M 30, A solid mass with calcification and cystic space on left lung base

Chondroid Hamartoma

Chondroid Hamartoma

Chondroid Hamartoma

Definition: Benign neoplasms composed of varying proportions of mesenchymal tissues, such as cartilage, fat, connective tissue and smooth muscle, typically combined with entrapped respiratory epithelium.

Histogenesis: Histogenesis is unknown, although genetic studies indicated a neoplastic rather than hamartomatous origin

Somatic genetics: Pulmonary hamartomas have a high frequency of genetic mutations, similar to those seen in other benign mesenchymal neoplasms such as lipomas. Most notable are mutations of high-mobility group (HMG) proteins, a family of non-histon, chromatin-associated proteins, which are important in regulating chromatin architecture and gene expression. Mutation in the regions 6p21 and 12q14-15 are most commonly found.