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Lipids
Dr Hadi Ansarihadipour
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References:
1. Molecular Cell Biology. Fifth Edition. Harvey Lodish. Copyright
© 2004 by W. H. Freeman & Company
2. Biochemistry. Lehninger. 4th Edition, 2005.
3. Wikipedia
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Cholesterol
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β-sitisterol
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saccharolipid
Structure of the saccharolipid
Kdo2-lipid A (a hexa-acylated
disaccharide of glucosamine
that is glycosylated with two
3-deoxy-D-manno-
octulosonic acid (Kdo)
residues).
Glucosamine residues in
blue, Kdo residues in
red, acyl chains in black
and phosphate groups in
green. dezazma.com
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The building block of isoprenoid alcohols dezazma.com
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isoprenoid alcohols
H – [ CH2CCH3=CHCH2 ]n – OH
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Important in the acylation of:
1. Proteins
2. Carotenoids
3. fat-soluble vitamins: A, E and K
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Cardiology
1. coronary heart disease:
angina and myocardial infarction
2. congestive heart failure
3. high blood pressure
4. abnormal cholesterol levels
5. deep vein thrombosis and pulmonary
embolism
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Endocrinology
1. diabetes mellitus
2. polycystic ovarian syndrome
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Reproductive medicine
1. menstrual disorders
2. infertility
3. complications during pregnancy
4. birth defects
5. intrauterine fetal death
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Neurology
1. stroke
2. migraines
3. carpal tunnel syndrome
4. meralgia paresthetica
5. dementia
6. idiopathic intracranial hypertension
7. multiple sclerosis
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Psychiatry
1. depression in women
2. social stigmatization
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Rheumatology and Orthopedics
1. Gout
2. poor mobility
3. osteoarthritis
4. low back pain
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Dermatology
1. stretch marks
2. acanthosis nigricans
3. lymphedema
4. cellulitis
5. hirsutism
6. intertrigo
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Gastroenterology
1. gastroesophageal reflux disease
2. fatty liver disease
3. cholelithiasis (gallstones)
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Oncology
1. esophageal
2. colorectal
3. pancreatic
4. gallbladder
5. endometrial
6. kidney
7. Leukemia
8. Hepatocellular carcinoma
9. malignant melanoma
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Respirology
1. obstructive sleep apnea
2. obesity hypoventilation syndrome
3. asthma
4. increased complications during general
anaesthesia
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Urology and Nephrology
1. erectile dysfunction
2. urinary incontinence
3. chronic renal failure
4. hypogonadism
5. buried penis
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