MAGNASIM: Computational Platform for MRI Guided Nanomagnetic Particle Aggregations

BIOMEDICAL MECHATRONICS LABORATORYWWW.ROBOTS.NEU.EDU233 FORSYTH BUILDING360 HUNTINGTON AVENUEBOSTON, MA, 02115

Approximately 7.6 million people die from cancer each year according to an article titled "ACS Report Focuses on Global Cancer Toll".• The new invention which is a development of a drug-

delivery robotic system for localized tumor therapy Injects magnetized therapeutic nanoparticles (liposomes, micelles, carbon nanotubes, etc.) through the body and magnetically guide them to deep-seated lesions to increase the therapeutic efficiency while significantly reducing the side effects on healthy tissue.

For more information, Visit: http://www.northeastern.edu/MAGNASIMContact: Constantinos Mavroidis, Ph.D., Professor Biomedical Mechatronics Laboratory, Northeastern University, Boston, MA Email: mavro@coe.neu.edu , Tel: 617-373-4121

MAGNASIM is software to simulate the movement of particles in a fluidic environment either in micro or nanoscale. Basically the software would be able:• To examine Self-assembly process and breakup process• To provide design guidelines for fabricating, control and

steering the nanocapsules After gathering all the initial conditions, software is able to provide the user the following information:• Forces on each particle in each timesep.• Position of each particle in each timestep.• Interactions between particles.• Control and steer the particles to the considered

destination.• Providing visualization of the particles movement.

1.Localize Tumor2.Inject Micro/Nano vehicle3.Steer to/near Tumor4.Release Therapeutics5.Cancer gets killed