ISCTE-MIT Venture Competition

Lisboa, 22 de Setembro de 2011

Treating complex

diseases

Biopharmaceuticals Market

2 | ISCTE-MIT Venture Competition | 22 September 2011 | MediaOmics

Cell culture

Media

80 Bln $ market

Cell culture

Process

× High production costs = 68 M US$/100 kg biomedicine

× Systemic production capacity shortage

Market Problem

Biomedicines are extremely difficult to manufacture

3 | ISCTE-MIT Venture Competition | 22 September 2011 | MediaOmics

Sources:

Heinzle, E., A.P. Biwer, and C.L. Cooney. Development of Sustainable Bioprocesses: Modeling and Assessment (2007). Wiley.

Challenges and Solutions for Biopharmaceutical Manufacturing. BioProcess Technology Consultants, Inc. http://www.bptc.com

46% 51% 50% 55%

61% 61% 62% 52%

62%

80% 87% 91%

0%

20%

40%

60%

80%

100%

0,0

1,0

2,0

3,0

4,0

2007 2008 2009 2010 2011 2012 2013

Capacity occupancy (%)

Volume (million L)

Capacity installed Demand Demand for 5 new blockbusters

Current methodology for culture media design

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However... Life could never have evolved by chance!

Francis Cricket, Nobel Prize winner

...Why should culture media?

Our Uniqueness

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Portuguese PATENT;

International patent

application scheduled.

Tailored Culture Media: Right ingredients

Right amounts

Higher performance

Less time

Cell Functional

Enviromics Technology

Pilot scale 50 L

Our Solution

6 | ISCTE-MIT Venture Competition | 22 September 2011 | MediaOmics

■ InvitrogenTM ■ MediaOmics®

50% fixed capital costs

100% production capacity

2 productivity

Our Partners

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Process

development CMO

Culture media

CMO

Clone developer

MediaOmics® needs a €2 million investment.

The expected payback is in 5 years.

Net present value of €1.6 million.

Investment and Return

8 | ISCTE-MIT Venture Competition | 22 September 2011 | MediaOmics

0,0

1,0

1,9

3,7 4,1

5,0

-2,0

-1,0

0,0

1,0

2,0

3,0

4,0

5,0

6,0

2012 2013 2014 2015 2016 2017Cash Flow

(million EUR

)

Free Cash Flow Cumulative Cash Flow Sales

Rui Oliveira

Rui Oliveira holds a chemical engineering degree and a Biochemical engineering Ph.D. since 1998. He is the head of the Systems Biology and Engineering Lab at FCT-UNL since 2001. He has been the lead scientist of several research projects with Biopharma companies in the US and Europe. He is author of more than 50 research papers in high impact scientific journals. He is inventor of two international patents and 3 national patents. He has coordinated the development of CFE-Media

® technology and of Pichia-FEM

TM.

António Dinis

António holds a Biotechnology degree and a MBA. Since 2007 He works as an Account Manager at Hovione promoting products and services to pharmaceutical companies. Previously he worked for seven years at DSM, where he held several managerial positions and was involved international strategic projects. António is also an experienced business catalyst and has helped a number of scientists to bring their technologies closer to market.

João Dias

João Dias holds a Chemical Engineering degree and a Chemical and Biochemical Engineering Ph.D. from FCT-UNL. He is currently a Post-doctoral researcher at the same institution. He has over 7 years’ experience in computational systems biology and bioinformatics. He has participated in 2008-2009 in a research project with Merck&Co - FASTPICHIA - for the optimization of Pichia pastoris cultivations. João has also been deeply involved in the development of CFE-Media

® technology and of Pichia-FEM

TM and he is one of

the inventors of MediaOmics® technology.

MediaOmics® Promoters

Nuno Carinhas

Nuno holds a Biology degree and is scheduled to defend his PhD thesis in Biotechnology this year. His work focuses on the application of Systems Biology approaches to biotechnology, the core of MediaOmics

® technology. In addition,

he has taken entrepreneurial and biotechnology short courses in leading universities, including UNL and MIT. Along the past 3 years, he has been an enthusiast of finance, particularly in the Biotech and Biopharma industries.

Filipe Ataíde

Filipe holds a M.Sc. degree in Chemical and Biochemical Engineering from FCT-UNL since 2007. He is currently developing his Ph.D. work in the field of nanobiotechnology. He has experience in designing and synthesizing magnetic nanoparticles with functional coatings to enhance the efficiency of oxygen transfer from gases to liquids. This technology is at the basis of reusable culture media ingredients and could be a valuable asset in the future. He is an enthusiast of operations management of Biotech/Chemical Plants and of entrepreneurial activities.

Ana Ferreira

Ana Raquel holds a Chemical Engineering degree from FCT-UNL since 2005. She started her PhD thesis in March 2008 at FCT-UNL in partnership with iBET. She has more than 5 years’ experience in Pichia pastoris laboratorial research. She has experience in Pichia pastoris cultivations for therapeutic proteins production at different scales, including shake flasks, laboratorial reactors and pilot scale reactors. She has been deeply involved in the development of Pichia-FEM

TM and she is one of the inventors of MediaOmics

® technology.

Ph.D. Biochem. Eng.

Assistant Professor at

Universidade Nova de Lisboa.

Inventor of the technology.

Biotechnol. Degree

MBA

Business Catalyst

Ph.D. Chem. Biochem. Eng.

Post-Doc researcher at

Universidade Nova de Lisboa.

Inventor of the technology.

Ph.D. Biotechnol.

Post-Doc researcher at

Universidade Nova de Lisboa.

M.Sc. Chem. Biochem. Eng.

PhD Student at Universidade

Nova de Lisboa.

Chem. Eng. Degree

PhD Student at Universidade

Nova de Lisboa.

Inventor of the Technology

9 | ISCTE-MIT Venture Competition | 22 September 2011 | MediaOmics