeorgetownedu

District of Columbia Maryland New York

Board Certification American Board ofNuclear Medicine

Date of Certification September 2001

Education (In Italy)

Undergraduate

Liceo Scientifico (Scientific High School) TLCaro Via Manzoni 53 80123 Naples Italy 1978 - 1983

Medical School

Medical School of the University Federico II Via Pansini 5 80131 Naples Italy 1984 -1990

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ResidencylNuclear Medicine

Division ofNuclear Medicine Department ofRadiology Medical School of the University Federico Ir ViaPansini 5 80131 Naples Italy 1991- 1992 Chairman Prof Marco Salvatore

Education (In USA)

Graduate

Visiting Fellow Post-doctoral fellowship National Institute on Mental Health NIH Unit on PET Clinical Brain Disorders Branch 9000 Rockville Pike Bethesda MD 20892 October 1992 - January 1998 Chief Dr Karen F Berman

Visiting Associate National Institute on Mental Health NIH Unit on PET Clinical Brain Disorders Branch 9000 Rockville Pike Bethesda MD 20892 February 1998 - June 1998 Chief Dr Karen F Berman

ResidencylNuclear Medicine

10hns Hopkins University Hospital Division ofNuclear Medicine 601 North Caroline Street Baltimore MD 21287 July 1998 - June 2000 Director Dr Szolt Zsabo

InternshiplIntemal Medicine

Franklin Square Hospital Department of Internal Medicine 9000 Fanklin Square Drive Baltimore MD 21237 July 2000 December 2001 Director Dr Daniel Hardesty

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Professional Experience

Staff Clinician Research Resources Branch National Institute on Aging NIH 5600 N Shock Dr Baltimore MD 21224 February 2002-August 2004

Staff Physician Department ofNuclear Medicine Franklin Square Hospital 9000 Franklin Square Dr Baltimore MD 21287 March 200S-present

Staff Physician Department ofNuclear Medicine Good Samaritan Hospital 5601 Loch Raven Blve Baltimore MD 21239 March 200S-present

Staff Physician Division ofNuclear Medicine Department ofMedicine Washington Hospital Center 110 Irving Street r-W Washington DC 20010 September 2004-July 2007

Director Nuclear Medicine (since November 1st) Department ofRadiology Georgetown University Hospital 3800 Reservoir Rd NW Washington DC 20007middot2113 August 2007 - present

Honors and Awards

1994 Smith Kline Beecham Award Society ofBiological Psychiatry Philadelphia P A

2003 Staff Recognition Award National Institute on Aging NIH

Professional Societies

2007-present European Society ofNuclear Medicine 200S-present Academy of Molecular Imaging 2002-present Society ofNuclear Medicine

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Public Service

June 2008 - present SecretarylTreasurer Executive Committee Mid-Eastern Chapter Society ofNuclear Medicine

September 2006 - present Intern Executive Committee - Mid-Eastern Chapter Society ofNuclear Medicine

Reviewer Neuropsychologia (Occasional)

Invited seminars and presentations

Neurology Grand Rounds - PET Evaluation of the dementi as

Washington Hospital Center Washington DC (February 2005)

HematologyOncology Grand Rounds - PET scans in Leuk(~mia and Multiple Myeloma

Washington Hospital Center Washington DC (June 2005)

Infectious Disease Grand Rounds - Nuclear Medicine Evaluation of InfectionlInflarnmation

Washington Hospital Center Washington DC (May 2006)

Head and Neck Surgery Grand Rounds - PET in the Management ofpatients with Head and Neck

Cancer Washington Hospital Center Washington DC (April 2007)

Multidisciplinary Management of Cancers A Case~Based Approach Seminar

LymphomaMyeloma Tumor Board Organized by Washington Cancer Institute Washington Hospital Center Washington DC (October 272007)

Tumor Board Grand Round - Clinical Indications ofPETCT

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University Service

Teaching Activities

Union Memorial Hospital Baltimore MD (April 2008)

Neuroradiology Grand Rounds - PET Imaging in Head and Neck Cancers

Deparment ofRadiology Georgetown University Hospital Center Washington DC (May 2008)

August 2007 - present Radiation Safety Committee Georgetown Universit~ Hospital

August 2007 - present Residency Education Committee Department ofRadiology Georgetown University Hospital

July 2008 - present Leader Imaging Response Assessment Team of the American Association of Cancer Institutes Lombardi Cancer CenterGeorgetown University Hospital Department ofRadiology

Internal Medicine Residency Program Washington Hospital Center Washington DC

Residents lectures The role ofmvlear medicine in the evaluation of infectiousinflammatory processes (May 2006) The role ofnuclear medicine in the evaluation of infectiousinflammatory processes (May 2006) Nuclear medicine evaluation of the hepatobiliary tract (November 2006)

Daily rounds in nuclear medicine reading room for residents on elective rotation in nUcielr medicine

Rounds in thyroid clinic for patients treated with radioiodine for residents on electiv-e rotation in nuclear medicine

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Cardiology Fellowship Program Georgetown UniversitylWashington Hospital Center 2004-2007 Washington DC

Daily rounds in nuclear medicine reading room (September 2004-July 2007)

Endocrinology Fellowship Program Georgetown UniversityWashington Hospital Center Washington DC

Weekly thyroid cancer conferences (September 2004-July 2007) Rounds in thyroid linic for patients treated with radioiodine for thyroid cancer or hyperthyroidism (September 2004-July 2007)

Radiology Residency Program Georgetown University Hospital Washington DC

Residents lectures - Radiopharmaceuticals commonly used in nuclear

medicine (August 2007) - VentilationlP~rfusion scan for pulmonary embolism

(September 2007) - Imaging of Infection in Nuclear Medicine (October 2007) -- Evaluation ofGI bl(led in Nuclear Medicine (November

2007) - Nuclear medicine imaging ofbenign thyroid diseases

(January 2008) - Imaging of thyroid nodules and thyroid cancer (January

2008) - Radionuclide ventriCUlography (April 2008) -- PETCT basics (June 2008) -- PETCT imaging of head and neck cancer (July 2008)

Daily rounds in nuclear medicine reading room (August 2007shypresent)

Ward rounds for patients with thyroid cancer treated with radioiodine (August 2007-present)

Georgetown University Medical School Washington DC

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- Basics ofNuclear Medicine Clinical Skill Prim~r Course 2008 (April 2008)

Monthly students lecture$ on the basics ofNuclear Medicine for selective rotations in Radiology (July 2008-present)

Scholarsbips

Italian Ministry for Scientific Research Fellowship Award 1991-1994

Grants Charles and Mary Latham Fund Comparison ofI-124 and 1-131 Radiopharmacokinetics Principal Investigator January 2007 ($10000)

PubUcations

Peer Reviewed

1 Sunderland T Esposito G Molchan SE Coppola R Jones OW Gorey J Little JT Cantillon M Bahro M Weinberger DR Differential Cholinergic Regulation in Alzheimers Patients Compared to Normal Controls Following Chronic Blockade with Scopolamine A SPECT Study Psychopharmachology 121231-241 1995

2 Mattay VS Berman KF Ostrem JL Esposito G Van Hom JD Bigelow LB Weinberger DR Dextroamphetamine Enhances Neural Network-Specific Physiological Signals A Positron - Emission Tomography rCBF Study J Neurosci 164816-4822 1996

3 Mattay VS Frank IA Duyn lH Kotrla KJ Santha AKS Esposito G Sexton RH Barker P Sunderland T Moonen CTW Weinberger DR 3D BUR8T FMRl Initial Clinical Applirations Acad Radiol 38379-8383 1996

4 RamseyNF KirkbyBS Van Gelderen P Berman KF Moonen CTW Duyn JH Frank lA Mattay V8 Van Hom JO Esposito G Moonen CTW Weinberger DR Functional mapping of human sensorimotor cortex with 3D-BOLD fMRI

correlates highly with H2150 PET rCBF J Cereb Blood Flow Metab 16755-764 1996

5 Esposito G Van Hom JO Ostrem JL Weinberger DR Berman KF Gender Differences in Cerebral Blood Flow as a Function of Cognitive State with PET J Nucl Med 37559-564 1996

6 Berman KF Schmidt PJ Rubinow D~ Danaceau MA Van Hom JD Esposito G Ostrem IL Weinberger DR Modulation ofCognitive-Specific Cortical Activity

Jun 16 10 OS53a Radiation SaTet~ 202 444 006S pS

by Gonadal Steroids a PET Study in Wom~~n Proc Natl Acad Sci 948836Al 1997

7 Goldberg TE Berman KF Fleming K Ostrem IL Van Hom JD Esposito G Mattay VS Gold JM Weinberger DR Uncoupling cognitive workload and prefrontal cortical physiology a PET rCBF study Neuroimage 7296-303 1998

8 Van Hom JD Ellmore TM Esposito G Bennan KF Mapping Voxel-Based Statistical Power on Parametric Images Neuroimage 797-107 1998

9 Van Hom JD Gold J Esposito G Ostrem JL Mattay VS Weinberger DR Berman KF Changing Patterns of Brain Activation During Maze Learning Brain Res 793 29-38 1998

10 Esposito G Kirkby BS VanHorn JD Weinberger DR Berman KF Contextshydependent Neural System-specific Neurophysiological Concomitants of Aging Mapping PET Correlates DUring Cognitive Activation Brain 122963-979 1999

11 Ye F Berman KF Ellmore T Esposit1 G Van Hom 10 Yang Y Duhn J Smith AM Frank JA Weinberger DR McLaughlin AC H2150 PET Validation of Steady-State Arterial Spin Tagging Cerebral Blood Flow Measurements in Humans Magn Reson Med 44450-456 2000

12 Bertolino A Esposito G Callicott JB Mattay VS Van Hom JD Frank JA Berman KF Weinberger DR Specific relationship between prefrontal neuronal N-acetyl-aspartate and activation of the working memory cortical network in schizophrenia Am J Psychiatry 15726-332000

13 Gourovitch ML Kirkby BS Goldberg TE Weinberger DR Gold 1M Esposito G Van Hom JD Bennan KF A comparison ofrCBF patterns during phonological and semantic fluency Neuropsychology 14353-360 2000

14 Meyer-Lindenberg A Miletich RS Kohn PO Esposito G CarsonRE Quarantelli M Weinberger DR Berman KF Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia Nature Neurosci 5267-71 2002

15 Chin BB Esposito G Kraitchman DL Myocardial contractile reserve and perfusion defect severity with rest and stress dobutamine (99m)Tc-sestamibi SPECT in canine stunning and subendocardial infarction J Nucl Med 43540-550 2002

16 Beason-Held LL Golski S Kraut MA Esposito G Resnick SM Brain activation during encoding and recognition of verbal and figural infonnation in older adults Neurobiol Aging 26(2)237-502005

17 Garcia CA Van Nostrand 0 Atkins F Acio E Butler C Esposito 0 Kulkarni K Majd M Reduction ofBrown Fat 2-Deoxy-2-[F-18]f1uoro-D-glucose Uptake by Controlling Environmental TemperatJre Prior to Positron Emission Tomography Scan Mol Imaging BioI 8 24-29 2006

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18 Garcia CA Esposito G Acio ER Van Nostrand D (18)F-FDG PET hemispheric cerebral hypometabolic activity patient motion artifact J Nucl Med Technol 34(2)86-72006

19 Esposito 0 Giovacchini G Der M Liow JS Ma K Herscovitch P Channing M Hallett M Bhattacharjee AK Eckelman WC Carson RE Rapoport SI Imaging signal transduction via Arachidonic Acid in the human brain during visual stimulation by means of Positron Emission Tomography Neuroimage 34(4)1342-512007

20 Walitt B Roebuck-Spencer T Esposito G Atkins F Bleiberg J Foster 0 Weinstein A The effects of multidisciplinary therapy on positron emission tomography of the brain in fibromyalgia a pilot study Rheumatol Int 27(11)1019-24 Epub 2007 Jul20 2007

21 Esposito G Giovacchini G Liow JS Bhattacharjee AK Greenstein D Schapiro M Hallett M Herscovitch P Eckelman we Carson RE Rapoport SI Imaging Neuroinflammation in Alzheimer Dis~Jase with Radiolabeled Arachidonic Acid and PET J Nucl Med (in press)

Book Chapters

1 Van Hom JD Ellmore TM Holt JL Esposito G Berman KF (1998) Multifiltering signal detection and statistical power in brain activation studies In Herschovitch P Carson RE (eds) Quantification ofBrain Function with PET Academic Press 237-240

2 Esposito G Radionuclide Imaging of Medullary Carcinoma Utility of Radiolabeled Somatostatin Analogs ~ld Other Radiotracers In Thyroid Cancer A Comprehensive Guide to Clinical Managl~ment 2e Edited by L Wartofsky MD and D Van Nostrand Humana Press Inc Totowa NJ 2006

Meeting Abstracts

Society ofNuclear Medicine

1 Esposito G Van Horn JD Weinberger DR Berman KF (1993) Gender Differences in Cerebral Blood Flow with PET Is there an Effect ofCognitive State J Nucl Med 34 67P

2 Berman KF Schmidt PJ Ostrem JL Danaceau MA Esposito G Van Hom lD Mattay VS Rubinow DR Weinberger DR (1994) Effects of gonadal steroids on cerebral blood flow patients with menstrual-related mood disorder and controls studied with PET during medical oophorectomy and hormone replacement J Nucl Med 3553P

J~n 16 10 0954a Radiation Safet~ 202 444 0069 p 11

3 Esposito G Kirkby BS Van Hom JD Ostrem JL Weinberger DR Berman KF (1995) Task-specific Neurophysioloeuroical Changes in Normal Aging PET rCBF Measurements During Cognition Journal ofNuclear Medicine vol 36 p16

4 Esposito G Saunders Re Jones DW Lee KS Gorey JG Coppola R Bennan KF Iadarola MJ DeCosta BR Rice KC Weinberger DR (1995) 1-123-Ioxy A Potential SPECT Imaging Agent for Opiate Receptors Journal ofNuclear Medicine voL 36 p 166P

5 Esposito G Kirkby BS Van Hom JD Ostr-em JL Weinberger DR Berman KF (1996) Different Pathophysiological Mechanisms ofhnpaired Wisconsin Card Sorting in Elderly Normal Subjects and Schizophrenics Studied with PET Journal ofNuclear Medicine 37(5) p 79P

6 Berman KF Austin-Lane JL Esposito G Van Hom JD Weinberger DR (1996) Neurophysiological and Neuropsychological Dissection of the IIWorking and the Memory in a PET Study ofWorking Memory Journal ofNuc1ear Medicine 37 5 p 284p

7 Esposito G Chin BB Kraitchrnan DL (2000) Tc-99m gated sestamibi SPECT evaluation of myocardial wall thickening correlates with tagged MRI measurements of radial strain J Nuel Med 41 755P

8 Chin BB Esposito G Kraitchrnan DL (2000) Characterization ofcanine myocardial contractile reserve with gated Tc-99m sestamibi SPECT in normal stunned and subendocardial infarction J Nuel Med 41 497P

9 Chin BB Esposito G Kraitchman DL (2000) Detailed characterization of gated and ungated Tc-99m sestamibi defect severity in normal stunned and subendocardial infarcted canine myo~ardiwn at rest and during low dose dobutamine infusion J Nuel Med 41 496P

10 Esposito G Bhattachrujee AK Schapro M Herscovitch P Eckelman WC Carson RE Rapoport SI (2005) PET shows ~ncreased brain incorporation of [I shyI IC]Arachidonic Acid a marker of neuroinflammation in patients with Alzheimers Disease J Nuel Med

11 Van Nostrand D Aiken M Atkins F Esposito G Moreau S Garcia C Acio E Burman K Wartofsky L (2007) The utility of radioiodine whole body scans prior to I~131 ablation in patients with well-differentiated thyroid cancer J Nuel Med 48 lSP

12 Aiken M Garcia C Acio E Suhag V Esposito G Moreau S Priebat D Van Nostrand D (2007) Doxorubicin-induced cardiac toxicity and gated cardiac blood pool imaging J Nuel Med 48 208P

13 Esposito G Sarikaya I (2008) Integr~ted nuclear medicine imaging ofmedullary thyroid cancer J Nuel Med 49 171P

J~n 18 10 0954a Radiation Safet~ 202 444 0089 p 12

BrainPET

14 Esposito G~ Giovacchini G Der MG Vuong BK Channing MA Lerner A Hallett M Battacharjee A Herscovitch P Eckelman WC Rapoport SI Carson RE llC]Arachidonic acid PET activation experiments in human subjects A feasibility study using visual stimulation J Cereb Blood Flow Metab Vol 23 (Suppl 1)711 (2003)

Radiological Society oNorth America

15 Esposito G Chin BB Kraitchman DL Correlation ofmyocardial strain measurements by 3D-tagged MR imging with Tc-99m gated sestamibi SPEeT thickening in normal stunned and infarcted myocardium Radiology 1999 213 p207

SOCiety for Neuroscience

16 Berman KF Ostrem IL Van Hom JD Mattay VS Esposito G Weinberger DR (1993) A Comparison Between Normal Monozygotic and Dizygotic Twins Studied During Cognition with Positron Emission Tomography Society for Neuroscience Abstracts Vol 19 Part I p 792

17 Gourovitch ML Kirkby BS Gold JM Esposito G Van Hom JD Ostrem JL Golberg TE Weinberger DR Berman KF(l994) A comparison ofletter and category fluency Cerebral Activation with Positron Emission Tomography Society for Neuroscience Abstracts Volume 20 Part 1 p 6

18 Weinberger DR Ramsey NF Kirkby BS Van Gelderen P Berman KF Mattay VS Frank JA Van Hom JD Esposito G Moonen CTW (1995) ThreeshyDimensional BOLD fMRI and 0-15 water PET neuroactivation maps are highly correlated Society for Neuroscience bstracts Vol 21 Part 1 p 273

19 Esposito G Kirkby BS Van Horn JD Weinberger DR Berman KF (1995) Different pathophysiological mechanisms of altered Wisconsin Card Sort performance in schizophrenics and elderly normal subjects Society for Neuroscience Abstracts Vol 21 Part 1 p 747

20 Kirkby BS Van Hom JD Esposito G Golberg TE Weinberger DR Berman KF (1995) Long term changes in rCBF during cognition following severe closed head injury a PET study Society for Neuroscience Abstracts Vol 21 Part 3 p 1924

21 Van Hom JD Esposito G Kirkby BS Weinberger DR Berman KF (1995) Appraisal ofunivariate and multivariate analysis techniques for PET brain image quantification Society for Neuroscience Abstracts Vol 21 Part 2 p 1208

22 Esposito G Kirkby BS Van Hom JD Weinberger DR Berman KF (1996) PET Evaluation of cognitively related neur9physiological sequelae accompanying

Jun 16 10 0955a Radiation SaTet~ 202 444 0069 p 13

incidental findings of microvascular ischemic disease in the elderly preliminary results Society for Neuroscience Abstracts Vol 22 Part 1 p 676

23 Weinberger DR Santha A Mattay VS Frank J Kirkby BS Van Horn JD Esposito G Bennan KF (1996) Within subject neuroactivation mapping with whole brain isotropic BPI and 3-D PET a direct comparison Society for Neuroscience Abstracts Vol 22 Part 1 p 7

24 Golberg TE Fleming K Berman KF Van Horn 10 Esposito G Ostrem JL Gold JM Weinberger DR (1996) Neurophysiology ofdual task perfonnance a PET 015 study Society for Neuroscience Abstracts Vol 22 Part 2 p 967

25 Van Horn JD Austin-Lane JL Kirkby BS Esposito G Weinberger DR Berman KF (1996) Characterizing rCBF response in a PET study of graded working memory load Society for Neuroscience Abstracts Vol 22 Part 2 p 1113

26 El1more TM Van Horn JD Esposito G Kirkby BS Austin-Lane JL Weinberger DR Berman KF (1996) Signal averaging in cognitive and motor PET paradigms Society for Neuroscience Abstracts Vol 22 Part 3 p 1858

27 BeITI1an KF Sclunidt Pl Rubinow DR Esposito G Van Hom lD Austin-LaneJL Danaceau MA Weinberger DR (1996) Modulation of cognitively related cortical activity by gonadal steroid hormones directly demonstrated with PET Society for Neuroscience Abstracts Vol 22 Part 3 p 1861

28 Berman KF Holt J Callicott J Esposito G Van Horn JD Egan M Weinberger DR (1997) Relations among rCBF Clinical and Cognitive Changes over Time in Medication-Free Patients with Schizophrenia Individual PET Activation Maps Society for Neuroscience Abstracts 101 23 Part 2 p 1406

American Psychiatric Association

29 Van Horn JD Bennan KF Esposito G Ostrem JL Weinberger DR (1993) Is There Frontal Lobe Lateralization A PET Study Abstracts of the 146th Meeting of the American Psychiatric Association (New Reseach) p 68

30 Ostrem JL Kirkby BS Van Hom JD Esposito G Gold J Weinberger DR Berman KF(1994) Effects ofcohort size on PET activation studies Abstracts of the Annual Meeting of the American Psychiatric Association (Symposium 118) p 153

American Academy ofNeurology

31 BeITI1an KF Ostrem JL Mattay VS Bsposito G Van Hom JD Torrey EF Weinberger DR (1993) The role of the dorsolateral prefrontal cortex and the hippocampus in working memory PET studies of normal and abnormal states Abstracts of the 46th Annual Meeting of the American Academy of Neurology

Jun 16 10 0955a Radiation Safet~ 202 444 0069 p 14

Biological Psychiatry

32 Ostrem JL Bennan KF Mattay VS Van Hom JD Esposito G Weinberger DR (1994) The Neural Basis ofAbstract Reasoning An Inverstigation ofTwo Problem Solving Tasks with PET Biological Psychiatry 35(9)686

33 Bennan KF Ostrem JL Mattay VS Esposito G Van Hom JD Abi-Dargham A Torrey EF Weinberger DR (1994) The role of the dorsolateral prefrontal corteK and hippocampus in working memory and schizophrenia Biological Psychiatry 35(9)622

34 Van Hom lD Gold J Esposito G Ostrem JL Weinberger DR AND Belman KF (1994) The role ofthe frontal lobe during maze learning assessed using PET Biological Psychiatry 35(9)686

35 Esposito G Van Horn JD Ostrem JLMattay VS Weinberger DR Bennan KF The effect of sex age and pC02 on cerebral blood flow during cognitive stimulation Biological Psychiatry 35(9)648 1994

Society ofMagnetic Resonance

36 Ramsey NF Kirkby BS Van Gelderen P Belman KF Moonen CTW Mattay VS Frank lA Van Hom JD Esposito G Weinberger DR (1995) A direct comparison

of 3D BOLD tMRI and ISO-Water PET imaging ofprimary sensory motor cortex in humans III Meeting of the Society of Magnetic Resonance

Cerebral Blood Flow and Metabolism

37 Mattay VS Kotrla KJ Santha AKS Sexton RH Sunderland T Esposito G Duyn JR Moonen CTW Frank JA Weinberger DR (1995) 3D-BURST tMRI Initial clinical application in Alzheimer1s disease XVII International Symposium on Cerebral Blood Flow and Metabolism

38 Esposito G Kirkby BS Van Horn JD Ostrem JL Mattay VS Weinberger DR Belman KF (1995) Normal Aging is Assodated witb Task-Specific Neuropbysiological Changes PET rCBF Measurements During Cognitive Stimulation Journal ofCerebral Blood Flow and Metabolism 15 p S594

39 Berman KF Schmidt PJ Ostrem IL Danaceau MA Van Horn JD Esposito G Rubinow DR Weinberger DR (1995) The Effects of Gonadal Steroid Honnones on Cognitively-Related Regional Cerebral Blood Flow A Positron Emission Tomography Study Journal of Cerebral Blood Flow and Metabolism 15 p S133

Functional Mapping ofthe Human Brain

40 Berman KF Ostrem JL Esposito G Van Hom ID Mattay VS Kirkby BS Weinberger DR (1995) Heritability of Cognitively-Related Regional Cerebral

Jun 16 10 0956a Radiation Saret~ 202 444 0069 p 15

Blood Flow A PET Study Comparing Normal Monozygotic and Dizygotic Twins Neuroimage p 359

41 Esposito G Kirkby BS Van Hom JD Ostrc~m JL Weinberger DR Berman KF (1996) Impaired Wisconsin Card Sorting Test Performance in Nonnal Aging and in Schizophrenia PET Evidence ofDifferent Pathophysiological Mechanisms for a Common Cognitive Deficit Neurolmage 3 3 p S482

42 Bennan KF Schmidt PJ Rubinow DR Esposito G Van Hom JD Austin-Lane JL Weinberger DR (1996) The Effects cfGonadal Steroid Hormones on Cognitive Activation in Men and Women Studied with Positron Emission Tomography Neurolmage 3 3 p S475

43 Kirkby BS Van Hom JD Esposito G Golberg TE Weinberger DR Berman KF (1996) A PET Study of Long-Term rCBF Changes during Cognition after Closed Head Injury Neurolmage 3 3 p S492

44 Van Hom lD Esposito G Weinberger DR Berman KF (1996) Volume-Based Multivariate Discriminant and Canonical Correlation Analysis of Neurophysiological Measures of Brain Function Neurolmage 3 3 p S103

45 Holt JL Van Hom JD Esposito G Ellmore T Weinberger DR Berman KF (1997) Mapping Neurophysiological Predictors of Good and Poor Performance on the Wisconsin Card Sorting Task Neuroimage 5 4 p S112

46 Bertolino A Esposito G Callicott JH Mat-tay VS Van Horn JD Frank JA Berman KF Weinberger FK (1997) IH-Magnetic Resonance Spectroscopic Imaging Correlates with rCBF Activation During Working Memory in Patients with Schizophrenia Neuroimage 54 p S281

47 Esposito G Van Hom ID Kirkby BS Weinberger DR Berman KF (1997) Functional Interactions between Dorsolateral Prefrontal Cortex and Other Brain Regions during Working Memory in Normal Subjects and Patients with Psychosis Neuroimage 54 p S284

48 Berman KF Holt J Callicott J Esposito G Van Hom JD Egan M Weinberger DR (1997) Neurophysiological Predictors of Clinical and Cognitive Changes over Time in Medication-Free Patients with Schizophrenia Individual Activation Maps Neuroimage 5 4 p S290

49 Van Hom ID EUmore T Esposito G Holt J Weinberger DR Berman KF (1997) Voxel-based Statistical Power in Functional Neuroimaging Studies Neuroimage 54pS464

50 Ye FQ Berman KF EUmore T Esposito G Van Hom JD Yang Y Duyn J Mattay VS Smith AM Frank JA Weinberger DR McLaughlin AC (1997) H2 1S0 PET Validation ofArterial Spin Tagg~ng CBF Measurements Neuroimage 54 p S533

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A copy of your action has been forwarded to our License Fee amp Accounts Receivable Branch who will contact you separately if there is a fee issue involved

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NRC FORM 532 (RI) Sincerely (6-96) licensing Assistance Team Leader

Ju n 1 6 1 0 09 52 a Radiation Safet~ 202 444 0069 p4

Professional Experience

Staff Clinician Research Resources Branch National Institute on Aging NIH 5600 N Shock Dr Baltimore MD 21224 February 2002-August 2004

Staff Physician Department ofNuclear Medicine Franklin Square Hospital 9000 Franklin Square Dr Baltimore MD 21287 March 200S-present

Staff Physician Department ofNuclear Medicine Good Samaritan Hospital 5601 Loch Raven Blve Baltimore MD 21239 March 200S-present

Staff Physician Division ofNuclear Medicine Department ofMedicine Washington Hospital Center 110 Irving Street r-W Washington DC 20010 September 2004-July 2007

Director Nuclear Medicine (since November 1st) Department ofRadiology Georgetown University Hospital 3800 Reservoir Rd NW Washington DC 20007middot2113 August 2007 - present

Honors and Awards

1994 Smith Kline Beecham Award Society ofBiological Psychiatry Philadelphia P A

2003 Staff Recognition Award National Institute on Aging NIH

Professional Societies

2007-present European Society ofNuclear Medicine 200S-present Academy of Molecular Imaging 2002-present Society ofNuclear Medicine

p5 Jun 16 10 0952a Radiation Safet~ 202 444 0069

Public Service

June 2008 - present SecretarylTreasurer Executive Committee Mid-Eastern Chapter Society ofNuclear Medicine

September 2006 - present Intern Executive Committee - Mid-Eastern Chapter Society ofNuclear Medicine

Reviewer Neuropsychologia (Occasional)

Invited seminars and presentations

Neurology Grand Rounds - PET Evaluation of the dementi as

Washington Hospital Center Washington DC (February 2005)

HematologyOncology Grand Rounds - PET scans in Leuk(~mia and Multiple Myeloma

Washington Hospital Center Washington DC (June 2005)

Infectious Disease Grand Rounds - Nuclear Medicine Evaluation of InfectionlInflarnmation

Washington Hospital Center Washington DC (May 2006)

Head and Neck Surgery Grand Rounds - PET in the Management ofpatients with Head and Neck

Cancer Washington Hospital Center Washington DC (April 2007)

Multidisciplinary Management of Cancers A Case~Based Approach Seminar

LymphomaMyeloma Tumor Board Organized by Washington Cancer Institute Washington Hospital Center Washington DC (October 272007)

Tumor Board Grand Round - Clinical Indications ofPETCT

p6 202 444 0069~un 16 10 0953a Radiation Safet~

University Service

Teaching Activities

Union Memorial Hospital Baltimore MD (April 2008)

Neuroradiology Grand Rounds - PET Imaging in Head and Neck Cancers

Deparment ofRadiology Georgetown University Hospital Center Washington DC (May 2008)

August 2007 - present Radiation Safety Committee Georgetown Universit~ Hospital

August 2007 - present Residency Education Committee Department ofRadiology Georgetown University Hospital

July 2008 - present Leader Imaging Response Assessment Team of the American Association of Cancer Institutes Lombardi Cancer CenterGeorgetown University Hospital Department ofRadiology

Internal Medicine Residency Program Washington Hospital Center Washington DC

Residents lectures The role ofmvlear medicine in the evaluation of infectiousinflammatory processes (May 2006) The role ofnuclear medicine in the evaluation of infectiousinflammatory processes (May 2006) Nuclear medicine evaluation of the hepatobiliary tract (November 2006)

Daily rounds in nuclear medicine reading room for residents on elective rotation in nUcielr medicine

Rounds in thyroid clinic for patients treated with radioiodine for residents on electiv-e rotation in nuclear medicine

Jun 1S 10 0953a Radiation Safet~ 202 444 00S9 p

Cardiology Fellowship Program Georgetown UniversitylWashington Hospital Center 2004-2007 Washington DC

Daily rounds in nuclear medicine reading room (September 2004-July 2007)

Endocrinology Fellowship Program Georgetown UniversityWashington Hospital Center Washington DC

Weekly thyroid cancer conferences (September 2004-July 2007) Rounds in thyroid linic for patients treated with radioiodine for thyroid cancer or hyperthyroidism (September 2004-July 2007)

Radiology Residency Program Georgetown University Hospital Washington DC

Residents lectures - Radiopharmaceuticals commonly used in nuclear

medicine (August 2007) - VentilationlP~rfusion scan for pulmonary embolism

(September 2007) - Imaging of Infection in Nuclear Medicine (October 2007) -- Evaluation ofGI bl(led in Nuclear Medicine (November

2007) - Nuclear medicine imaging ofbenign thyroid diseases

(January 2008) - Imaging of thyroid nodules and thyroid cancer (January

2008) - Radionuclide ventriCUlography (April 2008) -- PETCT basics (June 2008) -- PETCT imaging of head and neck cancer (July 2008)

Daily rounds in nuclear medicine reading room (August 2007shypresent)

Ward rounds for patients with thyroid cancer treated with radioiodine (August 2007-present)

Georgetown University Medical School Washington DC

p8 Jun 18 10 0953a Radiation Sa~et~ 202 444 0089

- Basics ofNuclear Medicine Clinical Skill Prim~r Course 2008 (April 2008)

Monthly students lecture$ on the basics ofNuclear Medicine for selective rotations in Radiology (July 2008-present)

Scholarsbips

Italian Ministry for Scientific Research Fellowship Award 1991-1994

Grants Charles and Mary Latham Fund Comparison ofI-124 and 1-131 Radiopharmacokinetics Principal Investigator January 2007 ($10000)

PubUcations

Peer Reviewed

1 Sunderland T Esposito G Molchan SE Coppola R Jones OW Gorey J Little JT Cantillon M Bahro M Weinberger DR Differential Cholinergic Regulation in Alzheimers Patients Compared to Normal Controls Following Chronic Blockade with Scopolamine A SPECT Study Psychopharmachology 121231-241 1995

2 Mattay VS Berman KF Ostrem JL Esposito G Van Hom JD Bigelow LB Weinberger DR Dextroamphetamine Enhances Neural Network-Specific Physiological Signals A Positron - Emission Tomography rCBF Study J Neurosci 164816-4822 1996

3 Mattay VS Frank IA Duyn lH Kotrla KJ Santha AKS Esposito G Sexton RH Barker P Sunderland T Moonen CTW Weinberger DR 3D BUR8T FMRl Initial Clinical Applirations Acad Radiol 38379-8383 1996

4 RamseyNF KirkbyBS Van Gelderen P Berman KF Moonen CTW Duyn JH Frank lA Mattay V8 Van Hom JO Esposito G Moonen CTW Weinberger DR Functional mapping of human sensorimotor cortex with 3D-BOLD fMRI

correlates highly with H2150 PET rCBF J Cereb Blood Flow Metab 16755-764 1996

5 Esposito G Van Hom JO Ostrem JL Weinberger DR Berman KF Gender Differences in Cerebral Blood Flow as a Function of Cognitive State with PET J Nucl Med 37559-564 1996

6 Berman KF Schmidt PJ Rubinow D~ Danaceau MA Van Hom JD Esposito G Ostrem IL Weinberger DR Modulation ofCognitive-Specific Cortical Activity

Jun 16 10 OS53a Radiation SaTet~ 202 444 006S pS

by Gonadal Steroids a PET Study in Wom~~n Proc Natl Acad Sci 948836Al 1997

7 Goldberg TE Berman KF Fleming K Ostrem IL Van Hom JD Esposito G Mattay VS Gold JM Weinberger DR Uncoupling cognitive workload and prefrontal cortical physiology a PET rCBF study Neuroimage 7296-303 1998

8 Van Hom JD Ellmore TM Esposito G Bennan KF Mapping Voxel-Based Statistical Power on Parametric Images Neuroimage 797-107 1998

9 Van Hom JD Gold J Esposito G Ostrem JL Mattay VS Weinberger DR Berman KF Changing Patterns of Brain Activation During Maze Learning Brain Res 793 29-38 1998

10 Esposito G Kirkby BS VanHorn JD Weinberger DR Berman KF Contextshydependent Neural System-specific Neurophysiological Concomitants of Aging Mapping PET Correlates DUring Cognitive Activation Brain 122963-979 1999

11 Ye F Berman KF Ellmore T Esposit1 G Van Hom 10 Yang Y Duhn J Smith AM Frank JA Weinberger DR McLaughlin AC H2150 PET Validation of Steady-State Arterial Spin Tagging Cerebral Blood Flow Measurements in Humans Magn Reson Med 44450-456 2000

12 Bertolino A Esposito G Callicott JB Mattay VS Van Hom JD Frank JA Berman KF Weinberger DR Specific relationship between prefrontal neuronal N-acetyl-aspartate and activation of the working memory cortical network in schizophrenia Am J Psychiatry 15726-332000

13 Gourovitch ML Kirkby BS Goldberg TE Weinberger DR Gold 1M Esposito G Van Hom JD Bennan KF A comparison ofrCBF patterns during phonological and semantic fluency Neuropsychology 14353-360 2000

14 Meyer-Lindenberg A Miletich RS Kohn PO Esposito G CarsonRE Quarantelli M Weinberger DR Berman KF Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia Nature Neurosci 5267-71 2002

15 Chin BB Esposito G Kraitchman DL Myocardial contractile reserve and perfusion defect severity with rest and stress dobutamine (99m)Tc-sestamibi SPECT in canine stunning and subendocardial infarction J Nucl Med 43540-550 2002

16 Beason-Held LL Golski S Kraut MA Esposito G Resnick SM Brain activation during encoding and recognition of verbal and figural infonnation in older adults Neurobiol Aging 26(2)237-502005

17 Garcia CA Van Nostrand 0 Atkins F Acio E Butler C Esposito 0 Kulkarni K Majd M Reduction ofBrown Fat 2-Deoxy-2-[F-18]f1uoro-D-glucose Uptake by Controlling Environmental TemperatJre Prior to Positron Emission Tomography Scan Mol Imaging BioI 8 24-29 2006

Jun 16 10 0954a Radiation Safet~ 202 444 0069 p 10

18 Garcia CA Esposito G Acio ER Van Nostrand D (18)F-FDG PET hemispheric cerebral hypometabolic activity patient motion artifact J Nucl Med Technol 34(2)86-72006

19 Esposito 0 Giovacchini G Der M Liow JS Ma K Herscovitch P Channing M Hallett M Bhattacharjee AK Eckelman WC Carson RE Rapoport SI Imaging signal transduction via Arachidonic Acid in the human brain during visual stimulation by means of Positron Emission Tomography Neuroimage 34(4)1342-512007

20 Walitt B Roebuck-Spencer T Esposito G Atkins F Bleiberg J Foster 0 Weinstein A The effects of multidisciplinary therapy on positron emission tomography of the brain in fibromyalgia a pilot study Rheumatol Int 27(11)1019-24 Epub 2007 Jul20 2007

21 Esposito G Giovacchini G Liow JS Bhattacharjee AK Greenstein D Schapiro M Hallett M Herscovitch P Eckelman we Carson RE Rapoport SI Imaging Neuroinflammation in Alzheimer Dis~Jase with Radiolabeled Arachidonic Acid and PET J Nucl Med (in press)

Book Chapters

1 Van Hom JD Ellmore TM Holt JL Esposito G Berman KF (1998) Multifiltering signal detection and statistical power in brain activation studies In Herschovitch P Carson RE (eds) Quantification ofBrain Function with PET Academic Press 237-240

2 Esposito G Radionuclide Imaging of Medullary Carcinoma Utility of Radiolabeled Somatostatin Analogs ~ld Other Radiotracers In Thyroid Cancer A Comprehensive Guide to Clinical Managl~ment 2e Edited by L Wartofsky MD and D Van Nostrand Humana Press Inc Totowa NJ 2006

Meeting Abstracts

Society ofNuclear Medicine

1 Esposito G Van Horn JD Weinberger DR Berman KF (1993) Gender Differences in Cerebral Blood Flow with PET Is there an Effect ofCognitive State J Nucl Med 34 67P

2 Berman KF Schmidt PJ Ostrem JL Danaceau MA Esposito G Van Hom lD Mattay VS Rubinow DR Weinberger DR (1994) Effects of gonadal steroids on cerebral blood flow patients with menstrual-related mood disorder and controls studied with PET during medical oophorectomy and hormone replacement J Nucl Med 3553P

J~n 16 10 0954a Radiation Safet~ 202 444 0069 p 11

3 Esposito G Kirkby BS Van Hom JD Ostrem JL Weinberger DR Berman KF (1995) Task-specific Neurophysioloeuroical Changes in Normal Aging PET rCBF Measurements During Cognition Journal ofNuclear Medicine vol 36 p16

4 Esposito G Saunders Re Jones DW Lee KS Gorey JG Coppola R Bennan KF Iadarola MJ DeCosta BR Rice KC Weinberger DR (1995) 1-123-Ioxy A Potential SPECT Imaging Agent for Opiate Receptors Journal ofNuclear Medicine voL 36 p 166P

5 Esposito G Kirkby BS Van Hom JD Ostr-em JL Weinberger DR Berman KF (1996) Different Pathophysiological Mechanisms ofhnpaired Wisconsin Card Sorting in Elderly Normal Subjects and Schizophrenics Studied with PET Journal ofNuclear Medicine 37(5) p 79P

6 Berman KF Austin-Lane JL Esposito G Van Hom JD Weinberger DR (1996) Neurophysiological and Neuropsychological Dissection of the IIWorking and the Memory in a PET Study ofWorking Memory Journal ofNuc1ear Medicine 37 5 p 284p

7 Esposito G Chin BB Kraitchrnan DL (2000) Tc-99m gated sestamibi SPECT evaluation of myocardial wall thickening correlates with tagged MRI measurements of radial strain J Nuel Med 41 755P

8 Chin BB Esposito G Kraitchrnan DL (2000) Characterization ofcanine myocardial contractile reserve with gated Tc-99m sestamibi SPECT in normal stunned and subendocardial infarction J Nuel Med 41 497P

9 Chin BB Esposito G Kraitchman DL (2000) Detailed characterization of gated and ungated Tc-99m sestamibi defect severity in normal stunned and subendocardial infarcted canine myo~ardiwn at rest and during low dose dobutamine infusion J Nuel Med 41 496P

10 Esposito G Bhattachrujee AK Schapro M Herscovitch P Eckelman WC Carson RE Rapoport SI (2005) PET shows ~ncreased brain incorporation of [I shyI IC]Arachidonic Acid a marker of neuroinflammation in patients with Alzheimers Disease J Nuel Med

11 Van Nostrand D Aiken M Atkins F Esposito G Moreau S Garcia C Acio E Burman K Wartofsky L (2007) The utility of radioiodine whole body scans prior to I~131 ablation in patients with well-differentiated thyroid cancer J Nuel Med 48 lSP

12 Aiken M Garcia C Acio E Suhag V Esposito G Moreau S Priebat D Van Nostrand D (2007) Doxorubicin-induced cardiac toxicity and gated cardiac blood pool imaging J Nuel Med 48 208P

13 Esposito G Sarikaya I (2008) Integr~ted nuclear medicine imaging ofmedullary thyroid cancer J Nuel Med 49 171P

J~n 18 10 0954a Radiation Safet~ 202 444 0089 p 12

BrainPET

14 Esposito G~ Giovacchini G Der MG Vuong BK Channing MA Lerner A Hallett M Battacharjee A Herscovitch P Eckelman WC Rapoport SI Carson RE llC]Arachidonic acid PET activation experiments in human subjects A feasibility study using visual stimulation J Cereb Blood Flow Metab Vol 23 (Suppl 1)711 (2003)

Radiological Society oNorth America

15 Esposito G Chin BB Kraitchman DL Correlation ofmyocardial strain measurements by 3D-tagged MR imging with Tc-99m gated sestamibi SPEeT thickening in normal stunned and infarcted myocardium Radiology 1999 213 p207

SOCiety for Neuroscience

16 Berman KF Ostrem IL Van Hom JD Mattay VS Esposito G Weinberger DR (1993) A Comparison Between Normal Monozygotic and Dizygotic Twins Studied During Cognition with Positron Emission Tomography Society for Neuroscience Abstracts Vol 19 Part I p 792

17 Gourovitch ML Kirkby BS Gold JM Esposito G Van Hom JD Ostrem JL Golberg TE Weinberger DR Berman KF(l994) A comparison ofletter and category fluency Cerebral Activation with Positron Emission Tomography Society for Neuroscience Abstracts Volume 20 Part 1 p 6

18 Weinberger DR Ramsey NF Kirkby BS Van Gelderen P Berman KF Mattay VS Frank JA Van Hom JD Esposito G Moonen CTW (1995) ThreeshyDimensional BOLD fMRI and 0-15 water PET neuroactivation maps are highly correlated Society for Neuroscience bstracts Vol 21 Part 1 p 273

19 Esposito G Kirkby BS Van Horn JD Weinberger DR Berman KF (1995) Different pathophysiological mechanisms of altered Wisconsin Card Sort performance in schizophrenics and elderly normal subjects Society for Neuroscience Abstracts Vol 21 Part 1 p 747

20 Kirkby BS Van Hom JD Esposito G Golberg TE Weinberger DR Berman KF (1995) Long term changes in rCBF during cognition following severe closed head injury a PET study Society for Neuroscience Abstracts Vol 21 Part 3 p 1924

21 Van Hom JD Esposito G Kirkby BS Weinberger DR Berman KF (1995) Appraisal ofunivariate and multivariate analysis techniques for PET brain image quantification Society for Neuroscience Abstracts Vol 21 Part 2 p 1208

22 Esposito G Kirkby BS Van Hom JD Weinberger DR Berman KF (1996) PET Evaluation of cognitively related neur9physiological sequelae accompanying

Jun 16 10 0955a Radiation SaTet~ 202 444 0069 p 13

incidental findings of microvascular ischemic disease in the elderly preliminary results Society for Neuroscience Abstracts Vol 22 Part 1 p 676

23 Weinberger DR Santha A Mattay VS Frank J Kirkby BS Van Horn JD Esposito G Bennan KF (1996) Within subject neuroactivation mapping with whole brain isotropic BPI and 3-D PET a direct comparison Society for Neuroscience Abstracts Vol 22 Part 1 p 7

24 Golberg TE Fleming K Berman KF Van Horn 10 Esposito G Ostrem JL Gold JM Weinberger DR (1996) Neurophysiology ofdual task perfonnance a PET 015 study Society for Neuroscience Abstracts Vol 22 Part 2 p 967

25 Van Horn JD Austin-Lane JL Kirkby BS Esposito G Weinberger DR Berman KF (1996) Characterizing rCBF response in a PET study of graded working memory load Society for Neuroscience Abstracts Vol 22 Part 2 p 1113

26 El1more TM Van Horn JD Esposito G Kirkby BS Austin-Lane JL Weinberger DR Berman KF (1996) Signal averaging in cognitive and motor PET paradigms Society for Neuroscience Abstracts Vol 22 Part 3 p 1858

27 BeITI1an KF Sclunidt Pl Rubinow DR Esposito G Van Hom lD Austin-LaneJL Danaceau MA Weinberger DR (1996) Modulation of cognitively related cortical activity by gonadal steroid hormones directly demonstrated with PET Society for Neuroscience Abstracts Vol 22 Part 3 p 1861

28 Berman KF Holt J Callicott J Esposito G Van Horn JD Egan M Weinberger DR (1997) Relations among rCBF Clinical and Cognitive Changes over Time in Medication-Free Patients with Schizophrenia Individual PET Activation Maps Society for Neuroscience Abstracts 101 23 Part 2 p 1406

American Psychiatric Association

29 Van Horn JD Bennan KF Esposito G Ostrem JL Weinberger DR (1993) Is There Frontal Lobe Lateralization A PET Study Abstracts of the 146th Meeting of the American Psychiatric Association (New Reseach) p 68

30 Ostrem JL Kirkby BS Van Hom JD Esposito G Gold J Weinberger DR Berman KF(1994) Effects ofcohort size on PET activation studies Abstracts of the Annual Meeting of the American Psychiatric Association (Symposium 118) p 153

American Academy ofNeurology

31 BeITI1an KF Ostrem JL Mattay VS Bsposito G Van Hom JD Torrey EF Weinberger DR (1993) The role of the dorsolateral prefrontal cortex and the hippocampus in working memory PET studies of normal and abnormal states Abstracts of the 46th Annual Meeting of the American Academy of Neurology

Jun 16 10 0955a Radiation Safet~ 202 444 0069 p 14

Biological Psychiatry

32 Ostrem JL Bennan KF Mattay VS Van Hom JD Esposito G Weinberger DR (1994) The Neural Basis ofAbstract Reasoning An Inverstigation ofTwo Problem Solving Tasks with PET Biological Psychiatry 35(9)686

33 Bennan KF Ostrem JL Mattay VS Esposito G Van Hom JD Abi-Dargham A Torrey EF Weinberger DR (1994) The role of the dorsolateral prefrontal corteK and hippocampus in working memory and schizophrenia Biological Psychiatry 35(9)622

34 Van Hom lD Gold J Esposito G Ostrem JL Weinberger DR AND Belman KF (1994) The role ofthe frontal lobe during maze learning assessed using PET Biological Psychiatry 35(9)686

35 Esposito G Van Horn JD Ostrem JLMattay VS Weinberger DR Bennan KF The effect of sex age and pC02 on cerebral blood flow during cognitive stimulation Biological Psychiatry 35(9)648 1994

Society ofMagnetic Resonance

36 Ramsey NF Kirkby BS Van Gelderen P Belman KF Moonen CTW Mattay VS Frank lA Van Hom JD Esposito G Weinberger DR (1995) A direct comparison

of 3D BOLD tMRI and ISO-Water PET imaging ofprimary sensory motor cortex in humans III Meeting of the Society of Magnetic Resonance

Cerebral Blood Flow and Metabolism

37 Mattay VS Kotrla KJ Santha AKS Sexton RH Sunderland T Esposito G Duyn JR Moonen CTW Frank JA Weinberger DR (1995) 3D-BURST tMRI Initial clinical application in Alzheimer1s disease XVII International Symposium on Cerebral Blood Flow and Metabolism

38 Esposito G Kirkby BS Van Horn JD Ostrem JL Mattay VS Weinberger DR Belman KF (1995) Normal Aging is Assodated witb Task-Specific Neuropbysiological Changes PET rCBF Measurements During Cognitive Stimulation Journal ofCerebral Blood Flow and Metabolism 15 p S594

39 Berman KF Schmidt PJ Ostrem IL Danaceau MA Van Horn JD Esposito G Rubinow DR Weinberger DR (1995) The Effects of Gonadal Steroid Honnones on Cognitively-Related Regional Cerebral Blood Flow A Positron Emission Tomography Study Journal of Cerebral Blood Flow and Metabolism 15 p S133

Functional Mapping ofthe Human Brain

40 Berman KF Ostrem JL Esposito G Van Hom ID Mattay VS Kirkby BS Weinberger DR (1995) Heritability of Cognitively-Related Regional Cerebral

Jun 16 10 0956a Radiation Saret~ 202 444 0069 p 15

Blood Flow A PET Study Comparing Normal Monozygotic and Dizygotic Twins Neuroimage p 359

41 Esposito G Kirkby BS Van Hom JD Ostrc~m JL Weinberger DR Berman KF (1996) Impaired Wisconsin Card Sorting Test Performance in Nonnal Aging and in Schizophrenia PET Evidence ofDifferent Pathophysiological Mechanisms for a Common Cognitive Deficit Neurolmage 3 3 p S482

42 Bennan KF Schmidt PJ Rubinow DR Esposito G Van Hom JD Austin-Lane JL Weinberger DR (1996) The Effects cfGonadal Steroid Hormones on Cognitive Activation in Men and Women Studied with Positron Emission Tomography Neurolmage 3 3 p S475

43 Kirkby BS Van Hom JD Esposito G Golberg TE Weinberger DR Berman KF (1996) A PET Study of Long-Term rCBF Changes during Cognition after Closed Head Injury Neurolmage 3 3 p S492

44 Van Hom lD Esposito G Weinberger DR Berman KF (1996) Volume-Based Multivariate Discriminant and Canonical Correlation Analysis of Neurophysiological Measures of Brain Function Neurolmage 3 3 p S103

45 Holt JL Van Hom JD Esposito G Ellmore T Weinberger DR Berman KF (1997) Mapping Neurophysiological Predictors of Good and Poor Performance on the Wisconsin Card Sorting Task Neuroimage 5 4 p S112

46 Bertolino A Esposito G Callicott JH Mat-tay VS Van Horn JD Frank JA Berman KF Weinberger FK (1997) IH-Magnetic Resonance Spectroscopic Imaging Correlates with rCBF Activation During Working Memory in Patients with Schizophrenia Neuroimage 54 p S281

47 Esposito G Van Hom ID Kirkby BS Weinberger DR Berman KF (1997) Functional Interactions between Dorsolateral Prefrontal Cortex and Other Brain Regions during Working Memory in Normal Subjects and Patients with Psychosis Neuroimage 54 p S284

48 Berman KF Holt J Callicott J Esposito G Van Hom JD Egan M Weinberger DR (1997) Neurophysiological Predictors of Clinical and Cognitive Changes over Time in Medication-Free Patients with Schizophrenia Individual Activation Maps Neuroimage 5 4 p S290

49 Van Hom ID EUmore T Esposito G Holt J Weinberger DR Berman KF (1997) Voxel-based Statistical Power in Functional Neuroimaging Studies Neuroimage 54pS464

50 Ye FQ Berman KF EUmore T Esposito G Van Hom JD Yang Y Duyn J Mattay VS Smith AM Frank JA Weinberger DR McLaughlin AC (1997) H2 1S0 PET Validation ofArterial Spin Tagg~ng CBF Measurements Neuroimage 54 p S533

r~ This is to acknowledge the receipt of YOuiletter~pPlication dated

elO dO 0 and to~you that the initial processing which includes an administrative review has been performed

[XJ TheJtmkl~~tJtve o9si~n~~pound~Ji2iqa~ IsSigned to a technical reviewer Please note that the technical review may identify additional omissions or require additional information

D Please provide to this office within 30 days of your receipt of this card

A copy of your action has been forwarded to our License Fee amp Accounts Receivable Branch who will contact you separately if there is a fee issue involved

Your action has been assigned Mail Control Number 5]31 (~ When calling to inquire about this action please refer to this control number You may call us on (610) 337-5398 or 337-5260

NRC FORM 532 (RI) Sincerely (6-96) licensing Assistance Team Leader

p5 Jun 16 10 0952a Radiation Safet~ 202 444 0069

Public Service

June 2008 - present SecretarylTreasurer Executive Committee Mid-Eastern Chapter Society ofNuclear Medicine

September 2006 - present Intern Executive Committee - Mid-Eastern Chapter Society ofNuclear Medicine

Reviewer Neuropsychologia (Occasional)

Invited seminars and presentations

Neurology Grand Rounds - PET Evaluation of the dementi as

Washington Hospital Center Washington DC (February 2005)

HematologyOncology Grand Rounds - PET scans in Leuk(~mia and Multiple Myeloma

Washington Hospital Center Washington DC (June 2005)

Infectious Disease Grand Rounds - Nuclear Medicine Evaluation of InfectionlInflarnmation

Washington Hospital Center Washington DC (May 2006)

Head and Neck Surgery Grand Rounds - PET in the Management ofpatients with Head and Neck

Cancer Washington Hospital Center Washington DC (April 2007)

Multidisciplinary Management of Cancers A Case~Based Approach Seminar

LymphomaMyeloma Tumor Board Organized by Washington Cancer Institute Washington Hospital Center Washington DC (October 272007)

Tumor Board Grand Round - Clinical Indications ofPETCT

p6 202 444 0069~un 16 10 0953a Radiation Safet~

University Service

Teaching Activities

Union Memorial Hospital Baltimore MD (April 2008)

Neuroradiology Grand Rounds - PET Imaging in Head and Neck Cancers

Deparment ofRadiology Georgetown University Hospital Center Washington DC (May 2008)

August 2007 - present Radiation Safety Committee Georgetown Universit~ Hospital

August 2007 - present Residency Education Committee Department ofRadiology Georgetown University Hospital

July 2008 - present Leader Imaging Response Assessment Team of the American Association of Cancer Institutes Lombardi Cancer CenterGeorgetown University Hospital Department ofRadiology

Internal Medicine Residency Program Washington Hospital Center Washington DC

Residents lectures The role ofmvlear medicine in the evaluation of infectiousinflammatory processes (May 2006) The role ofnuclear medicine in the evaluation of infectiousinflammatory processes (May 2006) Nuclear medicine evaluation of the hepatobiliary tract (November 2006)

Daily rounds in nuclear medicine reading room for residents on elective rotation in nUcielr medicine

Rounds in thyroid clinic for patients treated with radioiodine for residents on electiv-e rotation in nuclear medicine

Jun 1S 10 0953a Radiation Safet~ 202 444 00S9 p

Cardiology Fellowship Program Georgetown UniversitylWashington Hospital Center 2004-2007 Washington DC

Daily rounds in nuclear medicine reading room (September 2004-July 2007)

Endocrinology Fellowship Program Georgetown UniversityWashington Hospital Center Washington DC

Weekly thyroid cancer conferences (September 2004-July 2007) Rounds in thyroid linic for patients treated with radioiodine for thyroid cancer or hyperthyroidism (September 2004-July 2007)

Radiology Residency Program Georgetown University Hospital Washington DC

Residents lectures - Radiopharmaceuticals commonly used in nuclear

medicine (August 2007) - VentilationlP~rfusion scan for pulmonary embolism

(September 2007) - Imaging of Infection in Nuclear Medicine (October 2007) -- Evaluation ofGI bl(led in Nuclear Medicine (November

2007) - Nuclear medicine imaging ofbenign thyroid diseases

(January 2008) - Imaging of thyroid nodules and thyroid cancer (January

2008) - Radionuclide ventriCUlography (April 2008) -- PETCT basics (June 2008) -- PETCT imaging of head and neck cancer (July 2008)

Daily rounds in nuclear medicine reading room (August 2007shypresent)

Ward rounds for patients with thyroid cancer treated with radioiodine (August 2007-present)

Georgetown University Medical School Washington DC

p8 Jun 18 10 0953a Radiation Sa~et~ 202 444 0089

- Basics ofNuclear Medicine Clinical Skill Prim~r Course 2008 (April 2008)

Monthly students lecture$ on the basics ofNuclear Medicine for selective rotations in Radiology (July 2008-present)

Scholarsbips

Italian Ministry for Scientific Research Fellowship Award 1991-1994

Grants Charles and Mary Latham Fund Comparison ofI-124 and 1-131 Radiopharmacokinetics Principal Investigator January 2007 ($10000)

PubUcations

Peer Reviewed

1 Sunderland T Esposito G Molchan SE Coppola R Jones OW Gorey J Little JT Cantillon M Bahro M Weinberger DR Differential Cholinergic Regulation in Alzheimers Patients Compared to Normal Controls Following Chronic Blockade with Scopolamine A SPECT Study Psychopharmachology 121231-241 1995

2 Mattay VS Berman KF Ostrem JL Esposito G Van Hom JD Bigelow LB Weinberger DR Dextroamphetamine Enhances Neural Network-Specific Physiological Signals A Positron - Emission Tomography rCBF Study J Neurosci 164816-4822 1996

3 Mattay VS Frank IA Duyn lH Kotrla KJ Santha AKS Esposito G Sexton RH Barker P Sunderland T Moonen CTW Weinberger DR 3D BUR8T FMRl Initial Clinical Applirations Acad Radiol 38379-8383 1996

4 RamseyNF KirkbyBS Van Gelderen P Berman KF Moonen CTW Duyn JH Frank lA Mattay V8 Van Hom JO Esposito G Moonen CTW Weinberger DR Functional mapping of human sensorimotor cortex with 3D-BOLD fMRI

correlates highly with H2150 PET rCBF J Cereb Blood Flow Metab 16755-764 1996

5 Esposito G Van Hom JO Ostrem JL Weinberger DR Berman KF Gender Differences in Cerebral Blood Flow as a Function of Cognitive State with PET J Nucl Med 37559-564 1996

6 Berman KF Schmidt PJ Rubinow D~ Danaceau MA Van Hom JD Esposito G Ostrem IL Weinberger DR Modulation ofCognitive-Specific Cortical Activity

Jun 16 10 OS53a Radiation SaTet~ 202 444 006S pS

by Gonadal Steroids a PET Study in Wom~~n Proc Natl Acad Sci 948836Al 1997

7 Goldberg TE Berman KF Fleming K Ostrem IL Van Hom JD Esposito G Mattay VS Gold JM Weinberger DR Uncoupling cognitive workload and prefrontal cortical physiology a PET rCBF study Neuroimage 7296-303 1998

8 Van Hom JD Ellmore TM Esposito G Bennan KF Mapping Voxel-Based Statistical Power on Parametric Images Neuroimage 797-107 1998

9 Van Hom JD Gold J Esposito G Ostrem JL Mattay VS Weinberger DR Berman KF Changing Patterns of Brain Activation During Maze Learning Brain Res 793 29-38 1998

10 Esposito G Kirkby BS VanHorn JD Weinberger DR Berman KF Contextshydependent Neural System-specific Neurophysiological Concomitants of Aging Mapping PET Correlates DUring Cognitive Activation Brain 122963-979 1999

11 Ye F Berman KF Ellmore T Esposit1 G Van Hom 10 Yang Y Duhn J Smith AM Frank JA Weinberger DR McLaughlin AC H2150 PET Validation of Steady-State Arterial Spin Tagging Cerebral Blood Flow Measurements in Humans Magn Reson Med 44450-456 2000

12 Bertolino A Esposito G Callicott JB Mattay VS Van Hom JD Frank JA Berman KF Weinberger DR Specific relationship between prefrontal neuronal N-acetyl-aspartate and activation of the working memory cortical network in schizophrenia Am J Psychiatry 15726-332000

13 Gourovitch ML Kirkby BS Goldberg TE Weinberger DR Gold 1M Esposito G Van Hom JD Bennan KF A comparison ofrCBF patterns during phonological and semantic fluency Neuropsychology 14353-360 2000

14 Meyer-Lindenberg A Miletich RS Kohn PO Esposito G CarsonRE Quarantelli M Weinberger DR Berman KF Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia Nature Neurosci 5267-71 2002

15 Chin BB Esposito G Kraitchman DL Myocardial contractile reserve and perfusion defect severity with rest and stress dobutamine (99m)Tc-sestamibi SPECT in canine stunning and subendocardial infarction J Nucl Med 43540-550 2002

16 Beason-Held LL Golski S Kraut MA Esposito G Resnick SM Brain activation during encoding and recognition of verbal and figural infonnation in older adults Neurobiol Aging 26(2)237-502005

17 Garcia CA Van Nostrand 0 Atkins F Acio E Butler C Esposito 0 Kulkarni K Majd M Reduction ofBrown Fat 2-Deoxy-2-[F-18]f1uoro-D-glucose Uptake by Controlling Environmental TemperatJre Prior to Positron Emission Tomography Scan Mol Imaging BioI 8 24-29 2006

Jun 16 10 0954a Radiation Safet~ 202 444 0069 p 10

18 Garcia CA Esposito G Acio ER Van Nostrand D (18)F-FDG PET hemispheric cerebral hypometabolic activity patient motion artifact J Nucl Med Technol 34(2)86-72006

19 Esposito 0 Giovacchini G Der M Liow JS Ma K Herscovitch P Channing M Hallett M Bhattacharjee AK Eckelman WC Carson RE Rapoport SI Imaging signal transduction via Arachidonic Acid in the human brain during visual stimulation by means of Positron Emission Tomography Neuroimage 34(4)1342-512007

20 Walitt B Roebuck-Spencer T Esposito G Atkins F Bleiberg J Foster 0 Weinstein A The effects of multidisciplinary therapy on positron emission tomography of the brain in fibromyalgia a pilot study Rheumatol Int 27(11)1019-24 Epub 2007 Jul20 2007

21 Esposito G Giovacchini G Liow JS Bhattacharjee AK Greenstein D Schapiro M Hallett M Herscovitch P Eckelman we Carson RE Rapoport SI Imaging Neuroinflammation in Alzheimer Dis~Jase with Radiolabeled Arachidonic Acid and PET J Nucl Med (in press)

Book Chapters

1 Van Hom JD Ellmore TM Holt JL Esposito G Berman KF (1998) Multifiltering signal detection and statistical power in brain activation studies In Herschovitch P Carson RE (eds) Quantification ofBrain Function with PET Academic Press 237-240

2 Esposito G Radionuclide Imaging of Medullary Carcinoma Utility of Radiolabeled Somatostatin Analogs ~ld Other Radiotracers In Thyroid Cancer A Comprehensive Guide to Clinical Managl~ment 2e Edited by L Wartofsky MD and D Van Nostrand Humana Press Inc Totowa NJ 2006

Meeting Abstracts

Society ofNuclear Medicine

1 Esposito G Van Horn JD Weinberger DR Berman KF (1993) Gender Differences in Cerebral Blood Flow with PET Is there an Effect ofCognitive State J Nucl Med 34 67P

2 Berman KF Schmidt PJ Ostrem JL Danaceau MA Esposito G Van Hom lD Mattay VS Rubinow DR Weinberger DR (1994) Effects of gonadal steroids on cerebral blood flow patients with menstrual-related mood disorder and controls studied with PET during medical oophorectomy and hormone replacement J Nucl Med 3553P

J~n 16 10 0954a Radiation Safet~ 202 444 0069 p 11

3 Esposito G Kirkby BS Van Hom JD Ostrem JL Weinberger DR Berman KF (1995) Task-specific Neurophysioloeuroical Changes in Normal Aging PET rCBF Measurements During Cognition Journal ofNuclear Medicine vol 36 p16

4 Esposito G Saunders Re Jones DW Lee KS Gorey JG Coppola R Bennan KF Iadarola MJ DeCosta BR Rice KC Weinberger DR (1995) 1-123-Ioxy A Potential SPECT Imaging Agent for Opiate Receptors Journal ofNuclear Medicine voL 36 p 166P

5 Esposito G Kirkby BS Van Hom JD Ostr-em JL Weinberger DR Berman KF (1996) Different Pathophysiological Mechanisms ofhnpaired Wisconsin Card Sorting in Elderly Normal Subjects and Schizophrenics Studied with PET Journal ofNuclear Medicine 37(5) p 79P

6 Berman KF Austin-Lane JL Esposito G Van Hom JD Weinberger DR (1996) Neurophysiological and Neuropsychological Dissection of the IIWorking and the Memory in a PET Study ofWorking Memory Journal ofNuc1ear Medicine 37 5 p 284p

7 Esposito G Chin BB Kraitchrnan DL (2000) Tc-99m gated sestamibi SPECT evaluation of myocardial wall thickening correlates with tagged MRI measurements of radial strain J Nuel Med 41 755P

8 Chin BB Esposito G Kraitchrnan DL (2000) Characterization ofcanine myocardial contractile reserve with gated Tc-99m sestamibi SPECT in normal stunned and subendocardial infarction J Nuel Med 41 497P

9 Chin BB Esposito G Kraitchman DL (2000) Detailed characterization of gated and ungated Tc-99m sestamibi defect severity in normal stunned and subendocardial infarcted canine myo~ardiwn at rest and during low dose dobutamine infusion J Nuel Med 41 496P

10 Esposito G Bhattachrujee AK Schapro M Herscovitch P Eckelman WC Carson RE Rapoport SI (2005) PET shows ~ncreased brain incorporation of [I shyI IC]Arachidonic Acid a marker of neuroinflammation in patients with Alzheimers Disease J Nuel Med

11 Van Nostrand D Aiken M Atkins F Esposito G Moreau S Garcia C Acio E Burman K Wartofsky L (2007) The utility of radioiodine whole body scans prior to I~131 ablation in patients with well-differentiated thyroid cancer J Nuel Med 48 lSP

12 Aiken M Garcia C Acio E Suhag V Esposito G Moreau S Priebat D Van Nostrand D (2007) Doxorubicin-induced cardiac toxicity and gated cardiac blood pool imaging J Nuel Med 48 208P

13 Esposito G Sarikaya I (2008) Integr~ted nuclear medicine imaging ofmedullary thyroid cancer J Nuel Med 49 171P

J~n 18 10 0954a Radiation Safet~ 202 444 0089 p 12

BrainPET

14 Esposito G~ Giovacchini G Der MG Vuong BK Channing MA Lerner A Hallett M Battacharjee A Herscovitch P Eckelman WC Rapoport SI Carson RE llC]Arachidonic acid PET activation experiments in human subjects A feasibility study using visual stimulation J Cereb Blood Flow Metab Vol 23 (Suppl 1)711 (2003)

Radiological Society oNorth America

15 Esposito G Chin BB Kraitchman DL Correlation ofmyocardial strain measurements by 3D-tagged MR imging with Tc-99m gated sestamibi SPEeT thickening in normal stunned and infarcted myocardium Radiology 1999 213 p207

SOCiety for Neuroscience

16 Berman KF Ostrem IL Van Hom JD Mattay VS Esposito G Weinberger DR (1993) A Comparison Between Normal Monozygotic and Dizygotic Twins Studied During Cognition with Positron Emission Tomography Society for Neuroscience Abstracts Vol 19 Part I p 792

17 Gourovitch ML Kirkby BS Gold JM Esposito G Van Hom JD Ostrem JL Golberg TE Weinberger DR Berman KF(l994) A comparison ofletter and category fluency Cerebral Activation with Positron Emission Tomography Society for Neuroscience Abstracts Volume 20 Part 1 p 6

18 Weinberger DR Ramsey NF Kirkby BS Van Gelderen P Berman KF Mattay VS Frank JA Van Hom JD Esposito G Moonen CTW (1995) ThreeshyDimensional BOLD fMRI and 0-15 water PET neuroactivation maps are highly correlated Society for Neuroscience bstracts Vol 21 Part 1 p 273

19 Esposito G Kirkby BS Van Horn JD Weinberger DR Berman KF (1995) Different pathophysiological mechanisms of altered Wisconsin Card Sort performance in schizophrenics and elderly normal subjects Society for Neuroscience Abstracts Vol 21 Part 1 p 747

20 Kirkby BS Van Hom JD Esposito G Golberg TE Weinberger DR Berman KF (1995) Long term changes in rCBF during cognition following severe closed head injury a PET study Society for Neuroscience Abstracts Vol 21 Part 3 p 1924

21 Van Hom JD Esposito G Kirkby BS Weinberger DR Berman KF (1995) Appraisal ofunivariate and multivariate analysis techniques for PET brain image quantification Society for Neuroscience Abstracts Vol 21 Part 2 p 1208

22 Esposito G Kirkby BS Van Hom JD Weinberger DR Berman KF (1996) PET Evaluation of cognitively related neur9physiological sequelae accompanying

Jun 16 10 0955a Radiation SaTet~ 202 444 0069 p 13

incidental findings of microvascular ischemic disease in the elderly preliminary results Society for Neuroscience Abstracts Vol 22 Part 1 p 676

23 Weinberger DR Santha A Mattay VS Frank J Kirkby BS Van Horn JD Esposito G Bennan KF (1996) Within subject neuroactivation mapping with whole brain isotropic BPI and 3-D PET a direct comparison Society for Neuroscience Abstracts Vol 22 Part 1 p 7

24 Golberg TE Fleming K Berman KF Van Horn 10 Esposito G Ostrem JL Gold JM Weinberger DR (1996) Neurophysiology ofdual task perfonnance a PET 015 study Society for Neuroscience Abstracts Vol 22 Part 2 p 967

25 Van Horn JD Austin-Lane JL Kirkby BS Esposito G Weinberger DR Berman KF (1996) Characterizing rCBF response in a PET study of graded working memory load Society for Neuroscience Abstracts Vol 22 Part 2 p 1113

26 El1more TM Van Horn JD Esposito G Kirkby BS Austin-Lane JL Weinberger DR Berman KF (1996) Signal averaging in cognitive and motor PET paradigms Society for Neuroscience Abstracts Vol 22 Part 3 p 1858

27 BeITI1an KF Sclunidt Pl Rubinow DR Esposito G Van Hom lD Austin-LaneJL Danaceau MA Weinberger DR (1996) Modulation of cognitively related cortical activity by gonadal steroid hormones directly demonstrated with PET Society for Neuroscience Abstracts Vol 22 Part 3 p 1861

28 Berman KF Holt J Callicott J Esposito G Van Horn JD Egan M Weinberger DR (1997) Relations among rCBF Clinical and Cognitive Changes over Time in Medication-Free Patients with Schizophrenia Individual PET Activation Maps Society for Neuroscience Abstracts 101 23 Part 2 p 1406

American Psychiatric Association

29 Van Horn JD Bennan KF Esposito G Ostrem JL Weinberger DR (1993) Is There Frontal Lobe Lateralization A PET Study Abstracts of the 146th Meeting of the American Psychiatric Association (New Reseach) p 68

30 Ostrem JL Kirkby BS Van Hom JD Esposito G Gold J Weinberger DR Berman KF(1994) Effects ofcohort size on PET activation studies Abstracts of the Annual Meeting of the American Psychiatric Association (Symposium 118) p 153

American Academy ofNeurology

31 BeITI1an KF Ostrem JL Mattay VS Bsposito G Van Hom JD Torrey EF Weinberger DR (1993) The role of the dorsolateral prefrontal cortex and the hippocampus in working memory PET studies of normal and abnormal states Abstracts of the 46th Annual Meeting of the American Academy of Neurology

Jun 16 10 0955a Radiation Safet~ 202 444 0069 p 14

Biological Psychiatry

32 Ostrem JL Bennan KF Mattay VS Van Hom JD Esposito G Weinberger DR (1994) The Neural Basis ofAbstract Reasoning An Inverstigation ofTwo Problem Solving Tasks with PET Biological Psychiatry 35(9)686

33 Bennan KF Ostrem JL Mattay VS Esposito G Van Hom JD Abi-Dargham A Torrey EF Weinberger DR (1994) The role of the dorsolateral prefrontal corteK and hippocampus in working memory and schizophrenia Biological Psychiatry 35(9)622

34 Van Hom lD Gold J Esposito G Ostrem JL Weinberger DR AND Belman KF (1994) The role ofthe frontal lobe during maze learning assessed using PET Biological Psychiatry 35(9)686

35 Esposito G Van Horn JD Ostrem JLMattay VS Weinberger DR Bennan KF The effect of sex age and pC02 on cerebral blood flow during cognitive stimulation Biological Psychiatry 35(9)648 1994

Society ofMagnetic Resonance

36 Ramsey NF Kirkby BS Van Gelderen P Belman KF Moonen CTW Mattay VS Frank lA Van Hom JD Esposito G Weinberger DR (1995) A direct comparison

of 3D BOLD tMRI and ISO-Water PET imaging ofprimary sensory motor cortex in humans III Meeting of the Society of Magnetic Resonance

Cerebral Blood Flow and Metabolism

37 Mattay VS Kotrla KJ Santha AKS Sexton RH Sunderland T Esposito G Duyn JR Moonen CTW Frank JA Weinberger DR (1995) 3D-BURST tMRI Initial clinical application in Alzheimer1s disease XVII International Symposium on Cerebral Blood Flow and Metabolism

38 Esposito G Kirkby BS Van Horn JD Ostrem JL Mattay VS Weinberger DR Belman KF (1995) Normal Aging is Assodated witb Task-Specific Neuropbysiological Changes PET rCBF Measurements During Cognitive Stimulation Journal ofCerebral Blood Flow and Metabolism 15 p S594

39 Berman KF Schmidt PJ Ostrem IL Danaceau MA Van Horn JD Esposito G Rubinow DR Weinberger DR (1995) The Effects of Gonadal Steroid Honnones on Cognitively-Related Regional Cerebral Blood Flow A Positron Emission Tomography Study Journal of Cerebral Blood Flow and Metabolism 15 p S133

Functional Mapping ofthe Human Brain

40 Berman KF Ostrem JL Esposito G Van Hom ID Mattay VS Kirkby BS Weinberger DR (1995) Heritability of Cognitively-Related Regional Cerebral

Jun 16 10 0956a Radiation Saret~ 202 444 0069 p 15

Blood Flow A PET Study Comparing Normal Monozygotic and Dizygotic Twins Neuroimage p 359

41 Esposito G Kirkby BS Van Hom JD Ostrc~m JL Weinberger DR Berman KF (1996) Impaired Wisconsin Card Sorting Test Performance in Nonnal Aging and in Schizophrenia PET Evidence ofDifferent Pathophysiological Mechanisms for a Common Cognitive Deficit Neurolmage 3 3 p S482

42 Bennan KF Schmidt PJ Rubinow DR Esposito G Van Hom JD Austin-Lane JL Weinberger DR (1996) The Effects cfGonadal Steroid Hormones on Cognitive Activation in Men and Women Studied with Positron Emission Tomography Neurolmage 3 3 p S475

43 Kirkby BS Van Hom JD Esposito G Golberg TE Weinberger DR Berman KF (1996) A PET Study of Long-Term rCBF Changes during Cognition after Closed Head Injury Neurolmage 3 3 p S492

44 Van Hom lD Esposito G Weinberger DR Berman KF (1996) Volume-Based Multivariate Discriminant and Canonical Correlation Analysis of Neurophysiological Measures of Brain Function Neurolmage 3 3 p S103

45 Holt JL Van Hom JD Esposito G Ellmore T Weinberger DR Berman KF (1997) Mapping Neurophysiological Predictors of Good and Poor Performance on the Wisconsin Card Sorting Task Neuroimage 5 4 p S112

46 Bertolino A Esposito G Callicott JH Mat-tay VS Van Horn JD Frank JA Berman KF Weinberger FK (1997) IH-Magnetic Resonance Spectroscopic Imaging Correlates with rCBF Activation During Working Memory in Patients with Schizophrenia Neuroimage 54 p S281

47 Esposito G Van Hom ID Kirkby BS Weinberger DR Berman KF (1997) Functional Interactions between Dorsolateral Prefrontal Cortex and Other Brain Regions during Working Memory in Normal Subjects and Patients with Psychosis Neuroimage 54 p S284

48 Berman KF Holt J Callicott J Esposito G Van Hom JD Egan M Weinberger DR (1997) Neurophysiological Predictors of Clinical and Cognitive Changes over Time in Medication-Free Patients with Schizophrenia Individual Activation Maps Neuroimage 5 4 p S290

49 Van Hom ID EUmore T Esposito G Holt J Weinberger DR Berman KF (1997) Voxel-based Statistical Power in Functional Neuroimaging Studies Neuroimage 54pS464

50 Ye FQ Berman KF EUmore T Esposito G Van Hom JD Yang Y Duyn J Mattay VS Smith AM Frank JA Weinberger DR McLaughlin AC (1997) H2 1S0 PET Validation ofArterial Spin Tagg~ng CBF Measurements Neuroimage 54 p S533

r~ This is to acknowledge the receipt of YOuiletter~pPlication dated

elO dO 0 and to~you that the initial processing which includes an administrative review has been performed

[XJ TheJtmkl~~tJtve o9si~n~~pound~Ji2iqa~ IsSigned to a technical reviewer Please note that the technical review may identify additional omissions or require additional information

D Please provide to this office within 30 days of your receipt of this card

A copy of your action has been forwarded to our License Fee amp Accounts Receivable Branch who will contact you separately if there is a fee issue involved

Your action has been assigned Mail Control Number 5]31 (~ When calling to inquire about this action please refer to this control number You may call us on (610) 337-5398 or 337-5260

NRC FORM 532 (RI) Sincerely (6-96) licensing Assistance Team Leader

p6 202 444 0069~un 16 10 0953a Radiation Safet~

University Service

Teaching Activities

Union Memorial Hospital Baltimore MD (April 2008)

Neuroradiology Grand Rounds - PET Imaging in Head and Neck Cancers

Deparment ofRadiology Georgetown University Hospital Center Washington DC (May 2008)

August 2007 - present Radiation Safety Committee Georgetown Universit~ Hospital

August 2007 - present Residency Education Committee Department ofRadiology Georgetown University Hospital

July 2008 - present Leader Imaging Response Assessment Team of the American Association of Cancer Institutes Lombardi Cancer CenterGeorgetown University Hospital Department ofRadiology

Internal Medicine Residency Program Washington Hospital Center Washington DC

Residents lectures The role ofmvlear medicine in the evaluation of infectiousinflammatory processes (May 2006) The role ofnuclear medicine in the evaluation of infectiousinflammatory processes (May 2006) Nuclear medicine evaluation of the hepatobiliary tract (November 2006)

Daily rounds in nuclear medicine reading room for residents on elective rotation in nUcielr medicine

Rounds in thyroid clinic for patients treated with radioiodine for residents on electiv-e rotation in nuclear medicine

Jun 1S 10 0953a Radiation Safet~ 202 444 00S9 p

Cardiology Fellowship Program Georgetown UniversitylWashington Hospital Center 2004-2007 Washington DC

Daily rounds in nuclear medicine reading room (September 2004-July 2007)

Endocrinology Fellowship Program Georgetown UniversityWashington Hospital Center Washington DC

Weekly thyroid cancer conferences (September 2004-July 2007) Rounds in thyroid linic for patients treated with radioiodine for thyroid cancer or hyperthyroidism (September 2004-July 2007)

Radiology Residency Program Georgetown University Hospital Washington DC

Residents lectures - Radiopharmaceuticals commonly used in nuclear

medicine (August 2007) - VentilationlP~rfusion scan for pulmonary embolism

(September 2007) - Imaging of Infection in Nuclear Medicine (October 2007) -- Evaluation ofGI bl(led in Nuclear Medicine (November

2007) - Nuclear medicine imaging ofbenign thyroid diseases

(January 2008) - Imaging of thyroid nodules and thyroid cancer (January

2008) - Radionuclide ventriCUlography (April 2008) -- PETCT basics (June 2008) -- PETCT imaging of head and neck cancer (July 2008)

Daily rounds in nuclear medicine reading room (August 2007shypresent)

Ward rounds for patients with thyroid cancer treated with radioiodine (August 2007-present)

Georgetown University Medical School Washington DC

p8 Jun 18 10 0953a Radiation Sa~et~ 202 444 0089

- Basics ofNuclear Medicine Clinical Skill Prim~r Course 2008 (April 2008)

Monthly students lecture$ on the basics ofNuclear Medicine for selective rotations in Radiology (July 2008-present)

Scholarsbips

Italian Ministry for Scientific Research Fellowship Award 1991-1994

Grants Charles and Mary Latham Fund Comparison ofI-124 and 1-131 Radiopharmacokinetics Principal Investigator January 2007 ($10000)

PubUcations

Peer Reviewed

1 Sunderland T Esposito G Molchan SE Coppola R Jones OW Gorey J Little JT Cantillon M Bahro M Weinberger DR Differential Cholinergic Regulation in Alzheimers Patients Compared to Normal Controls Following Chronic Blockade with Scopolamine A SPECT Study Psychopharmachology 121231-241 1995

2 Mattay VS Berman KF Ostrem JL Esposito G Van Hom JD Bigelow LB Weinberger DR Dextroamphetamine Enhances Neural Network-Specific Physiological Signals A Positron - Emission Tomography rCBF Study J Neurosci 164816-4822 1996

3 Mattay VS Frank IA Duyn lH Kotrla KJ Santha AKS Esposito G Sexton RH Barker P Sunderland T Moonen CTW Weinberger DR 3D BUR8T FMRl Initial Clinical Applirations Acad Radiol 38379-8383 1996

4 RamseyNF KirkbyBS Van Gelderen P Berman KF Moonen CTW Duyn JH Frank lA Mattay V8 Van Hom JO Esposito G Moonen CTW Weinberger DR Functional mapping of human sensorimotor cortex with 3D-BOLD fMRI

correlates highly with H2150 PET rCBF J Cereb Blood Flow Metab 16755-764 1996

5 Esposito G Van Hom JO Ostrem JL Weinberger DR Berman KF Gender Differences in Cerebral Blood Flow as a Function of Cognitive State with PET J Nucl Med 37559-564 1996

6 Berman KF Schmidt PJ Rubinow D~ Danaceau MA Van Hom JD Esposito G Ostrem IL Weinberger DR Modulation ofCognitive-Specific Cortical Activity

Jun 16 10 OS53a Radiation SaTet~ 202 444 006S pS

by Gonadal Steroids a PET Study in Wom~~n Proc Natl Acad Sci 948836Al 1997

7 Goldberg TE Berman KF Fleming K Ostrem IL Van Hom JD Esposito G Mattay VS Gold JM Weinberger DR Uncoupling cognitive workload and prefrontal cortical physiology a PET rCBF study Neuroimage 7296-303 1998

8 Van Hom JD Ellmore TM Esposito G Bennan KF Mapping Voxel-Based Statistical Power on Parametric Images Neuroimage 797-107 1998

9 Van Hom JD Gold J Esposito G Ostrem JL Mattay VS Weinberger DR Berman KF Changing Patterns of Brain Activation During Maze Learning Brain Res 793 29-38 1998

10 Esposito G Kirkby BS VanHorn JD Weinberger DR Berman KF Contextshydependent Neural System-specific Neurophysiological Concomitants of Aging Mapping PET Correlates DUring Cognitive Activation Brain 122963-979 1999

11 Ye F Berman KF Ellmore T Esposit1 G Van Hom 10 Yang Y Duhn J Smith AM Frank JA Weinberger DR McLaughlin AC H2150 PET Validation of Steady-State Arterial Spin Tagging Cerebral Blood Flow Measurements in Humans Magn Reson Med 44450-456 2000

12 Bertolino A Esposito G Callicott JB Mattay VS Van Hom JD Frank JA Berman KF Weinberger DR Specific relationship between prefrontal neuronal N-acetyl-aspartate and activation of the working memory cortical network in schizophrenia Am J Psychiatry 15726-332000

13 Gourovitch ML Kirkby BS Goldberg TE Weinberger DR Gold 1M Esposito G Van Hom JD Bennan KF A comparison ofrCBF patterns during phonological and semantic fluency Neuropsychology 14353-360 2000

14 Meyer-Lindenberg A Miletich RS Kohn PO Esposito G CarsonRE Quarantelli M Weinberger DR Berman KF Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia Nature Neurosci 5267-71 2002

15 Chin BB Esposito G Kraitchman DL Myocardial contractile reserve and perfusion defect severity with rest and stress dobutamine (99m)Tc-sestamibi SPECT in canine stunning and subendocardial infarction J Nucl Med 43540-550 2002

16 Beason-Held LL Golski S Kraut MA Esposito G Resnick SM Brain activation during encoding and recognition of verbal and figural infonnation in older adults Neurobiol Aging 26(2)237-502005

17 Garcia CA Van Nostrand 0 Atkins F Acio E Butler C Esposito 0 Kulkarni K Majd M Reduction ofBrown Fat 2-Deoxy-2-[F-18]f1uoro-D-glucose Uptake by Controlling Environmental TemperatJre Prior to Positron Emission Tomography Scan Mol Imaging BioI 8 24-29 2006

Jun 16 10 0954a Radiation Safet~ 202 444 0069 p 10

18 Garcia CA Esposito G Acio ER Van Nostrand D (18)F-FDG PET hemispheric cerebral hypometabolic activity patient motion artifact J Nucl Med Technol 34(2)86-72006

19 Esposito 0 Giovacchini G Der M Liow JS Ma K Herscovitch P Channing M Hallett M Bhattacharjee AK Eckelman WC Carson RE Rapoport SI Imaging signal transduction via Arachidonic Acid in the human brain during visual stimulation by means of Positron Emission Tomography Neuroimage 34(4)1342-512007

20 Walitt B Roebuck-Spencer T Esposito G Atkins F Bleiberg J Foster 0 Weinstein A The effects of multidisciplinary therapy on positron emission tomography of the brain in fibromyalgia a pilot study Rheumatol Int 27(11)1019-24 Epub 2007 Jul20 2007

21 Esposito G Giovacchini G Liow JS Bhattacharjee AK Greenstein D Schapiro M Hallett M Herscovitch P Eckelman we Carson RE Rapoport SI Imaging Neuroinflammation in Alzheimer Dis~Jase with Radiolabeled Arachidonic Acid and PET J Nucl Med (in press)

Book Chapters

1 Van Hom JD Ellmore TM Holt JL Esposito G Berman KF (1998) Multifiltering signal detection and statistical power in brain activation studies In Herschovitch P Carson RE (eds) Quantification ofBrain Function with PET Academic Press 237-240

2 Esposito G Radionuclide Imaging of Medullary Carcinoma Utility of Radiolabeled Somatostatin Analogs ~ld Other Radiotracers In Thyroid Cancer A Comprehensive Guide to Clinical Managl~ment 2e Edited by L Wartofsky MD and D Van Nostrand Humana Press Inc Totowa NJ 2006

Meeting Abstracts

Society ofNuclear Medicine

1 Esposito G Van Horn JD Weinberger DR Berman KF (1993) Gender Differences in Cerebral Blood Flow with PET Is there an Effect ofCognitive State J Nucl Med 34 67P

2 Berman KF Schmidt PJ Ostrem JL Danaceau MA Esposito G Van Hom lD Mattay VS Rubinow DR Weinberger DR (1994) Effects of gonadal steroids on cerebral blood flow patients with menstrual-related mood disorder and controls studied with PET during medical oophorectomy and hormone replacement J Nucl Med 3553P

J~n 16 10 0954a Radiation Safet~ 202 444 0069 p 11

3 Esposito G Kirkby BS Van Hom JD Ostrem JL Weinberger DR Berman KF (1995) Task-specific Neurophysioloeuroical Changes in Normal Aging PET rCBF Measurements During Cognition Journal ofNuclear Medicine vol 36 p16

4 Esposito G Saunders Re Jones DW Lee KS Gorey JG Coppola R Bennan KF Iadarola MJ DeCosta BR Rice KC Weinberger DR (1995) 1-123-Ioxy A Potential SPECT Imaging Agent for Opiate Receptors Journal ofNuclear Medicine voL 36 p 166P

5 Esposito G Kirkby BS Van Hom JD Ostr-em JL Weinberger DR Berman KF (1996) Different Pathophysiological Mechanisms ofhnpaired Wisconsin Card Sorting in Elderly Normal Subjects and Schizophrenics Studied with PET Journal ofNuclear Medicine 37(5) p 79P

6 Berman KF Austin-Lane JL Esposito G Van Hom JD Weinberger DR (1996) Neurophysiological and Neuropsychological Dissection of the IIWorking and the Memory in a PET Study ofWorking Memory Journal ofNuc1ear Medicine 37 5 p 284p

7 Esposito G Chin BB Kraitchrnan DL (2000) Tc-99m gated sestamibi SPECT evaluation of myocardial wall thickening correlates with tagged MRI measurements of radial strain J Nuel Med 41 755P

8 Chin BB Esposito G Kraitchrnan DL (2000) Characterization ofcanine myocardial contractile reserve with gated Tc-99m sestamibi SPECT in normal stunned and subendocardial infarction J Nuel Med 41 497P

9 Chin BB Esposito G Kraitchman DL (2000) Detailed characterization of gated and ungated Tc-99m sestamibi defect severity in normal stunned and subendocardial infarcted canine myo~ardiwn at rest and during low dose dobutamine infusion J Nuel Med 41 496P

10 Esposito G Bhattachrujee AK Schapro M Herscovitch P Eckelman WC Carson RE Rapoport SI (2005) PET shows ~ncreased brain incorporation of [I shyI IC]Arachidonic Acid a marker of neuroinflammation in patients with Alzheimers Disease J Nuel Med

11 Van Nostrand D Aiken M Atkins F Esposito G Moreau S Garcia C Acio E Burman K Wartofsky L (2007) The utility of radioiodine whole body scans prior to I~131 ablation in patients with well-differentiated thyroid cancer J Nuel Med 48 lSP

12 Aiken M Garcia C Acio E Suhag V Esposito G Moreau S Priebat D Van Nostrand D (2007) Doxorubicin-induced cardiac toxicity and gated cardiac blood pool imaging J Nuel Med 48 208P

13 Esposito G Sarikaya I (2008) Integr~ted nuclear medicine imaging ofmedullary thyroid cancer J Nuel Med 49 171P

J~n 18 10 0954a Radiation Safet~ 202 444 0089 p 12

BrainPET

14 Esposito G~ Giovacchini G Der MG Vuong BK Channing MA Lerner A Hallett M Battacharjee A Herscovitch P Eckelman WC Rapoport SI Carson RE llC]Arachidonic acid PET activation experiments in human subjects A feasibility study using visual stimulation J Cereb Blood Flow Metab Vol 23 (Suppl 1)711 (2003)

Radiological Society oNorth America

15 Esposito G Chin BB Kraitchman DL Correlation ofmyocardial strain measurements by 3D-tagged MR imging with Tc-99m gated sestamibi SPEeT thickening in normal stunned and infarcted myocardium Radiology 1999 213 p207

SOCiety for Neuroscience

16 Berman KF Ostrem IL Van Hom JD Mattay VS Esposito G Weinberger DR (1993) A Comparison Between Normal Monozygotic and Dizygotic Twins Studied During Cognition with Positron Emission Tomography Society for Neuroscience Abstracts Vol 19 Part I p 792

17 Gourovitch ML Kirkby BS Gold JM Esposito G Van Hom JD Ostrem JL Golberg TE Weinberger DR Berman KF(l994) A comparison ofletter and category fluency Cerebral Activation with Positron Emission Tomography Society for Neuroscience Abstracts Volume 20 Part 1 p 6

18 Weinberger DR Ramsey NF Kirkby BS Van Gelderen P Berman KF Mattay VS Frank JA Van Hom JD Esposito G Moonen CTW (1995) ThreeshyDimensional BOLD fMRI and 0-15 water PET neuroactivation maps are highly correlated Society for Neuroscience bstracts Vol 21 Part 1 p 273

19 Esposito G Kirkby BS Van Horn JD Weinberger DR Berman KF (1995) Different pathophysiological mechanisms of altered Wisconsin Card Sort performance in schizophrenics and elderly normal subjects Society for Neuroscience Abstracts Vol 21 Part 1 p 747

20 Kirkby BS Van Hom JD Esposito G Golberg TE Weinberger DR Berman KF (1995) Long term changes in rCBF during cognition following severe closed head injury a PET study Society for Neuroscience Abstracts Vol 21 Part 3 p 1924

21 Van Hom JD Esposito G Kirkby BS Weinberger DR Berman KF (1995) Appraisal ofunivariate and multivariate analysis techniques for PET brain image quantification Society for Neuroscience Abstracts Vol 21 Part 2 p 1208

22 Esposito G Kirkby BS Van Hom JD Weinberger DR Berman KF (1996) PET Evaluation of cognitively related neur9physiological sequelae accompanying

Jun 16 10 0955a Radiation SaTet~ 202 444 0069 p 13

incidental findings of microvascular ischemic disease in the elderly preliminary results Society for Neuroscience Abstracts Vol 22 Part 1 p 676

23 Weinberger DR Santha A Mattay VS Frank J Kirkby BS Van Horn JD Esposito G Bennan KF (1996) Within subject neuroactivation mapping with whole brain isotropic BPI and 3-D PET a direct comparison Society for Neuroscience Abstracts Vol 22 Part 1 p 7

24 Golberg TE Fleming K Berman KF Van Horn 10 Esposito G Ostrem JL Gold JM Weinberger DR (1996) Neurophysiology ofdual task perfonnance a PET 015 study Society for Neuroscience Abstracts Vol 22 Part 2 p 967

25 Van Horn JD Austin-Lane JL Kirkby BS Esposito G Weinberger DR Berman KF (1996) Characterizing rCBF response in a PET study of graded working memory load Society for Neuroscience Abstracts Vol 22 Part 2 p 1113

26 El1more TM Van Horn JD Esposito G Kirkby BS Austin-Lane JL Weinberger DR Berman KF (1996) Signal averaging in cognitive and motor PET paradigms Society for Neuroscience Abstracts Vol 22 Part 3 p 1858

27 BeITI1an KF Sclunidt Pl Rubinow DR Esposito G Van Hom lD Austin-LaneJL Danaceau MA Weinberger DR (1996) Modulation of cognitively related cortical activity by gonadal steroid hormones directly demonstrated with PET Society for Neuroscience Abstracts Vol 22 Part 3 p 1861

28 Berman KF Holt J Callicott J Esposito G Van Horn JD Egan M Weinberger DR (1997) Relations among rCBF Clinical and Cognitive Changes over Time in Medication-Free Patients with Schizophrenia Individual PET Activation Maps Society for Neuroscience Abstracts 101 23 Part 2 p 1406

American Psychiatric Association

29 Van Horn JD Bennan KF Esposito G Ostrem JL Weinberger DR (1993) Is There Frontal Lobe Lateralization A PET Study Abstracts of the 146th Meeting of the American Psychiatric Association (New Reseach) p 68

30 Ostrem JL Kirkby BS Van Hom JD Esposito G Gold J Weinberger DR Berman KF(1994) Effects ofcohort size on PET activation studies Abstracts of the Annual Meeting of the American Psychiatric Association (Symposium 118) p 153

American Academy ofNeurology

31 BeITI1an KF Ostrem JL Mattay VS Bsposito G Van Hom JD Torrey EF Weinberger DR (1993) The role of the dorsolateral prefrontal cortex and the hippocampus in working memory PET studies of normal and abnormal states Abstracts of the 46th Annual Meeting of the American Academy of Neurology

Jun 16 10 0955a Radiation Safet~ 202 444 0069 p 14

Biological Psychiatry

32 Ostrem JL Bennan KF Mattay VS Van Hom JD Esposito G Weinberger DR (1994) The Neural Basis ofAbstract Reasoning An Inverstigation ofTwo Problem Solving Tasks with PET Biological Psychiatry 35(9)686

33 Bennan KF Ostrem JL Mattay VS Esposito G Van Hom JD Abi-Dargham A Torrey EF Weinberger DR (1994) The role of the dorsolateral prefrontal corteK and hippocampus in working memory and schizophrenia Biological Psychiatry 35(9)622

34 Van Hom lD Gold J Esposito G Ostrem JL Weinberger DR AND Belman KF (1994) The role ofthe frontal lobe during maze learning assessed using PET Biological Psychiatry 35(9)686

35 Esposito G Van Horn JD Ostrem JLMattay VS Weinberger DR Bennan KF The effect of sex age and pC02 on cerebral blood flow during cognitive stimulation Biological Psychiatry 35(9)648 1994

Society ofMagnetic Resonance

36 Ramsey NF Kirkby BS Van Gelderen P Belman KF Moonen CTW Mattay VS Frank lA Van Hom JD Esposito G Weinberger DR (1995) A direct comparison

of 3D BOLD tMRI and ISO-Water PET imaging ofprimary sensory motor cortex in humans III Meeting of the Society of Magnetic Resonance

Cerebral Blood Flow and Metabolism

37 Mattay VS Kotrla KJ Santha AKS Sexton RH Sunderland T Esposito G Duyn JR Moonen CTW Frank JA Weinberger DR (1995) 3D-BURST tMRI Initial clinical application in Alzheimer1s disease XVII International Symposium on Cerebral Blood Flow and Metabolism

38 Esposito G Kirkby BS Van Horn JD Ostrem JL Mattay VS Weinberger DR Belman KF (1995) Normal Aging is Assodated witb Task-Specific Neuropbysiological Changes PET rCBF Measurements During Cognitive Stimulation Journal ofCerebral Blood Flow and Metabolism 15 p S594

39 Berman KF Schmidt PJ Ostrem IL Danaceau MA Van Horn JD Esposito G Rubinow DR Weinberger DR (1995) The Effects of Gonadal Steroid Honnones on Cognitively-Related Regional Cerebral Blood Flow A Positron Emission Tomography Study Journal of Cerebral Blood Flow and Metabolism 15 p S133

Functional Mapping ofthe Human Brain

40 Berman KF Ostrem JL Esposito G Van Hom ID Mattay VS Kirkby BS Weinberger DR (1995) Heritability of Cognitively-Related Regional Cerebral

Jun 16 10 0956a Radiation Saret~ 202 444 0069 p 15

Blood Flow A PET Study Comparing Normal Monozygotic and Dizygotic Twins Neuroimage p 359

41 Esposito G Kirkby BS Van Hom JD Ostrc~m JL Weinberger DR Berman KF (1996) Impaired Wisconsin Card Sorting Test Performance in Nonnal Aging and in Schizophrenia PET Evidence ofDifferent Pathophysiological Mechanisms for a Common Cognitive Deficit Neurolmage 3 3 p S482

42 Bennan KF Schmidt PJ Rubinow DR Esposito G Van Hom JD Austin-Lane JL Weinberger DR (1996) The Effects cfGonadal Steroid Hormones on Cognitive Activation in Men and Women Studied with Positron Emission Tomography Neurolmage 3 3 p S475

43 Kirkby BS Van Hom JD Esposito G Golberg TE Weinberger DR Berman KF (1996) A PET Study of Long-Term rCBF Changes during Cognition after Closed Head Injury Neurolmage 3 3 p S492

44 Van Hom lD Esposito G Weinberger DR Berman KF (1996) Volume-Based Multivariate Discriminant and Canonical Correlation Analysis of Neurophysiological Measures of Brain Function Neurolmage 3 3 p S103

45 Holt JL Van Hom JD Esposito G Ellmore T Weinberger DR Berman KF (1997) Mapping Neurophysiological Predictors of Good and Poor Performance on the Wisconsin Card Sorting Task Neuroimage 5 4 p S112

46 Bertolino A Esposito G Callicott JH Mat-tay VS Van Horn JD Frank JA Berman KF Weinberger FK (1997) IH-Magnetic Resonance Spectroscopic Imaging Correlates with rCBF Activation During Working Memory in Patients with Schizophrenia Neuroimage 54 p S281

47 Esposito G Van Hom ID Kirkby BS Weinberger DR Berman KF (1997) Functional Interactions between Dorsolateral Prefrontal Cortex and Other Brain Regions during Working Memory in Normal Subjects and Patients with Psychosis Neuroimage 54 p S284

48 Berman KF Holt J Callicott J Esposito G Van Hom JD Egan M Weinberger DR (1997) Neurophysiological Predictors of Clinical and Cognitive Changes over Time in Medication-Free Patients with Schizophrenia Individual Activation Maps Neuroimage 5 4 p S290

49 Van Hom ID EUmore T Esposito G Holt J Weinberger DR Berman KF (1997) Voxel-based Statistical Power in Functional Neuroimaging Studies Neuroimage 54pS464

50 Ye FQ Berman KF EUmore T Esposito G Van Hom JD Yang Y Duyn J Mattay VS Smith AM Frank JA Weinberger DR McLaughlin AC (1997) H2 1S0 PET Validation ofArterial Spin Tagg~ng CBF Measurements Neuroimage 54 p S533

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NRC FORM 532 (RI) Sincerely (6-96) licensing Assistance Team Leader

Jun 1S 10 0953a Radiation Safet~ 202 444 00S9 p

Cardiology Fellowship Program Georgetown UniversitylWashington Hospital Center 2004-2007 Washington DC

Daily rounds in nuclear medicine reading room (September 2004-July 2007)

Endocrinology Fellowship Program Georgetown UniversityWashington Hospital Center Washington DC

Weekly thyroid cancer conferences (September 2004-July 2007) Rounds in thyroid linic for patients treated with radioiodine for thyroid cancer or hyperthyroidism (September 2004-July 2007)

Radiology Residency Program Georgetown University Hospital Washington DC

Residents lectures - Radiopharmaceuticals commonly used in nuclear

medicine (August 2007) - VentilationlP~rfusion scan for pulmonary embolism

(September 2007) - Imaging of Infection in Nuclear Medicine (October 2007) -- Evaluation ofGI bl(led in Nuclear Medicine (November

2007) - Nuclear medicine imaging ofbenign thyroid diseases

(January 2008) - Imaging of thyroid nodules and thyroid cancer (January

2008) - Radionuclide ventriCUlography (April 2008) -- PETCT basics (June 2008) -- PETCT imaging of head and neck cancer (July 2008)

Daily rounds in nuclear medicine reading room (August 2007shypresent)

Ward rounds for patients with thyroid cancer treated with radioiodine (August 2007-present)

Georgetown University Medical School Washington DC

p8 Jun 18 10 0953a Radiation Sa~et~ 202 444 0089

- Basics ofNuclear Medicine Clinical Skill Prim~r Course 2008 (April 2008)

Monthly students lecture$ on the basics ofNuclear Medicine for selective rotations in Radiology (July 2008-present)

Scholarsbips

Italian Ministry for Scientific Research Fellowship Award 1991-1994

Grants Charles and Mary Latham Fund Comparison ofI-124 and 1-131 Radiopharmacokinetics Principal Investigator January 2007 ($10000)

PubUcations

Peer Reviewed

1 Sunderland T Esposito G Molchan SE Coppola R Jones OW Gorey J Little JT Cantillon M Bahro M Weinberger DR Differential Cholinergic Regulation in Alzheimers Patients Compared to Normal Controls Following Chronic Blockade with Scopolamine A SPECT Study Psychopharmachology 121231-241 1995

2 Mattay VS Berman KF Ostrem JL Esposito G Van Hom JD Bigelow LB Weinberger DR Dextroamphetamine Enhances Neural Network-Specific Physiological Signals A Positron - Emission Tomography rCBF Study J Neurosci 164816-4822 1996

3 Mattay VS Frank IA Duyn lH Kotrla KJ Santha AKS Esposito G Sexton RH Barker P Sunderland T Moonen CTW Weinberger DR 3D BUR8T FMRl Initial Clinical Applirations Acad Radiol 38379-8383 1996

4 RamseyNF KirkbyBS Van Gelderen P Berman KF Moonen CTW Duyn JH Frank lA Mattay V8 Van Hom JO Esposito G Moonen CTW Weinberger DR Functional mapping of human sensorimotor cortex with 3D-BOLD fMRI

correlates highly with H2150 PET rCBF J Cereb Blood Flow Metab 16755-764 1996

5 Esposito G Van Hom JO Ostrem JL Weinberger DR Berman KF Gender Differences in Cerebral Blood Flow as a Function of Cognitive State with PET J Nucl Med 37559-564 1996

6 Berman KF Schmidt PJ Rubinow D~ Danaceau MA Van Hom JD Esposito G Ostrem IL Weinberger DR Modulation ofCognitive-Specific Cortical Activity

Jun 16 10 OS53a Radiation SaTet~ 202 444 006S pS

by Gonadal Steroids a PET Study in Wom~~n Proc Natl Acad Sci 948836Al 1997

7 Goldberg TE Berman KF Fleming K Ostrem IL Van Hom JD Esposito G Mattay VS Gold JM Weinberger DR Uncoupling cognitive workload and prefrontal cortical physiology a PET rCBF study Neuroimage 7296-303 1998

8 Van Hom JD Ellmore TM Esposito G Bennan KF Mapping Voxel-Based Statistical Power on Parametric Images Neuroimage 797-107 1998

9 Van Hom JD Gold J Esposito G Ostrem JL Mattay VS Weinberger DR Berman KF Changing Patterns of Brain Activation During Maze Learning Brain Res 793 29-38 1998

10 Esposito G Kirkby BS VanHorn JD Weinberger DR Berman KF Contextshydependent Neural System-specific Neurophysiological Concomitants of Aging Mapping PET Correlates DUring Cognitive Activation Brain 122963-979 1999

11 Ye F Berman KF Ellmore T Esposit1 G Van Hom 10 Yang Y Duhn J Smith AM Frank JA Weinberger DR McLaughlin AC H2150 PET Validation of Steady-State Arterial Spin Tagging Cerebral Blood Flow Measurements in Humans Magn Reson Med 44450-456 2000

12 Bertolino A Esposito G Callicott JB Mattay VS Van Hom JD Frank JA Berman KF Weinberger DR Specific relationship between prefrontal neuronal N-acetyl-aspartate and activation of the working memory cortical network in schizophrenia Am J Psychiatry 15726-332000

13 Gourovitch ML Kirkby BS Goldberg TE Weinberger DR Gold 1M Esposito G Van Hom JD Bennan KF A comparison ofrCBF patterns during phonological and semantic fluency Neuropsychology 14353-360 2000

14 Meyer-Lindenberg A Miletich RS Kohn PO Esposito G CarsonRE Quarantelli M Weinberger DR Berman KF Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia Nature Neurosci 5267-71 2002

15 Chin BB Esposito G Kraitchman DL Myocardial contractile reserve and perfusion defect severity with rest and stress dobutamine (99m)Tc-sestamibi SPECT in canine stunning and subendocardial infarction J Nucl Med 43540-550 2002

16 Beason-Held LL Golski S Kraut MA Esposito G Resnick SM Brain activation during encoding and recognition of verbal and figural infonnation in older adults Neurobiol Aging 26(2)237-502005

17 Garcia CA Van Nostrand 0 Atkins F Acio E Butler C Esposito 0 Kulkarni K Majd M Reduction ofBrown Fat 2-Deoxy-2-[F-18]f1uoro-D-glucose Uptake by Controlling Environmental TemperatJre Prior to Positron Emission Tomography Scan Mol Imaging BioI 8 24-29 2006

Jun 16 10 0954a Radiation Safet~ 202 444 0069 p 10

18 Garcia CA Esposito G Acio ER Van Nostrand D (18)F-FDG PET hemispheric cerebral hypometabolic activity patient motion artifact J Nucl Med Technol 34(2)86-72006

19 Esposito 0 Giovacchini G Der M Liow JS Ma K Herscovitch P Channing M Hallett M Bhattacharjee AK Eckelman WC Carson RE Rapoport SI Imaging signal transduction via Arachidonic Acid in the human brain during visual stimulation by means of Positron Emission Tomography Neuroimage 34(4)1342-512007

20 Walitt B Roebuck-Spencer T Esposito G Atkins F Bleiberg J Foster 0 Weinstein A The effects of multidisciplinary therapy on positron emission tomography of the brain in fibromyalgia a pilot study Rheumatol Int 27(11)1019-24 Epub 2007 Jul20 2007

21 Esposito G Giovacchini G Liow JS Bhattacharjee AK Greenstein D Schapiro M Hallett M Herscovitch P Eckelman we Carson RE Rapoport SI Imaging Neuroinflammation in Alzheimer Dis~Jase with Radiolabeled Arachidonic Acid and PET J Nucl Med (in press)

Book Chapters

1 Van Hom JD Ellmore TM Holt JL Esposito G Berman KF (1998) Multifiltering signal detection and statistical power in brain activation studies In Herschovitch P Carson RE (eds) Quantification ofBrain Function with PET Academic Press 237-240

2 Esposito G Radionuclide Imaging of Medullary Carcinoma Utility of Radiolabeled Somatostatin Analogs ~ld Other Radiotracers In Thyroid Cancer A Comprehensive Guide to Clinical Managl~ment 2e Edited by L Wartofsky MD and D Van Nostrand Humana Press Inc Totowa NJ 2006

Meeting Abstracts

Society ofNuclear Medicine

1 Esposito G Van Horn JD Weinberger DR Berman KF (1993) Gender Differences in Cerebral Blood Flow with PET Is there an Effect ofCognitive State J Nucl Med 34 67P

2 Berman KF Schmidt PJ Ostrem JL Danaceau MA Esposito G Van Hom lD Mattay VS Rubinow DR Weinberger DR (1994) Effects of gonadal steroids on cerebral blood flow patients with menstrual-related mood disorder and controls studied with PET during medical oophorectomy and hormone replacement J Nucl Med 3553P

J~n 16 10 0954a Radiation Safet~ 202 444 0069 p 11

3 Esposito G Kirkby BS Van Hom JD Ostrem JL Weinberger DR Berman KF (1995) Task-specific Neurophysioloeuroical Changes in Normal Aging PET rCBF Measurements During Cognition Journal ofNuclear Medicine vol 36 p16

4 Esposito G Saunders Re Jones DW Lee KS Gorey JG Coppola R Bennan KF Iadarola MJ DeCosta BR Rice KC Weinberger DR (1995) 1-123-Ioxy A Potential SPECT Imaging Agent for Opiate Receptors Journal ofNuclear Medicine voL 36 p 166P

5 Esposito G Kirkby BS Van Hom JD Ostr-em JL Weinberger DR Berman KF (1996) Different Pathophysiological Mechanisms ofhnpaired Wisconsin Card Sorting in Elderly Normal Subjects and Schizophrenics Studied with PET Journal ofNuclear Medicine 37(5) p 79P

6 Berman KF Austin-Lane JL Esposito G Van Hom JD Weinberger DR (1996) Neurophysiological and Neuropsychological Dissection of the IIWorking and the Memory in a PET Study ofWorking Memory Journal ofNuc1ear Medicine 37 5 p 284p

7 Esposito G Chin BB Kraitchrnan DL (2000) Tc-99m gated sestamibi SPECT evaluation of myocardial wall thickening correlates with tagged MRI measurements of radial strain J Nuel Med 41 755P

8 Chin BB Esposito G Kraitchrnan DL (2000) Characterization ofcanine myocardial contractile reserve with gated Tc-99m sestamibi SPECT in normal stunned and subendocardial infarction J Nuel Med 41 497P

9 Chin BB Esposito G Kraitchman DL (2000) Detailed characterization of gated and ungated Tc-99m sestamibi defect severity in normal stunned and subendocardial infarcted canine myo~ardiwn at rest and during low dose dobutamine infusion J Nuel Med 41 496P

10 Esposito G Bhattachrujee AK Schapro M Herscovitch P Eckelman WC Carson RE Rapoport SI (2005) PET shows ~ncreased brain incorporation of [I shyI IC]Arachidonic Acid a marker of neuroinflammation in patients with Alzheimers Disease J Nuel Med

11 Van Nostrand D Aiken M Atkins F Esposito G Moreau S Garcia C Acio E Burman K Wartofsky L (2007) The utility of radioiodine whole body scans prior to I~131 ablation in patients with well-differentiated thyroid cancer J Nuel Med 48 lSP

12 Aiken M Garcia C Acio E Suhag V Esposito G Moreau S Priebat D Van Nostrand D (2007) Doxorubicin-induced cardiac toxicity and gated cardiac blood pool imaging J Nuel Med 48 208P

13 Esposito G Sarikaya I (2008) Integr~ted nuclear medicine imaging ofmedullary thyroid cancer J Nuel Med 49 171P

J~n 18 10 0954a Radiation Safet~ 202 444 0089 p 12

BrainPET

14 Esposito G~ Giovacchini G Der MG Vuong BK Channing MA Lerner A Hallett M Battacharjee A Herscovitch P Eckelman WC Rapoport SI Carson RE llC]Arachidonic acid PET activation experiments in human subjects A feasibility study using visual stimulation J Cereb Blood Flow Metab Vol 23 (Suppl 1)711 (2003)

Radiological Society oNorth America

15 Esposito G Chin BB Kraitchman DL Correlation ofmyocardial strain measurements by 3D-tagged MR imging with Tc-99m gated sestamibi SPEeT thickening in normal stunned and infarcted myocardium Radiology 1999 213 p207

SOCiety for Neuroscience

16 Berman KF Ostrem IL Van Hom JD Mattay VS Esposito G Weinberger DR (1993) A Comparison Between Normal Monozygotic and Dizygotic Twins Studied During Cognition with Positron Emission Tomography Society for Neuroscience Abstracts Vol 19 Part I p 792

17 Gourovitch ML Kirkby BS Gold JM Esposito G Van Hom JD Ostrem JL Golberg TE Weinberger DR Berman KF(l994) A comparison ofletter and category fluency Cerebral Activation with Positron Emission Tomography Society for Neuroscience Abstracts Volume 20 Part 1 p 6

18 Weinberger DR Ramsey NF Kirkby BS Van Gelderen P Berman KF Mattay VS Frank JA Van Hom JD Esposito G Moonen CTW (1995) ThreeshyDimensional BOLD fMRI and 0-15 water PET neuroactivation maps are highly correlated Society for Neuroscience bstracts Vol 21 Part 1 p 273

19 Esposito G Kirkby BS Van Horn JD Weinberger DR Berman KF (1995) Different pathophysiological mechanisms of altered Wisconsin Card Sort performance in schizophrenics and elderly normal subjects Society for Neuroscience Abstracts Vol 21 Part 1 p 747

20 Kirkby BS Van Hom JD Esposito G Golberg TE Weinberger DR Berman KF (1995) Long term changes in rCBF during cognition following severe closed head injury a PET study Society for Neuroscience Abstracts Vol 21 Part 3 p 1924

21 Van Hom JD Esposito G Kirkby BS Weinberger DR Berman KF (1995) Appraisal ofunivariate and multivariate analysis techniques for PET brain image quantification Society for Neuroscience Abstracts Vol 21 Part 2 p 1208

22 Esposito G Kirkby BS Van Hom JD Weinberger DR Berman KF (1996) PET Evaluation of cognitively related neur9physiological sequelae accompanying

Jun 16 10 0955a Radiation SaTet~ 202 444 0069 p 13

incidental findings of microvascular ischemic disease in the elderly preliminary results Society for Neuroscience Abstracts Vol 22 Part 1 p 676

23 Weinberger DR Santha A Mattay VS Frank J Kirkby BS Van Horn JD Esposito G Bennan KF (1996) Within subject neuroactivation mapping with whole brain isotropic BPI and 3-D PET a direct comparison Society for Neuroscience Abstracts Vol 22 Part 1 p 7

24 Golberg TE Fleming K Berman KF Van Horn 10 Esposito G Ostrem JL Gold JM Weinberger DR (1996) Neurophysiology ofdual task perfonnance a PET 015 study Society for Neuroscience Abstracts Vol 22 Part 2 p 967

25 Van Horn JD Austin-Lane JL Kirkby BS Esposito G Weinberger DR Berman KF (1996) Characterizing rCBF response in a PET study of graded working memory load Society for Neuroscience Abstracts Vol 22 Part 2 p 1113

26 El1more TM Van Horn JD Esposito G Kirkby BS Austin-Lane JL Weinberger DR Berman KF (1996) Signal averaging in cognitive and motor PET paradigms Society for Neuroscience Abstracts Vol 22 Part 3 p 1858

27 BeITI1an KF Sclunidt Pl Rubinow DR Esposito G Van Hom lD Austin-LaneJL Danaceau MA Weinberger DR (1996) Modulation of cognitively related cortical activity by gonadal steroid hormones directly demonstrated with PET Society for Neuroscience Abstracts Vol 22 Part 3 p 1861

28 Berman KF Holt J Callicott J Esposito G Van Horn JD Egan M Weinberger DR (1997) Relations among rCBF Clinical and Cognitive Changes over Time in Medication-Free Patients with Schizophrenia Individual PET Activation Maps Society for Neuroscience Abstracts 101 23 Part 2 p 1406

American Psychiatric Association

29 Van Horn JD Bennan KF Esposito G Ostrem JL Weinberger DR (1993) Is There Frontal Lobe Lateralization A PET Study Abstracts of the 146th Meeting of the American Psychiatric Association (New Reseach) p 68

30 Ostrem JL Kirkby BS Van Hom JD Esposito G Gold J Weinberger DR Berman KF(1994) Effects ofcohort size on PET activation studies Abstracts of the Annual Meeting of the American Psychiatric Association (Symposium 118) p 153

American Academy ofNeurology

31 BeITI1an KF Ostrem JL Mattay VS Bsposito G Van Hom JD Torrey EF Weinberger DR (1993) The role of the dorsolateral prefrontal cortex and the hippocampus in working memory PET studies of normal and abnormal states Abstracts of the 46th Annual Meeting of the American Academy of Neurology

Jun 16 10 0955a Radiation Safet~ 202 444 0069 p 14

Biological Psychiatry

32 Ostrem JL Bennan KF Mattay VS Van Hom JD Esposito G Weinberger DR (1994) The Neural Basis ofAbstract Reasoning An Inverstigation ofTwo Problem Solving Tasks with PET Biological Psychiatry 35(9)686

33 Bennan KF Ostrem JL Mattay VS Esposito G Van Hom JD Abi-Dargham A Torrey EF Weinberger DR (1994) The role of the dorsolateral prefrontal corteK and hippocampus in working memory and schizophrenia Biological Psychiatry 35(9)622

34 Van Hom lD Gold J Esposito G Ostrem JL Weinberger DR AND Belman KF (1994) The role ofthe frontal lobe during maze learning assessed using PET Biological Psychiatry 35(9)686

35 Esposito G Van Horn JD Ostrem JLMattay VS Weinberger DR Bennan KF The effect of sex age and pC02 on cerebral blood flow during cognitive stimulation Biological Psychiatry 35(9)648 1994

Society ofMagnetic Resonance

36 Ramsey NF Kirkby BS Van Gelderen P Belman KF Moonen CTW Mattay VS Frank lA Van Hom JD Esposito G Weinberger DR (1995) A direct comparison

of 3D BOLD tMRI and ISO-Water PET imaging ofprimary sensory motor cortex in humans III Meeting of the Society of Magnetic Resonance

Cerebral Blood Flow and Metabolism

37 Mattay VS Kotrla KJ Santha AKS Sexton RH Sunderland T Esposito G Duyn JR Moonen CTW Frank JA Weinberger DR (1995) 3D-BURST tMRI Initial clinical application in Alzheimer1s disease XVII International Symposium on Cerebral Blood Flow and Metabolism

38 Esposito G Kirkby BS Van Horn JD Ostrem JL Mattay VS Weinberger DR Belman KF (1995) Normal Aging is Assodated witb Task-Specific Neuropbysiological Changes PET rCBF Measurements During Cognitive Stimulation Journal ofCerebral Blood Flow and Metabolism 15 p S594

39 Berman KF Schmidt PJ Ostrem IL Danaceau MA Van Horn JD Esposito G Rubinow DR Weinberger DR (1995) The Effects of Gonadal Steroid Honnones on Cognitively-Related Regional Cerebral Blood Flow A Positron Emission Tomography Study Journal of Cerebral Blood Flow and Metabolism 15 p S133

Functional Mapping ofthe Human Brain

40 Berman KF Ostrem JL Esposito G Van Hom ID Mattay VS Kirkby BS Weinberger DR (1995) Heritability of Cognitively-Related Regional Cerebral

Jun 16 10 0956a Radiation Saret~ 202 444 0069 p 15

Blood Flow A PET Study Comparing Normal Monozygotic and Dizygotic Twins Neuroimage p 359

41 Esposito G Kirkby BS Van Hom JD Ostrc~m JL Weinberger DR Berman KF (1996) Impaired Wisconsin Card Sorting Test Performance in Nonnal Aging and in Schizophrenia PET Evidence ofDifferent Pathophysiological Mechanisms for a Common Cognitive Deficit Neurolmage 3 3 p S482

42 Bennan KF Schmidt PJ Rubinow DR Esposito G Van Hom JD Austin-Lane JL Weinberger DR (1996) The Effects cfGonadal Steroid Hormones on Cognitive Activation in Men and Women Studied with Positron Emission Tomography Neurolmage 3 3 p S475

43 Kirkby BS Van Hom JD Esposito G Golberg TE Weinberger DR Berman KF (1996) A PET Study of Long-Term rCBF Changes during Cognition after Closed Head Injury Neurolmage 3 3 p S492

44 Van Hom lD Esposito G Weinberger DR Berman KF (1996) Volume-Based Multivariate Discriminant and Canonical Correlation Analysis of Neurophysiological Measures of Brain Function Neurolmage 3 3 p S103

45 Holt JL Van Hom JD Esposito G Ellmore T Weinberger DR Berman KF (1997) Mapping Neurophysiological Predictors of Good and Poor Performance on the Wisconsin Card Sorting Task Neuroimage 5 4 p S112

46 Bertolino A Esposito G Callicott JH Mat-tay VS Van Horn JD Frank JA Berman KF Weinberger FK (1997) IH-Magnetic Resonance Spectroscopic Imaging Correlates with rCBF Activation During Working Memory in Patients with Schizophrenia Neuroimage 54 p S281

47 Esposito G Van Hom ID Kirkby BS Weinberger DR Berman KF (1997) Functional Interactions between Dorsolateral Prefrontal Cortex and Other Brain Regions during Working Memory in Normal Subjects and Patients with Psychosis Neuroimage 54 p S284

48 Berman KF Holt J Callicott J Esposito G Van Hom JD Egan M Weinberger DR (1997) Neurophysiological Predictors of Clinical and Cognitive Changes over Time in Medication-Free Patients with Schizophrenia Individual Activation Maps Neuroimage 5 4 p S290

49 Van Hom ID EUmore T Esposito G Holt J Weinberger DR Berman KF (1997) Voxel-based Statistical Power in Functional Neuroimaging Studies Neuroimage 54pS464

50 Ye FQ Berman KF EUmore T Esposito G Van Hom JD Yang Y Duyn J Mattay VS Smith AM Frank JA Weinberger DR McLaughlin AC (1997) H2 1S0 PET Validation ofArterial Spin Tagg~ng CBF Measurements Neuroimage 54 p S533

r~ This is to acknowledge the receipt of YOuiletter~pPlication dated

elO dO 0 and to~you that the initial processing which includes an administrative review has been performed

[XJ TheJtmkl~~tJtve o9si~n~~pound~Ji2iqa~ IsSigned to a technical reviewer Please note that the technical review may identify additional omissions or require additional information

D Please provide to this office within 30 days of your receipt of this card

A copy of your action has been forwarded to our License Fee amp Accounts Receivable Branch who will contact you separately if there is a fee issue involved

Your action has been assigned Mail Control Number 5]31 (~ When calling to inquire about this action please refer to this control number You may call us on (610) 337-5398 or 337-5260

NRC FORM 532 (RI) Sincerely (6-96) licensing Assistance Team Leader

p8 Jun 18 10 0953a Radiation Sa~et~ 202 444 0089

- Basics ofNuclear Medicine Clinical Skill Prim~r Course 2008 (April 2008)

Monthly students lecture$ on the basics ofNuclear Medicine for selective rotations in Radiology (July 2008-present)

Scholarsbips

Italian Ministry for Scientific Research Fellowship Award 1991-1994

Grants Charles and Mary Latham Fund Comparison ofI-124 and 1-131 Radiopharmacokinetics Principal Investigator January 2007 ($10000)

PubUcations

Peer Reviewed

1 Sunderland T Esposito G Molchan SE Coppola R Jones OW Gorey J Little JT Cantillon M Bahro M Weinberger DR Differential Cholinergic Regulation in Alzheimers Patients Compared to Normal Controls Following Chronic Blockade with Scopolamine A SPECT Study Psychopharmachology 121231-241 1995

2 Mattay VS Berman KF Ostrem JL Esposito G Van Hom JD Bigelow LB Weinberger DR Dextroamphetamine Enhances Neural Network-Specific Physiological Signals A Positron - Emission Tomography rCBF Study J Neurosci 164816-4822 1996

3 Mattay VS Frank IA Duyn lH Kotrla KJ Santha AKS Esposito G Sexton RH Barker P Sunderland T Moonen CTW Weinberger DR 3D BUR8T FMRl Initial Clinical Applirations Acad Radiol 38379-8383 1996

4 RamseyNF KirkbyBS Van Gelderen P Berman KF Moonen CTW Duyn JH Frank lA Mattay V8 Van Hom JO Esposito G Moonen CTW Weinberger DR Functional mapping of human sensorimotor cortex with 3D-BOLD fMRI

correlates highly with H2150 PET rCBF J Cereb Blood Flow Metab 16755-764 1996

5 Esposito G Van Hom JO Ostrem JL Weinberger DR Berman KF Gender Differences in Cerebral Blood Flow as a Function of Cognitive State with PET J Nucl Med 37559-564 1996

6 Berman KF Schmidt PJ Rubinow D~ Danaceau MA Van Hom JD Esposito G Ostrem IL Weinberger DR Modulation ofCognitive-Specific Cortical Activity

Jun 16 10 OS53a Radiation SaTet~ 202 444 006S pS

by Gonadal Steroids a PET Study in Wom~~n Proc Natl Acad Sci 948836Al 1997

7 Goldberg TE Berman KF Fleming K Ostrem IL Van Hom JD Esposito G Mattay VS Gold JM Weinberger DR Uncoupling cognitive workload and prefrontal cortical physiology a PET rCBF study Neuroimage 7296-303 1998

8 Van Hom JD Ellmore TM Esposito G Bennan KF Mapping Voxel-Based Statistical Power on Parametric Images Neuroimage 797-107 1998

9 Van Hom JD Gold J Esposito G Ostrem JL Mattay VS Weinberger DR Berman KF Changing Patterns of Brain Activation During Maze Learning Brain Res 793 29-38 1998

10 Esposito G Kirkby BS VanHorn JD Weinberger DR Berman KF Contextshydependent Neural System-specific Neurophysiological Concomitants of Aging Mapping PET Correlates DUring Cognitive Activation Brain 122963-979 1999

11 Ye F Berman KF Ellmore T Esposit1 G Van Hom 10 Yang Y Duhn J Smith AM Frank JA Weinberger DR McLaughlin AC H2150 PET Validation of Steady-State Arterial Spin Tagging Cerebral Blood Flow Measurements in Humans Magn Reson Med 44450-456 2000

12 Bertolino A Esposito G Callicott JB Mattay VS Van Hom JD Frank JA Berman KF Weinberger DR Specific relationship between prefrontal neuronal N-acetyl-aspartate and activation of the working memory cortical network in schizophrenia Am J Psychiatry 15726-332000

13 Gourovitch ML Kirkby BS Goldberg TE Weinberger DR Gold 1M Esposito G Van Hom JD Bennan KF A comparison ofrCBF patterns during phonological and semantic fluency Neuropsychology 14353-360 2000

14 Meyer-Lindenberg A Miletich RS Kohn PO Esposito G CarsonRE Quarantelli M Weinberger DR Berman KF Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia Nature Neurosci 5267-71 2002

15 Chin BB Esposito G Kraitchman DL Myocardial contractile reserve and perfusion defect severity with rest and stress dobutamine (99m)Tc-sestamibi SPECT in canine stunning and subendocardial infarction J Nucl Med 43540-550 2002

16 Beason-Held LL Golski S Kraut MA Esposito G Resnick SM Brain activation during encoding and recognition of verbal and figural infonnation in older adults Neurobiol Aging 26(2)237-502005

17 Garcia CA Van Nostrand 0 Atkins F Acio E Butler C Esposito 0 Kulkarni K Majd M Reduction ofBrown Fat 2-Deoxy-2-[F-18]f1uoro-D-glucose Uptake by Controlling Environmental TemperatJre Prior to Positron Emission Tomography Scan Mol Imaging BioI 8 24-29 2006

Jun 16 10 0954a Radiation Safet~ 202 444 0069 p 10

18 Garcia CA Esposito G Acio ER Van Nostrand D (18)F-FDG PET hemispheric cerebral hypometabolic activity patient motion artifact J Nucl Med Technol 34(2)86-72006

19 Esposito 0 Giovacchini G Der M Liow JS Ma K Herscovitch P Channing M Hallett M Bhattacharjee AK Eckelman WC Carson RE Rapoport SI Imaging signal transduction via Arachidonic Acid in the human brain during visual stimulation by means of Positron Emission Tomography Neuroimage 34(4)1342-512007

20 Walitt B Roebuck-Spencer T Esposito G Atkins F Bleiberg J Foster 0 Weinstein A The effects of multidisciplinary therapy on positron emission tomography of the brain in fibromyalgia a pilot study Rheumatol Int 27(11)1019-24 Epub 2007 Jul20 2007

21 Esposito G Giovacchini G Liow JS Bhattacharjee AK Greenstein D Schapiro M Hallett M Herscovitch P Eckelman we Carson RE Rapoport SI Imaging Neuroinflammation in Alzheimer Dis~Jase with Radiolabeled Arachidonic Acid and PET J Nucl Med (in press)

Book Chapters

1 Van Hom JD Ellmore TM Holt JL Esposito G Berman KF (1998) Multifiltering signal detection and statistical power in brain activation studies In Herschovitch P Carson RE (eds) Quantification ofBrain Function with PET Academic Press 237-240

2 Esposito G Radionuclide Imaging of Medullary Carcinoma Utility of Radiolabeled Somatostatin Analogs ~ld Other Radiotracers In Thyroid Cancer A Comprehensive Guide to Clinical Managl~ment 2e Edited by L Wartofsky MD and D Van Nostrand Humana Press Inc Totowa NJ 2006

Meeting Abstracts

Society ofNuclear Medicine

1 Esposito G Van Horn JD Weinberger DR Berman KF (1993) Gender Differences in Cerebral Blood Flow with PET Is there an Effect ofCognitive State J Nucl Med 34 67P

2 Berman KF Schmidt PJ Ostrem JL Danaceau MA Esposito G Van Hom lD Mattay VS Rubinow DR Weinberger DR (1994) Effects of gonadal steroids on cerebral blood flow patients with menstrual-related mood disorder and controls studied with PET during medical oophorectomy and hormone replacement J Nucl Med 3553P

J~n 16 10 0954a Radiation Safet~ 202 444 0069 p 11

3 Esposito G Kirkby BS Van Hom JD Ostrem JL Weinberger DR Berman KF (1995) Task-specific Neurophysioloeuroical Changes in Normal Aging PET rCBF Measurements During Cognition Journal ofNuclear Medicine vol 36 p16

4 Esposito G Saunders Re Jones DW Lee KS Gorey JG Coppola R Bennan KF Iadarola MJ DeCosta BR Rice KC Weinberger DR (1995) 1-123-Ioxy A Potential SPECT Imaging Agent for Opiate Receptors Journal ofNuclear Medicine voL 36 p 166P

5 Esposito G Kirkby BS Van Hom JD Ostr-em JL Weinberger DR Berman KF (1996) Different Pathophysiological Mechanisms ofhnpaired Wisconsin Card Sorting in Elderly Normal Subjects and Schizophrenics Studied with PET Journal ofNuclear Medicine 37(5) p 79P

6 Berman KF Austin-Lane JL Esposito G Van Hom JD Weinberger DR (1996) Neurophysiological and Neuropsychological Dissection of the IIWorking and the Memory in a PET Study ofWorking Memory Journal ofNuc1ear Medicine 37 5 p 284p

7 Esposito G Chin BB Kraitchrnan DL (2000) Tc-99m gated sestamibi SPECT evaluation of myocardial wall thickening correlates with tagged MRI measurements of radial strain J Nuel Med 41 755P

8 Chin BB Esposito G Kraitchrnan DL (2000) Characterization ofcanine myocardial contractile reserve with gated Tc-99m sestamibi SPECT in normal stunned and subendocardial infarction J Nuel Med 41 497P

9 Chin BB Esposito G Kraitchman DL (2000) Detailed characterization of gated and ungated Tc-99m sestamibi defect severity in normal stunned and subendocardial infarcted canine myo~ardiwn at rest and during low dose dobutamine infusion J Nuel Med 41 496P

10 Esposito G Bhattachrujee AK Schapro M Herscovitch P Eckelman WC Carson RE Rapoport SI (2005) PET shows ~ncreased brain incorporation of [I shyI IC]Arachidonic Acid a marker of neuroinflammation in patients with Alzheimers Disease J Nuel Med

11 Van Nostrand D Aiken M Atkins F Esposito G Moreau S Garcia C Acio E Burman K Wartofsky L (2007) The utility of radioiodine whole body scans prior to I~131 ablation in patients with well-differentiated thyroid cancer J Nuel Med 48 lSP

12 Aiken M Garcia C Acio E Suhag V Esposito G Moreau S Priebat D Van Nostrand D (2007) Doxorubicin-induced cardiac toxicity and gated cardiac blood pool imaging J Nuel Med 48 208P

13 Esposito G Sarikaya I (2008) Integr~ted nuclear medicine imaging ofmedullary thyroid cancer J Nuel Med 49 171P

J~n 18 10 0954a Radiation Safet~ 202 444 0089 p 12

BrainPET

14 Esposito G~ Giovacchini G Der MG Vuong BK Channing MA Lerner A Hallett M Battacharjee A Herscovitch P Eckelman WC Rapoport SI Carson RE llC]Arachidonic acid PET activation experiments in human subjects A feasibility study using visual stimulation J Cereb Blood Flow Metab Vol 23 (Suppl 1)711 (2003)

Radiological Society oNorth America

15 Esposito G Chin BB Kraitchman DL Correlation ofmyocardial strain measurements by 3D-tagged MR imging with Tc-99m gated sestamibi SPEeT thickening in normal stunned and infarcted myocardium Radiology 1999 213 p207

SOCiety for Neuroscience

16 Berman KF Ostrem IL Van Hom JD Mattay VS Esposito G Weinberger DR (1993) A Comparison Between Normal Monozygotic and Dizygotic Twins Studied During Cognition with Positron Emission Tomography Society for Neuroscience Abstracts Vol 19 Part I p 792

17 Gourovitch ML Kirkby BS Gold JM Esposito G Van Hom JD Ostrem JL Golberg TE Weinberger DR Berman KF(l994) A comparison ofletter and category fluency Cerebral Activation with Positron Emission Tomography Society for Neuroscience Abstracts Volume 20 Part 1 p 6

18 Weinberger DR Ramsey NF Kirkby BS Van Gelderen P Berman KF Mattay VS Frank JA Van Hom JD Esposito G Moonen CTW (1995) ThreeshyDimensional BOLD fMRI and 0-15 water PET neuroactivation maps are highly correlated Society for Neuroscience bstracts Vol 21 Part 1 p 273

19 Esposito G Kirkby BS Van Horn JD Weinberger DR Berman KF (1995) Different pathophysiological mechanisms of altered Wisconsin Card Sort performance in schizophrenics and elderly normal subjects Society for Neuroscience Abstracts Vol 21 Part 1 p 747

20 Kirkby BS Van Hom JD Esposito G Golberg TE Weinberger DR Berman KF (1995) Long term changes in rCBF during cognition following severe closed head injury a PET study Society for Neuroscience Abstracts Vol 21 Part 3 p 1924

21 Van Hom JD Esposito G Kirkby BS Weinberger DR Berman KF (1995) Appraisal ofunivariate and multivariate analysis techniques for PET brain image quantification Society for Neuroscience Abstracts Vol 21 Part 2 p 1208

22 Esposito G Kirkby BS Van Hom JD Weinberger DR Berman KF (1996) PET Evaluation of cognitively related neur9physiological sequelae accompanying

Jun 16 10 0955a Radiation SaTet~ 202 444 0069 p 13

incidental findings of microvascular ischemic disease in the elderly preliminary results Society for Neuroscience Abstracts Vol 22 Part 1 p 676

23 Weinberger DR Santha A Mattay VS Frank J Kirkby BS Van Horn JD Esposito G Bennan KF (1996) Within subject neuroactivation mapping with whole brain isotropic BPI and 3-D PET a direct comparison Society for Neuroscience Abstracts Vol 22 Part 1 p 7

24 Golberg TE Fleming K Berman KF Van Horn 10 Esposito G Ostrem JL Gold JM Weinberger DR (1996) Neurophysiology ofdual task perfonnance a PET 015 study Society for Neuroscience Abstracts Vol 22 Part 2 p 967

25 Van Horn JD Austin-Lane JL Kirkby BS Esposito G Weinberger DR Berman KF (1996) Characterizing rCBF response in a PET study of graded working memory load Society for Neuroscience Abstracts Vol 22 Part 2 p 1113

26 El1more TM Van Horn JD Esposito G Kirkby BS Austin-Lane JL Weinberger DR Berman KF (1996) Signal averaging in cognitive and motor PET paradigms Society for Neuroscience Abstracts Vol 22 Part 3 p 1858

27 BeITI1an KF Sclunidt Pl Rubinow DR Esposito G Van Hom lD Austin-LaneJL Danaceau MA Weinberger DR (1996) Modulation of cognitively related cortical activity by gonadal steroid hormones directly demonstrated with PET Society for Neuroscience Abstracts Vol 22 Part 3 p 1861

28 Berman KF Holt J Callicott J Esposito G Van Horn JD Egan M Weinberger DR (1997) Relations among rCBF Clinical and Cognitive Changes over Time in Medication-Free Patients with Schizophrenia Individual PET Activation Maps Society for Neuroscience Abstracts 101 23 Part 2 p 1406

American Psychiatric Association

29 Van Horn JD Bennan KF Esposito G Ostrem JL Weinberger DR (1993) Is There Frontal Lobe Lateralization A PET Study Abstracts of the 146th Meeting of the American Psychiatric Association (New Reseach) p 68

30 Ostrem JL Kirkby BS Van Hom JD Esposito G Gold J Weinberger DR Berman KF(1994) Effects ofcohort size on PET activation studies Abstracts of the Annual Meeting of the American Psychiatric Association (Symposium 118) p 153

American Academy ofNeurology

31 BeITI1an KF Ostrem JL Mattay VS Bsposito G Van Hom JD Torrey EF Weinberger DR (1993) The role of the dorsolateral prefrontal cortex and the hippocampus in working memory PET studies of normal and abnormal states Abstracts of the 46th Annual Meeting of the American Academy of Neurology

Jun 16 10 0955a Radiation Safet~ 202 444 0069 p 14

Biological Psychiatry

32 Ostrem JL Bennan KF Mattay VS Van Hom JD Esposito G Weinberger DR (1994) The Neural Basis ofAbstract Reasoning An Inverstigation ofTwo Problem Solving Tasks with PET Biological Psychiatry 35(9)686

33 Bennan KF Ostrem JL Mattay VS Esposito G Van Hom JD Abi-Dargham A Torrey EF Weinberger DR (1994) The role of the dorsolateral prefrontal corteK and hippocampus in working memory and schizophrenia Biological Psychiatry 35(9)622

34 Van Hom lD Gold J Esposito G Ostrem JL Weinberger DR AND Belman KF (1994) The role ofthe frontal lobe during maze learning assessed using PET Biological Psychiatry 35(9)686

35 Esposito G Van Horn JD Ostrem JLMattay VS Weinberger DR Bennan KF The effect of sex age and pC02 on cerebral blood flow during cognitive stimulation Biological Psychiatry 35(9)648 1994

Society ofMagnetic Resonance

36 Ramsey NF Kirkby BS Van Gelderen P Belman KF Moonen CTW Mattay VS Frank lA Van Hom JD Esposito G Weinberger DR (1995) A direct comparison

of 3D BOLD tMRI and ISO-Water PET imaging ofprimary sensory motor cortex in humans III Meeting of the Society of Magnetic Resonance

Cerebral Blood Flow and Metabolism

37 Mattay VS Kotrla KJ Santha AKS Sexton RH Sunderland T Esposito G Duyn JR Moonen CTW Frank JA Weinberger DR (1995) 3D-BURST tMRI Initial clinical application in Alzheimer1s disease XVII International Symposium on Cerebral Blood Flow and Metabolism

38 Esposito G Kirkby BS Van Horn JD Ostrem JL Mattay VS Weinberger DR Belman KF (1995) Normal Aging is Assodated witb Task-Specific Neuropbysiological Changes PET rCBF Measurements During Cognitive Stimulation Journal ofCerebral Blood Flow and Metabolism 15 p S594

39 Berman KF Schmidt PJ Ostrem IL Danaceau MA Van Horn JD Esposito G Rubinow DR Weinberger DR (1995) The Effects of Gonadal Steroid Honnones on Cognitively-Related Regional Cerebral Blood Flow A Positron Emission Tomography Study Journal of Cerebral Blood Flow and Metabolism 15 p S133

Functional Mapping ofthe Human Brain

40 Berman KF Ostrem JL Esposito G Van Hom ID Mattay VS Kirkby BS Weinberger DR (1995) Heritability of Cognitively-Related Regional Cerebral

Jun 16 10 0956a Radiation Saret~ 202 444 0069 p 15

Blood Flow A PET Study Comparing Normal Monozygotic and Dizygotic Twins Neuroimage p 359

41 Esposito G Kirkby BS Van Hom JD Ostrc~m JL Weinberger DR Berman KF (1996) Impaired Wisconsin Card Sorting Test Performance in Nonnal Aging and in Schizophrenia PET Evidence ofDifferent Pathophysiological Mechanisms for a Common Cognitive Deficit Neurolmage 3 3 p S482

42 Bennan KF Schmidt PJ Rubinow DR Esposito G Van Hom JD Austin-Lane JL Weinberger DR (1996) The Effects cfGonadal Steroid Hormones on Cognitive Activation in Men and Women Studied with Positron Emission Tomography Neurolmage 3 3 p S475

43 Kirkby BS Van Hom JD Esposito G Golberg TE Weinberger DR Berman KF (1996) A PET Study of Long-Term rCBF Changes during Cognition after Closed Head Injury Neurolmage 3 3 p S492

44 Van Hom lD Esposito G Weinberger DR Berman KF (1996) Volume-Based Multivariate Discriminant and Canonical Correlation Analysis of Neurophysiological Measures of Brain Function Neurolmage 3 3 p S103

45 Holt JL Van Hom JD Esposito G Ellmore T Weinberger DR Berman KF (1997) Mapping Neurophysiological Predictors of Good and Poor Performance on the Wisconsin Card Sorting Task Neuroimage 5 4 p S112

46 Bertolino A Esposito G Callicott JH Mat-tay VS Van Horn JD Frank JA Berman KF Weinberger FK (1997) IH-Magnetic Resonance Spectroscopic Imaging Correlates with rCBF Activation During Working Memory in Patients with Schizophrenia Neuroimage 54 p S281

47 Esposito G Van Hom ID Kirkby BS Weinberger DR Berman KF (1997) Functional Interactions between Dorsolateral Prefrontal Cortex and Other Brain Regions during Working Memory in Normal Subjects and Patients with Psychosis Neuroimage 54 p S284

48 Berman KF Holt J Callicott J Esposito G Van Hom JD Egan M Weinberger DR (1997) Neurophysiological Predictors of Clinical and Cognitive Changes over Time in Medication-Free Patients with Schizophrenia Individual Activation Maps Neuroimage 5 4 p S290

49 Van Hom ID EUmore T Esposito G Holt J Weinberger DR Berman KF (1997) Voxel-based Statistical Power in Functional Neuroimaging Studies Neuroimage 54pS464

50 Ye FQ Berman KF EUmore T Esposito G Van Hom JD Yang Y Duyn J Mattay VS Smith AM Frank JA Weinberger DR McLaughlin AC (1997) H2 1S0 PET Validation ofArterial Spin Tagg~ng CBF Measurements Neuroimage 54 p S533

r~ This is to acknowledge the receipt of YOuiletter~pPlication dated

elO dO 0 and to~you that the initial processing which includes an administrative review has been performed

[XJ TheJtmkl~~tJtve o9si~n~~pound~Ji2iqa~ IsSigned to a technical reviewer Please note that the technical review may identify additional omissions or require additional information

D Please provide to this office within 30 days of your receipt of this card

A copy of your action has been forwarded to our License Fee amp Accounts Receivable Branch who will contact you separately if there is a fee issue involved

Your action has been assigned Mail Control Number 5]31 (~ When calling to inquire about this action please refer to this control number You may call us on (610) 337-5398 or 337-5260

NRC FORM 532 (RI) Sincerely (6-96) licensing Assistance Team Leader

Jun 16 10 OS53a Radiation SaTet~ 202 444 006S pS

by Gonadal Steroids a PET Study in Wom~~n Proc Natl Acad Sci 948836Al 1997

7 Goldberg TE Berman KF Fleming K Ostrem IL Van Hom JD Esposito G Mattay VS Gold JM Weinberger DR Uncoupling cognitive workload and prefrontal cortical physiology a PET rCBF study Neuroimage 7296-303 1998

8 Van Hom JD Ellmore TM Esposito G Bennan KF Mapping Voxel-Based Statistical Power on Parametric Images Neuroimage 797-107 1998

9 Van Hom JD Gold J Esposito G Ostrem JL Mattay VS Weinberger DR Berman KF Changing Patterns of Brain Activation During Maze Learning Brain Res 793 29-38 1998

10 Esposito G Kirkby BS VanHorn JD Weinberger DR Berman KF Contextshydependent Neural System-specific Neurophysiological Concomitants of Aging Mapping PET Correlates DUring Cognitive Activation Brain 122963-979 1999

11 Ye F Berman KF Ellmore T Esposit1 G Van Hom 10 Yang Y Duhn J Smith AM Frank JA Weinberger DR McLaughlin AC H2150 PET Validation of Steady-State Arterial Spin Tagging Cerebral Blood Flow Measurements in Humans Magn Reson Med 44450-456 2000

12 Bertolino A Esposito G Callicott JB Mattay VS Van Hom JD Frank JA Berman KF Weinberger DR Specific relationship between prefrontal neuronal N-acetyl-aspartate and activation of the working memory cortical network in schizophrenia Am J Psychiatry 15726-332000

13 Gourovitch ML Kirkby BS Goldberg TE Weinberger DR Gold 1M Esposito G Van Hom JD Bennan KF A comparison ofrCBF patterns during phonological and semantic fluency Neuropsychology 14353-360 2000

14 Meyer-Lindenberg A Miletich RS Kohn PO Esposito G CarsonRE Quarantelli M Weinberger DR Berman KF Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia Nature Neurosci 5267-71 2002

15 Chin BB Esposito G Kraitchman DL Myocardial contractile reserve and perfusion defect severity with rest and stress dobutamine (99m)Tc-sestamibi SPECT in canine stunning and subendocardial infarction J Nucl Med 43540-550 2002

16 Beason-Held LL Golski S Kraut MA Esposito G Resnick SM Brain activation during encoding and recognition of verbal and figural infonnation in older adults Neurobiol Aging 26(2)237-502005

17 Garcia CA Van Nostrand 0 Atkins F Acio E Butler C Esposito 0 Kulkarni K Majd M Reduction ofBrown Fat 2-Deoxy-2-[F-18]f1uoro-D-glucose Uptake by Controlling Environmental TemperatJre Prior to Positron Emission Tomography Scan Mol Imaging BioI 8 24-29 2006

Jun 16 10 0954a Radiation Safet~ 202 444 0069 p 10

18 Garcia CA Esposito G Acio ER Van Nostrand D (18)F-FDG PET hemispheric cerebral hypometabolic activity patient motion artifact J Nucl Med Technol 34(2)86-72006

19 Esposito 0 Giovacchini G Der M Liow JS Ma K Herscovitch P Channing M Hallett M Bhattacharjee AK Eckelman WC Carson RE Rapoport SI Imaging signal transduction via Arachidonic Acid in the human brain during visual stimulation by means of Positron Emission Tomography Neuroimage 34(4)1342-512007

20 Walitt B Roebuck-Spencer T Esposito G Atkins F Bleiberg J Foster 0 Weinstein A The effects of multidisciplinary therapy on positron emission tomography of the brain in fibromyalgia a pilot study Rheumatol Int 27(11)1019-24 Epub 2007 Jul20 2007

21 Esposito G Giovacchini G Liow JS Bhattacharjee AK Greenstein D Schapiro M Hallett M Herscovitch P Eckelman we Carson RE Rapoport SI Imaging Neuroinflammation in Alzheimer Dis~Jase with Radiolabeled Arachidonic Acid and PET J Nucl Med (in press)

Book Chapters

1 Van Hom JD Ellmore TM Holt JL Esposito G Berman KF (1998) Multifiltering signal detection and statistical power in brain activation studies In Herschovitch P Carson RE (eds) Quantification ofBrain Function with PET Academic Press 237-240

2 Esposito G Radionuclide Imaging of Medullary Carcinoma Utility of Radiolabeled Somatostatin Analogs ~ld Other Radiotracers In Thyroid Cancer A Comprehensive Guide to Clinical Managl~ment 2e Edited by L Wartofsky MD and D Van Nostrand Humana Press Inc Totowa NJ 2006

Meeting Abstracts

Society ofNuclear Medicine

1 Esposito G Van Horn JD Weinberger DR Berman KF (1993) Gender Differences in Cerebral Blood Flow with PET Is there an Effect ofCognitive State J Nucl Med 34 67P

2 Berman KF Schmidt PJ Ostrem JL Danaceau MA Esposito G Van Hom lD Mattay VS Rubinow DR Weinberger DR (1994) Effects of gonadal steroids on cerebral blood flow patients with menstrual-related mood disorder and controls studied with PET during medical oophorectomy and hormone replacement J Nucl Med 3553P

J~n 16 10 0954a Radiation Safet~ 202 444 0069 p 11

3 Esposito G Kirkby BS Van Hom JD Ostrem JL Weinberger DR Berman KF (1995) Task-specific Neurophysioloeuroical Changes in Normal Aging PET rCBF Measurements During Cognition Journal ofNuclear Medicine vol 36 p16

4 Esposito G Saunders Re Jones DW Lee KS Gorey JG Coppola R Bennan KF Iadarola MJ DeCosta BR Rice KC Weinberger DR (1995) 1-123-Ioxy A Potential SPECT Imaging Agent for Opiate Receptors Journal ofNuclear Medicine voL 36 p 166P

5 Esposito G Kirkby BS Van Hom JD Ostr-em JL Weinberger DR Berman KF (1996) Different Pathophysiological Mechanisms ofhnpaired Wisconsin Card Sorting in Elderly Normal Subjects and Schizophrenics Studied with PET Journal ofNuclear Medicine 37(5) p 79P

6 Berman KF Austin-Lane JL Esposito G Van Hom JD Weinberger DR (1996) Neurophysiological and Neuropsychological Dissection of the IIWorking and the Memory in a PET Study ofWorking Memory Journal ofNuc1ear Medicine 37 5 p 284p

7 Esposito G Chin BB Kraitchrnan DL (2000) Tc-99m gated sestamibi SPECT evaluation of myocardial wall thickening correlates with tagged MRI measurements of radial strain J Nuel Med 41 755P

8 Chin BB Esposito G Kraitchrnan DL (2000) Characterization ofcanine myocardial contractile reserve with gated Tc-99m sestamibi SPECT in normal stunned and subendocardial infarction J Nuel Med 41 497P

9 Chin BB Esposito G Kraitchman DL (2000) Detailed characterization of gated and ungated Tc-99m sestamibi defect severity in normal stunned and subendocardial infarcted canine myo~ardiwn at rest and during low dose dobutamine infusion J Nuel Med 41 496P

10 Esposito G Bhattachrujee AK Schapro M Herscovitch P Eckelman WC Carson RE Rapoport SI (2005) PET shows ~ncreased brain incorporation of [I shyI IC]Arachidonic Acid a marker of neuroinflammation in patients with Alzheimers Disease J Nuel Med

11 Van Nostrand D Aiken M Atkins F Esposito G Moreau S Garcia C Acio E Burman K Wartofsky L (2007) The utility of radioiodine whole body scans prior to I~131 ablation in patients with well-differentiated thyroid cancer J Nuel Med 48 lSP

12 Aiken M Garcia C Acio E Suhag V Esposito G Moreau S Priebat D Van Nostrand D (2007) Doxorubicin-induced cardiac toxicity and gated cardiac blood pool imaging J Nuel Med 48 208P

13 Esposito G Sarikaya I (2008) Integr~ted nuclear medicine imaging ofmedullary thyroid cancer J Nuel Med 49 171P

J~n 18 10 0954a Radiation Safet~ 202 444 0089 p 12

BrainPET

14 Esposito G~ Giovacchini G Der MG Vuong BK Channing MA Lerner A Hallett M Battacharjee A Herscovitch P Eckelman WC Rapoport SI Carson RE llC]Arachidonic acid PET activation experiments in human subjects A feasibility study using visual stimulation J Cereb Blood Flow Metab Vol 23 (Suppl 1)711 (2003)

Radiological Society oNorth America

15 Esposito G Chin BB Kraitchman DL Correlation ofmyocardial strain measurements by 3D-tagged MR imging with Tc-99m gated sestamibi SPEeT thickening in normal stunned and infarcted myocardium Radiology 1999 213 p207

SOCiety for Neuroscience

16 Berman KF Ostrem IL Van Hom JD Mattay VS Esposito G Weinberger DR (1993) A Comparison Between Normal Monozygotic and Dizygotic Twins Studied During Cognition with Positron Emission Tomography Society for Neuroscience Abstracts Vol 19 Part I p 792

17 Gourovitch ML Kirkby BS Gold JM Esposito G Van Hom JD Ostrem JL Golberg TE Weinberger DR Berman KF(l994) A comparison ofletter and category fluency Cerebral Activation with Positron Emission Tomography Society for Neuroscience Abstracts Volume 20 Part 1 p 6

18 Weinberger DR Ramsey NF Kirkby BS Van Gelderen P Berman KF Mattay VS Frank JA Van Hom JD Esposito G Moonen CTW (1995) ThreeshyDimensional BOLD fMRI and 0-15 water PET neuroactivation maps are highly correlated Society for Neuroscience bstracts Vol 21 Part 1 p 273

19 Esposito G Kirkby BS Van Horn JD Weinberger DR Berman KF (1995) Different pathophysiological mechanisms of altered Wisconsin Card Sort performance in schizophrenics and elderly normal subjects Society for Neuroscience Abstracts Vol 21 Part 1 p 747

20 Kirkby BS Van Hom JD Esposito G Golberg TE Weinberger DR Berman KF (1995) Long term changes in rCBF during cognition following severe closed head injury a PET study Society for Neuroscience Abstracts Vol 21 Part 3 p 1924

21 Van Hom JD Esposito G Kirkby BS Weinberger DR Berman KF (1995) Appraisal ofunivariate and multivariate analysis techniques for PET brain image quantification Society for Neuroscience Abstracts Vol 21 Part 2 p 1208

22 Esposito G Kirkby BS Van Hom JD Weinberger DR Berman KF (1996) PET Evaluation of cognitively related neur9physiological sequelae accompanying

Jun 16 10 0955a Radiation SaTet~ 202 444 0069 p 13

incidental findings of microvascular ischemic disease in the elderly preliminary results Society for Neuroscience Abstracts Vol 22 Part 1 p 676

23 Weinberger DR Santha A Mattay VS Frank J Kirkby BS Van Horn JD Esposito G Bennan KF (1996) Within subject neuroactivation mapping with whole brain isotropic BPI and 3-D PET a direct comparison Society for Neuroscience Abstracts Vol 22 Part 1 p 7

24 Golberg TE Fleming K Berman KF Van Horn 10 Esposito G Ostrem JL Gold JM Weinberger DR (1996) Neurophysiology ofdual task perfonnance a PET 015 study Society for Neuroscience Abstracts Vol 22 Part 2 p 967

25 Van Horn JD Austin-Lane JL Kirkby BS Esposito G Weinberger DR Berman KF (1996) Characterizing rCBF response in a PET study of graded working memory load Society for Neuroscience Abstracts Vol 22 Part 2 p 1113

26 El1more TM Van Horn JD Esposito G Kirkby BS Austin-Lane JL Weinberger DR Berman KF (1996) Signal averaging in cognitive and motor PET paradigms Society for Neuroscience Abstracts Vol 22 Part 3 p 1858

27 BeITI1an KF Sclunidt Pl Rubinow DR Esposito G Van Hom lD Austin-LaneJL Danaceau MA Weinberger DR (1996) Modulation of cognitively related cortical activity by gonadal steroid hormones directly demonstrated with PET Society for Neuroscience Abstracts Vol 22 Part 3 p 1861

28 Berman KF Holt J Callicott J Esposito G Van Horn JD Egan M Weinberger DR (1997) Relations among rCBF Clinical and Cognitive Changes over Time in Medication-Free Patients with Schizophrenia Individual PET Activation Maps Society for Neuroscience Abstracts 101 23 Part 2 p 1406

American Psychiatric Association

29 Van Horn JD Bennan KF Esposito G Ostrem JL Weinberger DR (1993) Is There Frontal Lobe Lateralization A PET Study Abstracts of the 146th Meeting of the American Psychiatric Association (New Reseach) p 68

30 Ostrem JL Kirkby BS Van Hom JD Esposito G Gold J Weinberger DR Berman KF(1994) Effects ofcohort size on PET activation studies Abstracts of the Annual Meeting of the American Psychiatric Association (Symposium 118) p 153

American Academy ofNeurology

31 BeITI1an KF Ostrem JL Mattay VS Bsposito G Van Hom JD Torrey EF Weinberger DR (1993) The role of the dorsolateral prefrontal cortex and the hippocampus in working memory PET studies of normal and abnormal states Abstracts of the 46th Annual Meeting of the American Academy of Neurology

Jun 16 10 0955a Radiation Safet~ 202 444 0069 p 14

Biological Psychiatry

32 Ostrem JL Bennan KF Mattay VS Van Hom JD Esposito G Weinberger DR (1994) The Neural Basis ofAbstract Reasoning An Inverstigation ofTwo Problem Solving Tasks with PET Biological Psychiatry 35(9)686

33 Bennan KF Ostrem JL Mattay VS Esposito G Van Hom JD Abi-Dargham A Torrey EF Weinberger DR (1994) The role of the dorsolateral prefrontal corteK and hippocampus in working memory and schizophrenia Biological Psychiatry 35(9)622

34 Van Hom lD Gold J Esposito G Ostrem JL Weinberger DR AND Belman KF (1994) The role ofthe frontal lobe during maze learning assessed using PET Biological Psychiatry 35(9)686

35 Esposito G Van Horn JD Ostrem JLMattay VS Weinberger DR Bennan KF The effect of sex age and pC02 on cerebral blood flow during cognitive stimulation Biological Psychiatry 35(9)648 1994

Society ofMagnetic Resonance

36 Ramsey NF Kirkby BS Van Gelderen P Belman KF Moonen CTW Mattay VS Frank lA Van Hom JD Esposito G Weinberger DR (1995) A direct comparison

of 3D BOLD tMRI and ISO-Water PET imaging ofprimary sensory motor cortex in humans III Meeting of the Society of Magnetic Resonance

Cerebral Blood Flow and Metabolism

37 Mattay VS Kotrla KJ Santha AKS Sexton RH Sunderland T Esposito G Duyn JR Moonen CTW Frank JA Weinberger DR (1995) 3D-BURST tMRI Initial clinical application in Alzheimer1s disease XVII International Symposium on Cerebral Blood Flow and Metabolism

38 Esposito G Kirkby BS Van Horn JD Ostrem JL Mattay VS Weinberger DR Belman KF (1995) Normal Aging is Assodated witb Task-Specific Neuropbysiological Changes PET rCBF Measurements During Cognitive Stimulation Journal ofCerebral Blood Flow and Metabolism 15 p S594

39 Berman KF Schmidt PJ Ostrem IL Danaceau MA Van Horn JD Esposito G Rubinow DR Weinberger DR (1995) The Effects of Gonadal Steroid Honnones on Cognitively-Related Regional Cerebral Blood Flow A Positron Emission Tomography Study Journal of Cerebral Blood Flow and Metabolism 15 p S133

Functional Mapping ofthe Human Brain

40 Berman KF Ostrem JL Esposito G Van Hom ID Mattay VS Kirkby BS Weinberger DR (1995) Heritability of Cognitively-Related Regional Cerebral

Jun 16 10 0956a Radiation Saret~ 202 444 0069 p 15

Blood Flow A PET Study Comparing Normal Monozygotic and Dizygotic Twins Neuroimage p 359

41 Esposito G Kirkby BS Van Hom JD Ostrc~m JL Weinberger DR Berman KF (1996) Impaired Wisconsin Card Sorting Test Performance in Nonnal Aging and in Schizophrenia PET Evidence ofDifferent Pathophysiological Mechanisms for a Common Cognitive Deficit Neurolmage 3 3 p S482

42 Bennan KF Schmidt PJ Rubinow DR Esposito G Van Hom JD Austin-Lane JL Weinberger DR (1996) The Effects cfGonadal Steroid Hormones on Cognitive Activation in Men and Women Studied with Positron Emission Tomography Neurolmage 3 3 p S475

43 Kirkby BS Van Hom JD Esposito G Golberg TE Weinberger DR Berman KF (1996) A PET Study of Long-Term rCBF Changes during Cognition after Closed Head Injury Neurolmage 3 3 p S492

44 Van Hom lD Esposito G Weinberger DR Berman KF (1996) Volume-Based Multivariate Discriminant and Canonical Correlation Analysis of Neurophysiological Measures of Brain Function Neurolmage 3 3 p S103

45 Holt JL Van Hom JD Esposito G Ellmore T Weinberger DR Berman KF (1997) Mapping Neurophysiological Predictors of Good and Poor Performance on the Wisconsin Card Sorting Task Neuroimage 5 4 p S112

46 Bertolino A Esposito G Callicott JH Mat-tay VS Van Horn JD Frank JA Berman KF Weinberger FK (1997) IH-Magnetic Resonance Spectroscopic Imaging Correlates with rCBF Activation During Working Memory in Patients with Schizophrenia Neuroimage 54 p S281

47 Esposito G Van Hom ID Kirkby BS Weinberger DR Berman KF (1997) Functional Interactions between Dorsolateral Prefrontal Cortex and Other Brain Regions during Working Memory in Normal Subjects and Patients with Psychosis Neuroimage 54 p S284

48 Berman KF Holt J Callicott J Esposito G Van Hom JD Egan M Weinberger DR (1997) Neurophysiological Predictors of Clinical and Cognitive Changes over Time in Medication-Free Patients with Schizophrenia Individual Activation Maps Neuroimage 5 4 p S290

49 Van Hom ID EUmore T Esposito G Holt J Weinberger DR Berman KF (1997) Voxel-based Statistical Power in Functional Neuroimaging Studies Neuroimage 54pS464

50 Ye FQ Berman KF EUmore T Esposito G Van Hom JD Yang Y Duyn J Mattay VS Smith AM Frank JA Weinberger DR McLaughlin AC (1997) H2 1S0 PET Validation ofArterial Spin Tagg~ng CBF Measurements Neuroimage 54 p S533

r~ This is to acknowledge the receipt of YOuiletter~pPlication dated

elO dO 0 and to~you that the initial processing which includes an administrative review has been performed

[XJ TheJtmkl~~tJtve o9si~n~~pound~Ji2iqa~ IsSigned to a technical reviewer Please note that the technical review may identify additional omissions or require additional information

D Please provide to this office within 30 days of your receipt of this card

A copy of your action has been forwarded to our License Fee amp Accounts Receivable Branch who will contact you separately if there is a fee issue involved

Your action has been assigned Mail Control Number 5]31 (~ When calling to inquire about this action please refer to this control number You may call us on (610) 337-5398 or 337-5260

NRC FORM 532 (RI) Sincerely (6-96) licensing Assistance Team Leader

Jun 16 10 0954a Radiation Safet~ 202 444 0069 p 10

18 Garcia CA Esposito G Acio ER Van Nostrand D (18)F-FDG PET hemispheric cerebral hypometabolic activity patient motion artifact J Nucl Med Technol 34(2)86-72006

19 Esposito 0 Giovacchini G Der M Liow JS Ma K Herscovitch P Channing M Hallett M Bhattacharjee AK Eckelman WC Carson RE Rapoport SI Imaging signal transduction via Arachidonic Acid in the human brain during visual stimulation by means of Positron Emission Tomography Neuroimage 34(4)1342-512007

20 Walitt B Roebuck-Spencer T Esposito G Atkins F Bleiberg J Foster 0 Weinstein A The effects of multidisciplinary therapy on positron emission tomography of the brain in fibromyalgia a pilot study Rheumatol Int 27(11)1019-24 Epub 2007 Jul20 2007

21 Esposito G Giovacchini G Liow JS Bhattacharjee AK Greenstein D Schapiro M Hallett M Herscovitch P Eckelman we Carson RE Rapoport SI Imaging Neuroinflammation in Alzheimer Dis~Jase with Radiolabeled Arachidonic Acid and PET J Nucl Med (in press)

Book Chapters

1 Van Hom JD Ellmore TM Holt JL Esposito G Berman KF (1998) Multifiltering signal detection and statistical power in brain activation studies In Herschovitch P Carson RE (eds) Quantification ofBrain Function with PET Academic Press 237-240

2 Esposito G Radionuclide Imaging of Medullary Carcinoma Utility of Radiolabeled Somatostatin Analogs ~ld Other Radiotracers In Thyroid Cancer A Comprehensive Guide to Clinical Managl~ment 2e Edited by L Wartofsky MD and D Van Nostrand Humana Press Inc Totowa NJ 2006

Meeting Abstracts

Society ofNuclear Medicine

1 Esposito G Van Horn JD Weinberger DR Berman KF (1993) Gender Differences in Cerebral Blood Flow with PET Is there an Effect ofCognitive State J Nucl Med 34 67P

2 Berman KF Schmidt PJ Ostrem JL Danaceau MA Esposito G Van Hom lD Mattay VS Rubinow DR Weinberger DR (1994) Effects of gonadal steroids on cerebral blood flow patients with menstrual-related mood disorder and controls studied with PET during medical oophorectomy and hormone replacement J Nucl Med 3553P

J~n 16 10 0954a Radiation Safet~ 202 444 0069 p 11

3 Esposito G Kirkby BS Van Hom JD Ostrem JL Weinberger DR Berman KF (1995) Task-specific Neurophysioloeuroical Changes in Normal Aging PET rCBF Measurements During Cognition Journal ofNuclear Medicine vol 36 p16

4 Esposito G Saunders Re Jones DW Lee KS Gorey JG Coppola R Bennan KF Iadarola MJ DeCosta BR Rice KC Weinberger DR (1995) 1-123-Ioxy A Potential SPECT Imaging Agent for Opiate Receptors Journal ofNuclear Medicine voL 36 p 166P

5 Esposito G Kirkby BS Van Hom JD Ostr-em JL Weinberger DR Berman KF (1996) Different Pathophysiological Mechanisms ofhnpaired Wisconsin Card Sorting in Elderly Normal Subjects and Schizophrenics Studied with PET Journal ofNuclear Medicine 37(5) p 79P

6 Berman KF Austin-Lane JL Esposito G Van Hom JD Weinberger DR (1996) Neurophysiological and Neuropsychological Dissection of the IIWorking and the Memory in a PET Study ofWorking Memory Journal ofNuc1ear Medicine 37 5 p 284p

7 Esposito G Chin BB Kraitchrnan DL (2000) Tc-99m gated sestamibi SPECT evaluation of myocardial wall thickening correlates with tagged MRI measurements of radial strain J Nuel Med 41 755P

8 Chin BB Esposito G Kraitchrnan DL (2000) Characterization ofcanine myocardial contractile reserve with gated Tc-99m sestamibi SPECT in normal stunned and subendocardial infarction J Nuel Med 41 497P

9 Chin BB Esposito G Kraitchman DL (2000) Detailed characterization of gated and ungated Tc-99m sestamibi defect severity in normal stunned and subendocardial infarcted canine myo~ardiwn at rest and during low dose dobutamine infusion J Nuel Med 41 496P

10 Esposito G Bhattachrujee AK Schapro M Herscovitch P Eckelman WC Carson RE Rapoport SI (2005) PET shows ~ncreased brain incorporation of [I shyI IC]Arachidonic Acid a marker of neuroinflammation in patients with Alzheimers Disease J Nuel Med

11 Van Nostrand D Aiken M Atkins F Esposito G Moreau S Garcia C Acio E Burman K Wartofsky L (2007) The utility of radioiodine whole body scans prior to I~131 ablation in patients with well-differentiated thyroid cancer J Nuel Med 48 lSP

12 Aiken M Garcia C Acio E Suhag V Esposito G Moreau S Priebat D Van Nostrand D (2007) Doxorubicin-induced cardiac toxicity and gated cardiac blood pool imaging J Nuel Med 48 208P

13 Esposito G Sarikaya I (2008) Integr~ted nuclear medicine imaging ofmedullary thyroid cancer J Nuel Med 49 171P

J~n 18 10 0954a Radiation Safet~ 202 444 0089 p 12

BrainPET

14 Esposito G~ Giovacchini G Der MG Vuong BK Channing MA Lerner A Hallett M Battacharjee A Herscovitch P Eckelman WC Rapoport SI Carson RE llC]Arachidonic acid PET activation experiments in human subjects A feasibility study using visual stimulation J Cereb Blood Flow Metab Vol 23 (Suppl 1)711 (2003)

Radiological Society oNorth America

15 Esposito G Chin BB Kraitchman DL Correlation ofmyocardial strain measurements by 3D-tagged MR imging with Tc-99m gated sestamibi SPEeT thickening in normal stunned and infarcted myocardium Radiology 1999 213 p207

SOCiety for Neuroscience

16 Berman KF Ostrem IL Van Hom JD Mattay VS Esposito G Weinberger DR (1993) A Comparison Between Normal Monozygotic and Dizygotic Twins Studied During Cognition with Positron Emission Tomography Society for Neuroscience Abstracts Vol 19 Part I p 792

17 Gourovitch ML Kirkby BS Gold JM Esposito G Van Hom JD Ostrem JL Golberg TE Weinberger DR Berman KF(l994) A comparison ofletter and category fluency Cerebral Activation with Positron Emission Tomography Society for Neuroscience Abstracts Volume 20 Part 1 p 6

18 Weinberger DR Ramsey NF Kirkby BS Van Gelderen P Berman KF Mattay VS Frank JA Van Hom JD Esposito G Moonen CTW (1995) ThreeshyDimensional BOLD fMRI and 0-15 water PET neuroactivation maps are highly correlated Society for Neuroscience bstracts Vol 21 Part 1 p 273

19 Esposito G Kirkby BS Van Horn JD Weinberger DR Berman KF (1995) Different pathophysiological mechanisms of altered Wisconsin Card Sort performance in schizophrenics and elderly normal subjects Society for Neuroscience Abstracts Vol 21 Part 1 p 747

20 Kirkby BS Van Hom JD Esposito G Golberg TE Weinberger DR Berman KF (1995) Long term changes in rCBF during cognition following severe closed head injury a PET study Society for Neuroscience Abstracts Vol 21 Part 3 p 1924

21 Van Hom JD Esposito G Kirkby BS Weinberger DR Berman KF (1995) Appraisal ofunivariate and multivariate analysis techniques for PET brain image quantification Society for Neuroscience Abstracts Vol 21 Part 2 p 1208

22 Esposito G Kirkby BS Van Hom JD Weinberger DR Berman KF (1996) PET Evaluation of cognitively related neur9physiological sequelae accompanying

Jun 16 10 0955a Radiation SaTet~ 202 444 0069 p 13

incidental findings of microvascular ischemic disease in the elderly preliminary results Society for Neuroscience Abstracts Vol 22 Part 1 p 676

23 Weinberger DR Santha A Mattay VS Frank J Kirkby BS Van Horn JD Esposito G Bennan KF (1996) Within subject neuroactivation mapping with whole brain isotropic BPI and 3-D PET a direct comparison Society for Neuroscience Abstracts Vol 22 Part 1 p 7

24 Golberg TE Fleming K Berman KF Van Horn 10 Esposito G Ostrem JL Gold JM Weinberger DR (1996) Neurophysiology ofdual task perfonnance a PET 015 study Society for Neuroscience Abstracts Vol 22 Part 2 p 967

25 Van Horn JD Austin-Lane JL Kirkby BS Esposito G Weinberger DR Berman KF (1996) Characterizing rCBF response in a PET study of graded working memory load Society for Neuroscience Abstracts Vol 22 Part 2 p 1113

26 El1more TM Van Horn JD Esposito G Kirkby BS Austin-Lane JL Weinberger DR Berman KF (1996) Signal averaging in cognitive and motor PET paradigms Society for Neuroscience Abstracts Vol 22 Part 3 p 1858

27 BeITI1an KF Sclunidt Pl Rubinow DR Esposito G Van Hom lD Austin-LaneJL Danaceau MA Weinberger DR (1996) Modulation of cognitively related cortical activity by gonadal steroid hormones directly demonstrated with PET Society for Neuroscience Abstracts Vol 22 Part 3 p 1861

28 Berman KF Holt J Callicott J Esposito G Van Horn JD Egan M Weinberger DR (1997) Relations among rCBF Clinical and Cognitive Changes over Time in Medication-Free Patients with Schizophrenia Individual PET Activation Maps Society for Neuroscience Abstracts 101 23 Part 2 p 1406

American Psychiatric Association

29 Van Horn JD Bennan KF Esposito G Ostrem JL Weinberger DR (1993) Is There Frontal Lobe Lateralization A PET Study Abstracts of the 146th Meeting of the American Psychiatric Association (New Reseach) p 68

30 Ostrem JL Kirkby BS Van Hom JD Esposito G Gold J Weinberger DR Berman KF(1994) Effects ofcohort size on PET activation studies Abstracts of the Annual Meeting of the American Psychiatric Association (Symposium 118) p 153

American Academy ofNeurology

31 BeITI1an KF Ostrem JL Mattay VS Bsposito G Van Hom JD Torrey EF Weinberger DR (1993) The role of the dorsolateral prefrontal cortex and the hippocampus in working memory PET studies of normal and abnormal states Abstracts of the 46th Annual Meeting of the American Academy of Neurology

Jun 16 10 0955a Radiation Safet~ 202 444 0069 p 14

Biological Psychiatry

32 Ostrem JL Bennan KF Mattay VS Van Hom JD Esposito G Weinberger DR (1994) The Neural Basis ofAbstract Reasoning An Inverstigation ofTwo Problem Solving Tasks with PET Biological Psychiatry 35(9)686

33 Bennan KF Ostrem JL Mattay VS Esposito G Van Hom JD Abi-Dargham A Torrey EF Weinberger DR (1994) The role of the dorsolateral prefrontal corteK and hippocampus in working memory and schizophrenia Biological Psychiatry 35(9)622

34 Van Hom lD Gold J Esposito G Ostrem JL Weinberger DR AND Belman KF (1994) The role ofthe frontal lobe during maze learning assessed using PET Biological Psychiatry 35(9)686

35 Esposito G Van Horn JD Ostrem JLMattay VS Weinberger DR Bennan KF The effect of sex age and pC02 on cerebral blood flow during cognitive stimulation Biological Psychiatry 35(9)648 1994

Society ofMagnetic Resonance

36 Ramsey NF Kirkby BS Van Gelderen P Belman KF Moonen CTW Mattay VS Frank lA Van Hom JD Esposito G Weinberger DR (1995) A direct comparison

of 3D BOLD tMRI and ISO-Water PET imaging ofprimary sensory motor cortex in humans III Meeting of the Society of Magnetic Resonance

Cerebral Blood Flow and Metabolism

37 Mattay VS Kotrla KJ Santha AKS Sexton RH Sunderland T Esposito G Duyn JR Moonen CTW Frank JA Weinberger DR (1995) 3D-BURST tMRI Initial clinical application in Alzheimer1s disease XVII International Symposium on Cerebral Blood Flow and Metabolism

38 Esposito G Kirkby BS Van Horn JD Ostrem JL Mattay VS Weinberger DR Belman KF (1995) Normal Aging is Assodated witb Task-Specific Neuropbysiological Changes PET rCBF Measurements During Cognitive Stimulation Journal ofCerebral Blood Flow and Metabolism 15 p S594

39 Berman KF Schmidt PJ Ostrem IL Danaceau MA Van Horn JD Esposito G Rubinow DR Weinberger DR (1995) The Effects of Gonadal Steroid Honnones on Cognitively-Related Regional Cerebral Blood Flow A Positron Emission Tomography Study Journal of Cerebral Blood Flow and Metabolism 15 p S133

Functional Mapping ofthe Human Brain

40 Berman KF Ostrem JL Esposito G Van Hom ID Mattay VS Kirkby BS Weinberger DR (1995) Heritability of Cognitively-Related Regional Cerebral

Jun 16 10 0956a Radiation Saret~ 202 444 0069 p 15

Blood Flow A PET Study Comparing Normal Monozygotic and Dizygotic Twins Neuroimage p 359

41 Esposito G Kirkby BS Van Hom JD Ostrc~m JL Weinberger DR Berman KF (1996) Impaired Wisconsin Card Sorting Test Performance in Nonnal Aging and in Schizophrenia PET Evidence ofDifferent Pathophysiological Mechanisms for a Common Cognitive Deficit Neurolmage 3 3 p S482

42 Bennan KF Schmidt PJ Rubinow DR Esposito G Van Hom JD Austin-Lane JL Weinberger DR (1996) The Effects cfGonadal Steroid Hormones on Cognitive Activation in Men and Women Studied with Positron Emission Tomography Neurolmage 3 3 p S475

43 Kirkby BS Van Hom JD Esposito G Golberg TE Weinberger DR Berman KF (1996) A PET Study of Long-Term rCBF Changes during Cognition after Closed Head Injury Neurolmage 3 3 p S492

44 Van Hom lD Esposito G Weinberger DR Berman KF (1996) Volume-Based Multivariate Discriminant and Canonical Correlation Analysis of Neurophysiological Measures of Brain Function Neurolmage 3 3 p S103

45 Holt JL Van Hom JD Esposito G Ellmore T Weinberger DR Berman KF (1997) Mapping Neurophysiological Predictors of Good and Poor Performance on the Wisconsin Card Sorting Task Neuroimage 5 4 p S112

46 Bertolino A Esposito G Callicott JH Mat-tay VS Van Horn JD Frank JA Berman KF Weinberger FK (1997) IH-Magnetic Resonance Spectroscopic Imaging Correlates with rCBF Activation During Working Memory in Patients with Schizophrenia Neuroimage 54 p S281

47 Esposito G Van Hom ID Kirkby BS Weinberger DR Berman KF (1997) Functional Interactions between Dorsolateral Prefrontal Cortex and Other Brain Regions during Working Memory in Normal Subjects and Patients with Psychosis Neuroimage 54 p S284

48 Berman KF Holt J Callicott J Esposito G Van Hom JD Egan M Weinberger DR (1997) Neurophysiological Predictors of Clinical and Cognitive Changes over Time in Medication-Free Patients with Schizophrenia Individual Activation Maps Neuroimage 5 4 p S290

49 Van Hom ID EUmore T Esposito G Holt J Weinberger DR Berman KF (1997) Voxel-based Statistical Power in Functional Neuroimaging Studies Neuroimage 54pS464

50 Ye FQ Berman KF EUmore T Esposito G Van Hom JD Yang Y Duyn J Mattay VS Smith AM Frank JA Weinberger DR McLaughlin AC (1997) H2 1S0 PET Validation ofArterial Spin Tagg~ng CBF Measurements Neuroimage 54 p S533

r~ This is to acknowledge the receipt of YOuiletter~pPlication dated

elO dO 0 and to~you that the initial processing which includes an administrative review has been performed

[XJ TheJtmkl~~tJtve o9si~n~~pound~Ji2iqa~ IsSigned to a technical reviewer Please note that the technical review may identify additional omissions or require additional information

D Please provide to this office within 30 days of your receipt of this card

A copy of your action has been forwarded to our License Fee amp Accounts Receivable Branch who will contact you separately if there is a fee issue involved

Your action has been assigned Mail Control Number 5]31 (~ When calling to inquire about this action please refer to this control number You may call us on (610) 337-5398 or 337-5260

NRC FORM 532 (RI) Sincerely (6-96) licensing Assistance Team Leader

J~n 16 10 0954a Radiation Safet~ 202 444 0069 p 11

3 Esposito G Kirkby BS Van Hom JD Ostrem JL Weinberger DR Berman KF (1995) Task-specific Neurophysioloeuroical Changes in Normal Aging PET rCBF Measurements During Cognition Journal ofNuclear Medicine vol 36 p16

4 Esposito G Saunders Re Jones DW Lee KS Gorey JG Coppola R Bennan KF Iadarola MJ DeCosta BR Rice KC Weinberger DR (1995) 1-123-Ioxy A Potential SPECT Imaging Agent for Opiate Receptors Journal ofNuclear Medicine voL 36 p 166P

5 Esposito G Kirkby BS Van Hom JD Ostr-em JL Weinberger DR Berman KF (1996) Different Pathophysiological Mechanisms ofhnpaired Wisconsin Card Sorting in Elderly Normal Subjects and Schizophrenics Studied with PET Journal ofNuclear Medicine 37(5) p 79P

6 Berman KF Austin-Lane JL Esposito G Van Hom JD Weinberger DR (1996) Neurophysiological and Neuropsychological Dissection of the IIWorking and the Memory in a PET Study ofWorking Memory Journal ofNuc1ear Medicine 37 5 p 284p

7 Esposito G Chin BB Kraitchrnan DL (2000) Tc-99m gated sestamibi SPECT evaluation of myocardial wall thickening correlates with tagged MRI measurements of radial strain J Nuel Med 41 755P

8 Chin BB Esposito G Kraitchrnan DL (2000) Characterization ofcanine myocardial contractile reserve with gated Tc-99m sestamibi SPECT in normal stunned and subendocardial infarction J Nuel Med 41 497P

9 Chin BB Esposito G Kraitchman DL (2000) Detailed characterization of gated and ungated Tc-99m sestamibi defect severity in normal stunned and subendocardial infarcted canine myo~ardiwn at rest and during low dose dobutamine infusion J Nuel Med 41 496P

10 Esposito G Bhattachrujee AK Schapro M Herscovitch P Eckelman WC Carson RE Rapoport SI (2005) PET shows ~ncreased brain incorporation of [I shyI IC]Arachidonic Acid a marker of neuroinflammation in patients with Alzheimers Disease J Nuel Med

11 Van Nostrand D Aiken M Atkins F Esposito G Moreau S Garcia C Acio E Burman K Wartofsky L (2007) The utility of radioiodine whole body scans prior to I~131 ablation in patients with well-differentiated thyroid cancer J Nuel Med 48 lSP

12 Aiken M Garcia C Acio E Suhag V Esposito G Moreau S Priebat D Van Nostrand D (2007) Doxorubicin-induced cardiac toxicity and gated cardiac blood pool imaging J Nuel Med 48 208P

13 Esposito G Sarikaya I (2008) Integr~ted nuclear medicine imaging ofmedullary thyroid cancer J Nuel Med 49 171P

J~n 18 10 0954a Radiation Safet~ 202 444 0089 p 12

BrainPET

14 Esposito G~ Giovacchini G Der MG Vuong BK Channing MA Lerner A Hallett M Battacharjee A Herscovitch P Eckelman WC Rapoport SI Carson RE llC]Arachidonic acid PET activation experiments in human subjects A feasibility study using visual stimulation J Cereb Blood Flow Metab Vol 23 (Suppl 1)711 (2003)

Radiological Society oNorth America

15 Esposito G Chin BB Kraitchman DL Correlation ofmyocardial strain measurements by 3D-tagged MR imging with Tc-99m gated sestamibi SPEeT thickening in normal stunned and infarcted myocardium Radiology 1999 213 p207

SOCiety for Neuroscience

16 Berman KF Ostrem IL Van Hom JD Mattay VS Esposito G Weinberger DR (1993) A Comparison Between Normal Monozygotic and Dizygotic Twins Studied During Cognition with Positron Emission Tomography Society for Neuroscience Abstracts Vol 19 Part I p 792

17 Gourovitch ML Kirkby BS Gold JM Esposito G Van Hom JD Ostrem JL Golberg TE Weinberger DR Berman KF(l994) A comparison ofletter and category fluency Cerebral Activation with Positron Emission Tomography Society for Neuroscience Abstracts Volume 20 Part 1 p 6

18 Weinberger DR Ramsey NF Kirkby BS Van Gelderen P Berman KF Mattay VS Frank JA Van Hom JD Esposito G Moonen CTW (1995) ThreeshyDimensional BOLD fMRI and 0-15 water PET neuroactivation maps are highly correlated Society for Neuroscience bstracts Vol 21 Part 1 p 273

19 Esposito G Kirkby BS Van Horn JD Weinberger DR Berman KF (1995) Different pathophysiological mechanisms of altered Wisconsin Card Sort performance in schizophrenics and elderly normal subjects Society for Neuroscience Abstracts Vol 21 Part 1 p 747

20 Kirkby BS Van Hom JD Esposito G Golberg TE Weinberger DR Berman KF (1995) Long term changes in rCBF during cognition following severe closed head injury a PET study Society for Neuroscience Abstracts Vol 21 Part 3 p 1924

21 Van Hom JD Esposito G Kirkby BS Weinberger DR Berman KF (1995) Appraisal ofunivariate and multivariate analysis techniques for PET brain image quantification Society for Neuroscience Abstracts Vol 21 Part 2 p 1208

22 Esposito G Kirkby BS Van Hom JD Weinberger DR Berman KF (1996) PET Evaluation of cognitively related neur9physiological sequelae accompanying

Jun 16 10 0955a Radiation SaTet~ 202 444 0069 p 13

incidental findings of microvascular ischemic disease in the elderly preliminary results Society for Neuroscience Abstracts Vol 22 Part 1 p 676

23 Weinberger DR Santha A Mattay VS Frank J Kirkby BS Van Horn JD Esposito G Bennan KF (1996) Within subject neuroactivation mapping with whole brain isotropic BPI and 3-D PET a direct comparison Society for Neuroscience Abstracts Vol 22 Part 1 p 7

24 Golberg TE Fleming K Berman KF Van Horn 10 Esposito G Ostrem JL Gold JM Weinberger DR (1996) Neurophysiology ofdual task perfonnance a PET 015 study Society for Neuroscience Abstracts Vol 22 Part 2 p 967

25 Van Horn JD Austin-Lane JL Kirkby BS Esposito G Weinberger DR Berman KF (1996) Characterizing rCBF response in a PET study of graded working memory load Society for Neuroscience Abstracts Vol 22 Part 2 p 1113

26 El1more TM Van Horn JD Esposito G Kirkby BS Austin-Lane JL Weinberger DR Berman KF (1996) Signal averaging in cognitive and motor PET paradigms Society for Neuroscience Abstracts Vol 22 Part 3 p 1858

27 BeITI1an KF Sclunidt Pl Rubinow DR Esposito G Van Hom lD Austin-LaneJL Danaceau MA Weinberger DR (1996) Modulation of cognitively related cortical activity by gonadal steroid hormones directly demonstrated with PET Society for Neuroscience Abstracts Vol 22 Part 3 p 1861

28 Berman KF Holt J Callicott J Esposito G Van Horn JD Egan M Weinberger DR (1997) Relations among rCBF Clinical and Cognitive Changes over Time in Medication-Free Patients with Schizophrenia Individual PET Activation Maps Society for Neuroscience Abstracts 101 23 Part 2 p 1406

American Psychiatric Association

29 Van Horn JD Bennan KF Esposito G Ostrem JL Weinberger DR (1993) Is There Frontal Lobe Lateralization A PET Study Abstracts of the 146th Meeting of the American Psychiatric Association (New Reseach) p 68

30 Ostrem JL Kirkby BS Van Hom JD Esposito G Gold J Weinberger DR Berman KF(1994) Effects ofcohort size on PET activation studies Abstracts of the Annual Meeting of the American Psychiatric Association (Symposium 118) p 153

American Academy ofNeurology

31 BeITI1an KF Ostrem JL Mattay VS Bsposito G Van Hom JD Torrey EF Weinberger DR (1993) The role of the dorsolateral prefrontal cortex and the hippocampus in working memory PET studies of normal and abnormal states Abstracts of the 46th Annual Meeting of the American Academy of Neurology

Jun 16 10 0955a Radiation Safet~ 202 444 0069 p 14

Biological Psychiatry

32 Ostrem JL Bennan KF Mattay VS Van Hom JD Esposito G Weinberger DR (1994) The Neural Basis ofAbstract Reasoning An Inverstigation ofTwo Problem Solving Tasks with PET Biological Psychiatry 35(9)686

33 Bennan KF Ostrem JL Mattay VS Esposito G Van Hom JD Abi-Dargham A Torrey EF Weinberger DR (1994) The role of the dorsolateral prefrontal corteK and hippocampus in working memory and schizophrenia Biological Psychiatry 35(9)622

34 Van Hom lD Gold J Esposito G Ostrem JL Weinberger DR AND Belman KF (1994) The role ofthe frontal lobe during maze learning assessed using PET Biological Psychiatry 35(9)686

35 Esposito G Van Horn JD Ostrem JLMattay VS Weinberger DR Bennan KF The effect of sex age and pC02 on cerebral blood flow during cognitive stimulation Biological Psychiatry 35(9)648 1994

Society ofMagnetic Resonance

36 Ramsey NF Kirkby BS Van Gelderen P Belman KF Moonen CTW Mattay VS Frank lA Van Hom JD Esposito G Weinberger DR (1995) A direct comparison

of 3D BOLD tMRI and ISO-Water PET imaging ofprimary sensory motor cortex in humans III Meeting of the Society of Magnetic Resonance

Cerebral Blood Flow and Metabolism

37 Mattay VS Kotrla KJ Santha AKS Sexton RH Sunderland T Esposito G Duyn JR Moonen CTW Frank JA Weinberger DR (1995) 3D-BURST tMRI Initial clinical application in Alzheimer1s disease XVII International Symposium on Cerebral Blood Flow and Metabolism

38 Esposito G Kirkby BS Van Horn JD Ostrem JL Mattay VS Weinberger DR Belman KF (1995) Normal Aging is Assodated witb Task-Specific Neuropbysiological Changes PET rCBF Measurements During Cognitive Stimulation Journal ofCerebral Blood Flow and Metabolism 15 p S594

39 Berman KF Schmidt PJ Ostrem IL Danaceau MA Van Horn JD Esposito G Rubinow DR Weinberger DR (1995) The Effects of Gonadal Steroid Honnones on Cognitively-Related Regional Cerebral Blood Flow A Positron Emission Tomography Study Journal of Cerebral Blood Flow and Metabolism 15 p S133

Functional Mapping ofthe Human Brain

40 Berman KF Ostrem JL Esposito G Van Hom ID Mattay VS Kirkby BS Weinberger DR (1995) Heritability of Cognitively-Related Regional Cerebral

Jun 16 10 0956a Radiation Saret~ 202 444 0069 p 15

Blood Flow A PET Study Comparing Normal Monozygotic and Dizygotic Twins Neuroimage p 359

41 Esposito G Kirkby BS Van Hom JD Ostrc~m JL Weinberger DR Berman KF (1996) Impaired Wisconsin Card Sorting Test Performance in Nonnal Aging and in Schizophrenia PET Evidence ofDifferent Pathophysiological Mechanisms for a Common Cognitive Deficit Neurolmage 3 3 p S482

42 Bennan KF Schmidt PJ Rubinow DR Esposito G Van Hom JD Austin-Lane JL Weinberger DR (1996) The Effects cfGonadal Steroid Hormones on Cognitive Activation in Men and Women Studied with Positron Emission Tomography Neurolmage 3 3 p S475

43 Kirkby BS Van Hom JD Esposito G Golberg TE Weinberger DR Berman KF (1996) A PET Study of Long-Term rCBF Changes during Cognition after Closed Head Injury Neurolmage 3 3 p S492

44 Van Hom lD Esposito G Weinberger DR Berman KF (1996) Volume-Based Multivariate Discriminant and Canonical Correlation Analysis of Neurophysiological Measures of Brain Function Neurolmage 3 3 p S103

45 Holt JL Van Hom JD Esposito G Ellmore T Weinberger DR Berman KF (1997) Mapping Neurophysiological Predictors of Good and Poor Performance on the Wisconsin Card Sorting Task Neuroimage 5 4 p S112

46 Bertolino A Esposito G Callicott JH Mat-tay VS Van Horn JD Frank JA Berman KF Weinberger FK (1997) IH-Magnetic Resonance Spectroscopic Imaging Correlates with rCBF Activation During Working Memory in Patients with Schizophrenia Neuroimage 54 p S281

47 Esposito G Van Hom ID Kirkby BS Weinberger DR Berman KF (1997) Functional Interactions between Dorsolateral Prefrontal Cortex and Other Brain Regions during Working Memory in Normal Subjects and Patients with Psychosis Neuroimage 54 p S284

48 Berman KF Holt J Callicott J Esposito G Van Hom JD Egan M Weinberger DR (1997) Neurophysiological Predictors of Clinical and Cognitive Changes over Time in Medication-Free Patients with Schizophrenia Individual Activation Maps Neuroimage 5 4 p S290

49 Van Hom ID EUmore T Esposito G Holt J Weinberger DR Berman KF (1997) Voxel-based Statistical Power in Functional Neuroimaging Studies Neuroimage 54pS464

50 Ye FQ Berman KF EUmore T Esposito G Van Hom JD Yang Y Duyn J Mattay VS Smith AM Frank JA Weinberger DR McLaughlin AC (1997) H2 1S0 PET Validation ofArterial Spin Tagg~ng CBF Measurements Neuroimage 54 p S533

r~ This is to acknowledge the receipt of YOuiletter~pPlication dated

elO dO 0 and to~you that the initial processing which includes an administrative review has been performed

[XJ TheJtmkl~~tJtve o9si~n~~pound~Ji2iqa~ IsSigned to a technical reviewer Please note that the technical review may identify additional omissions or require additional information

D Please provide to this office within 30 days of your receipt of this card

A copy of your action has been forwarded to our License Fee amp Accounts Receivable Branch who will contact you separately if there is a fee issue involved

Your action has been assigned Mail Control Number 5]31 (~ When calling to inquire about this action please refer to this control number You may call us on (610) 337-5398 or 337-5260

NRC FORM 532 (RI) Sincerely (6-96) licensing Assistance Team Leader

J~n 18 10 0954a Radiation Safet~ 202 444 0089 p 12

BrainPET

14 Esposito G~ Giovacchini G Der MG Vuong BK Channing MA Lerner A Hallett M Battacharjee A Herscovitch P Eckelman WC Rapoport SI Carson RE llC]Arachidonic acid PET activation experiments in human subjects A feasibility study using visual stimulation J Cereb Blood Flow Metab Vol 23 (Suppl 1)711 (2003)

Radiological Society oNorth America

15 Esposito G Chin BB Kraitchman DL Correlation ofmyocardial strain measurements by 3D-tagged MR imging with Tc-99m gated sestamibi SPEeT thickening in normal stunned and infarcted myocardium Radiology 1999 213 p207

SOCiety for Neuroscience

16 Berman KF Ostrem IL Van Hom JD Mattay VS Esposito G Weinberger DR (1993) A Comparison Between Normal Monozygotic and Dizygotic Twins Studied During Cognition with Positron Emission Tomography Society for Neuroscience Abstracts Vol 19 Part I p 792

17 Gourovitch ML Kirkby BS Gold JM Esposito G Van Hom JD Ostrem JL Golberg TE Weinberger DR Berman KF(l994) A comparison ofletter and category fluency Cerebral Activation with Positron Emission Tomography Society for Neuroscience Abstracts Volume 20 Part 1 p 6

18 Weinberger DR Ramsey NF Kirkby BS Van Gelderen P Berman KF Mattay VS Frank JA Van Hom JD Esposito G Moonen CTW (1995) ThreeshyDimensional BOLD fMRI and 0-15 water PET neuroactivation maps are highly correlated Society for Neuroscience bstracts Vol 21 Part 1 p 273

19 Esposito G Kirkby BS Van Horn JD Weinberger DR Berman KF (1995) Different pathophysiological mechanisms of altered Wisconsin Card Sort performance in schizophrenics and elderly normal subjects Society for Neuroscience Abstracts Vol 21 Part 1 p 747

20 Kirkby BS Van Hom JD Esposito G Golberg TE Weinberger DR Berman KF (1995) Long term changes in rCBF during cognition following severe closed head injury a PET study Society for Neuroscience Abstracts Vol 21 Part 3 p 1924

21 Van Hom JD Esposito G Kirkby BS Weinberger DR Berman KF (1995) Appraisal ofunivariate and multivariate analysis techniques for PET brain image quantification Society for Neuroscience Abstracts Vol 21 Part 2 p 1208

22 Esposito G Kirkby BS Van Hom JD Weinberger DR Berman KF (1996) PET Evaluation of cognitively related neur9physiological sequelae accompanying

Jun 16 10 0955a Radiation SaTet~ 202 444 0069 p 13

incidental findings of microvascular ischemic disease in the elderly preliminary results Society for Neuroscience Abstracts Vol 22 Part 1 p 676

23 Weinberger DR Santha A Mattay VS Frank J Kirkby BS Van Horn JD Esposito G Bennan KF (1996) Within subject neuroactivation mapping with whole brain isotropic BPI and 3-D PET a direct comparison Society for Neuroscience Abstracts Vol 22 Part 1 p 7

24 Golberg TE Fleming K Berman KF Van Horn 10 Esposito G Ostrem JL Gold JM Weinberger DR (1996) Neurophysiology ofdual task perfonnance a PET 015 study Society for Neuroscience Abstracts Vol 22 Part 2 p 967

25 Van Horn JD Austin-Lane JL Kirkby BS Esposito G Weinberger DR Berman KF (1996) Characterizing rCBF response in a PET study of graded working memory load Society for Neuroscience Abstracts Vol 22 Part 2 p 1113

26 El1more TM Van Horn JD Esposito G Kirkby BS Austin-Lane JL Weinberger DR Berman KF (1996) Signal averaging in cognitive and motor PET paradigms Society for Neuroscience Abstracts Vol 22 Part 3 p 1858

27 BeITI1an KF Sclunidt Pl Rubinow DR Esposito G Van Hom lD Austin-LaneJL Danaceau MA Weinberger DR (1996) Modulation of cognitively related cortical activity by gonadal steroid hormones directly demonstrated with PET Society for Neuroscience Abstracts Vol 22 Part 3 p 1861

28 Berman KF Holt J Callicott J Esposito G Van Horn JD Egan M Weinberger DR (1997) Relations among rCBF Clinical and Cognitive Changes over Time in Medication-Free Patients with Schizophrenia Individual PET Activation Maps Society for Neuroscience Abstracts 101 23 Part 2 p 1406

American Psychiatric Association

29 Van Horn JD Bennan KF Esposito G Ostrem JL Weinberger DR (1993) Is There Frontal Lobe Lateralization A PET Study Abstracts of the 146th Meeting of the American Psychiatric Association (New Reseach) p 68

30 Ostrem JL Kirkby BS Van Hom JD Esposito G Gold J Weinberger DR Berman KF(1994) Effects ofcohort size on PET activation studies Abstracts of the Annual Meeting of the American Psychiatric Association (Symposium 118) p 153

American Academy ofNeurology

31 BeITI1an KF Ostrem JL Mattay VS Bsposito G Van Hom JD Torrey EF Weinberger DR (1993) The role of the dorsolateral prefrontal cortex and the hippocampus in working memory PET studies of normal and abnormal states Abstracts of the 46th Annual Meeting of the American Academy of Neurology

Jun 16 10 0955a Radiation Safet~ 202 444 0069 p 14

Biological Psychiatry

32 Ostrem JL Bennan KF Mattay VS Van Hom JD Esposito G Weinberger DR (1994) The Neural Basis ofAbstract Reasoning An Inverstigation ofTwo Problem Solving Tasks with PET Biological Psychiatry 35(9)686

33 Bennan KF Ostrem JL Mattay VS Esposito G Van Hom JD Abi-Dargham A Torrey EF Weinberger DR (1994) The role of the dorsolateral prefrontal corteK and hippocampus in working memory and schizophrenia Biological Psychiatry 35(9)622

34 Van Hom lD Gold J Esposito G Ostrem JL Weinberger DR AND Belman KF (1994) The role ofthe frontal lobe during maze learning assessed using PET Biological Psychiatry 35(9)686

35 Esposito G Van Horn JD Ostrem JLMattay VS Weinberger DR Bennan KF The effect of sex age and pC02 on cerebral blood flow during cognitive stimulation Biological Psychiatry 35(9)648 1994

Society ofMagnetic Resonance

36 Ramsey NF Kirkby BS Van Gelderen P Belman KF Moonen CTW Mattay VS Frank lA Van Hom JD Esposito G Weinberger DR (1995) A direct comparison

of 3D BOLD tMRI and ISO-Water PET imaging ofprimary sensory motor cortex in humans III Meeting of the Society of Magnetic Resonance

Cerebral Blood Flow and Metabolism

37 Mattay VS Kotrla KJ Santha AKS Sexton RH Sunderland T Esposito G Duyn JR Moonen CTW Frank JA Weinberger DR (1995) 3D-BURST tMRI Initial clinical application in Alzheimer1s disease XVII International Symposium on Cerebral Blood Flow and Metabolism

38 Esposito G Kirkby BS Van Horn JD Ostrem JL Mattay VS Weinberger DR Belman KF (1995) Normal Aging is Assodated witb Task-Specific Neuropbysiological Changes PET rCBF Measurements During Cognitive Stimulation Journal ofCerebral Blood Flow and Metabolism 15 p S594

39 Berman KF Schmidt PJ Ostrem IL Danaceau MA Van Horn JD Esposito G Rubinow DR Weinberger DR (1995) The Effects of Gonadal Steroid Honnones on Cognitively-Related Regional Cerebral Blood Flow A Positron Emission Tomography Study Journal of Cerebral Blood Flow and Metabolism 15 p S133

Functional Mapping ofthe Human Brain

40 Berman KF Ostrem JL Esposito G Van Hom ID Mattay VS Kirkby BS Weinberger DR (1995) Heritability of Cognitively-Related Regional Cerebral

Jun 16 10 0956a Radiation Saret~ 202 444 0069 p 15

Blood Flow A PET Study Comparing Normal Monozygotic and Dizygotic Twins Neuroimage p 359

41 Esposito G Kirkby BS Van Hom JD Ostrc~m JL Weinberger DR Berman KF (1996) Impaired Wisconsin Card Sorting Test Performance in Nonnal Aging and in Schizophrenia PET Evidence ofDifferent Pathophysiological Mechanisms for a Common Cognitive Deficit Neurolmage 3 3 p S482

42 Bennan KF Schmidt PJ Rubinow DR Esposito G Van Hom JD Austin-Lane JL Weinberger DR (1996) The Effects cfGonadal Steroid Hormones on Cognitive Activation in Men and Women Studied with Positron Emission Tomography Neurolmage 3 3 p S475

43 Kirkby BS Van Hom JD Esposito G Golberg TE Weinberger DR Berman KF (1996) A PET Study of Long-Term rCBF Changes during Cognition after Closed Head Injury Neurolmage 3 3 p S492

44 Van Hom lD Esposito G Weinberger DR Berman KF (1996) Volume-Based Multivariate Discriminant and Canonical Correlation Analysis of Neurophysiological Measures of Brain Function Neurolmage 3 3 p S103

45 Holt JL Van Hom JD Esposito G Ellmore T Weinberger DR Berman KF (1997) Mapping Neurophysiological Predictors of Good and Poor Performance on the Wisconsin Card Sorting Task Neuroimage 5 4 p S112

46 Bertolino A Esposito G Callicott JH Mat-tay VS Van Horn JD Frank JA Berman KF Weinberger FK (1997) IH-Magnetic Resonance Spectroscopic Imaging Correlates with rCBF Activation During Working Memory in Patients with Schizophrenia Neuroimage 54 p S281

47 Esposito G Van Hom ID Kirkby BS Weinberger DR Berman KF (1997) Functional Interactions between Dorsolateral Prefrontal Cortex and Other Brain Regions during Working Memory in Normal Subjects and Patients with Psychosis Neuroimage 54 p S284

48 Berman KF Holt J Callicott J Esposito G Van Hom JD Egan M Weinberger DR (1997) Neurophysiological Predictors of Clinical and Cognitive Changes over Time in Medication-Free Patients with Schizophrenia Individual Activation Maps Neuroimage 5 4 p S290

49 Van Hom ID EUmore T Esposito G Holt J Weinberger DR Berman KF (1997) Voxel-based Statistical Power in Functional Neuroimaging Studies Neuroimage 54pS464

50 Ye FQ Berman KF EUmore T Esposito G Van Hom JD Yang Y Duyn J Mattay VS Smith AM Frank JA Weinberger DR McLaughlin AC (1997) H2 1S0 PET Validation ofArterial Spin Tagg~ng CBF Measurements Neuroimage 54 p S533

r~ This is to acknowledge the receipt of YOuiletter~pPlication dated

elO dO 0 and to~you that the initial processing which includes an administrative review has been performed

[XJ TheJtmkl~~tJtve o9si~n~~pound~Ji2iqa~ IsSigned to a technical reviewer Please note that the technical review may identify additional omissions or require additional information

D Please provide to this office within 30 days of your receipt of this card

A copy of your action has been forwarded to our License Fee amp Accounts Receivable Branch who will contact you separately if there is a fee issue involved

Your action has been assigned Mail Control Number 5]31 (~ When calling to inquire about this action please refer to this control number You may call us on (610) 337-5398 or 337-5260

NRC FORM 532 (RI) Sincerely (6-96) licensing Assistance Team Leader

Jun 16 10 0955a Radiation SaTet~ 202 444 0069 p 13

incidental findings of microvascular ischemic disease in the elderly preliminary results Society for Neuroscience Abstracts Vol 22 Part 1 p 676

23 Weinberger DR Santha A Mattay VS Frank J Kirkby BS Van Horn JD Esposito G Bennan KF (1996) Within subject neuroactivation mapping with whole brain isotropic BPI and 3-D PET a direct comparison Society for Neuroscience Abstracts Vol 22 Part 1 p 7

24 Golberg TE Fleming K Berman KF Van Horn 10 Esposito G Ostrem JL Gold JM Weinberger DR (1996) Neurophysiology ofdual task perfonnance a PET 015 study Society for Neuroscience Abstracts Vol 22 Part 2 p 967

25 Van Horn JD Austin-Lane JL Kirkby BS Esposito G Weinberger DR Berman KF (1996) Characterizing rCBF response in a PET study of graded working memory load Society for Neuroscience Abstracts Vol 22 Part 2 p 1113

26 El1more TM Van Horn JD Esposito G Kirkby BS Austin-Lane JL Weinberger DR Berman KF (1996) Signal averaging in cognitive and motor PET paradigms Society for Neuroscience Abstracts Vol 22 Part 3 p 1858

27 BeITI1an KF Sclunidt Pl Rubinow DR Esposito G Van Hom lD Austin-LaneJL Danaceau MA Weinberger DR (1996) Modulation of cognitively related cortical activity by gonadal steroid hormones directly demonstrated with PET Society for Neuroscience Abstracts Vol 22 Part 3 p 1861

28 Berman KF Holt J Callicott J Esposito G Van Horn JD Egan M Weinberger DR (1997) Relations among rCBF Clinical and Cognitive Changes over Time in Medication-Free Patients with Schizophrenia Individual PET Activation Maps Society for Neuroscience Abstracts 101 23 Part 2 p 1406

American Psychiatric Association

29 Van Horn JD Bennan KF Esposito G Ostrem JL Weinberger DR (1993) Is There Frontal Lobe Lateralization A PET Study Abstracts of the 146th Meeting of the American Psychiatric Association (New Reseach) p 68

30 Ostrem JL Kirkby BS Van Hom JD Esposito G Gold J Weinberger DR Berman KF(1994) Effects ofcohort size on PET activation studies Abstracts of the Annual Meeting of the American Psychiatric Association (Symposium 118) p 153

American Academy ofNeurology

31 BeITI1an KF Ostrem JL Mattay VS Bsposito G Van Hom JD Torrey EF Weinberger DR (1993) The role of the dorsolateral prefrontal cortex and the hippocampus in working memory PET studies of normal and abnormal states Abstracts of the 46th Annual Meeting of the American Academy of Neurology

Jun 16 10 0955a Radiation Safet~ 202 444 0069 p 14

Biological Psychiatry

32 Ostrem JL Bennan KF Mattay VS Van Hom JD Esposito G Weinberger DR (1994) The Neural Basis ofAbstract Reasoning An Inverstigation ofTwo Problem Solving Tasks with PET Biological Psychiatry 35(9)686

33 Bennan KF Ostrem JL Mattay VS Esposito G Van Hom JD Abi-Dargham A Torrey EF Weinberger DR (1994) The role of the dorsolateral prefrontal corteK and hippocampus in working memory and schizophrenia Biological Psychiatry 35(9)622

34 Van Hom lD Gold J Esposito G Ostrem JL Weinberger DR AND Belman KF (1994) The role ofthe frontal lobe during maze learning assessed using PET Biological Psychiatry 35(9)686

35 Esposito G Van Horn JD Ostrem JLMattay VS Weinberger DR Bennan KF The effect of sex age and pC02 on cerebral blood flow during cognitive stimulation Biological Psychiatry 35(9)648 1994

Society ofMagnetic Resonance

36 Ramsey NF Kirkby BS Van Gelderen P Belman KF Moonen CTW Mattay VS Frank lA Van Hom JD Esposito G Weinberger DR (1995) A direct comparison

of 3D BOLD tMRI and ISO-Water PET imaging ofprimary sensory motor cortex in humans III Meeting of the Society of Magnetic Resonance

Cerebral Blood Flow and Metabolism

37 Mattay VS Kotrla KJ Santha AKS Sexton RH Sunderland T Esposito G Duyn JR Moonen CTW Frank JA Weinberger DR (1995) 3D-BURST tMRI Initial clinical application in Alzheimer1s disease XVII International Symposium on Cerebral Blood Flow and Metabolism

38 Esposito G Kirkby BS Van Horn JD Ostrem JL Mattay VS Weinberger DR Belman KF (1995) Normal Aging is Assodated witb Task-Specific Neuropbysiological Changes PET rCBF Measurements During Cognitive Stimulation Journal ofCerebral Blood Flow and Metabolism 15 p S594

39 Berman KF Schmidt PJ Ostrem IL Danaceau MA Van Horn JD Esposito G Rubinow DR Weinberger DR (1995) The Effects of Gonadal Steroid Honnones on Cognitively-Related Regional Cerebral Blood Flow A Positron Emission Tomography Study Journal of Cerebral Blood Flow and Metabolism 15 p S133

Functional Mapping ofthe Human Brain

40 Berman KF Ostrem JL Esposito G Van Hom ID Mattay VS Kirkby BS Weinberger DR (1995) Heritability of Cognitively-Related Regional Cerebral

Jun 16 10 0956a Radiation Saret~ 202 444 0069 p 15

Blood Flow A PET Study Comparing Normal Monozygotic and Dizygotic Twins Neuroimage p 359

41 Esposito G Kirkby BS Van Hom JD Ostrc~m JL Weinberger DR Berman KF (1996) Impaired Wisconsin Card Sorting Test Performance in Nonnal Aging and in Schizophrenia PET Evidence ofDifferent Pathophysiological Mechanisms for a Common Cognitive Deficit Neurolmage 3 3 p S482

42 Bennan KF Schmidt PJ Rubinow DR Esposito G Van Hom JD Austin-Lane JL Weinberger DR (1996) The Effects cfGonadal Steroid Hormones on Cognitive Activation in Men and Women Studied with Positron Emission Tomography Neurolmage 3 3 p S475

43 Kirkby BS Van Hom JD Esposito G Golberg TE Weinberger DR Berman KF (1996) A PET Study of Long-Term rCBF Changes during Cognition after Closed Head Injury Neurolmage 3 3 p S492

44 Van Hom lD Esposito G Weinberger DR Berman KF (1996) Volume-Based Multivariate Discriminant and Canonical Correlation Analysis of Neurophysiological Measures of Brain Function Neurolmage 3 3 p S103

45 Holt JL Van Hom JD Esposito G Ellmore T Weinberger DR Berman KF (1997) Mapping Neurophysiological Predictors of Good and Poor Performance on the Wisconsin Card Sorting Task Neuroimage 5 4 p S112

46 Bertolino A Esposito G Callicott JH Mat-tay VS Van Horn JD Frank JA Berman KF Weinberger FK (1997) IH-Magnetic Resonance Spectroscopic Imaging Correlates with rCBF Activation During Working Memory in Patients with Schizophrenia Neuroimage 54 p S281

47 Esposito G Van Hom ID Kirkby BS Weinberger DR Berman KF (1997) Functional Interactions between Dorsolateral Prefrontal Cortex and Other Brain Regions during Working Memory in Normal Subjects and Patients with Psychosis Neuroimage 54 p S284

48 Berman KF Holt J Callicott J Esposito G Van Hom JD Egan M Weinberger DR (1997) Neurophysiological Predictors of Clinical and Cognitive Changes over Time in Medication-Free Patients with Schizophrenia Individual Activation Maps Neuroimage 5 4 p S290

49 Van Hom ID EUmore T Esposito G Holt J Weinberger DR Berman KF (1997) Voxel-based Statistical Power in Functional Neuroimaging Studies Neuroimage 54pS464

50 Ye FQ Berman KF EUmore T Esposito G Van Hom JD Yang Y Duyn J Mattay VS Smith AM Frank JA Weinberger DR McLaughlin AC (1997) H2 1S0 PET Validation ofArterial Spin Tagg~ng CBF Measurements Neuroimage 54 p S533

r~ This is to acknowledge the receipt of YOuiletter~pPlication dated

elO dO 0 and to~you that the initial processing which includes an administrative review has been performed

[XJ TheJtmkl~~tJtve o9si~n~~pound~Ji2iqa~ IsSigned to a technical reviewer Please note that the technical review may identify additional omissions or require additional information

D Please provide to this office within 30 days of your receipt of this card

A copy of your action has been forwarded to our License Fee amp Accounts Receivable Branch who will contact you separately if there is a fee issue involved

Your action has been assigned Mail Control Number 5]31 (~ When calling to inquire about this action please refer to this control number You may call us on (610) 337-5398 or 337-5260

NRC FORM 532 (RI) Sincerely (6-96) licensing Assistance Team Leader

Jun 16 10 0955a Radiation Safet~ 202 444 0069 p 14

Biological Psychiatry

32 Ostrem JL Bennan KF Mattay VS Van Hom JD Esposito G Weinberger DR (1994) The Neural Basis ofAbstract Reasoning An Inverstigation ofTwo Problem Solving Tasks with PET Biological Psychiatry 35(9)686

33 Bennan KF Ostrem JL Mattay VS Esposito G Van Hom JD Abi-Dargham A Torrey EF Weinberger DR (1994) The role of the dorsolateral prefrontal corteK and hippocampus in working memory and schizophrenia Biological Psychiatry 35(9)622

34 Van Hom lD Gold J Esposito G Ostrem JL Weinberger DR AND Belman KF (1994) The role ofthe frontal lobe during maze learning assessed using PET Biological Psychiatry 35(9)686

35 Esposito G Van Horn JD Ostrem JLMattay VS Weinberger DR Bennan KF The effect of sex age and pC02 on cerebral blood flow during cognitive stimulation Biological Psychiatry 35(9)648 1994

Society ofMagnetic Resonance

36 Ramsey NF Kirkby BS Van Gelderen P Belman KF Moonen CTW Mattay VS Frank lA Van Hom JD Esposito G Weinberger DR (1995) A direct comparison

of 3D BOLD tMRI and ISO-Water PET imaging ofprimary sensory motor cortex in humans III Meeting of the Society of Magnetic Resonance

Cerebral Blood Flow and Metabolism

37 Mattay VS Kotrla KJ Santha AKS Sexton RH Sunderland T Esposito G Duyn JR Moonen CTW Frank JA Weinberger DR (1995) 3D-BURST tMRI Initial clinical application in Alzheimer1s disease XVII International Symposium on Cerebral Blood Flow and Metabolism

38 Esposito G Kirkby BS Van Horn JD Ostrem JL Mattay VS Weinberger DR Belman KF (1995) Normal Aging is Assodated witb Task-Specific Neuropbysiological Changes PET rCBF Measurements During Cognitive Stimulation Journal ofCerebral Blood Flow and Metabolism 15 p S594

39 Berman KF Schmidt PJ Ostrem IL Danaceau MA Van Horn JD Esposito G Rubinow DR Weinberger DR (1995) The Effects of Gonadal Steroid Honnones on Cognitively-Related Regional Cerebral Blood Flow A Positron Emission Tomography Study Journal of Cerebral Blood Flow and Metabolism 15 p S133

Functional Mapping ofthe Human Brain

40 Berman KF Ostrem JL Esposito G Van Hom ID Mattay VS Kirkby BS Weinberger DR (1995) Heritability of Cognitively-Related Regional Cerebral

Jun 16 10 0956a Radiation Saret~ 202 444 0069 p 15

Blood Flow A PET Study Comparing Normal Monozygotic and Dizygotic Twins Neuroimage p 359

41 Esposito G Kirkby BS Van Hom JD Ostrc~m JL Weinberger DR Berman KF (1996) Impaired Wisconsin Card Sorting Test Performance in Nonnal Aging and in Schizophrenia PET Evidence ofDifferent Pathophysiological Mechanisms for a Common Cognitive Deficit Neurolmage 3 3 p S482

42 Bennan KF Schmidt PJ Rubinow DR Esposito G Van Hom JD Austin-Lane JL Weinberger DR (1996) The Effects cfGonadal Steroid Hormones on Cognitive Activation in Men and Women Studied with Positron Emission Tomography Neurolmage 3 3 p S475

43 Kirkby BS Van Hom JD Esposito G Golberg TE Weinberger DR Berman KF (1996) A PET Study of Long-Term rCBF Changes during Cognition after Closed Head Injury Neurolmage 3 3 p S492

44 Van Hom lD Esposito G Weinberger DR Berman KF (1996) Volume-Based Multivariate Discriminant and Canonical Correlation Analysis of Neurophysiological Measures of Brain Function Neurolmage 3 3 p S103

45 Holt JL Van Hom JD Esposito G Ellmore T Weinberger DR Berman KF (1997) Mapping Neurophysiological Predictors of Good and Poor Performance on the Wisconsin Card Sorting Task Neuroimage 5 4 p S112

46 Bertolino A Esposito G Callicott JH Mat-tay VS Van Horn JD Frank JA Berman KF Weinberger FK (1997) IH-Magnetic Resonance Spectroscopic Imaging Correlates with rCBF Activation During Working Memory in Patients with Schizophrenia Neuroimage 54 p S281

47 Esposito G Van Hom ID Kirkby BS Weinberger DR Berman KF (1997) Functional Interactions between Dorsolateral Prefrontal Cortex and Other Brain Regions during Working Memory in Normal Subjects and Patients with Psychosis Neuroimage 54 p S284

48 Berman KF Holt J Callicott J Esposito G Van Hom JD Egan M Weinberger DR (1997) Neurophysiological Predictors of Clinical and Cognitive Changes over Time in Medication-Free Patients with Schizophrenia Individual Activation Maps Neuroimage 5 4 p S290

49 Van Hom ID EUmore T Esposito G Holt J Weinberger DR Berman KF (1997) Voxel-based Statistical Power in Functional Neuroimaging Studies Neuroimage 54pS464

50 Ye FQ Berman KF EUmore T Esposito G Van Hom JD Yang Y Duyn J Mattay VS Smith AM Frank JA Weinberger DR McLaughlin AC (1997) H2 1S0 PET Validation ofArterial Spin Tagg~ng CBF Measurements Neuroimage 54 p S533

r~ This is to acknowledge the receipt of YOuiletter~pPlication dated

elO dO 0 and to~you that the initial processing which includes an administrative review has been performed

[XJ TheJtmkl~~tJtve o9si~n~~pound~Ji2iqa~ IsSigned to a technical reviewer Please note that the technical review may identify additional omissions or require additional information

D Please provide to this office within 30 days of your receipt of this card

A copy of your action has been forwarded to our License Fee amp Accounts Receivable Branch who will contact you separately if there is a fee issue involved

Your action has been assigned Mail Control Number 5]31 (~ When calling to inquire about this action please refer to this control number You may call us on (610) 337-5398 or 337-5260

NRC FORM 532 (RI) Sincerely (6-96) licensing Assistance Team Leader

Jun 16 10 0956a Radiation Saret~ 202 444 0069 p 15

Blood Flow A PET Study Comparing Normal Monozygotic and Dizygotic Twins Neuroimage p 359

41 Esposito G Kirkby BS Van Hom JD Ostrc~m JL Weinberger DR Berman KF (1996) Impaired Wisconsin Card Sorting Test Performance in Nonnal Aging and in Schizophrenia PET Evidence ofDifferent Pathophysiological Mechanisms for a Common Cognitive Deficit Neurolmage 3 3 p S482

42 Bennan KF Schmidt PJ Rubinow DR Esposito G Van Hom JD Austin-Lane JL Weinberger DR (1996) The Effects cfGonadal Steroid Hormones on Cognitive Activation in Men and Women Studied with Positron Emission Tomography Neurolmage 3 3 p S475

43 Kirkby BS Van Hom JD Esposito G Golberg TE Weinberger DR Berman KF (1996) A PET Study of Long-Term rCBF Changes during Cognition after Closed Head Injury Neurolmage 3 3 p S492

44 Van Hom lD Esposito G Weinberger DR Berman KF (1996) Volume-Based Multivariate Discriminant and Canonical Correlation Analysis of Neurophysiological Measures of Brain Function Neurolmage 3 3 p S103

45 Holt JL Van Hom JD Esposito G Ellmore T Weinberger DR Berman KF (1997) Mapping Neurophysiological Predictors of Good and Poor Performance on the Wisconsin Card Sorting Task Neuroimage 5 4 p S112

46 Bertolino A Esposito G Callicott JH Mat-tay VS Van Horn JD Frank JA Berman KF Weinberger FK (1997) IH-Magnetic Resonance Spectroscopic Imaging Correlates with rCBF Activation During Working Memory in Patients with Schizophrenia Neuroimage 54 p S281

47 Esposito G Van Hom ID Kirkby BS Weinberger DR Berman KF (1997) Functional Interactions between Dorsolateral Prefrontal Cortex and Other Brain Regions during Working Memory in Normal Subjects and Patients with Psychosis Neuroimage 54 p S284

48 Berman KF Holt J Callicott J Esposito G Van Hom JD Egan M Weinberger DR (1997) Neurophysiological Predictors of Clinical and Cognitive Changes over Time in Medication-Free Patients with Schizophrenia Individual Activation Maps Neuroimage 5 4 p S290

49 Van Hom ID EUmore T Esposito G Holt J Weinberger DR Berman KF (1997) Voxel-based Statistical Power in Functional Neuroimaging Studies Neuroimage 54pS464

50 Ye FQ Berman KF EUmore T Esposito G Van Hom JD Yang Y Duyn J Mattay VS Smith AM Frank JA Weinberger DR McLaughlin AC (1997) H2 1S0 PET Validation ofArterial Spin Tagg~ng CBF Measurements Neuroimage 54 p S533

r~ This is to acknowledge the receipt of YOuiletter~pPlication dated

elO dO 0 and to~you that the initial processing which includes an administrative review has been performed

[XJ TheJtmkl~~tJtve o9si~n~~pound~Ji2iqa~ IsSigned to a technical reviewer Please note that the technical review may identify additional omissions or require additional information

D Please provide to this office within 30 days of your receipt of this card

A copy of your action has been forwarded to our License Fee amp Accounts Receivable Branch who will contact you separately if there is a fee issue involved

Your action has been assigned Mail Control Number 5]31 (~ When calling to inquire about this action please refer to this control number You may call us on (610) 337-5398 or 337-5260

NRC FORM 532 (RI) Sincerely (6-96) licensing Assistance Team Leader

r~ This is to acknowledge the receipt of YOuiletter~pPlication dated

elO dO 0 and to~you that the initial processing which includes an administrative review has been performed

[XJ TheJtmkl~~tJtve o9si~n~~pound~Ji2iqa~ IsSigned to a technical reviewer Please note that the technical review may identify additional omissions or require additional information

D Please provide to this office within 30 days of your receipt of this card

A copy of your action has been forwarded to our License Fee amp Accounts Receivable Branch who will contact you separately if there is a fee issue involved

Your action has been assigned Mail Control Number 5]31 (~ When calling to inquire about this action please refer to this control number You may call us on (610) 337-5398 or 337-5260

NRC FORM 532 (RI) Sincerely (6-96) licensing Assistance Team Leader