liver histopathology eqa scheme
TRANSCRIPT
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Liver histopathology EQA Scheme
Circulation LU
Autumn 2019
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Case LU 1 45M Deranged LFTs, increased serum ACE level. Additional stains: none
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LU1
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LU1
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LU1
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LU1
A Granulomas most likely TB
B Granulomas most likely sarcoid
C Biliary disease
D Primary biliary cholangitis
E Granulomatous hepatitis, ? Drug induced liver injury
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Case LU2 66F Patient presented with jaundice and diagnosed with AIH. Trial of steroids - no improvement. This is a follow up biopsy. Specimen: Transjugular liver biopsy. 4 cores, 19,8,7 and 3mm. Additional stains: EPSR.
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LU2
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LU2
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LU2
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LU2
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LU2
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LU2
Elastic picro sirius red
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LU2
Elastic picro sirius red
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LU2
A Hepatitis chronic with fibrosis ikw AIH
B Hepatitis acute with necrosis ikw AIH
C Hepatitis most likely drug
D Hepatitis most likely viral e.g. Hep E
E Wilson disease
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Case LU3 59M Liver transplant for autoimmune hepatitis. Explant liver 1316g, cirrhotic appearance, no focal lesions seen. Additional stains: van Gieson, Shikata
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LU3
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LU3
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LU3
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LU3
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LU3
High magnification – inside the nodule
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LU3
Shikata
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LU3
Shikata
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LU3
Van Gieson
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LU3
A Wilson disease
B Dysplastic nodules
C Hepatocellular carcinoma
D Congenital hepatic fibrosis
D Post necrotic collapse/fibrosis ikw AIH
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Case LU4 22M New acute hepatitis ? cause. Persistently elevated ALT 330 and bilirubin 150 with pruritis/jaundice/headache for several weeks. ? viral ? autoimmune. USS no duct dilatation. Additional stains: Shikata, CK7, Retic, EVG.
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LU4
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LU4
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LU4
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LU4
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LU4
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LU4
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LU4
reticulin
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LU4
Van Gieson
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LU4
Shikata
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LU4
Keratin 7
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LU4
A Chronic biliary features, ? large bile duct obstruction,PSC
B Acute hepatitis ikw drug
C Acute hepatitis ikw AIH
D Chronic hepatitis
E Wilson disease
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Case LU5 55M NAFLD. Fibroscan 12. Moderate fibrosis? on Humira for rheumatoid arthritis. Additional stains: HVG.
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LU5
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LU5
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LU4
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LU5
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LU5
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LU5
HVG
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LU5
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LU5
A DILI with background steatosis
B steatohepatitis
C steatosis
D Rheumatoid related liver disease
E Biliary disease with background steatosis
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Case LU6 80F Liver cirrhosis, mass lesion in segment VIII/IVa, ?HCC. Specimen: Segment VIII/IVa segmentectomy, 70 x 68 x 35 mm containing a mass lesion 22 x 22 x 18mm. No additional stains.
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LU6
Background liver
Edge of lesion
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LU6
Inside lesion
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LU6
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LU6
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LU6
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LU6
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LU6
A Regenerative nodule background cirrhosis
B HCC background cirrhosis
C FNH background cirrhosis
D Adenoma background cirrhosis
E Focal Steatotic nodule
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Case LU7 24M Portal hypertension. being assessed for TIPPS; ? cirrhosis. Also PSR, Victoria Blue.
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LU7
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LU7
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LU7
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LU7
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LU7
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LU7
Picro Sirius red
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LU7
Picro Sirius red
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LU7
Victoria blue
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LU7
A Venous outflow obstruction
B Biliary disease +/- possible sclerosing cholangitis
C Normal liver
D Vascular disease ‘Non cirrhotic portal hypertension’
E Wilson disease
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Case LU8 73M Cirrhosis. Left lateral lesion, ?HCC. Ferritin 1708. AFP 5, CEA 2, CA19-9 42. MRI liver: Established cirrhosis with associated portal hypertension. Segment II lesion demonstrates radiological features suspicious for HCC. Specimen: Lesional liver biopsy, left lobe, Two cores 10mm and 11mm in length. Also: Reticulin, Perls, van Gieson, Hepato, Arginase, Glutamine Synthetase.
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LU8
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LU8
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LU8
reticulin
Background liver
Focal lesion
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LU8
Perls
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Hepato
LU8
Lesion
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Glutame synthetase
LU8
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LU8
Arginase
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LU8
A HCC and iron
B Dysplastic nodule, cirrhosis and iron deposition
C HCC, cirrhosis and iron deposition
D HCC and cirrhosis
E Hepatocellular adenoma and iron deposition
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Case LU9 30F History of COCP. Left lateral liver resection. Incidental 13 mm well-circumscribed haemorrhagic lesion in resection for larger lesion. No additional stains
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LU9
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LU9
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LU9
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LU9
A Epithelioid haemangioendothelioma
B Haemangioma/cavernous haemangioma
C Peliosis hepatis
Haemangiomatosis
C Angiosarcoma
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Case LU10 74M A1AT ?extent of fibrosis. Additional stains: PASD, HVG.
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LU10
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LU10
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LU10
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LU10
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LU10
PASD
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LU10
PASD
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LU10
HVG
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LU10
HVG
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LU10
A A1AT accumulation
B A1AT accumulation, steatosis and severe fibrosis/cirrhosis
C A1AT accumulation, steatosis and mild fibrosis
D A1AT-like globules due to alcoholic cirrhosis
E Chronic hepatitis with severe fibrosis/cirrhosis
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Case LU11 66M Abnormal LFTs. ANCA positive. Imaging normal. ? inflammation ? cirrhosis. Additional information - presented 3 weeks ago with 2 day history of nausea and vomiting; found to have deranged liver function tests. Had taken 2 courses of flucloxacillin from GP. Usual medications: levothyroxine, simvastatin, atenolol, ranitidine. Bili 100, ALT 8787, Alk phos 193. Additional stains: Retic, van Gieson, PASD.
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LU11
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LU11
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LU11
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LU11
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LU11
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LU11
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LU11
Van GIeson
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LU11
PASD
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LU11
reticulin
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LU11
A Chronic hepatitis, possible AIH
B Biliary features most likely drug
C Biliary features most likely biliary tract disease e.g. PSC or large duct obstruction
D Biliary features could be drug can’t exclude biliary tract disease/obstruction
E Cholestatic hepatitis
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Case LU12 45F Left lateral segmentectomy laparoscopically. ?FNH ?adenoma Macroscopic description: Specimen 187g. 129x 80x 43mm Capsule intact. Lesion 44 x 38 x 25mm with a cream, tan, congested appearance. Additional stains: Glutamine synthetase, Keratin 7, van Gieson.
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LU12
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LU12
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LU12
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Background liver
LU12
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LU12
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LU12
Keratin 7
![Page 107: Liver histopathology EQA Scheme](https://reader031.vdocuments.mx/reader031/viewer/2022020916/61b3440166c312363a5c0adc/html5/thumbnails/107.jpg)
LU12
![Page 108: Liver histopathology EQA Scheme](https://reader031.vdocuments.mx/reader031/viewer/2022020916/61b3440166c312363a5c0adc/html5/thumbnails/108.jpg)
LU12
Glutamine synthetase, background liver
![Page 109: Liver histopathology EQA Scheme](https://reader031.vdocuments.mx/reader031/viewer/2022020916/61b3440166c312363a5c0adc/html5/thumbnails/109.jpg)
LU12
A Focal nodular hyperplasia
B Hepatocellular adenoma
C Cirrhosis
D Nodular regenerative hyperplasia
E Hepatocellular carcinoma
![Page 110: Liver histopathology EQA Scheme](https://reader031.vdocuments.mx/reader031/viewer/2022020916/61b3440166c312363a5c0adc/html5/thumbnails/110.jpg)
The End