liposome technology leading scientists in · how do you distinguish the expert from the...

LEADING SCIENTISTS INLIPOSOME TECHNOLOGY

WHAT ARE LIPOSOMES?

• Phospholipid (lecithin) bilayer vesicles

• Nanoscale size (100 - 1000 nm)

• Bilayer can hold lipophilic actives

• Aqueous interior can hold water-soluble actives

• Used for drug and nutraceutical delivery

Phospholipid bilayer

Lipophilic actives

LIPOSOMES HAVE FREQUENTLYBEEN REPORTED TO:

• Protect actives in the gastrointestinal milieu

• Improve interaction with target cells

• Enhance uptake and delivery of actives

• Allow codelivery of synergistic substances

WHY LIPOSOMALNUTRACEUTICALS?

WHY LIPOSOMA HEALTH?

OUR LIPOSOME PRODUCTS FEATURE7 KEY QUALITY ASPECTS:

1. They only consist of real phospholipid bilayer vesicles

2. That hold the active in the bilayer or the interior

3. Are optimized for oral intake and intestinal delivery

4. Are custom designed for each active they hold

5. Are well-characterized and quality controlled

6. Preserve the liposomal structure on storage

7. And protect the active against degradation

CHALLENGES THAT ALL MANUFACTURERS DEAL WITH BUT FEW MANAGE TO CONTROL:

• Making robust and well-defined liposome vesicles

• Increasing the capacity of liposomes to hold actives

• Engineering the vesicles to sufficiently retain actives

• Protecting vulnerable actives against degradation

• Preserving the delicate vesicle structures on storage

• Implementing freeze drying as the ultimate way to conserve

LIPOSOMA MASTERS HIGH-QUALITY LIPOSOME TECHNOLOGY

WHY IS IT SO CHALLENGINGAND DEMANDING?

HOW DO YOU DISTINGUISH THE EXPERTFROM THE “QUICK-FIX”?

• Is it real nanosized vesicles or merely a emulsion or lipid dispersion?

• Is the active bound to the vesicles or mostly present

in solution outside?

• Has the product been optimized to survive the

gastrointestinal tract?

• How does one ensure the vesicles remain fully

preserved during storage?

LIPOSOME DESIGNMUST BE SCIENCE-BASED

ANDOPTIMIZATION

REQUIRES INTENSIVE ENGINEERING…




AND OPTIMIZATION REQUIRES INTENSIVE ENGINEERING…



✔ Test it by particle size analysis (DLS)

✔ Transmission electron microscopy (TEM)

✔ Or: simply dilute in water and look for opalescent shine!





• Is the active bound to the vesicles or mostly present in

solution outside?






solution outside?

✔ Test it by separating liposomes from solution with

gel chromatography or dialysis!






solution outside?

• Has the product been optimized to survive the gastrointestinal tract?






solution outside?


✔ Are there specific protective lipid excipients present?

✔ Is there a delayed release mechanism in the vehicle?






solution outside?


• How does one ensure the vesicles remain

fully preserved during storage?






solution outside?


• How does one ensure the vesicles remain

fully preserved during storage?

✔ assess physical stability over time

✔ what happens after rehydration of freeze dried powder?



LiposomesDissolvedClumped

YOU CAN REACH OUR TEAM

OF EXPERTS AS FOLLOWS:

Science Park 408, Building VI

1098 XH Amsterdam

The Netherlands

+31 20 237 3600

+31 6422 666 33

[email protected]

GET IN TOUCH

liposome technology leading scientists in · how do you distinguish the expert from the...

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