Life Sciences Statistics 2011

UNITED KINGDOM

About UsThe following statistical information has been obtained from Biotechgate. Biotechgate is a global, comprehensive, Life Sciences database encompassing the Biotechnology,Pharmaceutical and Medical Device industries. www.biotechgate.com

The UK Biotech Database is a part of the global Biotechgate and is brought to you in partnership with University of Oxford, Oxfordshire economic partnership and One Nucleus; a membership organisation for international life science and healthcare companies. ww.ukbiotech.com

Biotechgate is owned and operated by Venture Valuation AG, a Zurich based company specializing in independent assessment and valuation of technology-driven companies in high growth industries, such as the Life Sciences (Biotech, Pharma, Medtech), ICT, high-tech, Nanotech, Cleantech and Renewable energy. www.venturevaluation.com

Status of the Sector

605 Total Biotechnology Companies 173 Biotech - Therapeutics 379 Biotech – R&D Services 53 Biotech - Other

>34'000 Employees >1'000 R&D Employees 84% Percentage of SME's 7% Percentage of Companies Publicly Owned

GBP 290m Financing / Capital Raised in 2010 154 Products Available for Out-licensing

Source: www.biotechgate.com

Key Activities of Biotechnology Companies

AgroBio 1%

Bioinformatics and

Bioelectronics 4%

Contract Research and Manufacturing

17%

Cosmetics 1%

Diagnostics and Analytical

Services 20%Drug Delivery

4%Environment

1%Food and

Nutraceuticals 1%

Genomics and Proteomics

7%

Industrial Biotechnology

1%

Other Services and Suppliers

25%

Therapeutics 17%

Veterinary 1%

Source: www.biotechgate.com

Biotechnology Companies in the UKBreakdown by subcategory based on 1031 entries by 605 companies

Biotechnology Company Size

1-10:21%

11-50:44%

51-250:20%

>2506%

Source: www.biotechgate.comSource: www.biotechgate.com

Size of Biotechnology Companies in the UK(by number of employees)

Company Foundation Timeline

5 915 12 13 9

4 7 5 3 3

16

20

19

11 12

7 16 127

2 3

3

2

3

12

1

1

05

10152025303540

Biotechnology - Therapeutics Biotechnology / R&D Services Biotechnology - other

Source: www.biotechgate.com

Company Foundations in the UK(by year)

Company Ownership

Private / independent

73%

Public 7%

Subsidiary 20%

Source: www.biotechgate.com

Public, Private and Subsidiary Companies in the UK

Sources of Company Foundations

Independent foundation

47%

Management buy-out (MBO)

1%Merger

2%

Spin-off from company

3%

Spin-off from public institution /

NPO 3%

Spin-off from university

16%

Subsidiary 22%

Other 6%

Company Foundations in the UK(by source of foundation)

Source: www.biotechgate.com

Products in the Pipeline

174

70

88

27

0 50 100 150 200

Discovery & Preclinical

Phase I

Phase II

Phase III

Source: www.biotechgate.com

UK Biotechnology Pipeline

5 Largest Therapeutic Biotech Company Financing Rounds

Company Date Currency Amount (millions) Type

Archimedes Pharma Limited 02.03.2010 GBP 65 Equity - Later stage Syntaxin Ltd 11.11.2010 GBP 29 Equity - Later stage Oxford Immunotec 30.04.2010 USD 26 Equity - Later stage Convergence Pharmaceuticals 04.10.2010 GBP 22.4 Equity - Start-up Kymab Limited 19.07.2010 GBP 20 Equity - First stage

Source: www.biotechgate.com

Biotechnology in Selected Countries

Austria Canada France Germany Italy Switzerland U.K.

Biotech companies 90 572 348 780 561 310 605

Therapeutic biotech companies 27 148 80 113 66 84 173

New companies founded in 2010 3 1 2 2 - 4 6

Companies founded 2001 - 2010 41 128 128 212 134 122 199

% of companies with <10 employees 26% 29% 30% 25% 25% 33% 21%

Biotech products in development 74 332 264 270 130 217 359

% publicly listed companies 2% 18% 5% 3% 2% 5% 7% Source: www.biotechgate.com

About Biotechgate

Biotechgate contains over 20’000 high quality company profiles which include company descriptions, contact information, product pipeline information, financing rounds and management details. Profiles are regularly updated by the companies themselves, as well as by an experienced database team, to ensure the accuracy and relevance of the data.

To register for free or learn more about the different subscription options, please visit www.biotechgate.com.

Terms of Use

The „UK Life Sciences Survey“ is based on data entered in the Biotechgate Database available at www.biotechgate.com. The statistics and graphs in this presentation are based on figures and information entered in this database and we do not guarantee any accuracy hereof.

A new categorization system was installed in 2007 and modified in 2010; therefore, subsequent surveys cannot be directly compared .

The use of the figures and graphs provided in this report is free of charge for any presentations as long as www.biotechgate.com is clearly cited as the source. For all other uses please contact us for terms and conditions.

Biotechgatec/o Venture Valuation VV AGKasernenstrasse 11 +41 (43) 321 86 608004 Zurich info@venturevaluation.comSwitzerland www.venturevaluation.com