Lymphatic, immunity, & blood typing

Chapters 15, 20, and 21

Learning objectives

• Discuss the anatomy and role of the lymphatic system

• Discuss 1st, 2nd, and 3rd line of defenses of the body

• B-cells v T-cells• Various forms of immunity• Tissue Injury• Blood typing

Lymphatic system

• “Clean excess fluid”

• “Return excess fluid”

• Borders blood• Fluid in lymphatic

system?– Lymph

Lymphatic system

• Right lymphatic duct:–Right arm–Right head–Right thorax

• Thoracic duct:–Everything else

• Lymph nodes

Lymphatic system

• Tonsils• Thymus• Spleen

Immunity• Non-specific:• “Fights everything”• First Line– Mechanical

• Skin• Mucous membranes

– Chemical– Protective reflex

Immunity

• Non-specific• 2nd line• Phagocytosis• Inflammation• Fever– Review

thermoregulation

Tissue injury

• Ruptured defense– Pain– Fever– Inflammation– Histamine– WBCs

Colors to skin

• Jaundice— “yellow”

• Cyanosis—Lack of oxygen “blue”

• Flushed—Heated “red”

• White—“cold”

Immunity

• 3rd line• Specific:–“Fights unique

things”• B-cells• T-cells

Immunity

• B-cells–Antibodies–Antigens

• Antibody-mediated• Immune

memory

Immunity

• T-cells–Killer cells

• Cell-mediated

Immunity

• Primary response• Secondary

response• Immunotolerance

Immunity

• Active• Passive• Natural• Artificial

Group activity

Blood typing

• ABO system–A—A antigens–B—B antigens–AB—both A &B

antigens–O—no A or B

antigens

• Rh antigen– + or -

Blood TypingPractice

Rh “sensitization”

• Negative blood exposed to Positive blood– Accident– Pregnancy

• Erythroblastosis fetalis• RhoGam

• Hemolysis

• Agglutination

Group activity