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C U R R I C U L U M V I T A E

Professor Igor KONSTANTINOV MD PhD FRACS

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IDENTIFICATION:

Surname: Konstantinov First Name: Igor E. Qualifications: MD, PhD, FRACS Born in: Russia Citizen of: Russia, Canada and Australia Contact Address: Cardiac Surgery Unit Royal Children’s Hospital Flemington Road, PARKVILLE, VIC, 3052 Telephone: +61 3 9345 5200 Fax: +61 3 9345 6001 Email: [email protected] Spoken Languages: Russian & English CURRENT APPOINTMENTS

August 2011-August 2016 Professor, University of Melbourne June, 2009-May 2014 Clinical Professor, University of Melbourne July 2008-December 2011 Clinical Professor of Surgery, University of Western Australia July 2008 – Present Consultant Cardiothoracic Surgeon, Royal Children’s Hospital, Melbourne,

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C U R R I C U L U M V I T A E SUMMARY OF MAJOR ACHIEVEMENTS

PUBLICATIONS

Book Chapters 1. The Natural and Modified History of Congenital Heart Disease

Edited by Robert M. Freedom Futura Publishing Company Inc., New York, 2003 Chapter 3. Ventricular Septal Defect. Chapter 24A. Total Anomalous Pulmonary Venous Connections. Chapter 24E. Congenital Stenosis of the Individual Pulmonary Veins.

2. A Practical Approach to Perioperative Cardiac Anaesthesia and Surgery, Second Edition

Edited by Davy C.H. Cheng, MD and Tirone E. David, MD Lippincott Williams & Wilkins, Philadelphia, 2005 Chapter 37: Adult Congenital Heart Surgery

3. Dawn and Evolution of Cardiac Procedures

Edited by Marco Piciche, MD Springer-Verlag, New York, 2012 Chapter 9: The History of Experimental Heterotopic and Orthotopic Heart Transplantation Before Cardiopulmonary Bypass. Chapter 11: On the Path to Cardiopulmonary Bypass: From Le Gallois’ Experiments to Brukhonenko’s Machine.

Journal Articles Citation Factor: Prof. Konstantinov published 182 articles in international peer-reviewed journals (70 in the last 5 years) and counts 182 Scopus entries with H factor is 18 (Scopus), i.e., 18 articles has been quoted more than 18 times. The most frequently cited publication has been quoted 162 times. His 5 most quoted publications have been quoted more than 75 times. Journal Publication Summary:

Published (MEDLINE)

In Press Submitted

Primary Manuscripts 162 8 5

Reviews 1 0 1

Letters 21 1 0

Group studies* 0 0 0

* Listed in paper as part of multinational study group

Top 3 papers based on Journal Impact Factor: 1. Cheung MMH, Kharbanda RK, Konstantinov IE, Shimizu M, Frnova H, Li J, Holtby HM, Cox PN, Smallhorn JF, Van

Arsdell GS, Redington AN. Randomised controlled trial of the effects of remote ischemic preconditioning in children undergoing cardiac surgery: first clinical application in humans. J Am Coll Cardiol 2006;47:2277-82.

2. Konstantinov IE, Arab S, Kharbanda RK, Li J, Cheung MM, Cherepanov V, Downey GP, Liu P, Cukerman E, Coles

JG, Redington AN. The remote ischemic preconditioning stimulus modifies inflammatory gene expression in humans. Physiol Genomics 2004;19(1):143-50.

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3. Schmidt MR, Smerup M, Konstantinov IE, Shimizu M, Li J, Cheung MMH, White PA, Kristiansen SB, Sorensen K, Dzavik V, Redington AN, Kharbanda RK. Intermittent peripheral tissue ischemia during coronary ischemia reduces myocardial infarction: first demonstration of remote ischemic preconditioning. Am J Physiol Heart Circ Physiol 2007; 292(4):H1883-90.

Top 3 papers based on number of citations: 1. Cheung MMH, Kharbanda RK, Konstantinov IE, Shimizu M, Frnova H, Li J, Holtby HM, Cox PN, Smallhorn JF, Van

Arsdell GS, Redington AN. Randomised controlled trial of the effects of remote ischemic preconditioning in children undergoing cardiac surgery: first clinical application in humans. J Am Coll Cardiol 2006;47:2277-82.

2. Konstantinov IE, Arab S, Kharbanda RK, Li J, Cheung MM, Cherepanov V, Downey GP, Liu P, Cukerman E, Coles

JG, Redington AN. The remote ischemic preconditioning stimulus modifies inflammatory gene expression in humans. Physiol Genomics 2004;19(1):143-50.

3. Schmidt MR, Smerup M, Konstantinov IE, Shimizu M, Li J, Cheung MMH, White PA, Kristiansen SB, Sorensen K,

Dzavik V, Redington AN, Kharbanda RK. Intermittent peripheral tissue ischemia during coronary ischemia reduces myocardial infarction: first demonstration of remote ischemic preconditioning. Am J Physiol Heart Circ Physiol 2007; 292(4):H1883-90.

LEADERSHIP

Design and planning of clinical and experimental research projects Grant applications Grant reviewer for the NHMRC MAIN RESEARCH INTERESTS

Peri-operative cardio-pulmonary protection: its molecular mechanisms, genomic responses and clinical

application Clinical outcome studies Clinical monitoring of rejection after heart transplantation MAJOR EXTERNAL COLLABORATIONS

Professor William G. Williams, MD, FRCS, Congenital Heart Surgeons’ Society, CHSS Data Centre, Hospital for Sick Children, Toronto, Canada Collaborative multicenter outcome studies Professor Andrew N. Redington, MD, FRCP, Cardiology, Hospital for Sick Children, Toronto, Canada Molecular mechanisms of protection against ischemia-reperfusion injury INTERNATIONAL RECOGNITION

Invited speaker to: 1. Congres des 20 ans de la Chirurgie Cardiaque, 25-26 April 2007, Nimes, FRANCE

2. 15

th World Congress on Heart Disease, July 18-21, 2010 Vancouver, BC, CANADA

3. 5

th World Congress of Paediatric Cardiology and Cardiac Surgery, June 21-26, 2009 Cairns, AUSTRALIA

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Presentations: 1. Thubrikar MJ, Konstantinov IE, Selim GA, Gong GG, Fowler B, Robicsek F.

The influence of sizing on the dynamic function of the free-hand implanted porcine aortic homograft: an in vitro study. American Society of Artificial Internal Organs, May 23, 1999, San Diego, USA

2. Konstantinov IE, Coles JG, Takahashi M, Goncalves J, Boscarino C, Van Arsdell GS.

Age related gene expression in children undergoing cardiac surgery for tetralogy of Fallot. The American Association of Thoracic Surgeons, May 6, 2003, Boston, USA

3. Konstantinov IE.

Remote ischemic preconditioning modifies inflammatory gene expression in human: a microarray study. Clinical Genomics and Proteomics, University of Toronto Cardiovascular Scientific Day, May 23, 2003, Toronto, CANADA

4. McCrindle BW, Tchervenkov CI, Konstantinov IE, Williams WG, Neirotti R, Jacobs ML, Blackstone EH.

Risk factors associated with mortality and reinterventions in 474 neonates with interruption of the aortic arch: a congenital heart surgeons society study. The American Association of Thoracic Surgeons, April 19, 2004, Toronto, CANADA

5. Tan Tanny S, Kowalski R, d’Udekem Y, Wheaton G, d’Ogrsogna L, Brizard CP, Konstantinov IE.

Ross procedure in children. American Heart Association meeting, November 3-7, 2012 Los Angeles, USA.

6. d’Udekem Y, Galati JC, Rolley GJ, Konstantinov IE, et al.

Long-term outcomes after transatrial repair of tetralogy of Fallot: 25 years of experience. American Heart Association meeting, November 3-7, 2012 Los Angeles, USA.

7. Pepe S, Cheung M, Konstantinov IE.

Effect of remote ischemic preconditioning on phosphorylated protein signalling in children undergoing tetralogy of Fallot repair: a randomized controlled trial. American Heart Association meeting, November 3-7, 2012 Los Angeles, USA.

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C U R R I C U L U M V I T A E CV IN DETAIL

PAST APPOINTMENTS

1 Dec 2007- Jul 2008 Associate Professor of Surgery, University of Western Australia 1 Jul 2007- 30 Jun 2008 Consultant Cardiothoracic Surgeon, Cardiac Surgery Unit

Sir Charles Gairdner Hospital, Perth, WA 6009, Australia

EDUCATION & SURGICAL TRAINING

15 Jan 2007- 31 Jun 2007 Fellow, Cardiothoracic Surgery, Royal Children’s Hospital,

Flemington Road, Parkville, Melbourne, Australia 15 Jan 2006-15 Jan 2007 Senior Registrar, Cardiothoracic Surgery, Prince Charles Hospital

Rode Road, Chermside, QLD 4032, Australia 15 Jan 2005- 15 Jan 2006 Senior Registrar, Cardiothoracic Surgery, Sir Charles Gairdner

Hospital, Verdun Street, Perth, WA 6009, Australia 1 Jul 2002-15 Jan 2005 Cardiac Surgery Research Fellowship,

Ph.D. thesis: "Gene Expression in Cardiac Surgery: Impact of Ischaemia and Re-perfusion" Hospital for Sick Children, Univ. of Toronto, Toronto, Canada

1 Jul 2001-30 Jun 2002 Paediatric Cardiac Surgery Clinical Fellowship

Hospital for Sick Children, University of Toronto, Toronto, Canada 1 Jul 2000-30 Jun 2001 Cardiac Surgery Clinical Fellowship, Toronto General Hospital,

University of Toronto, Toronto, Canada

30 Jun 1999-1 Jul 2000 Advanced Cardiothoracic Surgery Clinical Fellowship, Mayo Clinic, Rochester, MN 55905, USA

1 Jul 1998-30 Jun 1999 Pediatric Cardiac Surgery Clinical Fellowship,

The Heart Institute for Children, Hope Children's Hospital, Oak Lawn, Chicago, USA

1 July 1997-30 Jun 1998 Clinical Fellowship in Thoracic and Cardiovascular Surgery The Carolina Heart Institute, 1000 Blythe Blvd., Charlotte, NC 28232

1 Jun 1994-1 Jul 1997 Fellowship in Thoracic and Cardiovascular Surgery University Hospital, S-581 85 Linkoping, SWEDEN 1 Jul 1992-1 Jan 1997 Internship/Residency in Thoracic and Cardiovascular Surgery St. Petersburg Cardiac Center, Pokrov Hospital, Bolshoy, St. Petersburg 199026 RUSSIA 1 Jul 1991-1Jun 1992 Internship in General Surgery

Military Medical Academy, St. Petersburg, RUSSIA 1986-1992 Military Medical Academy,

Lebedeva 6, 194044 St. Petersburg, RUSSIA Graduation: 20 June 1992

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FELLOWSHIPS AND MEMBERSHIPS

American Association For Thoracic Surgery - Member Mayo Clinic Alumni Society - Member New York Academy of Sciences - Invited Member American Physiological Society - Invited Member Section of Academic Surgery, Royal Australiasian College of Surgeons - Member International College of Angiology - Past Member Royal Australiasian College of Surgeons - Fellow School of Surgery and Pathology, University of Western Australia - Member of the Council UNDERGRADUATE AND POSTGRADUATE DEGREES

MD: Military Medical Academy, St. Petersburg, Russia, 20 June 1992 PhD: University of Toronto, Toronto, Canada, 25 June 2004

Ph.D. thesis title: "Gene Expression in Cardiac Surgery: Impact of Ischaemia and Re-perfusion" MEDICAL LICENSING EXAMINATIONS

1. United States Medical Licensing Examination:

ECFMG Certificate # 0-526-610-1, USMLE Steps 1,2,3 passed; Certificate valid indefinitely

2. Licentiate of the Medical Council of Canada:

Evaluating Exam: Passed (Feb., 2002); QE Part I: Passed (Nov., 2002) QE Part II: Passed (Oct., 2003); Certificate valid indefinitely

3. Australian Medical Council Certificate:

Certificate number 6924, issued on 2 June 2008 Certificate valid indefinitely

SPECIALIST STATUS

1. Thoracic and Cardiovascular Surgery Board Certificate (Russia)

Registration # 8810; Jan. 22, 1997 Board Certified in Cardiothoracic Surgery

2. Royal Australasian College of Surgeons (Australia)

Fellowship # 148822; May 4, 2011 Fellowship in Specialty of Cardiothoracic Surgery

INTERNAL PEER REVIEWED FUNDED GRANTS

2007 $ 45,996 Australian From The Prince Charles Hospital Foundation for the study entitled, “Does remote ischemic preconditioning improve human right atrial function in vitro and improve clinical outcomes post-operatively?” Co-applicants: Peter Molenaar, Igor E. Konstantinov, John Fraser, John Dunning.

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EXTERNAL PEER REVIEWED FUNDED GRANTS

2004 $ 84.000 Canadian From The Physicians’ Services Incorporated Foundation (PSIF) for the study titled: “The Effect of the Remote Ischemic Preconditioning Stimulus on Leukocyte Gene Expression and Functional Responses”. Co-applicants: Igor E. Konstantinov, Andrew N. Redington, Sara Arab, Peter P. Liu, Gregory Downey The PSIF, 5160 Yonge Street, Suite 1006, Toronto, ON, M2N 6L9, Canada Tel: (416) 266 6323; Fax: (416) 226 6080; E-mail: [email protected] 2007 $ 10,000 Australian From the Australasian Society of Cardiothoracic Surgery for the study titled: “Endothelin-1 blockade for the prevention of ischaemia-reperfusion injury post lung transplantation”. Co-applicants: Andrew Clarke, Igor E. Konstantinov, John Fraser. 2008 $ 39,825 Australian From NHF of Australia WA Branch for the project titled: “Role of Kallikrein-Kinin system in remote ischemic preconditioning” Chief Investigator: Igor E. Konstantinov NHF of Australia WA Branch Research Development Office, SCGH, Nedlands, WA Tel.: 61 8 9346 4534; Fax: 61 8 9346 4537; E-mail: [email protected] 2009 $ 6.000 Australian From Murdoch Children’s Research Institute for the project titled: “The proteomic response to remote ischemic preconditioning stimuli - a pilot study”. Chief Investigator: Igor E. Konstantinov Murdoch Children’s Research Institute, Flemington Road, Parkville, VIC 3052 Tel: (03) 8341 6200: Fax: (03) 9348 1391 National Health and Medical Research Grants: Chief Investigator: Igor E. Konstantinov NHMRC, Level 5, 20 Allara Street, Canberra, ACT, Australia Tel.: 61 2 6217 9000; Fax: 61 2 6217 9100; e-mail: [email protected] • 2009: NHMRC # 557507: Delayed phase of remote ischemic preconditioning: clinical application and the role of

kallikrein-kinin pathway. $154.500 • 2010: NHMRC # 628756: Identification of a plasma factor of remote ischemic preconditioning and its effect on

the proteome after heart surgery $375.250 • 2010: NHMRC # 607404: Does remote ischemic preconditioning induce protective mitochondrial function in

congenital heart defect surgery? $138.900 • 2013: NHMRC #1051113: Detection of cardiac allograft rejection by peripheral blood gene expression: a novel

concept of personalized approach to transplantation. $284.818 • 2013: NHMRC #1047923: detection of liver and renal function abnormalities in the Australian and New Zealand

population of Fontan patients. $336.162

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INDUSTRY FUNDED GRANTS

2008 $ 40.000 Australian From CellCept Australia Research Grants for the study titled, “The Implications of Brain Death in Donor Lung Injury: Investigation and Blockade of the Endothelin Axis” Co-applicants: Fraser J, Chambers D, Barnett A. CARG, Roche Products Pty Ltd 4-10 Inman Road, Dee Why NSW, Australia Tel.: (02) 9454 9000; Fax.: (02) 9981 3229 EDITORIAL/ REVIEWER ROLES

Journals: The Lancet (2007-9) Circulation (2005-8) European Journal of Cardiothoracic Surgery (2005-9) Journal of Catheterization and Interventions (2005-6) Journal of Thoracic and Cardiovacular Surgery (2006-9) Physiological Genomics (2005-9), Heart (2006-7) The Annals of Thoracic Surgery (2003-9) Journal of Clinical Anesthesia (2007) Thrombosis Research (2009-10) Clinical Anatomy (2010) Conferences: Member of the Scientific Advisory Boards to International Academy of Cardiologyand The 14

th World Congress on

Heart Disease, Toronto, ON, Canada, July 19-29, 2008 Invited Speaker to 5

th World Congress of Paediatric Cardiology and Cardiac Surgery, June 21-26, 2009 Cairns,

Australia Member of the Scientific Advisory Boards to International Academy of Cardiology and The 15

th World Congress on

Heart Disease, Vancourver, BC, Canada, July 24-27, 2010 SUPERVISION

PhD Supervision: 1. Dr Saxena, MCh, DNB, University of Western Australia – successful completion in 2010;

2. Ms Hepponstall, BMedSci, University of Melbourne – obtained NHMRC Postgraduate Sholarship Award 2011 for

her PhD project titled “Identifying a protective factor in the blood of children having heart surgery”. Advanced Medical Science (AMS) Students (Bachelor in Biomedical Sciences) Supervision: 2009-2010

Matthew Yong, University of Melbourne, Heart Foundation Scholarship

Nathalie Soszyn, University of Melbourne, Heart Foundation Scholarship

Tyson Fricke, University of Melbourne

Jeremy Ong, University of Melbourne 2010-2011

Jacqueline Cheung, University of Melbourne

Ryan Diggle, University of Melbourne

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2011-2012

Sharman TANNY – University of Melbourne 2012-2013

Ed Buratto – University of Melbourne

William Shi – University of Melbourne 2013-2014

Yen Huynh – University of Melbourne – Scholarly Selective

Victor Liu – University of Melbourne – Scholarly Selective

Philip Naimo – University of Melbourne – Scholarly Selective

Michael Rouse – University of Melbourne – Scholarly Selective 2014-2015

Jessica Saunders – University of Melbourne – Scholarly Selective

Annie Lee – University of Melbourne – Scholarly Selective

Julia Donald – University of Melbourne – Scholarly Selective PUBLICATIONS

BOOK CHAPTERS The Natural and Modified History of Congenital Heart Disease

Edited by Robert M. Freedom Futura Publishing Company Inc., New York, 2003

Chapter 3. Ventricular septal defect. Robert M. Freedom, Shi-Joon Yoo, John G. Coles, Igor Konstantinov.

Chapter 24A. Total anomalous pulmonary venous connections. Robert M. Freedom, Shi-Joon Yoo, John G. Coles, Igor Konstantinov.

Chapter 24E. Congenital stenosis of the individual pulmonary veins. Robert M. Freedom, Shi-Joon Yoo, John G. Coles, Igor Konstantinov.

A Practical Approach to Peri-operative Cardiac Anaesthesia and Surgery

Edited by Davy C.H. Cheng, MD and Tirone E. David, MD, Second Edition, Lippincott Williams & Wilkins, Philadelphia, 2005

Chapter 37: Adult Congenital Heart Surgery Glen Van Arsdell, Igor E. Konstantinov, William G. Williams

MANUSCRIPTS 1996 1. Hermansson U, Konstantinov I, Traff S. Lung injury with pleuropericardial rupture successfully treated by

video-assisted thoracoscopy. J Trauma 1996; 40: 1024-5.

2. Franzen SF, Huljebrant IE, Konstantinov IE, Nylander E, Olin CL. Aortic valve replacement for aortic stenosis

in patients with small aortic root. J Heart Valve Disease 1996; 5 (Suppl. III), S 284-8.

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1997 3. Konstantinov IE, Peterffy A. Tricuspid and pulmonary valve replacement in carcinoid heart disease.

J Heart Valve Disease 1997; 6:193-7. 4. Konstantinov IE, Franzen SF, Olin CL. Periprosthetic leaks and valve dehiscence. Alternative methods of

repair. J Heart Valve Disease 1997; 6:281-7.

5. Konstantinov IE. Eck-Pavlov shunt: the 120th anniversary of the first vascular anastomosis.

Surgery 1997; 121(6): 640-5. 6. Hermansson U, Konstantinov IE, Aren C. Tumor dissemination after VATS: What does it mean?

J Thorac Cardiovasc Surg 1997;114(2):300-302. 7. Konstantinov IE. The first coronary artery bypass operation and forgotten pioneers.

Ann Thorac Surg 1997;64:1522-3. 8. Konstantinov IE, Hermansson U, Peterzen B. An approach to intracardiac needles.

Asia Pacific Heart J 1997;6(2):24-7. 1998 9. Peterffy A, Konstantinov IE. Resection of distal tracheal and carinal tumors with the aid of cardiopulmonary

bypass. Scand Cardiovac J 1998;32(2):109-112 .

10. Konstantinov IE. Nikolai S. Korotkov: a story of an unknown surgeon with an immortal name.

Surgery 1998;123(4):371-81. 11. Konstantinov IE. A mystery of Vladimir P. Demikhov: the 50th anniversary of the first intrathoracic

transplantation. Ann Thorac Surg 1998;65:1171-7 .

12. Konstantinov IE. The life and death of professor Alexander P. Borodin: surgeon, chemist, and great musician.

Surgery 1998;123(6):606-16. 13. Hermansson U, Konstantinov IE, Aren C. Video-assisted thoracic surgery (VATS) lobectomy: the initial

Swedish experience. Semin Thorac Cardiovasc Surg 1998;10(4):285-90.

14. Konstantinov IE, Peterffy A. Distal tracheal tumor resection with cardiopulmonary bypass: revival of an old

technique? Ann Thorac Surg 1998; 66:1865-6.

1999 15. Thubrikar MJ, Konstantinov IE, Selim GA, Gong GG, Fowler B, Robicsek F. The influence of sizing on the

dynamic function of the free-hand implanted porcine aortic homograft: an in vitro study. J Heart Valve Disease 1999; 8(3)242-53.

16. Konstantinov IE, Alexi-Meskishvili VV. Cavo-pulmonary shunt: from the first experiments to clinical practice.

Ann Thorac Surg 1999;68:1100-6. 17. Konstantinov IE. The last word on "A proper name for the internal mammary artery?".

Ann Thorac Surg 1999;68:1440-41. 2000 18. Konstantinov IE, Alexi-Meskishvili VV. Early Italian contributions to cavopulmonary shunt procedures.

Ann Thorac Surg 2000;69:311-2.

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19. Konstantinov IE, Alexi-Meskhishvili VV. Sergei Brukhonenko: Development of the first heart-lung machine for total body perfusion. Ann Thorac Surg 2000;69:962-6.

20. Konstantinov IE. In search for Alexander A. Maximow: a man behind the Unitarian theory of haematopoiesis.

Perspectives in Biology and Medicine 2000;43(2):269-76. 21. Thubrikar MJ, Gong GG, Konstantinov IE, Selim GA, Fowler BL, Robicsek F. Influence of sizing and

subcoronary implantation technique on the function of porcine aortic homograft. J Med Eng Technol 2000;24(4):173-80.

22. Konstantinov IE. Robert H. Goetz: a surgeon who did the first successful coronary artery bypass operation.

Ann Thorac Surg 2000;69:1966-72. 23. Alexi-Meskhishvili VV, Konstantinov IE. Yustin Y. Djanelidze and the first successful repair of an injured

ascending aorta. Texas Heart Inst J 2000;27: 113-6.

24. Robicsek F, Konstantinov IE. Humer Hultl: the father of the surgical stapler. J Med Biography 2000;8:1-4. 2001 25. Konstantinov IE, Puga FJ. Surgical treatment of persistent esophageal compression by an unusual form of

right aortic arch. Ann Thorac Surg 2001;72:2121-3.

26. Konstantinov IE, Hermansson U. Intrathoracic migration of Kirschner pins: is video-assisted thoracic surgery

justified? Ann Thorac Surg 2001;72:668-9.

27. Konstantinov IE, Puga FJ, Alexi-Meskishvili VV. Thrombosis of intra and extracardiac conduits after modified

Fontan operation in patients with azygous continuation of the inferior vena cava. Ann Thorac Surg 2001 Nov;72(5):1641-4.

28. Konstantinov IE, Mickleborough LL, Graba J, Merchant N. Intraventricular mitral annuloplasty technique for

use with repair of posterior left ventricular aneurysm. J Thorac Cardiovasc Surg 2001;122:1244-7.

29. Konstantinov IE, Zehr KJ. Aortic root replacement in a patient with vancomycin-resistant Enterococcus

faecium endocarditis and leukemia. Chest 2001 Nov; 120(5):1744-6.

30. Van Son J, Konstantinov IE. Wilhelm Ebstein and Ebstein's malformation.

Eur J Cardiothorac Surg 2001 Nov;20(5):1082-5. 2002 31. Van Son J, Konstantinov IE. Burkhart Kommerell and Kommerell's diverticulum.

Texas Heart Inst J 2002;29:109-12. 32. Hakanson E, Konstantinov IE, Franson SG, Svedjeholm R. Management of life threatening hemoptysis: a

review of the literature apropos two cases. Br J Anesthesia 2002; 88:291-5.

33. O'Blenes SB, Roy N, Konstantinov I, Bohn D, Van Arsdell GS. Vasopressin reversal of phenoxybenzamine-

induced hypotension after the Norwood procedure. J Thorac Cardiovasc Surg 2002;123:1012-3.

34. Konstantinov IE. Resection of Kommerell's diverticulum and left subclavian artery transfer does not always

relieve symptoms.

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Eur J Cardiothorac Surg 2002;22:1038-9. 35. Konstantinov IE. Fontan operation in a patient with separate hepatic venous drainage: is there a problem?

Ann Thorac Surg 2002;74:2228-9. 36. Konstantinov IE. Cardiology's 10 greatest discoveries.

Texas Heart Inst J 2002;29:344. 2003 37. Konstantinov IE, Van Arsdell GS, O'Blenes SB, Roy N, Campbell A. The retro-aortic innominate vein with

coarctation of the aorta: surgical repair and embryology review. Ann Thorac Surg 2003;75:1014-6.

38. Konstantinov IE, Coles JG. The role of intraoperative device closure in the management of muscular

ventricular septal defects. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2003;6:84-9.

39. Alexi-Meskishvili VV, Konstantinov IE. Surgery for atrial septal defect: from the first experiments to clinical

practice. Ann Thorac Surg 2003;76:243-5. 40. Konstantinov IE, Zehr KJ. Mechanism and prevention of aortic insufficiency in a Marfan's patient after aortic

root reconstruction using a graft with tailored sinuses. Texas Heart Inst J 2003; 30(3):243-5.

2004 41. Fortuna RS, Ashburn DA, Konstantinov IE, Burkhart HM, De Oliveira N, Smallhorn JF, Williams WG, Van

Arsdell GS. Atrioventricular septal defects: effect of bridging leaflet division on early valve function. Ann Thorac Surg 2004;77(3):895-902.

42. Konstantinov IE, Coles JG, Boscarino C, Takahashi M, Goncalves J, Ritter J, Van Arsdell GS. Gene expression in

children undergoing cardiac surgery for right heart obstructive lesions. J Thorac Cardiovasc Surg 2004;127(3):746-54.

43. Konstantiniov IE, Alexi-Meskishvili VV, Williams WG, Freedom RM, Van Praagh R. Atrial switch operation:

past, present and future. Ann Thorac Surg 2004;77:2250-8. 44. Li J, Stokoe J, Konstantinov IE, Edgell D, Cheung M, Kharbanda R, Redington AN. Continuous measurement of

oxygen consumption during cardiopulmonary bypass: description of the method and first in-vivo observations. Ann Thorac Surg 2004;77:1671-7.

45. Konstantinov IE. Circular vascular stapling in coronary surgery.

Ann Thorac Surg 2004;78:369-73. 46. Konstantinov IE. The return of the coronary stapler: will a new technique overcome an old obstacle?

J Thorac Cardiovasc Surg 2004;128:330-1. 47. Konstantinov IE, Arab S, Kharbanda RK, Li J, Cheung MM, Cherepanov V, Downey GP, Liu P, Cukerman E,

Coles JG, Redington AN. The remote ischemic preconditioning stimulus modifies inflammatory gene expression in humans. Physiol Genomics 2004;19(1):143-50.

48. Konstantinov IE. Vasilii I. Kolesov: a surgeon to remember.

Texas Heart Inst J 2004;31:349-58. 49. Konstantinov IE, Lai L, Colan S, Williams WG, Li J, Jonas R, Van Praagh R. Atrioventricular discordance with

ventriculoarterial concordance: a remaining indication for the atrial switch operation. J Thorac Cardiovasc Surg 2004;128(6):944-5.

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2005 50. Konstantinov IE, Benson LN, Caldarone CA, Li J, Shimizu M, Coles JG, Van Arsdell GS, Williams WG. A simple

technique for interventional transcatheter completion of total cavopulmonary connection. J Thorac Cardiovasc Surg 2005; 129(1):210-2.

51. McCrindle BW, Tchervenkov CI, Konstantinov IE, Williams WG, Neirotti R, Jacobs ML, Blackstone EH. Risk

factors associated with mortality and reinterventions in 474 neonates with interruption of the aortic arch: a congenital heart surgeons society study. J Thorac Cardiovasc Surg 2005; 129(2):343-50.

52. Yun TJ, Coles JG, Konstantinov IE, Al-Radi OO, Wald RM, Guerra V, de Oliveira NC, Van Arsdell GS, Williams

WG, Smallhorn J, Caldarone CA. Conventional and sutureless technique for management of the pulmonary veins: evolution of indications from postrepair pulmonary vein stenosis to primary pulmonary vein anomalies. J Thorac Cardiovasc Surg 2005;129(1):167-74.

53. Burkhart HM, Ashburn DA, Williams WG, Konstantinov IE, Benson L, Van Arsdell GS. A novel technique to

prevent re-coarctation after the Norwood procedure. J Thorac Cardiovasc Surg 2005;130:61-5.

54. Konstantinov IE, Rosapepe F, Dearani JA, Alexi-Meskishvili VV, Li J. A tribute to Giancarlo Rastelli.

Ann Thorac Surg 2005; 79(5):1819-23. 55. Konstantinov IE, Li J, Cheung MM, Shimizu M, Stokoe J, Kharbanda RK, Redington AN. Prior remote ischemic

preconditioning of the recipient reduces myocardial ischemia-reperfusion injury of the denervated donor heart via a Katp channel-dependent mechanism: a porcine transplant model. Transplantation 2005;79(12):1691-5.

56. Konstantinov IE. A new technique of repair of mitral paravalvular leak?

J Thorac Cardiovasc Surg 2005; 130(2): 614-5. 57. Alexi-Meskishvili VV, Konstantinov IE. Pioneering contributions of Alexander A. Vishnevsky and his team to

cardiac surgery. J Card Surg 2005;20(6):569-73.

58. Konstantinov IE, Arab S, Li J, Cheung MMH, Redington AN. The remote ischemic preconditioning modifies

gene expression in mouse myocardium. J Thorac Cardiovasc Surg 2005;130(5):1326-32.

59. Shimizu M, Nii M, Konstantinov IE, Li J, Redington AN. Isovolumic but not ejection phase tissue Doppler

indices detect left ventricular dysfunction caused by coronary stenosis. J Am Soc Echocardiogr 2005;18(12):1241-6.

60. Cheung MMH, Konstantinov IE, Redington AN. Late complications of repair of tetralogy of Fallot and

indications for pulmonary valve replacement. Semin Thorac Cardiovasc Surg 2005;17(2):155-9.

61. Shimizu M, Konstantinov IE, Suess AM, Cheung M, McCrindle BW, Vogel M, Redington AN. Noninvasive

analysis of myocardial function using high-resolution Doppler tissue echocardiography in rats. J Am Soc Echocardiogr 2005; 18(5): 461-7.

62. Li J, Stokoe J, Konstantinov IE, Kharbanda RK, Redington AN. Evidence for a significant myocardial

contribution to total metabolic burden during hypothermic cardiopulmonary bypass. Perfusion 2005;20(5):277-83.

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2006 63. Konstantinov IE, Karamlou T, Blackstone EH, Mosca RS, Lofland GK, Caldarone CA, Williams WG, McCrindle

BW. Truncus arteriosus associated with interrupted aortic arch in 50 neonates: a congenital heart surgeons society study. Ann Thorac Surg 2006;81(1):214-22.

64. Alexi-Meskishvili VV, Konstantinov IE. Sergei S. Yudin: an untold story. Surgery 2006;139(1):115-22. 65. Li J, Konstantinov IE, Redington AN, Van Arsdell GS. Assumed oxygen consumption in the determination of

cardiac output in children after cardiac surgery. J Thorac Cardiovasc Surg 2006;131(1):251. 66. Saxena P, Konstantinov IE, Koniuszko M, Singh T, Newman MAJ. Persistent severe vasospasm in off-pump

coronary bypass surgery: the value of intraluminal stenting. J Thorac Cardiovasc Surg 2006;131:237-8. 67. Konstantinov IE, Karamlou T, Williams WG, Quaegebeur JM, del Nido PJ, Spray TL, Caldarone CA, Blackstone

EH, McCrindle BW. Surgical management of aorto-pulmonary window associated with interrupted aortic arch: a congenital heart surgeon’s society study. J Thorac Cardiovasc Surg 2006;131(5):1136-1141.

68. Konstantinov IE, Saxena P, Koniuszko MD, Singh T, Carter M, Alvarez J, Newman AJ. Prosthesis replacement

in a calcified mitral annulus with reconstruction of the intervalvular fibrous body: the value of an alternative repair. Texas Heart Inst J 2006; 33(2):232-4.

69. Konstantinov IE, Redington AN. Linking gene expression, nuclear factor kappa B, remote ischemic

preconditioning and transplantation: a quest for an elusive Holy Grail or a road to an amazing discovery? J Thorac Cardiovasc Surg 2006; 131(2):507-9.

70. Konstantinov IE, Li J, Redington AN. From mesothelioma to myocardial protection via the PI3K pathway: a

new vista in cardiothoracic surgery. J Thorac Cardiovasc Surg 2006; 131(2):509-10. 71. Nii M, Shimizu M, Roman KS, Konstantinov I, Li J, Redington AN, Jaeggi ET. Doppler tissue imaging in the

assessment of atrioventricular conduction time: validation of a novel technique and comparison with electrophysiologic and pulsed wave Doppler-derived equivalents in an animal model. J Am Soc Echocardiogr 2006; 19(3):314-21.

72. Konstantinov IE. Repair of persistent truncus arteriosus with interrupted aortic arch: what did we learn?

Eur J Cardiothorac Surg 2006;29(4):635-6. 73. Bala A, Saxena P, Konstantinov IE. Transthoracic drainage of S.milleri liver abscess.

J Thorac Cardiovasc Surg 2006; 131(3):744-5. 74. Saxena P, Konstantinov IE, Burstow D, Tam R. Surgical repair of a large coronary artery aneurysm with

arteriovenous fistula. J Thorac Cardiovasc Surg 2006;131(5):1167-8. 75. Cheung MMH, Kharbanda RK, Konstantinov IE, Shimizu M, Frnova H, Li J, Holtby HM, Cox PN, Smallhorn JF,

Van Arsdell GS, Redington AN. Randomised controlled trial of the effects of remote ischemic preconditioning in children undergoing cardiac surgery: first clinical application in humans. J Am Coll Cardiol 2006;47:2277-82.

76. Saxena P, Konstantinov IE, Koniuszko MD, Ghosh S, Low VHS, Newman MAJ. Hiatal herniation of the

pancreas: diagnosis and surgical management. J Thorac Cardiovasc Surg 2006;131(5):1204-5. 77. Konstantinov IE. Primary sutureless repair of total anomalous pulmonary venous connection: the value of

intrapleural hilar reapproximation. J Thorac Cardiovasc Surg 2006;132(3):729-30. 78. Kharbanda RK, Li J, Konstantinov IE, Cheung MM, White PA, Stokoe J, Cox P, Vogel M, Van Arsdell GS,

MacAllister R, Redington AN. Remote ischemic preconditioning protects against cardiopulmonary bypass induced tissue injury – preclinical study. Heart 2006; 92(10): 1506-11.

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79. Konstantinov IE, Alexi-Meskishvili VV. Intracardiac covered stent for transcatheter completion of total cavo-pulmonary connection: anatomical, physiological and technical considerations. Scandinavian Cardiovasc J 2006; 40(2):71-5.

80. Saxena P, Konstantinov IE, Newman MAJ. Use of a nasal speculum for chest-drain insertion: a simple

technique. Tex Heart Inst J 2006;33:402-3. 81. Saxena P, Konstantinov IE, Newman MAJ, Rosenfeldt F. Use of a recirculator device for pericardial cold

irrigation in cardiac surgery. Tex Heart Inst J 2006;33:412-3. 82. Tam R, Joshi P, Konstantinov IE. A simple method of preparing artificial chordae for mitral valve repair.

J Thorac Cardiovasc Surg 2006;132(6):1486-7. 83. Konstantinov IE, Saxena P, Stewart N, Newman MAJ. Acute massive pulmonary embolism following

migration of an inferior vena cava filter to the right ventricle. Texas Heart Inst J 2006;33(4):532-3. 84. Stewart NM, Saxena P, Newman MA, Konstantinov IE. Decompression of giant bulla in acute pneumonia:

surgical palliation prior to definitive management. Ann Thorac Surg 2006;82(6)2308-9. 85. Saxena P, Konstantinov IE, Newman AJ. Use of double wires in sternal closure: a useful technique.

Tex Heart Inst J 2006;33:540-1. 86. Konstantinov IE, Mejevoi N, Anichkov NM. Nikolai N. Anichkov and his theory of atherosclerosis.

Tex Heart Inst J 2006;33:417-23. 2007 87. Schmidt MR, Smerup M, Konstantinov IE, Shimizu M, Li J, Cheung MMH, White PA, Kristiansen SB, Sorensen

K, Dzavik V, Redington AN, Kharbanda RK. Intermittent peripheral tissue ischemia during coronary ischemia reduces myocardial infarction: first demonstration of remote ischemic perconditioning. Am J Physiol Heart Circ Physiol 2007; 292(4):H1883-90.

88. Saxena P, Konstantinov IE, Newman MA. Use of temporary epicardial pacing wires in cardiac surgery.

Heart Lung Circ 2007;16(1):60 89. Konstantinov IE, Pohlner P. An approach to interrupted aortic arch associated with transposition of great

arteries. J Thorac Cardiovasc Surg 2007;133(1):256-7. 90. Konstantinov IE, McNeil K, Yeung S, Fawcett J, Mullany D, Dunning J. Fast track recovery following en bloc

heart-lung-liver transplantation in a patient with cystic fibrosis complicated by severe portal hypertension. Heart Lung Circ 2007, Mar 20; [Epub ahead of print]. 2008;17(2):154-6.

91. Konstantinov IE, Saxena P, Friedrich L, Newman MAJ. Emergency surgery following failed device closure of

the atrial septal defect. J Thorac Cardiovasc Surg 2007;133(5):1370-1. 92. Li J, Konstantinov IE, Cai S, Shimizu M, Redington AN. Systemic and myocardial oxygen consumption

following brain death in pigs. Transplantation Proceedings 2007;39:21-6. 93. Konstantinov IE, Saxena P, Koniuszko MD, Alvarez JMP, Newman MAJ. Acute massive pulmonary embolism

with cardiopulmonary resuscitation: management and results. Texas Heart Inst J 2007;34(1):41-6.

94. Shimizu M, Konstantinov IE, Kharbanda RK, Cheung MH, Redington AN. Effects of intermittent lower limb

ischemia on coronary blood flow and coronary resistance in pigs. Acta Physiologica (Oxf) 2007;190(2):103-9.

95. Konstantinov IE, Newman MAJ, Koniuszko MD, Saxena P, Ghosh S, Low VHS, Khor TS, Naran A. Superior vena

cava obstruction by tumour thrombus in invasive thymoma: diagnosis and surgical management. Heart Lung Circ 2007;16:462-4.

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96. Saxena P, Konstantinov IE, Newman MAJ. Palliative surgical management of iatrogenic oesophageal

perforation in the setting of malignant disease. Heart Lung Circ 2008;17:434-6. 97. Konstantinov IE, Saxena P, Kiuszko M, Alvarez JM, Newman MA. Iatrogenic oesophageal perforation with

necrotizing mediastinitis: surgical management following delayed presentation. ANZ J Surgery 2007;77:399-401.

98. Konstantinov IE, Jalali H. Total cordal augmentation in a child with Marfan’s syndrome and severe mitral

insufficiency. Tex Heart Inst J 2007;34:423-4.

99. Saxena P, Konstantinov IE, Zelei D, Newman MA. Spontaneous subscapular abscess: a rare surgical condition.

Heart Lung Circ 2008;17(2):154-6 100. Saxena P, Konstantinov IE, Lee A, Newman MA. Papillary fibroelastoma of aortic valve: early diagnosis and

surgical management. J Thorac Cardiovasc Surg 2007;133(3):849-50.

101. Arab S, Konstantinov IE, Boscarino C, Cukerman E, Mori A, Li J, Liu PP, Redington AN, Coles JG. Early gene

expression profiles during intraoperative myocardial ischemia-reperfusion in cardiac surgery. J Thorac Cardiovasc Surg 2007;134:74-81.

102. Konstantinov IE. History of cardiology: Wilhelm Ebstein, MD. Interview by Mark Nicholls.

Circulation 2007; 116(17):f101-2. 103. Saxena P, Konstantinov IE, Newman MA. Severe vasospasm in off-pump coronary artery bypass surgery: a

difficult clinical problem. J Thorac Cardiovasc Surg 2007;134(5):1380-1.

104. Anichkov NM, Konstantinov IE. A.A. Maximow: on the 100

th anniversary of the unitarian theory of

hematopoiesis. Ark Path 2007;5:3-7. 2008 - 2009 105. Saxena P, Lee A, Konstantinov IE, Newman MAJ. Papillary fibroelastoma of aortic valve: diagnosis and

surgical management. Heart Lung Circ 2008;17:349-51.

106. Konstantinov IE, Saxena P, Vanden Dreisen R, Bala A, Carter M, Newman MAJ. Large bronchogenic cyst:

diagnosis and surgical management. Heart Lung Circ 2008;17:146-8.

107. Konstantinov IE, Pohlner P. One stage repair in a neonate with transposition of great arteries, interrupted

aortic arch and hypoplastic right ventricle. Tex Heart Inst J 2008;35(2):206-8.

108. Konstantinov IE. Pioneers in Cardiology: Vladimir P. Demikhov, PhD: a transplant pioneer.

Circulation 2008;117:f99-102. 109. Konstantinov IE. Total resection and complete reconstruction of tricuspid valve in acute infective

endocarditis. J Thorac Cardiovasc Surg 2008;136:531-2.

110. Konstantinov IE, Saxena P, Ling S, Barrett T. Repair of acute postinfarction atrioventricular dehiscence in

patient with posterior left ventricular aneurysm. J Thorac Cardiovasc Surg 2008;137(1):247-9.

111. Konstantinov IE. Partial bi-leaflet resection and reconstruction of mitral valve in acute infective endocarditis.

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J Thorac Cardiovasc Surg 2008;136:533-4. 112. Konstantinov IE, Saxena P, Barrett T, Jenkins G. Resection and reconstruction of the roof of the coronary

sinus for an unusually attached left atrial myxoma. J Thorac Cardiovasc Surg 2009;137(4):1032-4.

113. Konstantinov IE, Saxena P, Blackham R, Barrett T, Finn C, Newman MA. Thrombus straddling atrial septal

defect: surgical prevention of massive pulmonary and systemic embolism. Tex Heart Inst J 2008;35(4):475-6. 114. Saxena P, Konstantinov IE, Newman MA, Luthra S. In defence of aortocoronary top-end markers.

J Cardiac Surg 2008;23:411-2. 115. Newman MA, Saxena P, Luthra S, Konstantinov IE. “Gumnut” device for off-pump proximal aortocoronary

anastomosis. J Cardiac Surg 2008 Mar 31 [Epub ahead of print]

116. Konstantinov IE, Saxena P, Shehatha J. Coronary stent disease: when will enough be enough?

J Thoracic Cardiovasc Surg 2008;137(4):1020-1. 117. Saxena P, Newman MA, Redington AN, Konstantinov IE. Remote ischemic conditioning: evolution of the

concept, mechanisms and clinical application. J Cardiac Surg 2010; 21(1):127-34 (Epub 2009).

118. Saxena P, Shehatha J, Boyt A, Newman M, Konstantinov IE. Role of extracorporeal circulation in the

management of accidental deep hypothermia. Heart Lung Circ 2008, [Epub ahead of print].

119. Shehatha J, Saxena P, Clarke B, Dunning J, Konstantinov IE. Surgical management of extensive pulmonary

artery sarcoma. Ann Thorac Surg 2009;87(4):1269-71.

120. Shimizu M, Saxena P, Konstantinov IE, et al. Remote ischemic preconditioning decreases adhesion and

selectively modifies functional responses of human neutrophils. J Surg Research 2010;158;(1):155-61 (Epub 2009).

121. Messer S, Saxena P, Mickelburgh M, Jalali H, Konstantinov IE. Mitral valve replacement in calcified annulus

following ring annuloplasty. Asian Cardiovasc Thorac Ann 2008, 16(6):488-9.

122. Konstantinov IE, Saxena P. Independent lung ventilation in the postoperative management of large

bronchopleural fistula. J Thorac Cardiovasc Surg 2009[Epub ahead of print]; 2010;139(2):e21-2.

123. Konstantinov IE, Saxena P, Shehatha J, Mitchell A, Cheridan S. Novel aeration technique for necrotizing

fasciitis of the chest wall. Ann Thorac Surg 2008;86(6):1973-4.

124. Saxena P, Konstantinov IE, Downie S, Newman MA. Quadricuspid aortic valve: a rare clinical entity.

Heart Lung Circ 2009;18(1):50-1. 125. Konstantinov IE, Saxena P, Wood DJ. Stabilisation of chronic flail chest: a novel approach of surgical fixation

and osteogenesis. Thorax 2009;64(3):265-6. 126. Shehatha J, Alward M, Saxena P, Konstantinov IE. Surgical management of cardiac hydatidosis.

Tex Heart Inst J 2009;36(1):72-3. 127. Konstantinov IE, Saxena P. Sternal stabilization by interlocking wires: an alternative simple technique for

high-risk patients. J Card Surg 2009;24(5):510-1.

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128. Saxena P, Konstantinov IE. Bhagavant Kalke and his pioneering work on the bi-leaflet heart valve prosthesis. Ann Thorac Surg 2009;88(1):344-7.

129. Konstantinov IE, Saxena P, Shehatha J. Spontaneous multivessel coronary artery dissection: surgical

management in a postmenopausal woman. Tex Heart Inst J 2009;36(4):360-1.

130. Konstantinov IE. At the cutting edge of the impossible: a tribute to Vladimir P. Demikhov. Tex Heart Inst J

2009;36(5):453-8. 131. Saxena P, Bala A, Campbell K, Meloni B, d’Udekem Y, Konstantinov IE. Does remote ischemic preconditioning

prevent delayed hippocampal neuronal death following transient global cerebral ischemia in rats? Perfusion 2009;2493):207-11.

132. Konstantinov IE, Saxena P, d’Udekem Y, Brizard CP. Isolated subclavian artery : anatomical and surgical

considerations. Ann Thorac Surg 2009;88:1685-7. 133. Saxena P, Shaw OM, Misso NL, et al. Remote ischemic preconditioning stimulus decreases the expression of

kinin receptors in human neutrophils. J Surg Res 2009 [Epub ahead of print] 2011; 171: 311-6. 2010 134. Konstantinov IE, d’Udekem Y, Saxena P. Interposition pericardial flap after slide tracheoplasty in pulmonary

artery sling complex. Ann Thorac Surg 2010;89(1):289-91. 135. Liu JY, Kowalski R, Jones B, Konstantinov IE, et al. Moderately hypoplastic arches: do they reliably grow into

adulthood after conventional coarctation repair? Interactive Cardiovasc Thorac Surg 2010;10(4):582-6.

136. Konstantinov IE, Saxena P. Valve-sparing aortic root replacement and tricuspidization in a patient with an

asymmetric bicuspid aortic valve. Tex Heart Inst J 2010;37(1):79-81. 137. Saxena P, Shehatha J, Naran A, Rajaratnam S, Newman MA, Konstantinov IE. Papillary fibroelastoma of the

interventricular septum: mimicking a cardiac myxoma. Tex Heart Inst J 2010;37(1):119-20. 138. Iyengar AJ, Brizard CP, Konstantinov IE, d’Udekem Y. The opinion of taking down the Fontan circulation: the

Melbourne experience. J Thorac Cardiovasc Surg 2010;139(5):1346-8. 139. Hussein A, Iyengar AJ, Jones, Donath SM, Konstantinov IE, et al. Twenty-three years of single-stage end-to-

side anastomosis repair of interrupted aortic arches. J Thorac Cardiovasc Surg 2010;139(4):942-7. 140. 140.Saxena P, Downie S, Amanuel B, Newman M, Konstantinov IE. Giant pulmonary hamartoma: an

interesting clinico-pathologic entity. Heart Lung Circ 2010;19(9):573. 141. Konstantinov IE, Oka N, d’Udekem Y, Brizard CP. Surgical repair of aortopulmonary window associated with

interrupted aortic arch: long-term outcomes. J Thorac Cardiovasc Surg 2010;140(2):483-4. 142. Konstantinov IE. Carinal stabilization technique in severe tracheobronchial malacia after slide tracheoplasty.

J Thorac Cardiovasc Surg 2010;140(3):717-9. 143. Rotstein A, Konstantinov IE, Penny DJ. Kingella-infective endocarditis resulting in a perforated aortic root

abscess and fistulous connection between the sinus of Valsalva and the left atrium in a child. Cardiol Young 2010;20(3):332-3.

144. Oka N, Liava’a M, Saxena P, d’Udekem Y, Brizard CP, Konstantinov IE. Extended three-patch technique for

congenital supravalvular aortic stenosis. Asian Cardiovasc Thorac Ann 2010;18(3):297-8. 145. d’Udekem Y, Xu MY, Konstantinov IE. The optimal age at Fontan procedure and the ‘ticking clock’ theory: do

we have an answer? Eur J Cardiothorac Surg 2010 [Epub ahead of print]

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146. Konstantinov IE. Editorial comment: Transcathter completion of Fontan circulation: primum non nocere!

Eur J Cardiothorac Surg 2010 [Epub ahead of print] 147. Konstantinov IE, Fricke TA, d’Udekem Y, Radford DJ. Translocation of a single coronary artery from the

nionfacing sinus in the arterial switch operation: long-term patency of the interposition graft. J Thorac Cardiovasc Surg 2010;140(5):1193-4.

148. Saxena P, Thompson P, d’Udekem Y, Konstantinov IE. Kallikrein-Kinin System: a surgical perspective in post-

aprotinin era. J Surg Res 2010 [Epub ahead of print], 2011, 166: 138-145. 149. Konstantinov IE, Fricke TA, d’Udekem Y, Robertson T. Aortic dissection and rupture in adolescents after

tetralogy of Fallot repair. J Thorac Cardiovasc Surg 2010;140(5):e71-3. 2011 150. Fricke TA, Brizard C, d’Udekem Y, Konstantinov IE. Arterial switch operation in children with interrupted

aortic arch: long-term outcomes. J Thorac Cardiovasc Surg 2011;141:1547-8. 151. Setyapranata S, Brizard CP, Konstantinov IE, Iyengar A, Cheung M, d’Udekem Y. Should we always plan a

Fontan completion after a Kawashima procedure? Eur J Cardiothorac Surg 2011;40:1011-5. 152. Yong MS, d’Udekem Y, Robertson T, Horton S, Dronavalli M, Brizard C, Weintraub R, Shann F, Cheung M,

Konstantinov IE. Outcomes of surgery for simple total anomalous pulmonary venous drainage in neonates. Ann Thorac Surg 2011; 91:1921-7.

153. Konstantiniv IE, Saxena P, Barrett TL, Venkitachalam S, Keshavamurthy S, Newman MA. Salvage resection of

a large chemorefractory mediastinal germ cell tumor. Asian Cardiovasc Thorac Ann 2011;19:160-2. 154. Bohuta L, Hussein A, Fricke TA, d’Udekem Y, Bennett M, Brizard C, Konstantinov IE. Surgical repair of truncus

arteriosis associated with interrupted aortic arch: long-term outcomes. Ann Thorac Surg 2011;91:1473-7. 155. Liava’a M, Brooks P, Konstantinov I, Brizard C, d’Udekem Y. Changing trends in the management of

pulmonary atresia with intact ventricular septum: the Melbourne experience. Eur J Cardiothorac Surg 2011;40:1406-11.

156. d’Udekem Y, Hussin A, Xu M, Konstantinov I, Wilkinson J. Patients with interrupted aortic arches and small

aortic annulus: a rare entity? Ann Thorac Surg 2011;91:2026. 157. Yu X, Konstantinov IE, Kantich MJ, Rebeyka IM, Li J. Dynamic changes of myocardial oxygen consumption at

pacing increased heart rate – the first observation by the continuous measurement of systemic oxygen consumption. Scand Cardiovasc J 2011;45:301-6.

158. Soszyn N, Fricke TA, Whaeton GR, Ramsay JM, d’Udekem Y, Brizard CP, Konstantinov IE. Outcomes of the

arterial switch operation in patients with Taussig-Bing anomaly. Ann Thorac Surg 2011;92:673-9. 159. Barozzi L, Brizard CP, Galati JC, Konstantinov IE, Bohuta L, d’Udekem Y. Side-toside aorto-Gore Tex central

shunt warrants central patency and pulmonary arteries growth. Ann Thorac Surg 2011;92:1476-82. 160. Horton SB, Donath S, Thuys CA, et al. Integrated oxygenator FX05. ASAIO J 2011;57:522-6. 2012 161. Liava’a M, Brizard CP, Konstantinov IE, Robertson T, Cheung MM, Weintraub R, d’Udekem Y. Pulmonary

atresia, ventricular septal defect, and major aortopulmonary collaterals: neonatal pulmonary artery rehabilitation without unifocalization. Ann Thorac Surg 2012;93:185-91.

162. Ali N, Konstantinov I, Heath JA, Bhagwat K, Cheung M. Nonbacterial thrombotic endocarditis in a child with

non-Hodgkin’s lymphoma. Pediatr Cardiol 2012; 33(5):843-5.

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163. Pham NM, Alexander PM, Chow CW, Jones BO, d’Udekem Y, Konstantinov IE. Anterior mediastinal lymphagioma in an infant: diagnosis and surgical management. Heart Lung Circ 2012;21(5):289-91.

164. d’Udekem Y, Xu MY, Galati JC, Lu S, Iyengar AJ, Konstantinov IE, et al. Predictors of survival after single-

ventricle palliation: the impact of right ventricular dominance. J Am Coll Cardiol 2012;59(13):1178-85. 165. Ong J, Brizard CP, d’Udekem Y, Weintraub R, Robertson T, Cheung M, Konstantinov IE. Repair of

atrioventricular septal defect associated with tetralogy of Fallot or double-outlet right ventricle: 30 years of experience. Ann Thorac Surg 2012;94(1):172-8.

166. Wong DJ, Iyengar AJ, Wheaton GR, Ramsay JM, Grigg LE, Horton S, Konstantinov IE, Brizard CP, d’Udekem Y.

Long-term outcomes after atrioventricular valve operations in patients undergoing single-ventricle palliation. Ann Thorac Surg 2012;94(2):606-13.

167. Fricke TA, d’Udekem Y, Richardson M, Thuys C, Dronavalli M, Ramsay JM, Wheaton G, Grigg LE, Brizard CP,

Konstantinov IE. Outcomes of the arterial switch operation for transplantation of the great arteries: 25 years of experience. Ann Thorac Surg 2012;94(1):139-45.

168. Yong MS, d’Udekem Y, Brizard CP, Robertson T, Robertson CF, Weintraub R, Konstantinov IE. Surgical

management of pulmonary artery sling in children. J Thorac Cardiovasc Surg 2012. 169. Rakhra SS, Brizard CP, d’Udekem Y, Konstantinov IE. Valve-sparing aortic root replacement in children.

J Thorac Cardiovasc Surg 2012. 170. Yong MS, Shann F, d’Udekem Y, Cheung MHH, Weintraub RG, Brizard CP, Konstantinov IE. Hemodynamic

index for risk stratification after neonatal total anomalous pulmonary venous drainage repair. Ann Thorac Surg 2012.

171. Fricke TA, Brizard CP, d’Udekem Y, Konstantinov IE. Aortic root and valve surgery after arterial switch

operation. J Thorac Cardiovasc Surg 2012. 172. Hepponstall M, Ignjatovic V, Binos S, Monagle P, Jones B, Cheung MH, d’Udekem Y, Konstantinov IE. Remote

ischemic preconditioning (RIPC) modifies plasma proteome in humans. PLoS One 2012;7(11):e48284.

173. Brink J, Lee MG, Konstantinov IE, Cheung MM, Goh TH, Bennett M, Brizard CP, d’Udekem Y.

Ann Thorac Surg 2012 Nov 29, Epub ahead of print. 174. d’Udekem Y, Siddiqui J, Seaman CS, Konstantinov IE, Galati JC, Cheung MM, Brizard CP. Long-term results of

a strategy of aortic valve repair in the pediatric population. J Thorac Cardiovasc Surg 2012 Dec 12, Epub ahead of print.

2013 175. Rakhra SS, Lee M, Iyengar AJ, Wheaton GR, Grigg L, Konstantinov IE, Brizard CP, d'Udekem Y. Poor outcomes

after surgery for coarctation repair with hypoplastic arch warrants more extensive initial surgery and close long-term follow-up. Interact Cardiovasc Thorac Surg. 2013 Jan; 16(1):31-6.

176. Konstantinov IE.Remote ischemic preconditioning in children with cyanotic heart disease: lost in

translation? J Thorac Cardiovasc Surg. 2013 Feb;145(2):613-4 177. Brink J, Lee MG, Konstantinov IE, Cheung MM, Goh TH, Bennett M, Brizard CP, d'Udekem Y. Complications

of Extra-Anatomic Aortic Bypass for Complex Coarctation and Aortic Arch Hypoplasia. Ann Thorac Surg. 2013 Feb; 95(2):676-81.

178. d'Udekem Y, Siddiqui J, Seaman CS, Konstantinov IE, Galati JC, Cheung MM, Brizard CP. Long-term results of

a strategy of aortic valve repair in the pediatric population. J Thorac Cardiovascular Surg. 2013 Feb; 145(2):461-7; discussion 467-9.

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179. Yim D, Kothari D, Lane GK, Saundankar J, Konstantinov IE. Management of an unusual left coronary artery to right ventricular fistula in a neonate. Ann Thorac Surg. 2013 Feb;95(2):712-4.

180. Iyengar AJ, Konstantinov IE, Brizard CP, d'Udekem Y.Unreliable associations between type of Fontan and

early outcome? Ann Thorac Surg. 2013 Feb;95(2):774-5. 181. Tan TSP, Yong MS, d'Udekem Y, Kowalski R, Wheaton G, D'Orsogna L, Galati JC, Brizard CP, Konstantinov IE.

Ross procedure in children: 17-year experience at a single institution. J Am Heart Assoc. 2013 Apr 19;2(2) 182. Yong MS, d'Udekem Y, Robertson CF, Butt W, Brizard CP, Konstantinov IE. Tracheal repair in children:

reduction of mortality with advent of slide tracheoplasty. ANZ J Surg. 2013 Apr 18 (Epub ahead of print). 183. Yong MS, d'Udekem Y, Brizard CP, Robertson T, Robertson CF, Weintraub R, Konstantinov IE. Surgical

management of pulmonary artery sling in children. J Thorac Cardiovasc Surg. 2013 Apr; 145 (4): 1033-9. 184. Konstantinov IE, Jankovic GM. Alexander I. Ignatowski: a pioneer in the study of atherosclerosis. Tex Heart

Inst J. 2013;40(3):246-9. PMID: 23914012 [PubMed - indexed for MEDLINE] 185. Pepe A, Liaw NY, Hepponstall M, Sheeran FL, Yong MS, d’Udekem Y, Cheung MM, Konstantinov IE. Effect of

Remote Ischemic Preconditioning on Phosphorylated Protein Signalling in Children Undergoing Tetralogy of Fallot Repair: A Randomized Controlled Trial. J Am Heart Assoc 2013 May 10;2(3):e000095.

186. Lee MG, Brizard CP, Galati JC, Iyengar AJ, Rakhra SS, Konstantinov IE, Pflaumer A, d’Udekem Y. Outcomes of patients born with single-ventricle physiology and aortic arch obstruction: The 26 year Melbourne experience. J Thorac Cardiovasc Surg. 2013 Sept 24 (Epub ahead of print).

187. Saxena P, Aggarwal S, Misso NL, Passage J, Newman MA, Thompson PJ, d'Udekem Y, Praporski S, Konstantinov IE. Remote ischaemic preconditioning down-regulates kinin receptor expression in neutrophils of patients undergoing heart surgery. Interac Cardiovasc Thorac Surg. 2013 Oct:17(4):653-658.

188. Marcondes LD, Galati JC, Jones BO, Konstantinov IE, d’Udekem Y, Brizard CP, Cheung M. Abnormal left ventricular diastolic function at late follow-up after repair of total anomalous pulmonary venous drainage: The impact of altered ventricular loading in utero. J Thorac Cardiovasc Surg. 2013 Oct 4 (Epub ahead of print)

189. Siddiqui J, Brizard CP, Konstantinov IE, Galati J, Wheaton G, Cheung M, Horton S, d’Udekem Y. Outcomes after operations for bicuspid aortic valve disease in the paediatric population. Ann Thorac Surg. 2013 Oct 30 (Epub ahead of print).

190. Siddiqui J, Brizard CP, Iyegnar AJ, Hutchinson D, Konstantinov IE, Wheaton GR, Ramsay JM, d’Udekem Y. Surgical valvotomy and repair for neonatal and infant congenital aortic stenosis achieves better results than interventional catheterisation. J Am Coll Cardiol. 2013 Dec 3;62(22):2134-4

191. Jones BO, Pepe S, Sheeran FL, Donath S, Hardy P, Shekerdemian L, Penny DJ, McKenzie I, Horton S, Brizard CP, d'Udekem Y, Konstantinov IE, Cheung MM. Remote ischemic preconditioning in cyanosed neonates undergoing cardiopulmonary bypass: A randomized controlled trial. J Thorac Cardiovasc Surg. 2013 Dec;146(6):1334-40.

2014 192. Buratto E, McCrossan B, Galati J, Bullock A, Kelly A, d’Udekem Y, Brizard C, Konstantinov IE. Repair of partial

atrioventricular septal defect: a 37 year experience. Eur J Cardiothoracic Surg 2014 June 6 (Epub ahead of print)

193. Naimo P, Yong M, d’Udekem Y, Brizard C, Kelly A, Weintraub R, Konstantinov I.E. Outcomes of

Aortopulmonary Window Repair in Children: 33 Years of Experience. Ann Thoracic Surg 2014 June (Epub ahead of print)










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194. Lee M, Brink J, Galati JC, Rakhra SS, Konstantinov IE, Cheung MM, Brizard CP, d’Udekem Y. The end-to-side technique of repair for aortic arch offers excellent chances of growth to adulthood without reoperation. Ann Thorac Surg 2014 May (Epub ahead of print)

195. Iyengar AJ, Sharma VJ, d’Udekem Y, Konstantinov IE. Aortic arch and pulmonary artery reconstruction during

heart transplantation after failed fontan procedure. Interact Cardiovasc Thorac Surg 2014 May;18(5):693-4 196. Asakai H, Galati JC, Weskamp S, Jones B, Millar J, Konstantinov IE, d’Udekem Y, Brizard CP, Cheung MM.

Impact of Blalock-Taussig Shunt Size on Tricuspid Regurgitation in Hypoplastic Left Heart Syndrome. Ann Thorac Surg, 2014 April (Epub ahead of print)

197. Brink J, d’Udekem Y, Konstantinov IE. Slide Tracheoplasty with concomitant aortic arch repair in a low

weight neonate. Ann Thorac Surg 2014 Mar;97(3):1057-9 198. d’Udekem Y, Galati JC, Konstantinov IE, Cheung MH, Brizard CP. Intersurgeon variability in long-term

outcomes after transatrial repair of tetralogy of Fallot: 25 years’ experience with 675 patients. J Thoracic Cardiovasc Surg. 2014 Mar;147(3):880-6

199. Liu J, Jones B, Cheung M, Koleff J, Konstantinov IE, Grigg LE, Brizard C, d’Udekem Y. Favourable anatomy

after end-to-side repair of interrupted aortic arch. Heart, Lung Circ. 2014 Mar;23(3):256-64 200. Xie O, Brizard CP, d’Udekem Y, Galati JC, Kelly A, Yong MS, Weintraub RG, Konstantinov IE. Outcomes of

repair of complete atrioventricular septal defect in the current era. Eur J Cardiothoracic Surg. 2014;45:610-617

201. d’Udekem Y, Galati JC, Rolley GJ, Konstantinov IE, Weintraub RG, Grigg L et al. Low Risk Pulmonary Valve

Implantation after a Policy of Transatrial Repair of Tetralogy of Fallot delayed beyond the neonatal period: The Melbourne Experience over 25 years. J Am Coll Cardiol. 2014 Feb 18;63(6):563-8

202. Yong M.S, Yim D, Brizard C.P, Robertson T, Bullock A, d’Udekem Y, Konstantinov I.E. Long Term Outcomes of

Patients with Absent Pulmonary Valve Syndrome: 38 years of Experience. Ann Thorac Surg 2014 (accepted for publication).

203. Iyengar AI, Sharma VS, Weintraub R.G, Shipp A, Brizard C.P, d’Udekem Y, Konstantinov IE. Surgical strategies

to facilitate heart transplantation in children after failed univentricular palliations: the role of advanced intraoperative surgical preparation. Eur J Cardiothoracic Surg 2014 Feb 7 (Epub ahead of print)

ABSTRACTS 1. Konstantinov IE, Franzen SF, Olin CL. Repair of periprosthetic leaks.

Scand J Thorac Cardiovasc Surg 1995; 43 Suppl.: 45. 2. Hermansson U, Aren C, Konstantinov IE, Traff S. Video-assisted surgery - initial experience with

thoracoscopic lobectomy. Scand J Thorac Cardiovasc Surg 1996;44 Suppl.: 33. 3. Franzen SF, Huljebrant IE, Konstantinov IE, Nylander E, Olin CL. Aortic valve replacement with patch

enlargement of aortic root: analysis of 71 cases. Scand J Thorac Cardiovasc Surg 1996; 44 Suppl.: 84. 4. Thubrikar MJ, Konstantinov IE, Selim GA, Gong GG, Fowler B, Robicsek F. The influence of sizing on the

dynamic function of the free-hand implanted porcine aortic homograft: an in vitro study. ASAIOJ 1999; 45 (2): 134.

5. Kharbanda RK, Li J, Konstantinov IE, Cheung MM, White PA, Stokoe J, Cox P, Vogel M, Van Arsdell GS,

MacAllister R, Redington AN. Remote ischemic preconditioning protects from cardiopulmonary bypass injury in vivo. Circulation 2003;108:17(Suppl IV): IV-509-10.

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6. Konstantinov IE, Blackstone EH, Mosca RS, Lofland GK, Caldarone CA, Williams WG, McGrindle BW. Truncus arteriosus associated with interrupted aortic arch in 50 neonates: a congenital heart surgeons society study. Circulation 2004;110:17(Suppl III):III-530.

7. Cheung MM, Konstantinov IE, Kharbanda R, Shimizu M, Frndova H, Li J, Cox P, Holtby H, Smallhorn JF. Van

Arsdell G, Redington AN. Remote ischemic preconditioning reduces myocardial injury in children undergoing open heart surgery. Circulation 2004;110:17(Suppl III):III-568.

8. Shehatha J, Alward M, Yadav S, Konstantinov IE. Surgical management of 765 patients with thoracic

hydatidosis. Heart, Lung and Circulation 2007; 16(Suppl 1):S40 9. Konstantinov IE, Yadav S, McNeil K, Yeung S, Fawcett J, Mullany D, Munck L, Dunning J. En bloc heart-lung-

liver transplantation in patients with end-stage cystic fibrosis. Heart, Lung and Circulation 2007;16(Suppl 1):S42-3.

10. Wall D, Shehatha J, Konstantinov IE, Jalali H, Pohlner P. ALCAPA (anomalous origin of the left coronary artery

from the pulmonary artery) the 20 year Prince Charles hospital experience. Heart, Lung and Circulation 2007; 16(Suppl 1):S43.

11. Yadav S, Shehatha J, Konstantinov IE, Munck L, Tam R, McNeil K, Dunning J. Outcomes of en bloc heart-lung

transplantation: a report of 15 cases. Heart, Lung and Circulation 2007;16(Suppl 1):S45. INVITED PRESENTATIONS

Congres des 20 ans de la Chirurgie Cardiaque, 25-26 April 2007, Nimes, FRANCE 15

th World Congress on Heart Disease, July 18-21, 2009 Vancouver, BC, CANADA

5

th World Congress of Paediatric Cardiology and Cardiac Surgery, June 21-26, 2009 Cairns, AUSTRALIA

BOARDS/COMMITTEES

INTERNATIONAL Member of the Scientific Advisory Boards: International Academy of Cardiology The 14

th World Congress on Heart Disease, Toronto, ON, Canada, July 19-29, 2008

The 14th

World Congress on Heart Disease, Vancouver, BC, Canada, July 24-27, 2010 NATIONAL Member of the Counsel: School of Surgery and Pathology, University of Western Australia CURRENT MAJOR RESEARCH THEMES

Clinical application of remote ischemic preconditioning Molecular mechanisms of remote ischemic preconditioning Evaluation of inter-stage survival after stage 1 reconstruction of hypoplastic left heart syndrome Outcomes of double aortic arch repair Outcome of repair of pulmonary artery sling Long-term results of Taussig-Bing anomaly repair Long-term results of arterial switch operation

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CURRENT CLINICAL ACTIVITIES

Full time Consultant Cardiac Surgeon at RCH ADDITIONAL TRAINING

Aortic Root Surgery: Homograft and Autograft Replacement Conducted by: Prof. John Pepper/ Prof. Magdi Yacoub, The Royal College of Surgeons of England, London, UK October 14-16, 1996 REGISTRATION

ACTIVE: Russian Medical License and Full Registration # 225

Issued June 20, 1992 - valid indefinitely New Jersey Full Medical License

From January 2006 - current Australian Health Practitioner Regulation Agency - MED0001215943

July 1, 2008 – Current INACTIVE: North Carolina Graduate Medical Training License # 78890

From June 25, 1997 to June 30, 1998 Illinois Medical Temporary License # 125-038765

From July 21, 1998 to July 21, 1999 Minnesota Board of Medical Practice Residency Permit # 13861

From June 26, 1999 to July 30, 2000 College of Physicians and Surgeons of Ontario, Certificate of registration # 75348

From June 31, 2000 Medical Board of Western Australia, Registration

From January 1, 2005 to January 1, 2006, From July 1, 2007 to June 30, 2008

Medical Board of Queensland, Registration

From January 15, 2006 to January 20, 2007

md phd fracs - rch.org.au · md phd fracs . page 2 of 25 ... * listed in paper as part of...

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