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Case Study Project: Synthesis of 30 membered benzoimidazole libraries with two point of diversity Process: Parallel synthesis, with Buchwald and acid-amine coupling Deliverables: Delivered 95% purity and 25mg final product within 4 weeks Capabilities Design Target based Kinases (& other enzymes) GPCRs Ion-channel Nuclear receptors Natural product based De-Novo libraries Enumeration Synthesis Synthesize 600-700 compounds per month Synthesize molecules from 25 to 1500 compounds per library Use of 96-well plate platform One step to four steps synthesis depending on project requirement Chemistry Expertise (some representative reactions) Addition-elimination Condensation Hydrolysis, oxidation, reduction, Organometallic couplings (Suzuki, Stille, Heck, Buchwald’s amination) Transmetalation Amine-sulfonic acid coupling Protection and deprotection of functional groups Acid-amine coupling Infrastructure Tecan Freedom EVO-2 Liquid Handling System with Mettler Toledo balance LCMS analysis Mass Triggered Prep-HPLC Genevac (HT-4X, Eze2) Nitrogen Blow-down Waters UPLCMS for QQC Microwave (10-35ml): 48 stations 2D Barcode Readers Aluminum Reaction Blocks for Parallel synthesizers Hamilton Micro syringes Agilent Thermal Plate Loc Micro plate Sealer Library Synthesis GVK Biosciences offers high quality, cost effective library synthesis services using parallel synthesis. We design and synthesize drug like templates and libraries of compounds. Our services comprise of library design, parallel medicinal chemistry services, compound characterization, purification, quality control, quantitative quality control, documentation and shipment. We have the capability to design focused libraries using computational chemistry. Contact: [email protected] Visit: www.gvkbio.com

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GVK Biosciences offers high quality, cost effective library synthesis services using parallel synthesis. We design and synthesize drug like templates and libraries of compounds. Our services comprise of library design, parallel medicinal chemistry services

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Page 1: Library Synthesis

Case Study Project: Synthesis of 30 membered

benzoimidazole libraries with two point of

diversity

Process: Parallel synthesis, with Buchwald and

acid-amine coupling

Deliverables: Delivered 95% purity and 25mg

final product within 4 weeks

Capabilities

Design

Target based

Kinases (& other enzymes)

GPCRs

Ion-channel

Nuclear receptors

Natural product based

De-Novo libraries

Enumeration

Synthesis

Synthesize 600-700 compounds per month

Synthesize molecules from 25 to 1500 compounds

per library

Use of 96-well plate platform

One step to four steps synthesis depending on

project requirement

Chemistry Expertise

(some representative reactions)

Addition-elimination

Condensation

Hydrolysis, oxidation, reduction,

Organometallic couplings (Suzuki, Stille, Heck,

Buchwald’s amination)

Transmetalation

Amine-sulfonic acid coupling

Protection and deprotection of functional groups

Acid-amine coupling

Infrastructure

Tecan Freedom EVO-2 Liquid Handling System with

Mettler Toledo balance

LCMS analysis

Mass Triggered Prep-HPLC

Genevac (HT-4X, Eze2)

Nitrogen Blow-down

Waters UPLCMS for QQC

Microwave (10-35ml): 48 stations

2D Barcode Readers

Aluminum Reaction Blocks for Parallel synthesizers

Hamilton Micro syringes

Agilent Thermal Plate Loc Micro plate Sealer

Library Synthesis

GVK Biosciences offers high quality, cost effective library synthesis services using parallel

synthesis. We design and synthesize drug like templates and libraries of compounds. Our services

comprise of library design, parallel medicinal chemistry services, compound characterization,

purification, quality control, quantitative quality control, documentation and shipment. We have the

capability to design focused libraries using computational chemistry.

Contact: [email protected] Visit: www.gvkbio.com

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