media information 2014 - hpci media€¦ · rates and data magazine advertising rates single...

A PERSON OFCALIBREDr Graham Rideal reveals how he built abusiness based on being consistent 22

IMPROVE GLOBAL SAFETY REPORTINGHow to give global partnerships clarity in

managing pharmacovigilance 24

BETTER PROTEINPREDICTIONS

New tool detects and quantifiesaggregations and impurities 29

SPECIAL REPORT:PERSONALISED MEDICINE

Pharma development Formulation Processing Outsourcing July/August 2013 Volume 84 Number 7/8

MEDIA INFORMATION 2014








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The pharmaceutical manufacturing sector is remarkable notonly for its complexity but also for the speed at which itchanges – both in terms of technological innovation and thedynamic of the market.

The format of Manufacturing Chemist allows us to bring youup–to-the-minute developments as well as in-depth technicalarticles, market analysis and the views and insights of thosewho are shaping the industry on a daily basis.

The experienced editorial team brings you the news as ithappens through the constantly updated website, with amonthly digest of the top stories in print, covering researchand development, business, drugs, process technology,packaging, laboratory equipment and regulatory affairs. Eachissue contains technical articles that pick out the emergingtrends and developing technologies across all areas of thepharma supply chain.

Every issue includes an Interview feature, where top industryfigures have the chance to put industry events in context,discuss current challenges and opportunities and express theirhopes and fears concerning what the future may hold for theircompanies and the sector as a whole.

Each month there is a Focus on Pharma special marketreport. Over the course of the year this looks in detail atingredients, packaging, drug discovery, process technology,high potency and sterility, clinical trials, personalisedmedicine, drug delivery, outsourcing, biotechnology andQA/QC.

This discrete section of the publication includes an overview ofthe market and its trends, articles on technical innovations,and new product stories. With its own front cover andcontents, Focus on Pharma forms a pull-out library of valuableinformation.

However, because the industry is changing at such a rapidpace, every issue of Manufacturing Chemist also brings youfeatures on the latest technical developments as they occur toensure that your knowledge base is constantly kept up-to-dateacross all sectors of the industry.

In combination with the Focus on Pharma section, this pipelineof new product and technology articles enables us to give youthe best of both worlds: a focused view of the major marketsectors as well as details of the latest developments as theyhappen.

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APPROVED NCENUMBERS RISEWhile numbers of new entities bounceback, the targets remain niche vii

BUILDING FORDISCOVERY

With its modern facility in Pune (above), SAIlooks at outsourcing services in India xiii

SOFTWARE FORSMARTER R&D

Software has evolved to speed discoveryR&D without losing flexibility xvi

SPECIAL REPORT:DRUG DISCOVERY

SAI Life Sciences | Discovery Unit - Pune, India

You may be thinking ‘discovery’Let’s talk about ‘discoveries’

March 2013

manufacturingchemist.com

CONTACT [email protected] T +44 (0)20 7193 1279

2014 EDITORIAL FEATURES

JANUARYBusiness news, laboratory equipment, pharma packaging, drug delivery, R&D,process technology, manufacturing equipment, vaccines, anticounterfeiting,contract services, clinical trials, legislation and regulatory affairsFocus on Pharma: INGREDIENTSRaw materials, intermediates, excipients, taste-masking, coatings, catalysts,APIs, colourings, enzymes, disintegrants, binders, fillers, compression agents,ligands, peptidesShows: Informex USA 21-24 January

FEBRUARYBusiness news, laboratory equipment, pharma packaging, drug delivery, R&D,process technology, manufacturing equipment, vaccines, anticounterfeiting,contract services, clinical trials, legislation and regulatory affairsFocus on Pharma: HIGH POTENCY AND STERILE FORMULATIONSContainment, particle monitoring, detection & identification, isolators &gloveboxes, fume cupboards, garments & consumables, aseptic and sterilefilling, blow/fill/seal, CIP/SIP systems, decontamination technology, handlingof highly potent materialsShows: Pharmapack 12-13 Feb, HPAPI World Congress 26-27 February

MARCHBusiness news, laboratory equipment, pharma packaging, drug delivery, R&D,process technology, manufacturing equipment, vaccines, anticounterfeiting,contract services, clinical trials, legislation and regulatory affairsFocus on Pharma: PROCESS TECHNOLOGY AND EQUIPMENTAutomation and control systems, mixing and blending, pumps and valves, drying,granulation, lyophilisation, extrusion, milling, sieving, materials handling andtransfer, reactors, tanks and vesselsShows: Interphex 18-20 March

APRILBusiness news, laboratory equipment, pharma packaging, drug delivery, R&D,process technology, manufacturing equipment, vaccines, anticounterfeiting,contract services, clinical trials, legislation and regulatory affairsFocus on Pharma: DRUG DISCOVERYNew chemical entities, proteomics, genomics, pharmacokinetics, geneexpression, chiral chemistry, high throughput screening, libraries, assays,bioavailability, purification, chromatography, spectroscopy, conjugation, protein engineering, knock-out genes, gene silencing, gene shuffling, laboratory equipmentShows: Pharma Pro & Pack Exhibition 24-26 April, ExcipientFest 28-30 April

MAYBusiness news, laboratory equipment, pharma packaging, drug delivery, R&D,process technology, manufacturing equipment, vaccines, anticounterfeiting,contract services, clinical trials, legislation and regulatory affairsFocus on Pharma: PHARMACEUTICAL PACKAGINGContainers, closures, materials, labels, track and trace, anticounterfeiting,tamper-evidence, child-resistance, syringes, cartons, inspection systems,machinery and equipmentShows: Interpack 8-14 May, 3C/Medtech 14-15 May

JUNEBusiness news, laboratory equipment, pharma packaging, drug delivery, R&D,process technology, manufacturing equipment, vaccines, anticounterfeiting,contract services, clinical trials, legislation and regulatory affairsFocus on Pharma: PERSONALISED MEDICINEGenomics, regenerative medicine, stem cells, biomarkers, diagnostics,radiolabelling, SNPs, genetic engineering, molecular chemistry, cell therapy,epigeneticsShows: Chemspec Europe 18-19 June, CPhI China 26-28 June

JULY/AUGUSTBusiness news, laboratory equipment, pharma packaging, drug delivery, R&D,process technology, manufacturing equipment, vaccines, anticounterfeiting,contract services, clinical trials, legislation and regulatory affairsFocus on Pharma: CLINICAL TRIALSSmall batch manufacturing, recruitment, packaging, data handling/informatics,trial management, preclinical studies, in silico, in vitro and in vivo studies,pharmacovigilance, legislationShows: CPhI South America 5-7 August

SEPTEMBERBusiness news, laboratory equipment, pharma packaging, drug delivery, R&D,process technology, manufacturing equipment, vaccines, anticounterfeiting,contract services, clinical trials, legislation and regulatory affairsFocus on Pharma: DRUG DELIVERYInhalers, syringes, tablets, capsules, injectables, parenterals, soluble films,extended release formulations, chewing gum, transdermal patches, medicaldevices, nanotechnology, vaccines, containers and closuresShows: Technopharm 30 September - 2 October, PPMA 30 September - 2 October

OCTOBERBusiness news, laboratory equipment, pharma packaging, drug delivery, R&D,process technology, manufacturing equipment, vaccines, anticounterfeiting,contract services, clinical trials, legislation and regulatory affairsFocus on Pharma: OUTSOURCINGContract research, contract manufacturing, contract process development,analytical services, consultancy, facility design and build, custom synthesis,contract packing, contract clinical trial services, logistics, waste managementShows: CPhI Worldwide 7-9 October

NOVEMBERBusiness news, laboratory equipment, pharma packaging, drug delivery, R&D,process technology, manufacturing equipment, vaccines, anticounterfeiting,contract services, clinical trials, legislation and regulatory affairsFocus on Pharma: QUALITY ASSURANCEValidation, calibration, measurement, testing and analytical equipment, weighingequipment, sampling, vision systems, metal detection, microbiological testing,leak testing, tablet counting, anticounterfeiting, batch identification, particlesizing, stability studiesShows: PharmaExpo 2-5 November, PharmaTech Moscow 25-28November

DECEMBERBusiness news, laboratory equipment, pharma packaging, drug delivery, R&D,process technology, manufacturing equipment, vaccines, anticounterfeiting,contract services, clinical trials, legislation and regulatory affairsFocus on Pharma: BIOTECHNOLOGYFermentation, culture media, microbiology, mAbs, cell culture, biocatalysis,biosensors, purification, bioreactors, peptides, vaccines

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CIRCULATION AND READERSHIPManufacturing Chemist is circulated to 7,816 managers, scientists, engineers working for the world’s leading companies involvedin manufacturing and marketing the world’s top selling biopharma and pharmaceutical prescription, generic and over-the-countermedicines.

Abbott Laboratories, Alexion, Allergen, Astellas, AstraZeneca, Amgen, Bayer Schering, Baxter BioScience, Biogen Idec, Boehringer-Ingelheim, Bristol Myers Squibb, CSL Ltd, Daiichi-Sankyo, Dendreon, EISAI, Eli Lilly & Co, Gilead Sciences, GlaxoSmithKline,Johnson & Johnson, Merck & Co, Merck Serono, Mylan, Novartis, Novo Nordisk, Otsuka Pharmaceutical, Pfizer, Roche, Sanofi,Takeda Pharma, Teva, Vertex

Geographical profile Primary Job function profile

Extra distributionIn addition Manufacturing Chemist and Focus on Pharma will be distributed at Informex USA; Pharmapack; Interphex;Tecnopharm; 3C/Medtech; Pharmtech; Chemspec; CPhI

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Americas 26%

Asia 16%

ROW 2%

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Prime positions deliver anunbeatable package thatincludes a cover position andreserves a double page spreaddedicated to communicating yourkey messages to ManufacturingChemist subscribers.

Hygienic processing places high demands onthe reliability and cleanability of productionfacilities. Common challenges such ascorrosion in pipe systems, valve manifoldsand tank installations in differentpharmaceutical, chemical and biotechfacilities for example can be reduced, therebyreducing costs and improving plantavailability - by using multiport valves andmultiport-based manifolds. Multi-portsolutions such as the Robolux valve weredeveloped with exactly this type of high-purityinstallation in mind.

REDUCED INSTALLATION SPACE

The stand-out feature of the patentedRobolux valve design is that two independentprocess switching functions can be achievedwith one membrane. This reduces theinstallation space requirement, eliminates T-adapters and minimises the overall number ofvalves and membranes required. The multi-port membrane valves were designed forhigh-purity installations and make it possibleto design complex systems that areconsiderably more compact than those usingconventional fluid control valves.The design is also intended to minimise theinternal volume and produce no dead flowzones, which results in a number ofadvantages: In addition to improved flow andevacuation properties, both cleaning andchangeover of the interfaces for themanufacture of other products is easier andfaster, with less wastage of expensivechemicals and ingredients.This technology makes it possible to replacetwo traditional shut-off diaphragm valves andat the same time eliminate all dead legs andone tee-piece with one single valve. Whencombined with reduced installation andcommissioning costs, the Robolux valvedelivers a number of crucial advantages toprocess control within hygienic applications.

UNIQUE TESTING ABILITY

Bürkert is able to test cleaning cycles andprovide 100% reliability on the flow propertiesand cleanability of the complete valve byusing a riboflavin test rig. As part of a factoryacceptance test, Bürkert is currently the onlymanufacturer of fittings and valve interfacesin the world that owns and operates such atest rig. In hygienic applications where CIP /SIP are operated, it is essential to be able toensure the cleaning cycle is both effectiveand efficient; a criterion which can be

completely fulfilled and demonstrated byBürkert.

INTELLIGENT FIELD DEVICE

As part of the concept to decentralise valvecontrol systems, the Robolux valve can nowbe combined with Bürkert's ELEMENT controlhead to provide a complete process solutionwhich is compatible with the entire valveproduct range. The valves at field level can beequipped with all the required automationcomponents including pilot valves, electricalfeedback units and optical status indicators.By integrating an AS interface as a field businterface, the entire range of advantages ofthis approach can be fully utilised. All that isrequired for power supply, feedback andcommunication is a two-wire line connectingthe PLC with up to 62 valves.

DECENTRALISED CONTROL

The new decentralized automation conceptcan provide a viable and extremely compactalternative to the use of central switchingcabinets by integrating all the requiredautomation functions in the control headsthemselves. This provides considerablesavings in installation costs and also providescommissioning and maintenance engineerswith an instant indication of the status ofeach valve, which reduces the amount of timerequired for installation and trouble-shooting.

OPERATIONAL FEEDBACK

Using the control head as a central unit forthe control of the hygienic process valves,enables it to perform all pneumatic actuation,feedback and diagnostic functions, as well asbus communication. A three-colour opticalstatus display with high-power LEDs, which isintegrated in the control head, provides for avisual overview of the valve status at the fieldlevel. In addition to electrical feedback to themaster controller, it also signals the currentswitching position of the process valve,facilitating diagnosis and maintenance withinthe system itself.Due to the compatibility of the IP67ELEMENT control head with a wide range ofprocess control valves from Bürkert and manyother manufacturers, greater plantstandardisation can be achieved by equippingprocess system with components from theELEMENT platform.

NEW INTELLIGENTVALVE FROM BÜRKERTREDUCES PIPEWORKBY SWITCHINGMULTIPLE FLOWSThe ideal valve for use in a hygienic processing environment is easy to cleanusing CIP, contains a low internal volume and a minimum number of connectionsas well as offer super precise flow control abilities. These exact criteria were used to design the revolutionary Robolux valve fromBürkert, which, now compatible with its ELEMENT control heads offers a costsaving, space saving, intelligent field device which is ideally suited for use inpharmaceutical, chemical, food and beverage processing applications.

CONTACT

BÜRKERTFluid Control Centre, 1 Bridge End,Cirencester, Gloucestershire, GL7 1QY,United Kingdom T: +44 (0)1285 648720E: [email protected]: +44 (0)1285 648721W: www.burkert.co.uk

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Google analytics report that 360,896 unique people visited Manufacturing Chemist online. Visitors includeprofessionals working for the leading companies involved manufacturing and marketing the world’s top-sellingbiopharma and pharmaceutical products.

Abbott Laboratories, Alexion, Allergen, Astellas,AstraZeneca, Amgen, Bayer Schering, BaxterBioScience, Biogen Idec, Boehringer-Ingelheim,Bristol Myers Squibb, CSL Ltd, Daiichi-Sankyo,Dendreon, EISAI, Eli Lilly & Co, Gilead Sciences,GlaxoSmithKline, Johnson & Johnson, Merck & Co, Merck Serono, Mylan, Novartis,Novo Nordisk, Otsuka Pharmaceutical, Pfizer,Roche, Sanofi, Takeda Pharma, Teva, Vertex.

Visitors were involved in research and development, drug discovery, formulation, analytics, production, containmentand sterility, quality assurance/quality control, regulatory affairs and procurement and were responsible forpurchasing ingredients, packaging, machinery and equipment, drug delivery, IT, and selecting outsourcing partners.

359,078 new visitors and 92,951 returning visitors spent an average of 00.01.32 on each visit reading news,features and articles, researching information on the pharmaceutical market, and sourcing ingredients suppliers andproduct manufacturers.

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