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Axia Medical

James F. Krulisky President

August 14, 2009

Lycogel Products

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Anti-Aging Camouflage - 10 shades

(5 yellow, 5 blue)Acne Control Camouflage – 6 shades

(3 yellow, 3 blue)SPF 300.7oz (20ml)Acne has 2% salicylic acid

Two Concealers (triple thickness)Yellow and Blue

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LYCOGEL ProductsChoices are based on Blue or Yellow

BaseUndertones*Undertone Concealers FoundationsBlue Blue Ivory, Taupe, Mocha,

Ebony, CocoaYellow Yellow Crème, Beige, Honey,

Tawny, Almond*Determine by looking at the palms of the hand and forearms

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LYCOGEL Key Ingredients Silicone Gel Base LYCD (Live Yeast Cell Derivative) Titanium Dioxide Salicylic Acid (Acne line)

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LYCOGEL ActivesSilicone Gel Base

Isododecane (C12 isoparaffin ester) allows for the formation of a linear polymer meshwork that provides a stable foundation for fine particles such as pigments and titanium dioxide providing an unusually smooth texture when applied to the skin. The meshwork is water resistant and rub-off resistant but is gas permeable (breathable).

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LYCOGEL ActivesLYCD (Live Yeast Cell Derivative)

Also known as Biodynes, Skin Respiratory Factor, and Tissue Respiratory Factor is a nuclear extract of Saccharomyces cerevisiae after applying heat, UV, or chemical injury stress (Demple, B. 1998, Science 279, 1655).

Extracts include: Tissue Growth Factor beta (TGFb), Interlukin 1a (IL-1a), Epidermal Growth Factor (EGF), heat stress proteins, and other cytokines which are determined by SDS gel electrophoresis.

Cells are lysed using proteolytic enzymes, centrifuged, and the supernatant collected (Fishman, H.M., 2001 HAPPI, July, 42)

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Silicone Gel Base Benefits Uniform coverage- polymer complex for

universal color matching (10 shades) Breathability – permeability and coolness Long Lasting – water,rub-off resistant Good vehicle for actives (LYCD, TiDx) Forms a clear, dry, non-tacky meshwork

referred to as a “second skin”

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LYCD Benefits Oxygen Consumption – cell

proliferation and collagen and elastin synthesis (Fishman, H.M., 2001 HAPPI, July, 42), (Debelle L, Tamburro AM, Inter J Biochem. 1999; 31: 261-272)

Wound Healing – Beneficial nutrients to area of treatment (Kaplan, J.Z. 1984 Arch Surg 119, 1005-8).

Tissue Regeneration – Fibroblast activity (Lods, L., Scholz, C. Cosmet & Toil, 2000, 115(12) 616), (Meger WH, Ferreira PM, J of Biochem. 1999; 290: 1-13)

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LYCOGEL UsesImmediate post-procedure care:

CO2 Laser, Chemical Peel, Eye Surgery, Dermabrasion, Facial Surgery Bruising, Rhinoplasty, Laser Hair Removal, Skin Resurfacing, Scar Revision, Acne/Rosacea Treatments, Topical Skin Care TreatmentsFor anything that causes redness, swelling, or bruising

Results

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Patient had a 30% TCA peel. Lycogel is only being used on the left side.This slide shows the coverage potential of Lycogel on the left side.

Results

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After 7 days, the left side has healed faster than the right due to the daily use of Lycogel. In the after photo, Lycogel is now acting as a foundation.

No Lycogel Lycogel applied to left side

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Background Initial use by Hollywood makeup artists

because of breathability and being sweat-proof under set lighting (didn’t get on cloths)

Makeup artists volunteer at hospitals for burn victims and notice benefits of ease of application, comfort, coverage, and some healing advantages

Product moves to aesthetic procedures and is available through physicians only