medhat a. al-ghobashy 1 -...

Medhat A. Al-Ghobashy 1

Tel.: +20 (0114) 650 66 53 (Cell), +20 (02) 25 35 - 3481 (Office) Email: [email protected], [email protected] Google Scholar: http://scholar.google.com.eg/citations?user=z9-HrWMAAAAJ&hl=en Website: http://scholar.cu.edu.eg/?q=medhatalghobashy/ ORCID: http://orcid.org/0000-0002-3270-6804

Qualifications & Awards

PhD (Chemistry), Massey University, New Zealand – Jul. 09

Topic : Quality Control of Biotechnology-derived Pharmaceuticals.

Title : Downstream Purification and Analysis of the Recombinant Human Myelin Basic

Protein Produced in the Milk of Transgenic Cows.

(http://hdl.handle.net/10179/1186)

M.Pharm.Sci (Analytical Chemistry), Faculty of Pharmacy, Cairo University, Egypt – Mar. 03

Topic : Quality Control of Pharmaceuticals.

Title : Analytical Study on Some Skeletal Muscle Relaxants and Anti-spastic Drugs.

B.Pharm.Sci., Faculty of Pharmacy, Cairo University, Egypt - May 97

Cairo University International Publication Award – 2010, 2012, 2013, 2014 & 2015

Massey University PhD Early Completion Award (4000.00 NZD), New Zealand – Apr. 09

PhD Scholarship, Ministry of High Education, Egypt – Oct. 05

Academic & Professional Work Profile

Director, Central Laboratory, Faculty of Pharmacy, Cairo University, Sep. 14 - until now.

A/Prof., Analytical Chemistry, Faculty of Pharmacy, Cairo University, Jun. 15 – until now.

Vice-Director, Biotechnology Centre, Faculty of Pharmacy, Cairo University, Feb. 10 – Jul. 14.

Lecturer, Analytical Chemistry, Faculty of Pharmacy, Cairo University, Oct. 09 – Jun. 15.

A/Lecturer, Analytical Chemistry, Faculty of Pharmacy, Cairo University, Jul. 03 – Oct. 09

Lab. Supervisor (Part time), IFS, Massey University, New Zealand, Feb. 06 – Jun. 09

Medical Advisor / Trainer (Part time), City Pharma, Egypt, Aug. 00 – Jul. 05.

Demonstrator, Analytical chemistry, Faculty of Pharmacy, Cairo University, Dec. 97 – Jul. 03

mailto:[email protected]

mailto:[email protected]

http://scholar.google.com.eg/citations?user=z9-HrWMAAAAJ&hl=en

http://scholar.cu.edu.eg/?q=medhatalghobashy/

http://orcid.org/0000-0002-3270-6804

http://hdl.handle.net/10179/1186


Contribution in Funded Projects

IRG, Faculty of Pharmacy, Cairo University, Egypt, Ahmed Sherif (PI), Engy Mahrous, Hala Zaki,

Riham George & Medhat Al-Ghobashy, Identification and Characterization of Synthetic and

Naturally Occurring Virulence Inhibitors as Non-conventional Antimicrobial Agents, (125,000.00 EGP)

- May 15 – Now.

IRG, Faculty of Pharmacy, Cairo University, Egypt, Maggie Abbassi (PI), Ramy Aziz, Medhat Al-

Ghobashy, Mohammed Nooh & Marwa ElRakaiby, Investigating the Combined Effect of Hepatitis C

Viral Infection and the Genetic Polymorphisms on the Adverse Events of Methotrexate and 6-

Mercaptopurine in Childhood Acute Lymphoblastic Leukemia, (125,000.00 EGP) - May 15 – Now.

STDF, Academy of Scientific Research, Egypt, Marianne Nebsen (PI), Medhat Al-Ghobashy

(Co-PI), Rasha S.M. Elkholy, Olivia Atallah & Maissa Y. Salem Assessment of Pectin Magnetic

Nanoparticles in low energy water desalination and sustainable water treatment”,

(100,000.00 EGP) – Dec. 14 - Now

STDF, Academy of Scientific Research, Egypt, Medhat Al-Ghobashy (PI), Aliaa El-Meshad (PI),

Ahmed Attia, Wael Mamdouh & Samia Shouman, Formulation and Evaluation of Surface

Functionalized Liver-targeted Nanoparticles Enclosing Interferon for Treatment of HCV,

(900,000.00 EGP) – Jul. 14 - Now.

IRG, Faculty of Pharmacy, Cairo University, Egypt, Nermin Sabry(PI), Ahmed Sherif & Medhat

Al-Ghobashy, Investigating the Combined Effect of Hepatitis C Viral Infection and the Genetic

Polymorphisms on the Adverse Events of Methotrexate and 6-Mercaptopurine in Childhood Acute

Lymphoblastic Leukemia, (75,000.00 EGP) - May 12 – Now.

IRG, Faculty of Pharmacy, Cairo University, Egypt & MURF, New Zealand, Medhat Al-

Ghobashy (PI), Aliaa El-Meshad, Rania Mohsen, Mohamed Nooh, Goetz Laible & David Harding,

Development, characterization & evaluation of a therapeutic vaccine for treatment of multiple

sclerosis, (500,000.00 EGP) - May 12 – Apr. 14.

Cairo University, Egypt, Ayman A. AbdelHamid, Medhat A. Al-Ghobashy, Manal Fawzy, Mona B.

Mohamed & Mohamed M. Abdel-Mottaleb, Plant-mediated synthesis and characterization of

nanomaterials and their application in photodynamic therapy, (10,000.00 EGP) – Jan. – Dec. 12.

Cairo University Research Projects, Tamer Essam (PI), Medhat Al-Ghobashy , Marwa El-Rakaiby,

Maha Omran & Azza Agha, Enhanced solar powered algal-bacterial sustainable wastewater

treatment,(200,000.00 EGP) - May 11 – May 13.

MURF, Massey University, New Zealand, David Harding (PI) & Medhat Al-Ghobashy,

Downstream purification of recombinant protein pharmaceuticals, (Capacity building,

150,000.00 NZD) – Apr. 07 – Jul. 09.


PGRF, Institute of Fundamental Sciences, New Zealand, Medhat Al-Ghobashy (PI) & David

Harding, Quality Control of Recombinant Proteins Using Various Capillary Electrophoresis

Techniques, (3500.00 NZD), – Apr. 06 – Apr. 09.

Research Management

Bioanalysis Research Group

Our research covers analysis of biopharamceuticals, biomarkers and

pharmaceuticals in body fluids. The research group has been

established in Jan 2012 and is hosted by Analytical Chemistry Department, Faculty of Pharmacy,

Cairo University. Our main research partners are National Organization for Research & Control of

Biologicals (NORCB), NAMRU-3, Egypt & National Cancer Institute (NCI), Egypt.

Research Management Activities:

Cairo University Strategic Research Plan (Health sector) 2012 – 2017, Coordinator, Jan. 11 – Now

Future University, Faculty of Pharmacy Research Plan 2014 – 2019, Team leader, Oct. 13 – Jul. 14.

Research Management Workshop, DAAD Kairo Akademie, Egypt, Attendee, 12 Nov. 13

Cairo University, Proposal for CU Excellence Center, Team Member, Oct. 11.

Research Interests

Biopharmaceuticals & Biologicals

Biopharmaceuticals are biotechnology-derived pharmaceuticals and diagnostics. Quality Control

(QC) of biopharmaceuticals involves a number of activities that ranges from designing a suitable

chromatographic purification strategy, selective enrichment of the active form(s) of the drug to

developing suitable analysis strategies.

Current research is focused on the analysis of the posttranslational modifications of recombinant

protein biopharmaceuticals in relation to their pharmacological activity and stability. This work

involves collaboration with Massey University and Agresearch Ltd from New Zealand as well as the

Academy of Sciences of the Czech Republic. This project is focused on the analysis of the

recombinant human myelin basic protein (rhMBP). This protein is a prospective biopharmaceutical

for the treatment of Multiple Sclerosis.

Downstream purification, pre-formulation studies, analysis and physical / chemical stability of

biopharmaceuticals are also part of our research spectrum. We are working towards the

development of activity-, stability- and purity-indicating chemical analysis protocols. Main

techniques involved are chromatography, capillary electrophoresis (CE) and immuno-analytical

techniques. Established techniques are implemented for optimization of nano drug delivery systems

for biopharmaceuticals. This is carried out in collaboration with the Egyptian National Organization

for Research and Control of Biologicals.


Immunoanalytical Techniques & Nano-biosensors

A biosensor is an analytical device for the detection of an analyte. It combines a biomolecular

recognition component with a physicochemical detector component. Our research is mainly focused

on developing multiplexed biosensors on the surface of micro and nanoparticles. Detection is carried

out fluorimetrically, either through development or quenching of fluorescence. Developed sensors

are mainly used for diagnostic purposes (e.g. HBV & HCV) and quality control of vaccines (e.g.

Polyvalent Influenza vaccine). Currently, we are working towards incorporation of novel

nanoparticles into sensor design. This work is being carried out in collaboration with National

Research Centre & Nile University.

Bioanalysis in Clinical Research

Bioanalysis is the sub-discipline of analytical chemistry that deals with the qualitative & quantitative

measurement of drugs, metabolites & endogenous substances in complex biological samples.

Optimization of sample preparation techniques using Solid Phase Extraction (SPE) & analysis using

ultrasensitive hyphenated chromatographic & electrophoretic techniques is carried out. Our work

forms an integral part in a current research project that involves the assessment of response to

chemotherapeutic agents for Acute Lymphoblastic Leukemia. Other applications cover evaluation of

the bioavailability, bioequivalence, pharmacokinetics / pharmacodynamics of drugs and therapeutic

dose adjustment.

Capillary Electrophoresis

Separation by Capillary Electrophoresis (CE) depends on the differential migration of analytes under

the effect of electric field. Typically the capillary wall-generated electroosmotic flow (EOF) is

responsible for mobilization of analytes in CE. Developing and characterization of novel covalent and

dynamic modifications to the capillary wall is the main objective of this project. Such modifications

affect the magnitude and direction of the EOF as well as capillary wall affinity to certain analytes.

This work is carried out in collaboration with Centre for Separation Sciences - Institute of

Fundamental Sciences - Massey University in New Zealand. Applications cover the following: QC of

pharmaceuticals and biopharmaceuticals, monitoring of biomarkers in biological fluids and analysis

of Nutraceuticals in herbal extracts and food products. Main applications are pharmaceutical

analysis using CZE & MEKC. Currently, we are establishing a facility to support our research in the

field of QC of biopharmaceuticals. New techniques involved are CIEF for determination of the

isoelectric point of protein variants & CGE for determination of protein molecular weight.

Stability of Nutraceuticals

“Nutraceuticals” are food ingredients or dietary supplements that demonstrate medicinal health

benefits. Certain nutraceuticals demonstrated inhibitory effects on cancer cell growth. Moreover,

nutraceuticals were found to protect high risk populations from cancer. Herbal extracts are the

main source of nutraceuticals. Our research is focused on stability of Nutraceuticals such as

catechins present in green tea and flavonoids in ginkgo biloba. Effect of various environmental

factors on the total content as well as antioxidant activity of green tea is being investigated.

http://en.wikipedia.org/wiki/Analyte


Publications

Ahmed H. Nadim, Medhat A Al-Ghobashy, Marianne Nebsen & Mostafa A Shehata, Gallic acid

magnetic nanoparticles for photocatalytic degradation of meloxicam: Synthesis, characterization and

application to pharmaceutical wastewater treatment, RSC Adv. (2016), In-press (DOI:

10.1039/C5RA20281G).

Amr H. Shendy, Medhat A. Al-Ghobashy, Sohair A. Gad-Allah & Hayam M. Lotfy, Simultaneous

Determination of 200 Pesticide Residues in Honey using Gas Chromatography-Tandem Mass

Spectrometry in Conjunction with Streamlined Quantification Approach, J. Chromatogr. A (2016), In-

press (DOI: 10.1016/j.chroma.2015.11.068).

Amr H. Shendy, Medhat A. Al-Ghobashy, Sohair A. Gad-Allah & Hayam M. Lotfy, Development and

Validation of a Modified QuEChERS Protocol Coupled to LC-MS/MS for Simultaneous Determination

of Multi-class Antibiotic Residues in Honey, Food Chem. 190 (2016), 982–989.

Ahmed A. Ali, Samar F. Farid, Mona Amin, Mohamed A. Kassem, Nouman Al-Garem & Medhat A. Al-

Ghobashy, Comparative Clinical Pharmacokinetics of Midodrine and Its Active Metabolite

Desglymidodrine in Cirrhotic Patients with Tense Ascites Versus Healthy Volunteers, Clin. Drug Invest.

(2015), In-press (DOI: 10.1007/s40261-015-0359-6).

Heba-Alla H. Abd-ElSalam, Medhat A. Al-Ghobashy, Hala E. Zaazaab, Mohamed A. Ibrahim, On-

column Decaffeination and HPLC Analysis of Epigallocatechin Gallate in Green Tea Nutraceuticals,

Sep. Sci. Technol., (2015), In-press (DOI: 10.1080/01496395.2015.1116571).

Ahmed H. Nadim, Medhat A Al-Ghobashy, Marianne Nebsen & Mostafa A Shehata, Optimization of

photocatalytic degradation of meloxicam using titanium dioxide nanoparticles: application to

pharmaceutical wastewater analysis, treatment, and cleaning validation, Environ. Sci. Pollution Res.

22 (2015), 15516-15525.

Lamiaa A. Hassan, Medhat A. Al-Ghobashy, Faten A. Fath-Allah and Samah S. Abbas, Assessment of

the effects of glycosylation on the pattern and kinetics of degradation of Lenograstim in comparison

to Filgrastim using a stability-indicating orthogonal testing protocol, Chromatographia 78 (2015),

1005-1015.

Ahmed A. Ali, Medhat A. Al-Ghobashy, Samar F. Farid & Mohamed A. Kassem, Development and

Validation of LC-MSMS Assay for the Determination of the Prodrug Midodrine and its Active

Metabolite Desglymidodrine in Plasma of Ascitic Patients: Application to Individualized Therapy and

Comparative Pharmacokinetics, J. Chromatogr. B, 991 (2015) 34 – 40.

Eman G. Nouman, Medhat A. Al-Ghobashy & Hayam M. Lotfy, Development and Validation of LC-

MSMS Assay for the Determination of the Prodrug Dabigatran Etexilate and its Active Metabolites in

Human Plasma, J. Chromatogr. B, 989 (2015), 37 - 45.

Mohamed A. Abdallah, Medhat A. Al-Ghobashy & Hayam M. Lotfy, Investigation of the Profile and

Kinetics of Degradation of Rivaroxaban using HPLC, TLC-densitometry and LC/MSMS: Application to

Pre-formulation Studies, B-FOPCU, 53 (2015), 53-61.


Fatma I. Khattab, Nesrin K. Ramadan, Maha A. Hegazy, Medhat A. Al-Ghobashy & Nermine S.

Ghoniem, Validated spectrophotometric methods for simultaneous determination of troxerutin and

carbazochrome in dosage form, Spectrochimica Acta Part A: Molecular & Biomolecular Spectroscopy,

139 (2015), 206 – 213.

Basma M. El-Tanany, Maha A. Hegazy, Medhat A. Al-Ghobashy, Fatma I. Khattab, Spectral resolution

and simultaneous determination of oxymetazoline hydrochloride and sodium cromoglycate by

derivative and ratio‐based spectrophotometric methods, Eur. J. Chem. 11 (2015).

Basma M. El-Tanany, Maha A. Hegazy, Medhat A. Al-Ghobashy, Fatma I. Khattab, Validated

Chromatographic Methods for the Simultaneous Determination of Sodium Cromoglycate and

Oxymetazoline Hydrochloride in a Combined Dosage Form, J. Adv. Chem.6 (2015), 319‐324.

Heba S. Abed, Medhat A. Al-Ghobashy, Faten A. Fath-Allah and Maissa Y. Salem, Assessment of the

Degradation Pattern and Extent of PEG Interferon α-2b using a Stability-indicating SE-HPLC Assay,

Chromatographia, 77 (2014), 1661-1669.

Eman L. Shaltout, Medhat A. Al-Ghobashy, Faten A. Fath-Allah and Maissa Y. Salem,

Chromatographic and Electrophoretic Assessment of Stability and Purity of Filgrastim Biosimilars in

Pharmaceutical Formulations, Journal of Pharmaceutical & Biomedical Analysis, 97 (2014), 72 – 80.

Medhat A. Al-Ghobashy, Electrophoretic behaviour of zwitterionic buffers in covalently and

dynamically coated fused silica capillaries, B-FOPCU, 52 (2014), 71 - 78.

Heba-Alla H. Abd-ElSalam, Medhat A. Al-Ghobashy, Hala E. Zaazaab, Mohamed A. Ibrahim, Storage

Stability of Catechins in Green Tea Nutaceutical products: Application of Solid Phase Extraction - Thin

Layer Chromatography Densitometry, Food Chemistry, 156, (2014), 94 - 99.

Yehia Z.Baghdady, Medhat A. Al-Ghobashy, Abdel-Aziz E.Abdel-Aleem, Soheir Weshahy,

Simultaneous Determination of Ezetimibe and Atorvastatin Calcium in Spiked Human Plasma using

SPE Coupled to HPLC-MS/MS, Analytical Chemistry, An Indian Journal, 14(3), (2014), 115 - 20.

Ayman A. AbdelHamid, Medhat A. Al-Ghobashy, Manal Fawzy, Mona B. Mohamed & Mohamed M.

Abdel-Mottaleb, Phytosynthesis of Au, Ag and Au-Ag bimetallic nanoparticles using aqueous extract

of sago pondweed, ACS Sustainable Chemistry & Engineering, 1 (12), (2013), 1520–29.

Medhat A Al-Ghobashy, Martin A K Williams, Goetz Laible and David R K Harding, Coupled solid

phase extraction and microparticle-based stability and purity-indicating immunosensor for the

determination of recombinant human myelin basic protein in transgenic milk, Talanta, 109, (2013),

7 – 12.


Development and Validation of a Simple RP-HPLC Method for Simultaneous Estimation of Ezetimibe

and Atorvastatin Calcium in Pharmaceutical Dosage Form and Spiked Human Plasma, International

Journal of Advanced Research, 1(6) (2013), 302-312.

Yehia Z.Baghdady, Medhat A. Al-Ghobashy, Abdel-Aziz E.Abdel-Aleem, Soheir Weshahy, Two New

Spectrophotometric Approaches to the Simultaneous Determination of Ezetimibe and Atorvastatin

Calcium, International Journal of Chemical Studies, 1(2) (2013), 14-25.



Simultaneous Determination Of Ezetimibe And Atorvastatin Calcium In Binary Mixture By Second

Derivative (D2) Spectrofluorimetric Method, Australian Journal of Basic and Applied Sciences, 7(8)

(2013), 842-850.


Spectrophotometric and TLC-densitometric methods for the simultaneous determination of binary

mixture of Ezetimibe and Atorvastatin Calcium without prior separation, Journal of Applied Research,

4 (2013), 51-59.

Medhat A. Al-Ghobashy, Martin A. K. Williams, Goetz Laible and David R. K. Harding, Capillary zone

electrophoresis with on-line micellar sample stacking for determination of protein concentration of

biopharmaceuticals, Chromatographia, 73 (2011), 1145–1153.

Medhat A. Al-Ghobashy, Aurelie Cucheval, Martin A. K. Williams, Goëtz Laible and David R. K.

Harding, Probing the interaction between recombinant human myelin basic protein and caseins using

surface plasmon resonance and diffusing wave spectroscopy, Journal of Molecular Recognition, 23

(2010), 84–92.

Medhat A. Al-Ghobashy, Martin A. K. Williams, Brigid Brophy, Goetz Laible and David R. K. Harding,

On-line casein micelle disruption for downstream purification of recombinant human myelin basic

protein produced in the milk of transgenic cows, Journal of Chromatography B, 877 (2009), 1667–

1677.

Aurelie Cucheval, Medhat A. Al-Ghobashy, Yasin Hemar, Don Otter and Martin A. K. Williams, Direct

measurements of interfacial interactions between pectin and κ-casein and implications for the

stabilisation of calcium-free casein micelle mimics, Journal of Colloid and Interface Science, 338

(2009), 450–462.

Medhat A. Al-Ghobashy, Martin A. K. Williams and David R. K. Harding, Factors affecting the

performance of capillary isoelectric focusing in dynamically coated capillaries using polyethylene

oxide polymer, Analytical Letters, 41 (2008), 1914-1931.

Nariman A. El-Ragehy, Mostafa. M. Ellaithy and Medhat A. Al-Ghobashy, Application of chemometric

methods for simultaneous determination of the binary mixtures chlorzoxazone - paracetamol and

chlorzoxazone – ketoprofen, Egyptian Journal of Pharmaceutical Sciences, 45 (2004), 95-111.

Mostafa. M. Ellaithy, Nariman A. El-Ragehy and Medhat A. Al-Ghobashy, Kinetic study of alkaline

induced hydrolysis of the skeletal muscle relaxant chlorzoxazone using ratio spectra first derivative

spectrophotometry, Farmaco, 58 (2003), 337-742.

Nariman A. El-Ragehy Mostafa.M. Ellaithy and Medhat A. Al-Ghobashy, Determination of

thiocolchicoside in its binary mixtures; thiocolchicoside - glafenine and thiocolchicoside-floctafenine

by TLC-densitometry, Farmaco, 58 (2003), 463-468.

http://www.ingentaconnect.com.ezproxy.massey.ac.nz/content/tandf/lanl;jsessionid=9qb5kgcru5esj.alice


Research Projects

Samah Mamdouh, Medhat A. Al-Ghobashy and Waheed M. Salem, Development & validation of

bioanalytical techniques for therapeutic drug monitoring, (2015), MSc project in collaboration with

National Organization for Drug Control & Research (NODCR).

Olivia Atallah, Medhat A. Al-Ghobashy, Marianne Nebsen Morcos and Maissa Y. Salem, Analytical

applications of magnetic nanoparticles in pharmaceutical technology, (2014), MSc project in

collaboration with Heliopolis University.

Hadeer Gamaleldin Mohamed, Medhat A. Al-Ghobashy, Mervat Foaad and Hala E. Zaazaa, Quality

assessment of some nutraceuticals derived from milk (2014) MSc Project in collaboration with

National Nutritional Institute

Eman Moenes, Medhat A. Al-Ghobashy, Abeer Abdel Azim Mohamed and Maissa Y. Salem,

Analytical & Stability Evaluation Study of Some Biologically Active Proteins By Different Techniques

(2014), MSc Project in collaboration with National Organization for Research and Control of

Biologicals.

Hanan Karam Mikhael, Medhat A. Al-Ghobashy, Abeer Abdel Azim Mohamed and Yasser El-Saharty,

Stability evaluation study of some biological products by different analytical techniques, (2014), MSc

Project in collaboration with National Organization for Research and Control of Biologicals.

Mai Ahmed, Medhat A. Al-Ghobashy, Faten A. Fath-Allah and Yasser El-Saharty, Analytical Study of

Some Biologically Active Proteins, (2012), MSc Project in collaboration with National Organization

for Research and Control of Biologicals.

Mai Ibrahim Abd El Shakour, Medhat A. Al-Ghobashy, Safa'a Mohamed Riad & Mohamed Refaat Al-

Ghobashy, Monitoring and Treatment of Some Residual Drugs in Waste Water, (2012), MSc project

in collaboration with El Asher University & EPICO Pharmaceuticals.

Alshaimaa Mohamed, Medhat A. Al-Ghobashy, Faten A. Fath-Allah and Maissa Y. Salem The use of

advanced analytical techniques for the evaluation of the endotoxin content of some biologic, (2012),

MSc Project in collaboration with National Organization for Research and Control of Biologicals.

Hoda El-Saeed Mohamed, Medhat A. Al-Ghobashy, Faten A. Fath-Allah and Samah Abbas

Assessment of protein aggregate in biological products, (2012), MSc Project in collaboration with

National Organization for Research and Control of Biologicals.

Sara Magdy Shatat, Medhat A. Al-Ghobashy, Faten A. Fath-Allah and Samah Abbas, Peptide

mapping of recombinant therapeutic proteins & its applications in quality assessment, (2012), MSc

Project in collaboration with National Organization for Research and Control of Biologicals.

Heba Sayed Abed, Medhat A. Al-Ghobashy, Faten A. Fath-Allah and Maissa Y. Salem, Analytical

study on the stability of modified recombinant proteins, (2012), MSc Project in collaboration with

National Organization for Research and Control of Biologicals.


Mohamed A. Korashy, Medhat A. Al-Ghobashy & Mohamed AbdelKawy, Analytical study on some

non-steroidal anti-inflammatory drug residues in waste water from Pharmaceutical industry (2011),

MSc Project in collaboration with Egyptian pharma industry & Ministry of Environment.

Heba K. AbdelHady, Medhat A. Al-Ghobashy & Mohamed AbdelKawy, Analytical study on some

antibiotic residues in waste water from Pharmaceutical industry (2011), MSc Project in

collaboration with Egyptian pharma industry & Ministry of Environment.

Nermin Samir, Medhat A. Al-Ghobashy, Maha Hegazy, Nesrin Khamis and Fatma Khattab, Capillary

electrophoresis analysis of pharmaceuticals (2010), PhD Project.

Moushira Mamdoh, Medhat A. Al-Ghobashy, Faten A. Fath-Allah and Maissa Y. Salem, Application of

advanced analytical methodologies for the quality control of some vaccines (2010), MSc Project in

collaboration with National Organization for Research and Control of Biologicals.

Completed Projects

Ahmed Hafez Naguib, Medhat A. Al-Ghobashy, Marianne Nebsen Morcos, Mostafa Abdel Aty

Shehata, Analytical applications of nanotechnology in pharmaceutical industry, (2012), MSc project.

Lamiaa Anwar, Medhat A. Al-Ghobashy, Faten A. Fath-Allah and Samah Abbas, Stability assessment

of therapeutic proteins, (2012), MSc Project in collaboration with National Organization for

Research and Control of Biologicals.

Eman Ezz El-Din, Medhat A. Al-Ghobashy & Gelan Ahmed, The Effect of Root Canal Irrigants & Self-

etching Adhesive Agents on Collagenolytic Activity of Matrix Metalloproteinase Enzyme in Radicular

Dentin (2011), MSc Project in collaboration with Faculty of Oral & Dental Medicine.

Mohamed Adel Abd-Allah, Medhat A. Al-Ghobashy, Hayam M. Lotfy, Development of new analytical

methods for some new pharmaceutical products in the Egyptian market (2010), MSc project in

collaboration with SIGMA pharmaceuticals industries.

Amr H. Shendy, Medhat A. Al-Ghobashy, Sohair A. Gad-Allah & Hayam M. Lotfy, Analytical Study on

Some Residual Drugs and Undesirable Compounds in Honey (2010), MSc project in collaboration

with Central Lab of Residue Analysis, Agricultural Research Center.

Eman Lotfi Shaltout, Medhat A. Al-Ghobashy, Faten A. Fath-Allah and Maissa Y. Salem, Quality

assessment of biosimilars relative to innovator products using instrumental methods of analysis

(2011), MSc Project in collaboration with National Organization for Research and Control of

Biologicals. Completion date: Dec. 14.

Heba-Allah Hussein, Medhat A. Al-Ghobashy, Hala Zaazaa and Mohamed AbdelKawy, Analytical

Study of Some Nutraceuticals Used for Treatment of Autoimmune Diseases, (2012), MSc Project.

Completion date: Jul. 14.

Ayman amin Abdelhamid, Manal Fawzy, Mona Bakr, Medhat Al-Ghobashy & Mohamed Abdel-

Mottaleb, Noble metal nanoparticles: green synthesis & application in KRAS mutation detection,

(2012), PProject in collaboration with Alexandria University & Nile University. Completion date:

Dec. 12.


Yehia Zakaria, Medhat A. Al-Ghobashy, Sohair Elweshahy, AbdelAziz Bayoumi, Quality control of

anti-hyperlipidemics, (2010), MSc Project in collaboration with Future University. Completion date:

Jul. 12.

Conferences, Seminars & Workshops

FUE International Conference on Pharmaceutical Technologies (ICPT), Plenary lecture, Analytical

Biotechnology for Biopharmaceutical Drug Discovery, Characterization and Control, Cairo, 7 – 9 Feb.

15.

FUE International Conference on Pharmaceutical Technologies (ICPT), Poster, Correlation of

Antioxidant Activity to Total Polyphenol and Epigallocatechin Gallate Content of Green Tea

Nutraceuticals: Photo and Hydrolytic Degradation, Cairo, 7 – 9 Feb. 15.

5th Scientific Conference of Faculty of Pharmacy Cairo University on Pharmacy at the Cutting-Edge:

Facing Future Challenges, Spectral Resolution and Simultaneous Determination of Oxymetazoline

Hydrochloride and Sodium Cromoglycate by Derivative and Ratio-Based Spectrophotometric

Methods, Cairo, Poster presentation, 23-24 Apr. 14.

5th Scientific Conference of Faculty of Pharmacy Cairo University on Pharmacy at the Cutting-Edge:

Facing Future Challenges, Cairo, Member of Organization committee, 23-24 Apr. 14.

4th Scientific Conference of Faculty of Pharmacy Cairo University on Pharmacy Education and

Community Expectations, Cairo, Member of Organization committee, 24-25 Apr. 13.

4th Scientific Conference of Faculty of Pharmacy Cairo University on Pharmacy Education and

Community Expectations, Cairo, Development, Characterization and Evaluation of a Therapeutic

Vaccine for Treatment of Multiple Sclerosis, Oral presentation, 24-25 Apr. 13

4th Scientific Conference of Faculty of Pharmacy Cairo University on Pharmacy Education and Community Expectations, Cairo, Photocatalytic Degradation of Meloxicam using Titanium Dioxide Nanoparticles for Pharmaceutical Waste Water Treatment, Poster presentation, 24-25 Apr. 13

4th Scientific Conference of Faculty of Pharmacy Cairo University on Pharmacy Education and Community Expectations, Cairo, Development and Validation of a Reversed Phase Liquid Chromatographic Method for the Assessment of Filgrastim Biosimilars in their Pharmaceutical Formulation, Poster presentation, 24-25 Apr. 13

4th Scientific Conference of Faculty of Pharmacy Cairo University on Pharmacy Education and Community Expectations, Cairo, Monitoring the Stability of Pegylated Interferon alfa-2b using Size Exclusion Chromatography, Poster presentation, 24-25 Apr. 13

4th Scientific Conference of Faculty of Pharmacy Cairo University on Pharmacy Education and Community Expectations, Cairo, Spectrophotometric and Solid Phase Extraction – HPLC for Assessment of the Photostability of Green Tea Catechins, Poster presentation, 24-25 Apr. 13

4th Scientific Conference of Faculty of Pharmacy Cairo University on Pharmacy Education and Community Expectations, Cairo, Stress Degradation Studies of Rivaroxaban By Validated Stability Indicating Chromatographic Methods, Poster presentation, 24-25 Apr. 13


4th Scientific Conference of Faculty of Pharmacy Cairo University on Pharmacy Education and Community Expectations, Cairo, Optimization and Validation of ELISA Immunoassay for the Evaluation of in-vitro Relative Potency of a Four-component Human Papillomavirus Vaccine Product, Poster presentation, 24-25 Apr. 13

International Conference of GUC, “Pharmaceutical and Biotechnological Therapies”, German

University in Cairo; Egypt, Attendee, 28 Sep. - 1 Oct.12.

International Conference of Young Chemists (ICYC), Poster, Spectrophotometric, TLC-densitometric

& HPLC methods for the simultaneous determination of ezetimibe & atorvastatin calcium, Amman, 8

- 10 April 12.

3rd Scientific Conference of Faculty of Pharmacy Cairo University on Good Pharmacy Practice, Cairo,

Member of Organization committee, 25 - 26 Apr. 12.

FUE International Conference on Pharmaceutical Technologies (ICPT), Poster, Chromatographic

methods for the simultaneous determination of ezetimibe and atorvastatin calcium, Cairo, 6 – 9 Feb.

12.

FUE International Conference on Pharmaceutical Technologies (ICPT), Poster, Spectrophotometric

and spectrofluorimetric methods for the simultaneous determination of ezetimibe and atorvastatin

calcium, Cairo, 6 – 9 Feb. 12.

32nd international conference of the Egyptian Pharmaceutical society, Cairo, Poster

Spectrophotometric Simultaneous Determination of Troxerutin and Carbazohrome in their Binary

Mixture, Cairo, 20-22 Dec. 11.

Quality impact on efficacy & safety outcomes: starting materials, process & finished products,

organized by Ministry of Health in collaboration with Novartis Pharma, Attendee, 17-19 Jul 11.

2nd Scientific Conference of Faculty of Pharmacy Cairo University on Quality Assurance in Pharmacy

Education, Cairo, Member of Organization committee, 26 Apr. 12.

CIQAP Seminar Series, Internationalization of Pharmaceutical Education in Egypt: A Marketing

Prospective, Faculty of Pharmacy, Cairo University, Attendee, 6 Apr. 10.

The 13th International Conference on Petroleum, Mineral Resources & Development, EPRI, Cairo,

“Nutracutical for Chemoprevention of Petroleum Induced Carcinogenesis”, Plenary lecture & Review

article, 9 Feb. 10.

The 5th International Conference of Cairo University on Scientific Research and its Applications,

Cairo, Attendee, 21 – 24 Dec. 09.

Implementation of Technology in Teaching Workshop, FLDC, Cairo University, 28 – 30 Sep. 09.

NZ Nano and Microfluidics Workshop, Victoria University, New Zealand, Attendee, 6 Jun. 09.

IFS Seminar Series, “Solving the rhMBP Puzzle: Pre-clinical Evaluation of a Transgenic

Biopharmaceutical “, Institute of Fundamental Sciences, New Zealand, Plenary lecture, 6 May 09.


Inaugural Postgraduate Research Symposium, “Quality Control of Biopharmaceuticals:

Understanding the starting Material”, awarded the “Best plenary talk”, Massey University, New

Zealand, Plenary lecture, 20 Feb 08.

Milk Proteins II: From Molecules to Mozzarella, Massey University, New Zealand, Attendee, Feb. 07.

The 7th Annual Chemistry Research Symposium, “Capillary Isoelectric Focusing in Quality Control of

Biopharmaceuticals”, Massey University, New Zealand, Abstract & presentation, 21 Feb. 07.

Milk Proteins: From Expression to Food, Massey University, New Zealand, Attendee, 15 - 17 Feb 06.

Training Courses

QC of Nutraceuticals, Biotechnology Center, Faculty of Pharmacy, Cairo University, Trainer, May 15.

Research Team Management Workshop, FLDC, Cairo University, Jul. 14.

Academic Ethics Workshop, FLDC, Cairo University, Jul. 14.

Academic Ethics Workshop, FLDC, Cairo University, Jul. 14.

Assessment and Examination Methods, FLDC, Cairo University, Jul. 14.

Financial and Legal Aspects in Academia Workshop, FLDC, Cairo University, Aug. 14.

Academic Management Workshop, FLDC, Cairo University, Aug. 14.

Effective Teaching Skills Workshop, FLDC, Cairo University, Aug. 14.

Research Financing and Proposal Writing Workshop, FLDC, Cairo University, Sep. 14.

Research Management Workshop, DAAD Kairo Akademie, Egypt, Attendee, 12 Nov. 13

Advanced Pharmaceutical Analysis workshop “Advanced detection techniques”, Biotechnology

Center, Faculty of Pharmacy, Cairo University, Trainer, June 13.

Quality Control in Pharmaceutical Industry “Instrument Validation”, Trainer, Faculty of Pharmacy,

Cairo University, Sep. 12.

Quality Control in Pharmaceutical Industry “Drug Stability”, Trainer, Faculty of Pharmacy, Cairo

University, Jun. 12.

Advanced Pharmaceutical Analysis workshop “Advanced detection techniques”, Biotechnology

Center, Faculty of Pharmacy, Cairo University, Trainer, April 12.

Immunology Updates Workshop “Immunochemical techniques”, Faculty of Pharmacy, Cairo

University, May 11.

New Trends in Biotechnology “Optical immunosensors for characterization of biopharmaceuticals”,

Trainer, Faculty of Pharmacy, Cairo University, Dec 10.

Time Management Workshop, FLDC, Cairo University, Sep 10.


Scientific Writing Workshop, FLDC, Cairo University, Aug 10.

Strategic Planning Workshop, FLDC, Cairo University, May 10.

Quality Standards in Teaching, FLDC, Cairo University, May 10.

Obtaining External Research Funds, Massey University, New Zealand, May 07

Tutor Training Skills Programme, Massey University, New Zealand, Mar 07

HSNO Laboratory Managers’ Training, Massey University, New Zealand, Sep. 06

Protein Structure and Function, Massey University, New Zealand, Mar. - May. 06

Professional Associations

Committee member, National Committee for IUPAC, Dec. 13 – NOW.

Editor, British Journal of Pharmaceutical Research, Science Domain International, Jan. 13 – NOW.

Reviewer, large number of scientific journals such as: Biochemical Sciences, J. Chromatography A

(JCA) & Journal of Chromatography B (JCB), Electrophoresis, Analytical Letters, Journal of Association

of Official Analytical Chemists (AOAC), J. Liquid Chromatography & Related Technologies, Journal of

Advanced Research (JAR) & Bulletin of Faculty of Pharmacy, CU (B-FOPCU), Jul. 09 – until now

Committee member & organizer of “Cairo University Strategic Research Plan (Health sector) 2012 -

2017”, Jan. 11 – Now

Committee member of “Strategic Plan for Improvement of Higher Education in Egypt (Health Sector),

Ministry of Higher Education, Egypt, Oct. 10 – Dec. 12.

Member of “Follow-up Committee of the Strategic and Executive Plans”, Faculty of Pharmacy, Cairo

University, Mar. 10 - until now

Member of “International Society for Molecular Recognition”, Oct. 09 - until now

Fellow of “Australia New Zealand Microfluidics Research Group”, Mar. 09 - until now

Fellow of “Egyptian Pharmaceutical Society”, Oct. 03 - until now

Coordinator, “Strategic Research Plan 2012 - 2017”, Cairo University, Sep. 10 – Aug. 13

Member of “International Relations Bureau”, Faculty of Pharmacy, Cairo University, Feb.10 – Aug. 11

Member of “Centre for Separation Sciences”, Massey University, New Zealand, Oct. 05 - Aug. 09

Member of “Biomaterials Group”, Massey University, New Zealand, Apr. 06 - Aug. 09

Member of “Management Committee of Institute of Fundamental Sciences”, Jan – Dec 06

Industrial Pharmacist (Trainee), October Pharma, Egypt, Jul. – Aug. 96

medhat a. al-ghobashy 1 -...

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