major histocompatibility complex · qa-1 . qa- 2 . tl . tla . figure 8-1 . mhc •haplotype: –...
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Major Histocompatibility Complex Chapter 8
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I
TLA
Qa-1 Qa- 2
TL
TLA
Figure 8-1
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MHC
• Haplotype: – The set of alleles present on each
chromosome – Outbred individuals have 2 haplotypes – Inbred individuals have 2 identical
haplotypes
• MHC molecules are co-dominantly expressed.
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Inbred Mice
• In a given inbred strain of mice, every mouse is genetically identical to every other mouse in that strain. – Syngenic – Allogenic
• Strains or individuals express different alleles.
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Graft Nomenclature • Isograft
– Graft from one individual to itself
• Syngenic – Graft between identical individuals
• Allograft – Graft between individuals of different strain.
• Xenograft – Graft between different species
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Diversity • MHC molecules exhibit a high degree of
diversity • Diversity is due to polymorphism or the
presence of multiple alleles in the population for a given locus.
• The sequence variation between alleles is clustered to the α1/α2 and α1/β1 regions of class I and class II molecules respectively.
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Ting and Trowsdale, 2002
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