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Biomedicine springer.com/NEWSonline

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J. Basu, Tengion, Inc., Winston-Salem, NC, USA; J. W. Ludlow, Zen-Bio, Research Triangle Park, NC, USA (Eds)

Organ RegenerationMethods and Protocols

Contents Isolation and Characterization of Human Adipose-Derived Stem Cells for Use in Tissue Engineering.- Isolation of Smooth Muscle Cells from Bladder for Generation of Engineered Urologic Organs.- Isolation of Urothelial Cells from Bladder Tissue.- Isolation of Pulsatile Cell Bodies from Esophageal Tissue.- Cell Isolation Through Whole Liver Perfusion and Preparation of Hepatocytes for Cytochrome P450 Analysis.- Ex Vivo Culture and Separation of Functional Renal Cells.- Isolation and Myogenic Differentiation of Mesenchymal Stem Cells (MSC) for Urologic Tissue Engineering.- Xeno-Free Adaptation and Culture of Human Pluripotent Stem Cells.- Re-verse Engineering Life: Physical and Chemical Mimetics for Controlled Stem Cell Differentiation into Cardiomyocytes.- Phenotypic Analysis of Bioactive Cells for Application in Regenerative Medicine.- Preparation and Evaluation of Natural Scaffold Materials for Kidney Regenerative Appli-cations.- Rapid Production of Autologous Fibrin Hydrogels for Cellular Encapsulation in Organ Regeneration.- Electrospinning Tubular Scaf-folds with Tissue-Like Mechanical Properties and Biomimetic Surface Features.- Design, Fabrica-tion, and Preparation of Synthetic Scaffolds for Urologic Tissue Engineering.- Characterization of a PGA Based Scaffold for Use in a Tissue Engi-neered Neo-Urinary Conduit.- Migration Assay to Evaluate Cellular Interactions with Biomaterials for Tissue Engineering/Regenerative Medicine Applications. [...]

Fields of interestMolecular Medicine; Regenerative Medicine/Tis-sue Engineering

Target groupsProfessional/practitioner

Product categoryContributed volume

Due March 2013

2013. X, 250 p. 104 illus., 45 in color. (Methods in Molecular Biology, Volume 1001)7 * € (D) 117,69 | € (A) 120,99 | sFr 146,507 € 109,99 | £99.00ISBN 978-1-62703-362-6

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D. G. Capelluto, Virginia Tech, Blacksburg, VA, USA (Ed)

Lipid-mediated Protein SignalingThis book provides the most updated information of how membrane lipids mediate protein signaling from studies carried out in animal and plant cells.

Features 7 Summarizes innovative research in lipid-me-diated signaling 7 Presents contributions from internationally recognized scientists 7 Offers a valuable resource for cell biologists, structural bi-ologists, and pharmacologists with interest in lipid signaling 7 Emphasizes on sphingolipid- and phospholipid-mediated protein signaling 7 Ex-amines lipid signaling from plasma membrane and intracellular organelles

Contents Sphingomyelin and its role in cellular signaling.- The driving force of alpha-synuclein insertion and amyloid channel formation in the plasma membrane of neural cells: key role of ganglio-side- and cholesterol-binding domains.- The enigmatic role of sulfatides: new insights into cellular functions and mechanisms of protein recognition.- Phosphoinositides and PDZ Domain Scaffolds.- PtdIns(4)P signalling and recognition systems.- PtdIns(4,5)P2-Mediated Cell Signaling: Emerging Principles and PTEN as a Paradigm for Regulatory Mechanism.- Role of Phosphatidylino-sitol 3,4,5-trisphosphate in Cell Signaling.- The Role of Phosphoinositides and Inositol Phosphates in Plant Cell Signaling.- Phosphatidic Acid-Me-diated Signaling.- Phosphatidylserine-mediated cellular signaling.- Cardiolipin-mediated cellular signaling.

Fields of interestBiomedicine general; Life Sciences, general; Spec-troscopy/Spectrometry

Target groupsResearch


Due May 2013

2013. XIV, 314 p. 44 illus., 29 in color. (Advances in Experimental Medicine and Biology, Volume 991) Hardcover7 * € (D) 149,79 | € (A) 153,99 | sFr 186,507 € 139,99 | £126.00ISBN 978-94-007-6330-2

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P. Capodaglio, Istituto Auxologico Italiano IRCCS, Piancavallo, Italy; J. Faintuch, São Paulo University, Brazil; A. Liuzzi, Istituto Auxologico Italiano IRCCS, Piancavallo, Italy (Eds)

Disabling ObesityFrom Determinants to Health Care Models

Features 7 Provides a current vision on obesity from a rehabilitative perspective 7 Deals with aetiology and epidemiology of obesity as well as with mor-bid obesity 7 Includes genetical, physiological, biomechanical determinants, functional limita-tions and disability, measures of disability, oc-cupational issues as well as rehabilitation models and programs 7 Evidence-based discussion on effective care models and rehabilitation treatments

Contents An Up-To-Date Vision on the Aetiology and on the Epidemiology of Obesity and Morbid Obesity.- Physiological Bases of Physical Limitations During Exercise.- Biomechanics of Basic Activities.- The Obesity-Related Disability.- Critical Aspects in Nursing.- Effectiveness of Multidisciplinary Inpa-tient and Outpatient Rehabilitation on Functional Outcomes in Obese Patients with Orthopaedic Comorbidities.- Cardiac Rehabilitation.- Work Capacity, Sleep Apnoea and Respiratory Rehabili-tation.- Psychological Aspects and Rehabilitation Protocols Psychiatric Aspects.- Principles and Protocols in Nutritional Rehabilitation.- Bariatric Surgery: Current Techniques and Results.- Dis-ability in the Post-Obese Bariatric Patient: Old and New Problems.- Aesthetic Rehabilitation after Bariatric Surgery.- New Technologies for Improv-ing the Psychological Treatment.- Chronic Care Models for Obesity Management.

Fields of interestHuman Physiology; Rehabilitation; Human Genetics


Product categoryMonograph

Due March 2013

2013. IX, 300 p. 56 illus., 36 in color.7 * € (D) 106,99 | € (A) 109,99 | sFr 133,507 € 99,99 | £90.00ISBN 978-3-642-35971-2

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www.springer.com/978-1-62703-362-6



News 3/2013 Biomedicine

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M. F. Casanova, A. S. El-Baz, University of Louisville, KY, USA; J. S. Suri, Biomedical Technologies, Inc., Denver, CO, USA (Eds)

Imaging the Brain in AutismData compiled by the Center for Disease Con-trol and Prevention indicates an alarming and continuing increase in the prevalence of autism. Despite intensive research during the last few decades, autism remains a behavioral defined syndrome wherein diagnostic criteria lack in construct validity. And, contrary to other condi-tions like diabetes and hypertension, there are no biomarkers for autism.

Features 7 Looking at autism from an imaging perspec-tive 7 Ranging from the microscopic (i.e., post-mortem) to the macroscopic (fMRI) 7 Emphasis will be on techniques which have helped map the brain of the autistic person as well as normative individuals

Contents Introduction to Neuropathology.- The Neuropa-thology of Autism.- QEEG-Guided Neurofeedback for the Autism: Clinical Observations and Out-comes.- Event-Related Potential Studies of Cogni-tive Processing Abnormalities in Autism.- Evoked and Induced Gamma Frequency Oscillations in Autism.- Neurofeedback for Autistic Disorders: Emerging Empirical Evidence.- Structural Imaging in Autism.- Diffusion Tensor Magnetic Resonance Imaging in Autism.- Spectroscopic Brain Imaging in Autism.- Functional MRI in Autism.- Function-al Connectivity MRI in Autism.- EEG Analyses in the Assessment of Autistic Disorders.- Behavior Imaging®’s Assessment Technology.

Fields of interestBiomedicine general; Computer Imaging, Vision, Pattern Recognition and Graphics; Medicine/Pub-lic Health, general



Due April 2013

2013. XII, 448 p. 39 illus., 16 in color.7 * € (D) 149,79 | € (A) 153,99 | sFr 186,507 € 139,99 | £126.00ISBN 978-1-4614-6842-4

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W. C. Cho, Queen Elizabeth Hospital, Hong Kong (Ed)

Cancer Chemoprevention and Treatment by Diet TherapyFeatures 7 This is a specialized book presenting the research evidence relevant to the use of specific diet therapy in cancer chemoprevention and treatment 7 This book brings together inter-national opinion leaders’ brilliant chapters and will contribute great to the cancer, academic, and clinical community by providing evidence-based information on the cancer chemoprevention and treatment effects by diet therapy 7 Although written primarily for medical and scientific profes-sionals, this book can be used as useful references to cancer patients and those who are interested in diet therapy for cancer

Contents Preface.- Effect of Dietary Resveratrol in the Treat-ment of Cancer.- Effect of Flavonoids from Fruits and Vegetables in the Prevention and Treatment of Cancer.- Beneficial Influence of Diets Enriched with Flaxseed and Flaxseed Oil on Cancer.- Can-cer Prevention with Green Tea Polyphenols.- Soy Foods: Towards the Development of Novel Thera-peutics for Breast Cancer.- Association between High Intake of Lycopene-rich Foods and Reduced Risk of Cancer.- Effect of Antioxidant-rich Foods and Supplements on Cancer Risk.- Effect of the Mediterranean Diet on Cancer Reduction.- Modu-lation of Proteasome Pathways by Nutraceuticals.- Attenuation of Multifocal Cell Survival Signaling by Bioactive Phytochemicals in the Prevention and Therapy of Cancer. Index.

Fields of interestBiomedicine general; Complementary & Alterna-tive Medicine; Oncology



Due April 2013

2013. VIII, 327 p. 19 illus., 15 in color. (Evidence-based Anticancer Complementary and Alternative Medicine, Volume 5) Hardcover7 * € (D) 149,79 | € (A) 153,99 | sFr 186,507 € 139,99 | £126.00ISBN 978-94-007-6442-2

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A. J. Dannenberg, Weill Cornell Medical College, New York, NY USA; N. A. Berger, Case Western Reserve University, Cleveland, OH, USA (Eds)

Obesity, Inflammation and CancerFeatures 7 Provides the latest information implicating a link between obesity, inflammation and specific tumor types 7 Describes innovative research on novel NSAIDS, omega 3 fatty acids, natural products, vascular targeting, caloric restriction and exercise in regards to cancer therapy 7 Pres-ents research connecting persistent inflammation to some of the comorbidities associated with cancer survivorship

Contents Preface.- Obesity, Inflammation and Insulin Resistance.- Inflammasomes and Obesity.- Un-coupling Obesity from Cancer: Bromodomain Co-regulators that Control Inflammatory Net-works.- Adipose Tissue Macrophages in Obesity, Inflammation and Cancer.- Dietary Fats as Media-tors of Obesity, Inflammation and Colon Cancer.- Inflammation, Obesity, Barrett’s Esophagus and Esophageal Adenocarcinoma.- Obesity, Inflamma-tion and Breast Cancer.- Obesity, Inflammation, Nonalcoholic Fatty Liver Disease and Hepatocel-lular Carcinoma.- Obesity, Inflammation and Prostate Cancer.- Pharmacologic Interventions With NSAIDs.- Omega-3 Fatty Acids in Cancer Prevention and Control: A Membrane Perspec-tive.- Natural Products as Anti-inflammatory Agents.- Calorie Restriction and Cancer Preven-tion: Established and Emerging Mechanisms.- Vascular Targeting of Adipose Tissue.- Anti-Inflammatory Effects of Exercise.- Index.

Fields of interestCancer Research; Human Physiology; Biomedi-cine general



Due May 2013

2013. X, 370 p. 36 illus., 29 in color. (Energy Balance and Cancer, Volume 7)7 * € (D) 160,49 | € (A) 164,99 | sFr 200,007 € 149,99 | £135.00ISBN 978-1-4614-6818-9

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Current Topics in Microbiology and ImmunologyR. W. Compans, M. D. Cooper, F. Melchers, Series editors: M. B. Oldstone, P. K. Vogt, T. Honjo, Y. Y. Gleba, B. Malissen, Y. Kawaoka, K. Aktories, R. Rappuoli, J. E. Galan

Volume 358

U. Dobrindt, Universität Münster, Germany; J. H. Hacker, Deutsche Akademie der Naturforscher Leopoldina, Halle, Germany; C. Svanborg, Lund University, Sweden (Eds)

Between Pathogenicity and CommensalismContents Between Commensalism and Pathogenicity:Bacterial and Host Aspects.- E. coli as an all-rounder: The thin line between com-mensalism and pathogenicity.- What distin-guishes non-pathogenic, from medium and highly pathogenic staphylococci?.- Microevolution of Pseudomonas aeruginosa to a chronic pathogen of the cystic fibrosis lung.- Lactobacillus: Host-Microbe Relationships.- Bacterial Moonlighting Proteins and Bacterial Virulence.- Symbionts and pathogens - what is the difference?.- Host-microbe Interaction in the Intestinal Tract.- Ecol-ogy and physiology of the intestinal tract.- The gut microflora and its variety of roles in health and disease.- Mammalian intestinal host-microbe relationships.- Contribution of the intestinal mi-crobiota to human health - from birth to 100 years of age.- Subject index.

Fields of interestMedical Microbiology; Immunology; Vaccine



Due April 2013

2013. X, 380 p. 25 illus., 17 in color. Hardcover7 * € (D) 160,49 | € (A) 164,99 | sFr 200,007 € 149,99 | £135.00ISBN 978-3-642-36559-1

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L. D. Frappier, University of Toronto, ON, Canada

EBNA1 and Epstein-Barr Virus Associated TumoursThis SpringerBrief will a comprehensive account of the functions and effects of the Epstein-Barr virus (EBV) EBNA1 protein that relate to EBV-associated cancers and evidence for EBNA1 contributions to these cancers. EBNA1 was the first EBV protein detected and the most critical for EBV latent infection. EBNA1 fulfills multiple functions at EBV genomes which have been described in many (sometimes confusing) reports over the last 28 years. While these were initially thought to be the only roles of EBNA1, many reports in recent years have shown that EBNA1 also directly affects cellular processes in ways that would be expected to contribute to oncogenesis. However, the degree to which EBNA1 promotes cell survival and oncogenesis in various types of human tumours is not entirely clear and a matter of debate. This Brief would offer a current synopsis of EBNA1 functions in EBV latency, including functions in DNA replication, mitotic segregation and transcription. Mechanisms of these EBNA1 functions will also be discussed as well as implica-tions for tumourigenesis.

Features 7 Provide a comprehensive account of all EBNA1 functions and cellular effects 7 Discusses mechanistic basis of these EBNA1 functions and effects 7 Gives a balanced perspective by of-fering the most current evidence for and against EBNA1’s direct contribution to various cancers

Contents Introduction.- Roles of EBNA1 at EBV Episomes.- EBNA1-DNA Interactions.- EBNA1 Contributions to EBV-associated Tumours.- Cellular Effects of EBNA1.- Conclusion .

Fields of interestCancer Research; Virology; Medical Microbiology


Product categoryBrief

Due April 2013

2013. V, 50 p. 5 illus. in color. (SpringerBriefs in Cancer Research, Volume 3)7 * € (D) 53,49 | € (A) 54,99 | sFr 67,007 € 49,99 | £44.99ISBN 978-1-4614-6885-1

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F. H. Gage, The Salk Institute for Biological Studies, La Jolla, CA, USA; Y. Christen, Fondation Ipsen, Boulogne Billancourt, France (Eds)

Programmed Cells from Basic Neuroscience to TherapyThe recent advances in Programming Somatic Cell (PSC) including induced Pluripotent Stem Cells (iPS) and Induced Neuronal phenotypes (iN), has changed our experimental landscape and opened new possibilities.

Features 7 Presents latest research on neurodegenerative diseases 7 Presents prospects for novel thera-pies 7 Written by leading experts in the field

Contents Nuclear reprogramming by eggs and oocytes and eventual prospects of cell replacement thera-py.- iPS technology and disease research: issues to be resolved.- ES and iPS cells as tools for modeling human aging .-Characterizing neural circuitry with programmed human neurons.- Direct con-version of fibroblasts to neuronal cells.- Human pluripotent stem cells as tools for modelling neu-rodegeneration.- From Rett syndrome to classical autism: modeling autism spectrum disorders using human neurons.- Testing evolutionary principles in a dish using embryonic stem cells: the example of the Huntington’s Disease gene.- Using stem cells to discover therapeutic targets in ALS and SMA .- Using stem cells to understand and treat Alzheimer’s disease.- Using pluripotent stem cells to decipher mechanisms and identify treatments for diseases that affect the brain.- Modeling neural development and disease in human pluripotent stem cells.- Subject index.

Fields of interestNeurosciences; Stem Cells; Neurology



Due May 2013

2013. X, 140 p. 14 illus., 13 in color. (Research and Perspectives in Neurosciences, Volume 20)7 * € (D) 106,99 | € (A) 109,99 | sFr 133,507 € 99,99 | £90.00ISBN 978-3-642-36647-5

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J. Geigert, BioPharmaceutical Quality Solutions, Carlsbad, CA, USA

The Challenge of CMC Regulatory Compliance for BiopharmaceuticalsThis book highlights the challenges facing quality assurance/quality control (QA/QC) in today’s biopharmaceutical environment and presents the strategic importance and value generated by QA/QC for their involvement in control of manufac-turing. It will put into perspective the need for a graded approach to QA/QC from early clinical trials through market approval.

Features 7 Highlights the challenges facing quality assurance/quality control (QA/QC) in today's biopharmaceutical environment 7 Presents the strategic importance and value generated by QA/QC for their involvement in control of manufac-turing 7 Revised 2nd Edition is broadened to include biopharmaceuticals (biotech drugs) and other biologics (vaccines, cell therapy, plasma-derived proteins, etc.)

Contents Complexity of Biologica CMC Regulation.- Biologics are Not Chemical Drugs.- An Effec-tive CMC Strategy is Possible.- Challenge of Adventitious Agent Control.- Source Materials for Biologics.- Manufacture of the Biologic API.- The Biologic Final Product Process.- Complex Process-Related Impurities.- Molecular Structural Analysis.- Functional Activity (Potency).- Setting Specifications and Expiry Dates.- Demonstrating Product Comparability.- CMC-Focused Regula-tory Meetings.- References.

Fields of interestPharmaceutical Sciences/Technology; Biomedi-cine general



Due May 2013

2nd ed. 2013. X, 390 p. 24 illus., 11 in color. Hardcover7 * € (D) 160,49 | € (A) 164,99 | sFr 200,007 € 149,99 | £135.00ISBN 978-1-4614-6915-5

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E. Gulbins, University of Duisburg-Essen, Germany; I. Petrache, Indiana University, Indianapolis, IN, USA (Eds)

Sphingolipids in DiseaseContents Sphingolipids in Cancer: Sphingosine Kinase / Sphingosine 1-Phosphate Signaling in Cancer Therapeutics and Drug Resistance.- Using ASMase knockout Mice to Model Human Diseases.- New Perspectives on the Role of Sphingosine 1-Phos-phate in Cancer.- Sphingolipids and Response to Chemotherapy.- Lung Cancer and Lung Injury: The Dual Role of Ceramide.- Sphingolipids Role in Radiotherapy for Prostate Cancer.- Sphingolipids in Cardio-Reno-vascular diseases: Sphingolipid Metabolism and Atherosclerosis.- Cardiovascular Effects of Sphingosine-1-Phosphate S1P.- Cross-Talk between Ceramide and Redox Signaling: Im-plications for Endothelial Dysfunction and Renal Disease.- Sphingolipids in Inflammation, Infection and Lung Diseases.- Sphingolipids in Lung Endothelial Biology and Regulation of Vascular Integrity.- Sphingolipids in Acute Lung Injury.- The Involvement of Sphingolipids in Chronic Obstructive Pulmonary Diseases.- Ceramide in Cystic Fibrosis.- Regulation of the Sphingosine Kinase/Sphingosine 1 Phosphate Pathway.- Bacte-rial Infections and Ceramide.- Viral Infections and Sphingolipids.- Ceramide in Plasma Membrane Repair.- Sphingolipids and Inflammatory Diseases of the Skin.- Sphingolipids in Diabetes.- Sphingo-lipids in Neuro-psychiatry and Muscle Diseases: Neuronal Forms of Gaucher Disease.- Sphingo-lipids in Neuroinflammation.- Sphingolipids in Psychiatric Disorders and Pain Syndromes.- Role of Sphingosine-1-Phosphate in Sceletal Muscle Cell Biology.

Fields of interestPharmacology/Toxicology; Cardiology; Cancer Research


Product categoryHandbook

Due March 2013

2013. VIII, 564 p. 38 illus., 34 in color. (Handbook of Experimental Pharmacology, Volume 216) Hardcover7 * € (D) 362,73 | € (A) 372,90 | sFr 451,507 € 339,00 | £305.50ISBN 978-3-7091-1510-7

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A. Haim, B. A. Portnov, University of Haifa, Israel

Light Pollution as a New Risk Factor for Human Breast and Prostate CancersContents Preface.- Introduction.- PART 1: ARTIFICIAL LIGHT AND HUMAN TEMPORAL ORGANI-ZATION.- Artificial light and its physicochemi-cal properties (by Fabio Falchi).- Light and dark cycles as a basis of temporal organization.- The biological clock and its entrainment by photope-riod.- LAN exposure and its potential effects on daily rhythms and seasonal disruptions.- Melato-nin (MLT) –“hormone of darkness” and a “jack of all traits”.- PART II: LIGHT POLLUTION, ITS KNOWN HEALTH EFFECTS AND IMPACT ON ENERGY CONSERVATION.- Introduction and spread of artificial illumination – a human history retrospective.- Biological definition of light pol-lution.- Light pollution as a general stressor.- The effects of light pollution on animal rhythms and ecology.- Light pollution and hormone-dependent cancers: summary of accumulated empirical evi-dence.- PART III: LIGHT POLLUTION AND ITS POTENTIAL LINKS TO BREAST AND PROS-TATE CANCERS.- Geographic patterns of breast and prostate cancers (BC&PC) worldwide.- Light pollution and its association with breast and pros-tate cancers (BC&PC) in population-level studies.- Selected methodological issues of Light-at-Night (LAN) – Breast and Prostate Cancers (BC&PC) research.- Dark-less world – what is next? (Con-clusions and prospects for future research).- BIB-LIOGRAPHY.- ADDITIONAL READING.

Fields of interestCancer Research; Environmental Health; Bio-medicine general



Due March 2013

2013. X, 166 p. 26 illus., 16 in color.7 * € (D) 106,99 | € (A) 109,99 | sFr 133,507 € 99,99 | £90.00ISBN 978-94-007-6219-0

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P. A. Iaizzo, R. W. Bianco, University of Minnesota, Minneapolis, MN, US; A. J. Hill, Medtronic Inc., Mounds View, MN, US; J. D. St. Louis, University of Minnesota, Minneapolis, MN, US (Eds)

Heart ValvesFrom Design to Clinical Implantation

Features 7 Chapters written by scientists and clinicians from leading academic and industrial institu-tions across the world 7 A helpful reference for patients, educators, students, device designers/de-velopers, clinical study specialists, clinicians, and other associated healthcare providers 7 Follows a translational approach to heart valves

Contents Part I - ANATOMY, PHYSIOLOGY, CONGENI-TAL DEFECTS, and DISEASE.- The anatomy and function of the atrioventricular valves.- The anatomy and function of the semilunar valves.- Congenital heart defects that include cardiac valve abnormalities.- Acquired valve disease and processes.- Part II - VALVE REPAIR AND REPLACEMENT.- History of heart valve repair.- Heart valve disease.- Advanced 3D imaging and transcatheter valve repair/ implantation.- Trans-catheter mitral repair and replacement.- Percu-taneous pulmonary valve implantation: the first transcatheter valve.- Transcatheter aortic valve im-plantation.- Tissue engineered heart valves.- Part III - TESTING AND REGULATORY ISSUES.- In vitro testing of heart valve substitutes.- Numerical methods for design and evaluation of prosthetic heart valves.- Animal models for cardiac valve research.- The use of isolated heart models and anatomic specimens as means to enhance the design and testing of cardiac valve therapies.- Suc-cessful development and regulatory approval of replacement cardiac valves.- Clinical trial require-ments for cardiac valves.- Index.

Fields of interestBiomedicine general; Cardiology; Cardiac Surgery

Target groupsGraduate


Due February 2013

2013. XIII, 440 p. 169 illus., 111 in color. Hardcover7 * € (D) 160,45 | € (A) 164,94 | sFr 200,007 € 149,95 | £135.00ISBN 978-1-4614-6143-2

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R. L. Jirtle, University of Wisconsin-Madison, Madison, WI, USA; F. L. Tyson, National Institutes of Health, Research Triangle Park, NC, USA (Eds)

Environmental Epigenomics in Health and DiseaseEpigenetics and Disease Origins

There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to envi-ronmental factors. Epigenetics refers to heritable changes in gene function that occur without a change in the sequence of the DNA. The main components of the epigenetic code are DNA methylation, histone modifications, and non-cod-ing RNAs. The epigenetic programs are established as stem cell differentiate during embryogenesis, and they are normally faithfully reproduced dur-ing mitosis.

Features 7 Provides evidence that environmental expo-sures during early development can alter the risk of developing medical conditions 7 Presents epigenetic processes that occur in human embry-onic stem cells, as well as in differentiating cells and organs such as the brain, discussing autism, schizophrenia and even sexual dimorphism in the developing brains of males and females. 7 Sum-marizes the latest epigenetic advances in the understanding of cancer development and pro-gression, with a special focus on DNA methylation alterations and their value in clinical oncology for cancer management

Fields of interestHuman Genetics; Cancer Research; Gene Func-tion



Due April 2013

2013. X, 314 p. 40 illus., 33 in color. (Epigenetics and Human Health)7 * € (D) 149,79 | € (A) 153,99 | sFr 186,507 € 139,99 | £126.00ISBN 978-3-642-23379-1

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R. L. Jirtle, University of Wisconsin-Madison,WI, USA; F. L. Tyson, NIH, Research Triangle Park, NC, USA (Eds)

Environmental Epigenomics in Health and DiseaseEpigenetics and Complex Diseases

Contents Preface.- Epigenetic programming of the brain.- Epigenetics and maternal brain evolution.- So-cial environment and DNA methylation: A mechanism for linking nurture and nature.- Sex differences in epigenetic programming of brain differentiation: Implications for mental health and disease.- Epigenetics and neurological disorders.- Phenotypic plasticity, pleiotropy, and the growth-first theory of imprinting.- The imprinted brain: How genes set the balance between autism and psychosis.- Epigenetics at the interface of genetics and environmental factors in autism.- Epigenomic and non-coding RNA regulation in addictive processes.- Epigenetic therapies in neurological diseases.- Epigenetics, nutrition, diabetes, and obesity.- Nutrition, histone epigenetic marks, and disease.- Chromatin switching and gene dynam-ics associated with type 2 diabetes.- Develop-mental epigenetic programming in diabetes and obesity.- Epigenetics and cancer.- Developmental reprogramming by environmental estrogens: How early life exposures affect cancer risk in adult-hood.- Human cancer epigenetics.- Epigenetics and the law.- Legal and ethical implications of epigenetics.- Subject index.

Fields of interestHuman Genetics; Cancer Research; Neurosciences



Due May 2013

2013. X, 310 p. 24 illus., 13 in color. (Epigenetics and Human Health)7 * € (D) 160,49 | € (A) 164,99 | sFr 200,007 € 149,99 | £135.00ISBN 978-3-642-36826-4

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P. D. Katsikis, Drexel University College of Medicine, Philadelphia, PA, USA; S. P. Schoenberger, La Jolla Institute for Allergy and Immunology, CA, USA; B. Pulendran, Emory University, Atlanta, GA, USA (Eds)

Crossroads Between Innate and Adaptive Immunity IVThis volume presents a collection of reviews derived from work presented at the Aegean Conference: “4th Crossroads between innate and adaptive immunity”.

Features 7 Covers the prestigious Aegean Conferenc-es 7 Edited by experts on vaccines and immune response 7 Draws on research in multiple fields of immunologic research

Contents Is Transcription the Dominant Force during Dynamic Changes in Gene Expression?.- MicroR-NAs: Key Components of Immune Regulation.- KIR/HLA: Genetic Clues for a Role of NK cells in the Control of HIV.- Natural Killer cell Licensing during Viral Infection.- Bridging Innate NK cell Functions with Adaptive Immunity.- Control of Innate Immunity by Memory CD4 T cells.- Strate-gies and Implications for Prime-Boost Vaccina-tions to Generate Memory CD8 T Cells.- Blimp1: Driving Terminal Differentiation to a T.- A new Role for Myeloid HO-1 in the Innate to Adaptive Crosstalk and Immune Homeostasis.- Impact of Differential Glycosylation on IgG Activity.- Mu-rine Model of Chronic Respiratory Inflamma-tion.- Incorporation of Innate Immune Effector Mechanisms in the Formulation of a Vaccine Against HIV-1.- Influenza Vaccines: What do we Want and How can we Get it?.

Fields of interestImmunology; Microbiology; Virology



Due March 2013

2013. X, 172 p. 15 illus., 12 in color. (Advances in Experimental Medicine and Biology, Volume 785) Hardcover7 * € (D) 149,79 | € (A) 153,99 | sFr 186,507 € 139,99 | £126.00ISBN 978-1-4614-6216-3

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Y. Kohwi, C. T. McMurray, Lawrence Berkeley National Laboratory, CA, USA (Eds)

Trinucleotide Repeat ProtocolsContents A Brief History of Triplet Repeat Disease.- Hun-tington’s Disease and Cell Therapies: Past, Present and Future.- Transcranial Two-Photon Imaging of Synaptic Structures in the Cortex of Awake Head-Restrained Mice.- In vivo Imaging of Synapse Plasticity in the Mouse Motor Cortex.- Pluripotent Hybrid Stem Cells from Transgenic Huntington’s Disease Monkey.- Mesenchymal Stem Cells for Trinucleotide Repeat Disorders.- Lentiviral-Me-diated Gene Transfer of siRNAs for the Treatment of Huntington’s Disease.- Purification of dFMR1-Containing Complexes Using Tandem Affinity Purification.- Combined FISH and Immunofluo-rescent Staining Methods to Co-localize Proteins and mRNA in Neurons and Brain Tissue.- Epigen-etic Modifications of the FMR1 Gene.- The CGG Repeat and the FMR1 Gene.- Study of Oxida-tive Damage and Antioxidant Systems in Two Huntington´s Disease Rodent Models.- Regulation of Ataxin-1 Phosphorylation and Its Impact on Bi-ology.- Towards Understanding Region-Specificity of Triplet Repeat Diseases: Coupled Immuno-histology and Mass Spectrometry Imaging.- An-tibodies and Intrabodies Against Huntingtin: Production and Screening of Monoclonals and Single-Chain Recombinant Forms.- Cell Recovery from DM1 Transgenic Mouse Tissue to Study (CTG)n Instability and DM1 Pathogenesis.- Mark-erless Modification of Trinucleotide Repeat Loci in BACs.- DRPLA: Recent Advances in Research Using Transgenic Mouse Models.

Fields of interestMolecular Medicine; Gene Expression; Neurology



Due April 2013

2nd ed. 2013. XX, 322 p. 64 illus., 24 in color. (Methods in Molecular Biology, Volume 1010)7 * € (D) 101,64 | € (A) 104,49 | sFr 126,507 € 94,99 | £85.50ISBN 978-1-62703-410-4

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A. Kramer, Charité Universitätsmedizin Berlin, Germany; M. Merrow, LMU München, Germany (Eds)

Circadian ClocksThis book provides the reader with a contem-porary and comprehensive overview about the molecular, cellular and system-wide principles of circadian clock regulation. Emphasis is placed on the importance of circadian clocks for the timing of therapeutic interventions.

Feature 7 A timely book about the widespread impact of circadian clocks for a broad readership in basic science but also translational and clinical medicine

Fields of interestPharmacology/Toxicology; Human Physiology; Neurosciences



Due March 2013

2013. X, 334 p. 57 illus., 33 in color. (Handbook of Experimental Pharmacology, Volume 217) Hardcover7 * € (D) 330,63 | € (A) 339,90 | sFr 411,507 € 309,00 | £278.50ISBN 978-3-642-25949-4

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Volume 365

J. S. Mackenzie, Curtin University, Perth, WA, Australia; M. Jeggo, CSIRO Australian Animal Health Laboratory, East Geelong, VIC, Australia; P. S. Daszak, EcoHealth Alliance, New York, NY, USA; J. A. Richt, College of Veterinary Medicine, Manhattan, KS, USA (Eds)

One Health: The Human-Animal-Environment Interfaces in Emerging Infectious DiseasesThe Concept and Examples of a One Health Approach

Contents Introduction.- One Health: its origins and its future.- The concept of One Health.- One Health and emerging infectious diseases: clinical perspec-tives.- The historical, present, and future role of veterinarians in One Health. - The importance of understanding the human-animal interface. - The importance of understanding the environmental interface.- Wildlife: the need to better understand the linkages.- The economic value of One Health in relation to the mitigation of zoonotic disease risks. - Examples of a One Health approach to specific diseases from the field.- The application of One Health approaches to henipavirus research. - H5N1 highly pathogenic avian influenza in Indonesia: Retrospective considerations. - Rabies in Asia: the classical zoonosis. [...]

Fields of interestVirology; Parasitology



Due April 2013

2013. XVI, 325 p. 23 illus., 10 in color. Hardcover7 approx. * € (D) 160,45 | € (A) 164,94 | sFr 200,007 approx. € 149,95 | £135.00ISBN 978-3-642-36888-2

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Volume 366

J. S. Mackenzie, Curtin University, Perth, WA, Australia; M. Jeggo, Australian Animal Health Laboratory, East Geelong, VIC, Australia; P. S. Daszak, EcoHealth Alliance, New York, NY, USA; J. A. Richt, Kansas State University, Manhattan, KS, USA (Eds)

One Health: The Human-Animal-Environment Interfaces in Emerging Infectious DiseasesFood Safety and Security, and International and National Plans for Implementation of One Health Activities

Contents Food Safety and Food Security: a One Health Paradigm.- Food safety: at the center of a One Health approach for combating zoonoses.- The importance of a One Health approach to prevent-ing the development and spread of antibiotic resistance.- Bovine spongiform encephalopa-thy: A tipping point in One Health and food safety.- Pathogenic Escherichia coli and One Health implications.-Wet markets as a One Health problem in food safety and food security.- Na-tional Plans for Developing a One Health Ap-proach.- FAO and the One Health approach. [...]

Fields of interestVirology; Parasitology; Chemistry/Food Science, general



Due April 2013

2013. X, 215 p. 23 illus., 16 in color. Hardcover7 approx. * € (D) 149,75 | € (A) 153,94 | sFr 186,507 approx. € 139,95 | £126.00ISBN 978-3-642-35845-6

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S. A. Mousa, P. J. Davis, Albany College of Pharmacy and Health Sciences, Rensselaer, NY, USA

Angiogenesis Modulations in Health and DiseasePractical Applications of Pro-and Anti-angiogenesis targets

Contents Preface.- Angiogenesis assays: an appraisal of cur-rent techniques.- Survey of pro-angiogenesis strat-egies.- Angiogenesis modulation by arachidonic acid – derived lipids: positive and negative regula-tors of angiogenesis.- Pro-angiogenic activity of thyroid hormone analogues: Mechanisms, physiol-ogy and clinical prospects.- Actions of steroids and peptide hormones on angiogenesis.- Role of non-neuronal nicotinic acetylcholine receptors in angiogenesis modulation.- Catecholamine neurotransmitters: an angiogenic switch in the tumor microenvironment.- Impact of nanotech-nology on therapeutic angiogenesis.- Survey of anti-angiogenesis strategies.- Tetraiodothyroacetic acid (tetrac), nanotetrac and anti-Angiogenesis.- Integrin antagonists and angiogenesis.- Anti-angiogenesis therapy as an adjunct to chemother-apy in oncology.- Anti-vegf strategies in ocular angiogenesis- mediated disorders, with special emphasis on age-related macular degeneration.- Application of nanotechnology to targeting tumor angiogenesis for therapeutic benefit.- Biomark-ers of response and resistance to anti-angiogenic treatment.- Speculations on new directions in which angiogenesis may proceed. Index.

Fields of interestBiomedicine general; Neurosciences; Pharmacy



Due April 2013


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25

L. O. Narhi, Amgen, Inc., Thousand Oaks, CA, USA (Ed)

Biophysics for Therapeutic Protein DevelopmentFeatures 7 Organized to mimic biotherapeutic prod-uct lifecycle 7 Focuses on the applications of biophysics to different disciplines; in particu-lar, focusing on protein therapeutic develop-ment 7 First fully comprehensive book to cover protein aggregation and the biophysical techniques used in the development lifecycle of biopharmaceuticals

Contents Introduction.- High Throughput Biophysical Approaches to Therapeutic Protein Develop-ment.- Techniques for Higher Order Structure Determination.- Biophysical Techniques for Protein Size Distribution Analysis.- Qualification of biophysical methods for the analysis of protein therapeutics.- Application of Biophysics to the Early Developability Assessment of Therapeutic Candidates and its Application to Enhance Devel-opability Properties.- Application of Biophysics in Formulation, Process and Product Characteriza-tion: Selected Case Studies.- Biophysical Analysis in Support of Development of Protein Pharmaceu-ticals.- Case Studies Applying Biophysical Tech-niques to Better Characterize Protein Aggregates and Particulates of Varying Size.- Investigation of Non Conformance During Protein Therapeu-tic Manufacturing.- Higher order structure and protein aggregate characterization of protein therapeutics: perspectives from good manufactur-ing practices and regulatory guidance.- Index.

Fields of interestPharmacology/Toxicology; Medical Biochemistry; Protein Science



Due March 2013

2013. IX, 293 p. 77 illus., 31 in color. (Biophysics for the Life Sciences, Volume 4) Hardcover7 * € (D) 149,75 | € (A) 153,94 | sFr 186,507 € 139,95 | £126.00ISBN 978-1-4614-4315-5

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T. Paus, University of Toronto, ON, Canada

Population NeuroscienceIs Newton’s brain different from Rembrandt’s? Does a mother’s diet during pregnancy impact brain growth? Do adolescent peers leave a signa-ture in the social brain? Does the way we live in our middle years affect how our brains age? To answer these and many other questions, we can now turn to population neuroscience. Population neuroscience endeavors to identify environmental and genetic factors that shape the function and structure of the human brain; it uses the tools and knowledge of genetics (and the “omics” sciences), epidemiology and neuroscience. This text attempts to provide a bridge spanning these three disci-plines so that their practitioners can communicate easily with each other when working together on large-scale imaging studies of the developing, mature and aging brain. By understanding the processes driving variations in brain function and structure across individuals, we will also be able to predict an individual’s risk of (or resilience against) developing a brain disorder.

Features 7 First book-length treatment of population neuroscience 7 Breaks new ground in its effort to interlink genetics, epidemiology and cognitive neuroscience 7 Provides the practitioners of these three fields with the tools and knowledge base to collaborate on large-scale imaging studies of the developing, mature and aging brain

Contents Terms and Concepts.- History of the Key Dis-ciplines.- Enviromics.- Genomics.- Epigenom-ics.- Molecular Phenomics.- Systems Phenomics.- Cohorts.- Challenges.- Personalized Preventive Medicine.

Fields of interestNeurosciences; Imaging / Radiology; Epidemiol-ogy



Due March 2013

2013. VII, 162 p. 72 illus., 46 in color.7 * € (D) 106,99 | € (A) 109,99 | sFr 133,507 € 99,99 | £90.00ISBN 978-3-642-36449-5

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G. N. Pierce, St. Boniface Hospital Research Centre, Winnipeg, MB, Canada; V. I. Mizin, Crimean State Humanitarian University, Yalta, Ukraine; A. Omelchenko, St. Boniface Hospital Research Centre, Winnipeg, MB, Canada (Eds)

Advanced Bioactive Compounds Countering the Effects of Radiological, Chemical and Biological AgentsStrategies to Counter Biological Damage

Contents Targeting NF-κB to Prevent Radiation-Induced Carcinogenesis.- Antioxidants as a Bio-Shield against Radiological Weapons; Kedar.- Sensing Mechanisms of the Low-Power Infrared Radia-tion: From Molecular Target to Clinical Applica-tion.- Correction of the Cancer Therapy-Induced Anemia by the Grape Polyphenol Concentrate Enoant. [...]

Fields of interestPharmacology/Toxicology; Environmental Health; Public Health


Product categoryProceedings

Due May 2013

Hardcover2013. Approx. 340 p. (NATO Science for Peace and Security Series A: Chemistry and Biology) 7 * € (D) 181,89 | € (A) 186,99 | sFr 226,507 € 169,99 | £153.00ISBN 978-94-007-6512-2

9<HTUELA=hgfbcc> Softcover2013. Approx. 340 p. (NATO Science for Peace and Security Series A: Chemistry and Biology) 7 * € (D) 96,29 | € (A) 98,99 | sFr 120,007 € 89,99 | £81.00ISBN 978-94-007-6532-0

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26

S. Puria, Stanford University, CA, USA; R. R. Fay, Marine Biological Laboratory, Woods Hole, MA, USA; A. N. Popper, University of Maryland, College Park, MD, USA (Eds)

The Middle EarScience, Otosurgery, and Technology

The middle ear plays a vital role in the sense and sensitivity of hearing. Of the various charac-teristics that distinguish mammals from other vertebrates, several pertain specifically to the middle-ear system, such as the presence of three middle-ear bones and the four-layer composite structure of the tympanic membrane. The Middle Ear attempts to elucidate the role this system plays in sound transmission, as viewed from both scien-tific and clinical perspectives.

Features 7 In-depth description of the middle ear in mammals and other vertebrates 7 Details hear-ing ranges of various vertebrates 7 Describes sound transmission through the middle ear

Fields of interestNeurosciences; Human Physiology; Neurobiology



Due March 2013

2013. XIV, 452 p. 58 illus., 24 in color. (Springer Handbook of Auditory Research, Volume 46)7 * € (D) 117,69 | € (A) 120,99 | sFr 146,507 € 109,99 | £99.00ISBN 978-1-4614-6590-4

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R. Resende, Universidade Federal de Minas Gerais; Belo Horizonte; Brazil; H. Ulrich, Universidade de São Paulo; Brazil (Eds)

Trends in Stem Cell Proliferation and Cancer ResearchContents Part I Molecular bases for stem and cancer cells proliferation.- An introduction to proliferation and migration of stem cells and cancer.- the role of cell adhesions, cell junctions and extracellular ma-trix in normal development and carcinogenesis.- The embryonic rest hypothesis of cancer develop-ment: 150 years later.- Are calcium channels more important than calcium influx for cell proliferation ?- Role of calcium signaling in stem cells and can-cer cells proliferation.- |Formation and function of lipid droplets in inflammation and cancer.- The role of sphingolipids in modulating pluripo-tency of stem cells.- Part II Signaling pathways to cancer cells fate.- Signaling pathways of cbl-b and its role on peripheral t cell tolerance.- Bh3-only proteins in cancer and apoptosis.- Signaling pathways of mta family proteins as regulators of cancer progression and metastasis.- Signalling pathways of β-catenin/jnk on carcinogenesis.- The regulation of the jnk cascade and programmed cell death by nf-κb: mechanisms and functions.- Part III Uncontrolled physiology process guiding to cancer cells.- Migration, metastasis and more: the role of chemokines in the proliferation, spreading and metastasis of tumors.- Autophagy, cell death, and cancer.- the duality of stem cells – double edged sword in tumour evolution and treatment.- Glioblastoma stem cells and implications for chemoresistance.- The tumor microenvironment as a transient niche: a modulator of epigenetic states and stem cell functions.- Tumor-associated neutrophils (tans). [...]

Fields of interestCancer Research; Stem Cells; Cell Biology



Due March 2013

2013. XXXII, 904 p. 77 illus., 58 in color. Hardcover7 * € (D) 213,99 | € (A) 219,99 | sFr 266,507 € 199,99 | £180.00ISBN 978-94-007-6210-7

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S. T. Sonis, Brigham and Women’s Hospital, Boston, MA, USA; D. M. Keefe, Royal Adelaide Hospital, Adelaide, SA, Australia (Eds)

Pathobiology of Cancer Regimen-Related ToxicitiesThe contents of this book will be organized into three sections. The first section defines the scope, impact and behaviour of cancer regimen-related toxicities and frames the issue of balancing treat-ment success and physiological cost.

Features 7 Defines the scope, impact and behavior of cancer regimen-related toxicities 7 Discusses the most current thinking around the pathobi-ology of specific, common, and representative toxicities 7 Discusses the common biological relationships between toxicities, bioinformati-cal approaches to analysing key and common pathways, and strategies for the development of effective interventions

Contents Preface.-Epidemiology and outcomes of regi-men-related toxicities.- The biological basis for differences in normal tissue response to radiation therapy and strategies to establish predictive assays for individual complication risk.- The bystander effect: Ionizing radiation-induced non-targeted ef-fects: Evidence, mechanism and significance.- The role of genes on the metabolism of chemothera-peutic agents and their impact on toxicity.- Ani-mal models of regimen-related toxicities.- Nausea and Vomiting.- Mucositis.- Dermatitis and Alope-cia.- Fibrosis.- Myelosuppression.- Neuropathy.- Fatigue.- Xerostomia.- Osteonecrosis.- Conclu-sions and therapeutic opportunities.- Index.

Fields of interestCancer Research; Pharmacology/Toxicology



Available


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27

S. K. Srivastava, Texas Tech University Health Sciences Center; Amarillo; TX; USA (Ed)

Role of Capsaicin in Oxidative Stress and CancerFeatures 7 Thoroughly reviews the preventive and thera-peutic effects of capsaicin in melanoma, pancreatic cancer, colon cancer, breast cancer, lung cancer, multiple myeloma and others 7 Identifies molec-ular and cellular targets of capsaicin and describes the role of mitochondria in capsaicin-mediated therapeutic effects 7 Benefits medical students, oncologists and cancer researchers

Contents Preface.- Role of capsaicin in cancer preven-tion.- Role of death receptors belonging to the TNF family in capsaicin-induced apoptosis of tumor cells.- Role of capsaicin in prostate cancer.- Capsaicin and the urinary bladder.- Inhi-bition of pancreatitis and carcinogenesis by capsa-icin.- Cytochrome P450-dependent modification of capsaicinoids: pharmacological inactivation and bioactivation mechanisms.- The cancer sup-pressing and promoting actions of capsaicin.- Oxi-dative stress by capsaicin in cancer.

Fields of interestCancer Research; Science, general; Apoptosis



Due May 2013

2013. V, 156 p. 25 illus., 7 in color. (Diet and Cancer, Volume 3) Hardcover7 * € (D) 106,99 | € (A) 109,99 | sFr 133,507 € 99,99 | £90.00ISBN 978-94-007-6316-6

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G. Stephens, University of Reading, UK; S. Mochida, Tokyo Medical University, Japan (Eds)

Modulation of Presynaptic Calcium ChannelsFeatures 7 Written by the world's leading ex-perts 7 A highly important scientific field 7 Clear relevance to current therapeutic drug development

Contents Spatial and temporal regulation of Ca2+ chan-nels.- Neuronal functions of auxiliary calcium channel subunits.- Reciprocal regulation of neuronal calcium channels by synaptic pro-teins.- Molecular architecture of Ca2+ channel complexes organized by β subunits in presynaptic active zones.- Control of CaV2 calcium channels and neurosecretion by heterotrimeric G protein coupled receptors.- Regulation of CaV2 channels by small GTPases.- Protein interaction partners of Cav2.3 R-type voltage-gated calcium chan-nels.- Voltage-gated calcium channel signaling to the nucleus.- Presynaptic Ca2+ influx and its modulation at auditory calyceal terminals.- Use of synthetic Ca2+ channel peptides to study presynaptic function.- Impact of a loss-of-function P/Q type Ca2+ channel mutation on excitatory synaptic control of cerebellar Purkinje neurons.- CaV2.1 (P/Q) voltage activated Ca2+ channels and synaptic transmission in genetic and autoim-mune diseases.- Splicing and editing to customize CaV channel structures for optimal neural func-tion.- Presynaptic calcium channels as drug targets for pain.- Sensory pathway modulation by calcium channel a2d1 subunit.

Fields of interestBiomedicine general; Neurobiology; Membrane Biology



Due April 2013


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D. J. Tindall, Mayo Clinic, Rochester, MN, USA (Ed)

Prostate CancerBiochemistry, Molecular Biology and Genetics

Contents Preface.- Section 1: Cell Biology.- Stem Cells in the Normal and Malignant Prostate.- Role of Reactive Stroma in Prostate Cancer.- The Role of Cho-lesterol in Prostate Cancer.- Section 2: Genetics: PTEN in Prostate Cancer.- ETS fusion genes in prostate cancer.- Section 3: Cell Signaling.- Sig-naling Mechanisms of Vav3, a Guanine Nucleo-tide Exchange Factor and Androgen Receptor Coactivator, in Physiology and Prostate Cancer Progression.- Transforming Growth Factor-beta (TGF-b) in Prostate Cancer.- The p38 MAPK Pathway in Prostate Cancer.- NF-kappaB2/p52 in Prostate Cancer.- The functional role of DAB2IP, a homeostatic factor, in prostate cancer.- Tyrosine Kinases in Prostate Cancer.- Human prostatic acid phosphatase in prostate carcinogenesis.- Section 4: Hormonal.- Truncated Androgen Receptor Splice Variants in Prostate Cancer.- Biology and Clini-cal Relevance of Estrogen Receptors in Prostate Cancer.- Vitamin D and Prostate Cancer.- HDAC6 regulation of androgen signaling in prostate can-cer.- Beyond the cell cycle: Implications of D-type cyclin deregulation in Pca.- Section 5: Cell Death.- Role of Par- in Prostate Cancer.- Autophagy and Prostate Cancer Therapeutics.- Index.

Fields of interestCancer Research; Medical Biochemistry; Cell Biology



Due May 2013

2013. XIV, 566 p. 41 illus., 38 in color. (Protein Reviews, Volume 16)7 * € (D) 181,89 | € (A) 186,99 | sFr 226,507 € 169,99 | £153.00ISBN 978-1-4614-6827-1

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28

H. Vančik, University of Zagreb, Croatia

Aromatic C-nitroso CompoundsThis book is designed to collect and review the re-search covering main directions in investigations of aromatic nitroso compounds in last decades, and to present both, the academic aspects of this chemistry, as well as the open field of its applica-bility. The book is divided in five chapters. The basic structural properties of the nitroso aromatic molecules are described in the first chapter. The second chapter is an overview of the methods of preparations of aromatic nitroso and polynitroso compounds, including classical synthetic methods and some new preparative approaches. The third part deals with the physico-chemical properties of nitroso aromates and azodioxides, its structure, crystallography, quantum chemical calculations, spectroscopy, typical reactions, and especially it is focused on the dimerizations in the solid-state.

Features 7 Offers important scientific information to physical organic chemists and scientists in the field of material and solid-state science 7 The first book to cover C-nitroso compounds from different contemporary scientific research disci-plines, including synthetic, structural, spectros-copy, photochemistry, organometallic as well as bioorganic applications 7 Describes opportu-nities for studying general chemical concepts, especially solid-state reactions, by using nitroso aromatic molecules as models 7 Provides a comprehensive interdisciplinary look at this class of compounds

Contents Molecular structures.- An overview of synthetic methods for preparation of nitrosoaromatic com-pounds.- Molecular properties and spectroscopy.- Organometallic compounds.- Bilological systems.

Fields of interestBiomedicine general; Organic Chemistry; Physical Chemistry



Due March 2013


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F. Vivanco, Universidad Complutense, Madrid, Spain (Ed)

Heart ProteomicsMethods and Protocols

Contents Large-Scale Characterization of the Murine Car-diac Proteome.- Determining Protein Concentra-tions of the Human Ventricular Proteome.- Mul-tidimensional Protein Identification Technology for Direct-Tissue Proteomics of Heart.- Global Protein Quantification of Mouse Heart Tissue Based on the SILAC Mouse.- Global Proteomic Profiling and Enrichment Maps of Dilated Car-diomyopathy.- Characterization of the Human Myocardial Proteome in Dilated Cardiomyopathy by Label-Free Quantitative Shotgun Proteomics of Heart Biopsies.- Systems Proteomics of Healthy and Diseased Chromatin.- Proteomic Analysis of Interstitial Aortic Valve Cells Acquiring a Pro-Calcific Profile.- Differential Protein Expression Analysis of Degenerative Aortic Stenosis by Itraq Labeling.- Characterization of Zebrafish Cardiac Proteome Using On Line PH Gradient SCX -RP HPLC MS/MS Platform.- Proteomic Analysis of Brain Mitochondrial Proteome and Mitochondrial Complexes.- Oxidative Modifications of Mito-chondria Complex II.- Detection of O-GLCNAC Modifications on Cardiac Myofilament Proteins.- Quantification of Mitochondrial S-Nitrosylation by CYSTMT6 Switch Assay.- Identification of Thioredoxin Target Protein Networks in Car-diac Tissues of a Transgenic Mouse.- Using Pure Protein to Build a Multiple Reaction Monitoring Mass Spectrometry Assay for Targeted Detec-tion and Quantitation.- A Sequential Extraction Methodology for Cardiac Extracellular Matrix Prior to Proteomics Analysis.- Optimized Method for Identification of the Proteomes Secreted by Cardiac Cells.- Secretome of Human Aortic Valves. [...]

Fields of interestMolecular Medicine; Cardiology; Proteomics



Due May 2013

2013. XIV, 286 p. 46 illus., 31 in color. (Methods in Molecular Biology, Volume 1005) Hardcover7 * € (D) 101,64 | € (A) 104,49 | sFr 126,507 € 94,99 | £85.50ISBN 978-1-62703-385-5

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