FINAL EXAMDECEMBER 2011

NATIONAL BOARD OF EXAMINATIONS

MEDICAL ONCOLOGY

PAPER. ITime : 3 hours MED. ONCO/D/1111711Max. Marks : 100Attempt all questions in order.Each question carries 10 marks.

1. Discuss briefly the molecular biology of non small cell lung 5+5cancer. How does the knowledge of various histological subtypesassists in management?

2. Discuss role of monoclonal antibodies in the treatment of 5+5Hodgkin's and non-Hodgkin's lymphoma.

3. Describe briefly the pharmacology of immuno-suppressive drugs 10as applied to allogenic bone marrow / stem celltransplantation.

4. Discuss briefly the principles of newer techniques for radiation 5+5with reference to IMRT and Cyber knife.

5. How does 'PET Scan' compare with 'CT Scan' in the evaluation 5+5of a new case of Hodgkin's lymphoma? Briefly describe itsimpact on the outcome.

6. What are 'T-Regulatory cells'? Describe briefly the role of 'T- 5+5Regulatory cells' in the pathophysiology bf cancer.

7. Define bone marrow micro-environment. Briefly discuss role of 3+7newer molecules in the treatment of 'Mantle cell' lymphoma.

8. Discuss briefly the molecular biology of head and neck cancer. 5+5How this information is being used in the management atpresent?

L Discuss impact of various prognostic factors on outcome of 10chronic lymphocytic leukemia.

10. Discuss briefly the mechanism of late effects of anticancer 10treatment (with special reference to radiation).

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FINAL EXAM NATIONAL BOARD OF EXAMINATIONSDECEMBER 2011

MEDICAL ONCOLOGY

PAPER. I ITime : 3 hours MED. ONCO lDl11l17lllMax. Marks : 100Attempt all questions in order.Each question carries 10 marks

1. Give plan of management for a newly diagnosed case of multiple 5+5myeloma in a 43 years old lady. How will you prognosticate her?

2. A 50 years old lady has been diagnosed to have metastatic 10adenocarcinoma. Discuss plan of investigations,with rationale todetermine the primary site.

3. Discuss the role of 'Life style' as a contributing factor for cancer. 6+4lllustrate this with example of colon cancer.

4. Discuss staging of 'Prostate cancer' and its implications on the 5+5management.

5. Qutline investigations with rationale for a 10 years old child with 10acute lymphoblastic leukemia who has re,lapsed after 1 year.

6. Discuss pathology of breast cancer in. young age. How this 6+4information helps in planning treatment.

7. What are common childhood tumours? How do they differ from 4+4+2those in adults? What are the adverse prognostic factors fortreatment failure in neuroblastoma?

8. Discuss approach to diagnosis and management of a 67 year old 10lady with history of weight loss of 10 kg in past 3 months; CTscan shows 4X3 cm mass in tail of pancreas and a singlehypodense lesion in left lobe of liver.

9. Define various scales used to assess 'Performance status'. How 6+4will you apply this knowledge in planning treatment of a 70 yearsold person with lung cancer?

10. What are the differences between a 'Hospital based' versus 4+6'Population based' cancer Registry? How will you plan to studyjncidence of 'Stomach cancer' in Chennai city?

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POSSESSIONruSE OF CELL PHONES OR ANY SACH ELECTRONIC GADGETS IS NOT PERMITTED INSIDETTIE EXAMINATION HALL

FINAL EXAMDECEMBER 2011

PAPER. IIITime :3 hoursMax. Marks : 100Attempt all questions in order.Each question carries 10 marks.

1. Discuss epidemiology and trends of fiveIndia.

NATIONAL BOARD OF EXAMINATIONS

MED. ONCO tDI11t17t/,,l

common cancers in 1 0

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Discuss irnpact of age on cancer chemotherapy planning.

Discuss management of muscle invasive urinary bladder cancgrin a 60 years old male.

Discuss briefly various steps involved in planning a clinical trial.lllustrate this with an example of recurrent ovarian cancer orcervix cancer.

How does pathology of endometrial cancer differ in young andold age? How will you treat high risk stage I endometrial cancer?

Discuss management of recurrent testicular germ cell tumours.

Briefly discuss issues involved in the palliative management ofadvanced gall bladder cancer with liver metastasis.

A three years child has been diagnosed to have left orbital mass.Discuss the differentialdiagnosis and outline the management.

Describe role of chemotherapy and newer agents in thetreatment of malignant brain tumours.

Discuss briefly role of 'Epigenetics' in cancer. lllustrate this withexample of myelodysplastic syndrome'.

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POSSESSION/USE OF CELL PHONES OR ANY SACH ELECTRANIC GADGETS IS NOT PERMITTED INSIDETHE EXAMINATION HALL