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Limsoon WongKent Ridge Digital Labs

Singapore

Role of Bioinformaticsin the Genomic Era

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What are the Themes of Bioinformatics?What are the Themes of Bioinformatics?

Bioinformatics =

Data Mgmt + Knowledge Discovery

Data Mgmt =

Integration + Transformation + Cleansing

Knowledge Discovery =

Statistics + Algorithms + Databases

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What are the Benefits of Bioinformatics?What are the Benefits of Bioinformatics?

To the patient:

Better drug, better treatment To the pharma:

Save time, save cost, make more $ To the scientist:

Better science

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Transcription Start PredictionTranscription Start Prediction

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Transcription Start Prediction ResultsTranscription Start Prediction Results

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Medical Record AnalysisMedical Record Analysis

Looking for patterns that are valid novel useful understandable

age sex chol ecg heart sick49 M 266 Hyp 171 N64 M 211 Norm 144 N58 F 283 Hyp 162 N58 M 284 Hyp 160 Y58 M 224 Abn 173 Y

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Medical Record Analysis ResultsMedical Record Analysis Results

DeEPs, the “emerging pattern’’ method

Beats C4.5, CBA, LB, NB, TAN in 21 out of 32 UCI benchmarks

Works for gene expressions ALL vs AML:

DeEPS (1 gene) - 0/38 & 3/34 Slonim (50 genes) - 2/38 & 5/34

Colon: DeEPS (35 genes) - 4/62 Alon (1000 genes) - 6/62

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Genome-Enabled FruitsGenome-Enabled Fruits

A lot of genes & proteins that are

candidate diagnosis indicators candidate prognosis indicators candidate drug targets

What’s Next?What’s Next?

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Evaluate & Choose the Better CandidatesEvaluate & Choose the Better Candidates

Easier to access

Uncomplicated to modulate

Clear path to $

Has experience

To do that, you will need to have ….To do that, you will need to have ….

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STRUCTURE

EXPRESSION

RELATED MOLECULES

MUTATIONS

DISEASES

PATENTS

INTERACTIONS

A Molecular Connections Database consisting of...A Molecular Connections Database consisting of...

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Thank YouThank You