medicated chewing gum

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  • Ministry of Health Care of UkraineSHEI Ivano-Frankivsk National Medical University The Chair of Organization and Economics in Pharmacy and Drug TechnologyMedicated chewing gum, a novel drug delivery systemPrepared by: Anyadiegwu EbukaScientific coordinator: A. Sinichenko assistant the Chair of OEPh and Drug Technology

  • Relevance: oral route of application of medications is the most preferred among patients and doctors through several advantages, including the most important is its simplicity, besides it can provide a faster onset of action. These dosage forms deliver the drug to the target through a local or systemic delivery of the drug in the mouth. For the drugs having significant buccal absorption, dosage forms such as chewable tablets and chewing gums permit more rapid therapeutic action as compared to per-oral dosage forms. Besides chewable tablets and chewing gums have been very well received by the parents for their use in children with full dentition. The purpose of the work: to characterize medicated chewing gum (MCG) like drug delivery system, to research perspectives of application and developing drugs in a forms of chewing gum, place and value of MCG at the pharmaceutical market.

  • Medicated chewing gum- it is solid dosing medicinal form like a pillow or plates with a base consisting mainly of gum, which is intended for chewing. It contains one or more active substances that are released during chewing by providing local or systemic action after absorption through the buccal mucosa and gastrointestinal tract.

  • Chewing gum has several advantages:1. Increased rate of effectiveness rather than other oral delivery systems.2. Removal of gum at any time.3. Reduced risk of overdosing while it's whole swallowed.4. Requiring no water to drink.5. Protection of the susceptible drugs contained from chemical or enzymatic attack in gastrointestinal tract.6. Both systemic and local drug delivery.7. High acceptance by children and teenagers.8. Good for rapid delivery.9. Fewer side effects.10. Good stability.11. Possibility of prolonging the release of active substances.12. Drugs come to the gastrointestinal tract in dissolved or suspended form in the saliva, in bioavailable form.13. Reduced hypoglycemic shocks in people taking anti-diabetic drugs.14. Stimulating alertness through increased blood flow to brain.15. Help reduce food cravings.

  • By aim of application chewing gums divided for:Dental caries Systemic therapy:

    Therapeutic useDrugTreatment of motion sicknessDimenhydrinate hydrochloride,Diphenhydramine hydrochloride,GingerSmoking cessationNicotinePain relieverAspirin, lobeline, silver acetateAnti-plaque, and gingivitis, preventing of dental caries an tooth decayXylitol, chlorhexidineOral antifungalMiconazoleTreatment of otitis mediaXylitolAlertness and CNS stimulantCaffeineAntioxidantGreen teaAnti-nausea and anti-emetic, effective in GI problemsGinger

  • At this slide present the percentage of people who chew gum by country:

    1

    0.82

    0.79

    0.59

    0.54

    0.52

    0.5

    0.49

    0.44

    0.43

    0.18

    0.16

    3

    1

    312

    Iran82%

    Saudi Arabia79%

    USA59%

    Spain54%

    France52%

    Poland50%

    Hungary49%

    Great Britain44%

    South Africa43%

    Malaysia18%

    Thailand16%

  • Countries manufacturers of medical chewing gum

    1

    17.3

    9.3

    8

    8

    5.3

    5.3

    4

    4

    4

    34.8

    1

    1

    1

    USA17.3

    UK9.3

    Germany8

    Switzerland8

    Australia5.3

    Norway5.3

    Belgium4

    Spain4

    Denmark4

    Other34.8

  • Medical chewing gum by the application

    1

    0.7

    0.3

    1

    1

    1

    Dental gums70%

    Gums for systemic therapy30%

  • Composition of MCG include:Gum baseElastomersPlasticizersAdjuvantsAntioxidantsSweeteners Coloring agentsFlavoring Agents

  • Gum base 15-30%The particles of active ingredients should be less than 100 micronsThe active substance can be a part of nuclei and shell

  • Manufacturing process of MCG include next stages:Softening or melting components of gum base Administration of sweeteners and syrups, active ingredients and other excipientsThe gum is then sent through a series of rollers that forms into a thin wide ribbon. Tow of gum is cut into equal parts and transfer into a room with controlled temperature.The resulting gum for a few days ready to a coating shell .

  • Quality control for MCG conduct by the next indicators:Dissolution testMicrobiological purityUniformity of contentUniformity of massUniformity of dosing units

  • CONCLUSIONSResearch of pharmaceutical market showed that currently chewing gum is quite common in the population but medicated chewing gum has not found significant distribution due to its small nomenclature. According to the results of research among presented at pharmaceutical market MCG is dominated dental due to their wide range.So considering all advantages of these medical form actual questions of modern medicine and pharmacy is to develop medicines in the form of MCG, with the purpose to expand nomenclature as this medicinal form is an alternative for patients who have difficulty swallowing exercise, or for children who are not able to swallow the medicine.

  • THANKS FOR YOUR ATTENTION!Prepared by: Anyadiegwu Ebuka Scientific coordinator: A. Sinichenko Ministry of Health Care of UkraineSHEI Ivano-Frankivsk National Medical University The Chair of Organization and Economics in Pharmacy and Drug Technology