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Code No. 6001 / SFACULTY OF PHARMACY

M. Pharmacy I – Semester (Suppl.) Examination, November 2015(Common To All)

Subject: Pharmaceutical Analytical TechniquesTime: 3 Hours Max.Marks: 70

Note: Answer any Five questions. All questions carry equal marks.

1 a) Describe the instrumentation and applications of UV-visible spectrophotometer. 7b) Discuss Woodward-Fieser rules for calculating the max for conjugated dienes

by taking suitable example. 7

2 a) Discuss the principle, instrumentation along with a sketch diagram and applicationsof Fourier Transform Infra Red) (FTIR) spectrometer. 7

b) Draw schematic IR spectra for the following compounds and write the interpretationi) C2H5COCH3 ii) C6H5-CH2COOH iii) C6H5-CHO 7

3 a) Write the theory and principle of proton NMR spectroscopy. Write about shieldingand deshielding effects in NMR spectrum. 7

b) Discuss the effect of spin-spin coupling and explain how it is useful in structureelucidation of a compound with the help of a schematic NMR spectrum of asuitable compound. 7

4 a) Write a detailed account on various ionization techniques in Mass Spectrometry. 7b) Discuss the fragmentation patterns and fragment characteristics in relation to parent

structure and functional groups by taking suitable examples from straight chain andcyclic compounds containing hetero atoms. 7

5 a) Discuss various stationary phases and their applications in HPLC. 7b) Write the instrumentation and applications of HPTLC. 7

6 Write notes on: 2x7a) Derivatisation methods in GCb) Gel permeation chromatography

7 a) Write about preparative electrophoresis. 7b) Write the principle and applications of capillary electrophoresis. 7

8 Write notes on: 2x7a) Radioimmuno assayb) Chiral chromatography.

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Code No. 6004 / SFACULTY OF PHARMACY

M. Pharmacy (Ph.Chem. / Ph.cognosy) I – Semester (Supplementary) Examination,November 2015

Subject: Advanced Chemistry of Natural ProductsTime: 3 Hours Max.Marks: 70

Note: Answer any Five questions. All questions carry equal marks.

1 a) Discuss the role of natural products in development of new drugs with suitableexamples. 8

b) Discuss the sources, chemistry, structural modifications and uses of Rauwolfia. 6

2 Write the sources, structural features and elucidate the structure of Morphine. 14

3 a) Describe the problems in synthesis of peptides and systematically synthesize anyone tripeptide. 8

b) Write the structural features and mechanism action of artemisicin. 4

4 Write about:a) Discuss the basic chemistry and structural features of a steroids. 7b) Write about the structural modifications of steroids to develop into

anti-inflammatory and antifertility agents. 7

5 Write structural features and modifications, mechanism of action and therapeutic uses ofi) Gymnemic acids ii) Taxanes 14

6 Give the color reactions of steroids and elucidate the structure of cholesterol. 14

7 a) Discuss the chemistry of insulin. 7b) Write about primary, secondary and tertiary structure of proteins. 7

8 a) Write about the criteria in selection of lead. 5b) Define and classify alkaloids and write a note on general methods of structure

elucidation. 9

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Code No. 6015 / SFACULTY OF PHARMACY

M. Pharmacy (Pharmacognosy) I – Semester (Suppl.) Examination, November 2015Subject: Advanced Pharmacognosy – I

Time: 3 Hours Max.Marks: 70

Note: Answer any Five questions. All questions carry equal marks.

1 Describe the various traditional systems of medicines practiced in India. Discuss theconcept, principles, merits and demerits of Ayurvedic system of medicine. 14

2 Give the sources, chemistry, cultivation aspects and infective profile of Opium andCommiphora mukul. 14

3 Write a note on:a) Pharmacology of Allium sativum 4b) Weed management 5c) Cultivation of turmeric 5

4 a) Discuss the importance of medicinal plants in economy of the country. 6b) Write a note on herbal drug industries and research organizations in India and

their area of research. 8

5 a) Write the history and principles of Homeopathy system of medicines. 7b) List the various Ayurvedic preparations and describe any three. 7

6 a) Discuss the methods to retrieval of the plant data base. 6b) Give the source and pharmacological action of Phyllanthus emblica and

Ammi majus. 8

7 Discuss about:a) Good storage practices 5b) Natural pesticides 5c) Principles of Unani system of medicine 4

8 Describe the sources, chemistry and cultivation aspects and economy of Pepper andClove. 14

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Code No. 6016 / SFACULTY OF PHARMACY

M. Pharmacy (Pharmacognosy) I – Semester (Suppl.) Examination, November 2015Subject: Medicinal Plant Biotechnology

Time: 3 Hours Max.Marks: 70

Note: Answer any Five questions. All questions carry equal marks.1 a) Give an account of any two plant breeding methods with examples. 8

b) Write about structural and molecular organization of chromosome in plant cell. 6

2 a) Write a note on the types of bioreactors used for immobilization. 8b) Give a brief account of synthetic seed technology. 6

3 a) Explain various strategies used for production of Shikonin and Artemisin by tissueculture. 7

b) Give a brief account of Agrobacterium mediated gene transfer. 7

4 a) Explain the role of transgenic plants in crop quality improvement. 8b) Write a note on micropropagation. 6

5 a) What are the various tools used in biotransformation? Explain the role of precursorsand elicitors. 8

b) What is DNA hybridization? Explain. 6

6 Write about:i) Chemodenes 3ii) Electroporation 4iii) Edible vaccines 7

7 a) Give an account of the use of selectable marker genes in the production oftransgenic plants. 8

b) Write about somaclonal variation. Give its applications. 6

8 a) Write about various methods for haploid production. 7b) Give a brief account of hairy root cultures. 7

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Code No. 8001 / M

FACULTY OF PHARMACYM. Pharmacy (Common to All) I-Semester (Main) Examination, April 2015

Subject: Pharmaceutical Analytical TechniquesTime: 3 Hours Max.Marks: 70

Note: Answer any Five questions. All questions carry equal marks.

1 (a) Write a detailed account of various types of electronic transitions induced by theinteraction of UV radiation with organic molecules. 7

(b) Explain the effect of solvent and pH on the UV absorption maxima of organicmolecules. 7

2 (a) Write about the fundamental principles of NMR. Explain the instrument used inNMR by means of a neat sketch. 8

(b) Discuss applications of 1H-NMR in structure elucidation. 6

3 (a) Explain the basic principles involved in mass spectrometry. Discuss theconstruction of a mass spectrometer in detail. 8

(b) Give a detailed account of fragmentation patterns for carboxylic acids andalcohols. 6

4 (a) Write in brief about the basic principles involved in HPLC. Enlist variousstationary phases used in HPLC. 6

(b) In HPLC, explain how do you increase the resolution of compounds in a givenmixture. 8

5 Write about:(a) Finger print region in IR spectroscopy. 7(b) Mc Lafferty rearrangement in mass spectrometry. 7

6 Write an account of:(a) Principle and Applications of Radioimmuno Assay Methods 7(b) Principles, Instrumentation and Applications of Zone electrophoresis. 7

7 (a) What is necessary criterion for absorption to occur in the IR region? What typesof molecular vibrations are associated with IR absorption? 7

(b) Compare and contrast between conventional IR and FTIR spectrophotometerwith respect to working principle, sensitivity and instrumentation. 7

8 (a) Discuss about various derivatisation methods in gas chromatographic analysis. 6(b) Explain in detail the principle and working of any three detectors in GC. 8

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Code No. 8004 / M

FACULTY OF PHARMACYM. Pharmacy (Pharm.Chem./ Pharmacognosy) I-Semester (Main) Examination,

April 2015Subject : Advanced Chemistry of Natural Products

Time : 3 hours Max. Marks : 70

Note : Answer any FIVE questions. All questions carry equal marks.

1 a) Discuss the approaches for drug discovery from natural products.b) What is the lead and write the methods for the selection of lead? 8+6

2 Explain the general methods of peptide synthesis and give the preparation of anyone tripeptide. 14

3 a) Give the sources and color reactions of steroids.b) Elucidate the structure of cholesterol. 4+10

4 Write abouta) Structure and mechanism action of artemisicin and reserpineb) Sources and chemistry of insulin 7+7

5 a) What are alkaloids, classify and give the color reactions?b) Elucidate the structure of morphine. 4+10

6 Give an informative note ona) Stereochemistry of steroidsb) Morphine analogs and antagonists 6+8

7 a) Give the sources, chemistry, structural modifications and mechanism action ofvincristine.

b) Structures and structural features of anti-inflammatory agents. 6+8

8 Discuss abouta) Tertiary and quaternary structures of proteinsb) End group analysis of proteins 7+7

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Code No. 8015 / M

FACULTY OF PHARMACYM. Pharmacy (Pharmacognosy) I – Semester (Main) Examination, April 2015

Subject : Advanced Pharmacognosy - ITime : 3 hours Max. Marks : 70

Note : Answer any FIVE questions. All questions carry equal marks.

1 Discuss the methods of propagation and write in detail about the collection,harvesting and drying techniques in procurement of crude drugs from medicinalplants. 14

2 a) Write about the good storage practices of herbal drugs.b) Explain the chemistry of Opium.c) Write the chemical and pharmacological profile of Tinospora cardifolia. 4+5+5

3 Give the sources, infective profile and controlling measures for the turmeric,pepper and clove.

4 a) Write the history and principles of Ayurvedic system of medicines.b) List the various Ayurvedic preparations and describe any three. 6+8

5 Write abouta) Advantage and disadvantage of ‘Traditional systems of medicine.b) Chemistry, therapeutic uses and post harvesting techniques of any one crude

drug. 6+8

6 a) Discuss the laws in homeopathy systems of medicine.b) Write the principles and mode of diagnosis in Unani system of medicine. 7+7

7 a) Discuss about the cultivation aspects and therapeutic profile of Senna andAswagandha.

b) Give an informative note on weed management and control measures. 9+5

8 Discuss the pharmacological and phytochemical literature review on any twomedicinal plants. 14

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Code No. 8016 / MFACULTY OF PHARMACY

M. Pharmacy (Pharmacognosy) I–Semester (Main) Examination, April 2015Subject: Medicinal Plant Biotechnology

Time: 3 Hours Max.Marks: 70

Note: Answer any five Questions. All questions carry equal marks.

1 (a) Describe the cell cycle. (9)(b) Write a note on a genetic code. (5)

2 Discuss the various methods of gene transfer. (14)

3 (a) Write applications of transgenic plants with examples. (9)(b) Explain mutation and polyploidy. (5)

4 (a) Define biotransformation. Write the conditions, advantages and factors influencingbiotransformation. (7)

(b) Explain various biotransformation reactions with examples. (7)

5 Discuss various strategies for production of secondary metabolites using plant cellcultures. (14)

6 Write short notes on:a) Synthetic seeds (7)b) Nutritional requirement of plant cell cultures. (7)

7 (a) Define immobilization. Write the advantages and polymers used for immobilization. (7)(b) Explain the different methods of immobilizations using plant cells. (7)

8 (a) How do you produce shikonin using plant cell cultures? (7)(b) Explain the differences between hairy roots and normal roots. Write the applications

of hairy root cultures. (7)

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