malignant vascular neoplasms
TRANSCRIPT
Moritz Kaposi
Close up of Kaposi's sarcoma on the sole of the feet & toes.
Nodular stage
Characteristic purplish hue is seen in multifocal Kaposi's of the palate and gingiva.
Numerous violet papules & nodules grouped in glans penis
Visceral involvement with Kaposi's sarcoma in AIDS is common. Here are multiple reddish
nodules seen over the gastric mucosa.
Patch-stage lesion with the characteristic "PROMONTORY" SIGN (blood vessel with plump
endothelial cells protruding into abnormal dilated vessels) indicated by the arrow.
Patch stage KS: slit-like vascular spaces in the dermis.
Plaque stage
Plaque stage KS: Large numbers of intracellular and extracellular eosinophilic hyaline globules
are visible. The arrows indicate so-called "AUTOLUMINATION", with paranuclear vacuoles
containing erythrocytes.
KS: characteristically has hyaline globules, as seen here stained with PAS.
KS: characteristically has deposits of hemosiderin granules and faint, pale pink
hyaline globules, as seen here.
KS: slit-like vascular spaces in the dermis of the skin with extravasation of RBCs.
The low power view of KS is cellular dermal nodule
Nodular KS
KS Schools of fish
Nodular KS: A. The dermis is expanded by a solid tumor nodule (H&E).
B. Fascicles of relatively monomorphic spindled cells, with slit-like vascular channels containing RBCs (H&E).
C. The nuclei of the tumor cells demonstrate immuno-reactivity for HHV-8 (LNA-1 immunohistochemical stain).
CD31
KS: immunohistochemical stain with antibody to CD34, which stains the
cells forming the vascular slits.
The antibody to HHV-8 latent nuclear antigen-1 (LNA-1)