Long Term Transdermal Clonidine Gets Under The Skin

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<ul><li><p>Long Term Transdermal Clonidine Gets Under The Skin In the treatment of patients with mild to moderate essential hypertension </p><p>The long term antihypertensive efficacy of transdermal clonidine was assessed in an open study 23 patients with mild to moderate essential hypertension (diastolic BP 90-104mm Hg) received transdermal clonidine (delivering 0.1, 0.2 or 0.3mg daily) applied once a week for 2 years, following a 2-week transdermal placebo run-in. If BP was uncontrolled (diastolic BP ~ 90mm Hg or reduced by &lt; 5mm Hg for patients with baseline diastolic BP 90-99mm Hg or &lt; 10mm Hg for patients with baseline diastolic BP 100-104mm Hg) by clonidine monotherapy, chlorthalidone 25mg daily was given instead of, or in addition to, clonidine. </p><p>After dose titration, BP was controlled by clonidine alone in 14 patients and by combination therapy in 6 patients. Diastolic BP was reduced from 99 to 81 mm Hg (p &lt; 0.01) in 11 patients who received clonidine monotherapy for 1 month after achieving BP control, but rose to 92mm Hg 1 month later. After 12 months of clonidine monotherapy (n = 8), diastolic BP was reduced from 100 to 87mm Hg (p &lt; 0.05), and after 2 years (n = 4) diastolic BP had fallen from 99 to 84mm Hg (p &lt; 0.05). Systolic BP was not significantly different from baseline after 12, 18 or 24 months of monotherapy. 14/20 patients whose BP was controlled by clonidine or combination therapy withdrew from the study because of severe skin reactions (n = 10) or non skin-related adverse effects (4). The most frequent of other adverse effects were fatigue, dry mouth and impotence. </p><p>The authors concluded that in those patients who do not develop skin reactions, transdermal clonidine is ' ... a safe and efficacious agent for shortterm therapy' of mild to moderate essential hypertension. Horning JR. Zawada ET. Simmons JL. Williams L. McNulty R. Chesl 93 941945. May 1988 103~ </p><p>8 INPHARMA 2 July 1988 0156-2703/ 88/ 0702-0008/ 0$01.00/ 0 ADIS Press </p></li></ul>

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