HEMATOLOGY 1

© Copyright 2015; Revised 9/24/15

LEUKEMIA/MDS

0 - Not having achieved remission 1 - In remission 2 - In relapse

Leukemia,

LYMPHOID 0 - Acute lymphoblastic leukemia 1- Chronic lymphocytic leukemia of B-cell type 3 - Prolymphocytic leukemia of B-cell type 4 - Hairy cell leukemia 5 - Adult T-cell lymphoma/leukemia (HTLV-1-associated) 6 - Prolymphocytic leukemia of T-cell type A - Mature B-cell leukemia Burkitt-type Z - Other lymphoid leukemia 9 - Unspecified

C91.

Unspecified Malignant Neoplasms of

LYMPHOID, HEMATO POIETIC & RELATED TISSUE

0 - Multifocal and multisystemic (disseminated) Langerhans-cell histiocytosis 2 - Malignant mast cell tumor 4 - Sarcoma of dendritic cells (accessory cells) 5 - Multifocal and unisystemic Langerhans-cell histiocytosis 6 - Unifocal Langerhans-cell histiocytosis A - Histiocytic sarcoma Z - Other specified 9 - Unspecified

C96.

0 -Not having achieved remission 1 - In remission 2 - In relapse

Leukemia,

MYELOID

0 - Acute myeloblastic leukemia 1 - Chronic myeloid leukemia, BCR/ABL- positive 2 - Atypical chronic myeloid leukemia, BCR/ABL-negative 3 - Myeloid sarcoma 4 - Acute promyelocytic leukemia 5 - Acute myelomonocytic leukemia 6 -Acute myeloid leukemia with 11q23- abnormality A - Acute myeloid leukemia with multilineage dysplasia Z - Other myeloid leukemia 9 - Unspecified

C92.

0 - Acute monoblastic/monocytic leukemia 1 - Chronic myelomonocytic leukemia 3 - Juvenile myelomonocytic leukemia Z - Other monocytic leukemia 9 - Unspecified

0 - Not having achieved remission 1- In remission 2– In relapse

Leukemia,

MONOCYTIC C93.

Poisoning by Adverse Effect of & Underdosing of,

ANTINEOPLASTIC & IMMUNOSUPPRESSIVE DRUGS

1- Poisoning by antineoplastic and immunosuppressive drugs, accidental (unintentional) 5- Adverse effect of antineoplastic & immunosuppressive drugs

A - initial encounter D - subsequent encounter S - sequela

T45.1X

0 - Not having achieved remission 1 - In remission 2 - In relapse

Other Leukemias of

SPECIFIED CELL TYPE 0 - Acute erythroid leukemia 2 - Acute megakaryoblastic leukemia 3 - Mast cell leukemia 4 - Acute panmyelosis with myelofibrosis 8 - Other specified leukemias

STOP 6 - Myelodysplastic disease, not classified

C94.

0 - Not having achieved remission 1- In remission 2– In relapse

C95. Leukemia of UNSPECIFIED CELL TYPE

0 - Acute 1 - Chronic 9 - Unspecified

MYELODYSPLASTIC SYNDROME (MDS)

0 - Not having achieved remission 1- 1 2– 2

2 - Refractory anemia with excess of blasts

STOP

Use T45.1X code for adverse effect, if applicable

D46.

0 - Refractory anemia without ring sideroblasts, so stated 1 - Refractory anemia with ring sideroblasts A - Refractory cytopenia with multilineage dysplasia B - Refractory cytopenia with multilineage dysplasia and ring sideroblasts C - Myelodysplastic syndrome with isolated del(5q) chromosomal abnormality 4 - Refractory anemia, unspecified Z - Other myelodysplastic syndromes 9 - Unspecified

0 - Not having achieved remission 1 - In remission 2 – In relapse

Multiple Myeloma & Malignant

PLASMA CELL NEOPLASM

C90.

0 - Multiple Myeloma 1 - Plasma cell leukemia 2 - Extramedullary plasmacytoma 3 - Solitary plasmacytoma

HEMATOLOGY 2

© Copyright 2015; Revised 9/24/15

B-CELL LYMPHOMA

Lymphoma,

FOLLICULAR

0 - Unspecified site 1 - Head, neck, face 2 - Intrathoracic 3 - Intra-abdominal 4 - Axilla and upper limb 5 - Inguinal region and lower limb 6 -Intrapelvic 7 -Spleen 8 - Multiple-sites 9 - Extranodal and solid organ site

0 - Grade I 1 - Grade II 2 - Grade III unspecified 3 - Grade IIIa 4 - Grade IIIb 5 - Diffuse follicle center lymphoma 6 - Cutaneous follicle center lymphoma 8 - Other types lymphoma 9 - Unspecified

C82. Lymphomas, MALIGNANT IMMUNOPROLIFERATIVE & OTHER B-CELLS

0 - Waldenstrom macroglobulinemia 2 - Heavy chain disease 3 - Immunoproliferative small intestinal disease 4 - Extranodal marginal zone B-cell lymphoma of mucosa-

associated lymphoid tissue [MALT-lymphoma] 8 - Other malignant immunoproliferative diseases 9 - Unspecified.

C88.

Lymphoma,

HODGKIN 0 - Nodular lymphocyte predominant 1 - Nodular sclerosis classical 2 - Mixed cellularity classical 3 - Lymphocyte-depleted classical 4 - Lymphocyte-rich classical 7 - Other classical 9 - Unspecified

0 - Unspecified site 1 - Head, neck, face 2 - Intrathoracic 3 - Intra-abdominal 4 - Axilla and upper limb 5 - Inguinal region and lower limb 6 -Intrapelvic 7 -Spleen 8 - Multiple-sites 9 - Extranodal and solid organ site

C81.

Lymphoma,

NON-FOLLICULAR 0 - Unspecified site 1 - Head, neck, face 2 - Intrathoracic 3 - Intra-abdominal 4 - Axilla and upper limb 5 - Inguinal region and lower limb 6 -Intrapelvic 7 -Spleen 8 - Multiple-sites 9 - Extranodal and solid organ site

0 - Small cell B-cell Lymphoma 1 - Mantle cell Lymphoma 3 - Diffuse Large B-cell lymphoma 5 - Lymphoblastic (diffuse lymphoma) 7 - Burkitt lymphoma 8 - Other non-follicular Lymphoma (includes PEL/ intravascular) 9 - Unspecified

C83.

Lymphoma,

OTHER NON-HODGKIN

0 - Unspecified site 1 - Head, neck, face 2 - Intrathoracic 3 - Intra-abdominal 4 - Axilla and upper limb 5 - Inguinal region and lower limb 6 -Intrapelvic 7 -Spleen 8 - Multiple-sites 9 - Extranodal and solid organ site

1 - Unspecified B-cell lymphoma 2 - Mediastinal (thymic) large B-cell 8 - Other specified types of non-Hodgkin’s 9 - Unspecified

C85.

Lymphoma, Other

SPECIFIED T/NK-CELL 0 - Extranodal NK/T-cell lymphoma, nasal type 1 - Hepatosplenic T-cell lymphoma 2 - Enteropathy-type (intestinal) T-cell lymphoma 3 - Subcutaneous panniculitis-like-T-cell lymphoma 4 - Blastic NK-cell lymphoma 5 - Angiommunoblastic T-cell lymphoma 6 - Primary cutaneous CD-30-positive T-cell proliferations

C86.

HEMATOLOGY

© Copyright 2015; Revised 9/24/15

MYELOPROLIF/MGUS

0 - Histiocytic and mast cell tumors of uncertain behavior 1 - Chronic myeloproliferative disease 2 - Monoclonal gammopathy 3 - Essential (hemorrhagic) thrombocythemia 4 - Osteomyelofibrosis 9 - Unspecified

Neoplasms of Uncertain Behavior of

LYMPHOID, HEMA-TOPOIETIC & RELATED TISSUE

Z - Other specified neoplasms

1- Post-transplant lymphoproliferative disorder (PTLD) 9 - Other specified neoplasms

For MYELOFIBROSIS, use D75.81

D47.

STOP

POLYCYTHEMIA VERA

D45

MONOCLONAL GAMMOPATHY

D47.2

ESSENTIAL (HEMORRHAGIC) THROMBOCYTHEMIA

D47.3

0 - Familial erythrocytosis 1 - Secondary polycythemia 9 - Unspecified

Other & Unspecified Diseases of

BLOOD & BLOOD-FORMING ORGANS (MYELOFIBROSIS)

8 - Other specified diseases of blood and blood- forming organs

1- MYELOFIBROSIS (Code first underlying disorder such as neoplasm. If applicable, code for associated therapy-related MDS and for adverse effects to identify drug) 2 - Heparin induced thrombocytopenia (HIT) 9 - Other specified diseases of blood and blood-forming organs

STOP

D75.

0 - Secondary to blood loss (chronic) 1 - Sideropenic dysphagia 8 - Other iron deficiency anemias 9 - Unspecified

Anemia,

IRON DEFICIENCY D50.

Anemia, VITAMIN B12 DEFICIENCY 0 - Intrinsic factor deficiency 1 - Selective vitamin B12 malabsorption with proteinuria 2 - Transcobalamin II deficiency 3 - Other dietary Vitamin B12 deficiency 8 - Other 9 - Unspecified

D51.

Anemia,

FOLATE DEFICIENCY 0 –Dietary 1 - Drug-induced (Use additional code for adverse effects, if applicable, to identify drug) 8 - Other 9 - Unspecified

D52.

Anemias,

OTHER NUTRITIONAL 0 - Protein deficiency anemia 1 - Other megaloblastic anemias, not elsewhere classified 2 - Scorbutic anemia 8 - Other 9 - Unspecified

D53.

NUTRITIONAL ANEMIAS

MYELOFIBROSIS D75.81

IRON OVERLOAD & OTHERS

0 - Disorder of Iron Metabolism, unspecified

0 - Hereditary 1 - Due to repeated red blood cell transfusions 8 - Other 9 - Unspecified

STOP

1 - Hemochromatosis

E83.1

HEMATOLOGY 4

© Copyright 2015; Revised 9/24/15

OTHER ANEMIAS

0 - Due to glucose-6-phosphate dehydrogenase [G6PD] deficiency 1 - Other disorders of glutathione metabolism 2 - Disorders of glycolytic enzymes 3 - Disorders of nucleotide metabolism 8 - Other anemias 9 - Unspecified

Anemia due to

ENZYME DISORDERS D55.

D59. Hemolytic Anemia,

ACQUIRED

0 -Drug-induced autoimmune (Use additional code for adverse effects, if applicable, to identify drug) 1 - Other autoimmune 2 - Drug-induced non-autoimmune (Use additional code for adverse effects, if applicable, to identify drug) 3 - Hemolytic-uremic syndrome (Use additional code to identify associated: E. coli, Pneumoncoccal pneumonia, or Shigella dysenteriae) 4 - Other non-autoimmune 5 - Paroxysmal nocturnal hemoglobinuria (Marchiafava-Micheli) 6 - Hemoglobinuria due to hemolysis from other external causes 8 - Other acquired hemolytic anemias 9 - Unspecified

0 –Alpha 1 - Beta 2 - Delta-beta 3 - Minor 4 - HPFH (Hereditary persistence of fetal hemoglobin) 5 - Hemoglobin E-beta 8 - Other 9 - Unspecified

THALASSEMIA D56.

SICKLE CELL DISORDERS

0 - Without crisis

1 - Acute chest syndrome

2 - Splenic sequestration

9 - Unspecified

1 - Sickle cell without crisis 3 - Sickle-cell trait

0 - Hb-SS with crisis

2 - Hb-C disease 4 - Thalassemia 8 - Other Sickle-Cell

1 - With crisis

STOP

Use additional code for any associated fever

STOP

STOP

D57.

0 - Unspecified 1 - Acute chest syndrome 2 - Splenic sequestration

1 - Drug-induced aplastic anemia (If applicable, use additional code for adverse effects to identify drug) 2 - Aplastic anemia due to other external agents (If applicable, code first toxic effects of substance chiefly non-medicinal as to source (T51-T65) 3 - Idiopathic aplastic anemia 9 - Unspecified

Other Aplastic Anemias & Other BONE MARROW FAILURE SYNDROMES

1 - Constitutional (pure) red blood cell aplasia 9 - Other constitutional aplastic anemia

0– Constitutional aplastic anemia

1- Pancytopenia

0 - Antineoplastic chemotherapy induced

pancytopenia 1 - Other drug-induced

pancytopenia 8 - Other pancytopenia

2 - Myelophthisis 9- Other specified aplastic anemias

& other bone marrow failure

syndrome

8 - Other specified aplastic anemias & other bone marrow failure syndromes

STOP

STOP

D61.

0 - Anemia in neoplastic disease (Code first neoplasm) 1 - Anemia in chronic kidney disease (Code first underlying CKD) 8 - Anemia in other chronic diseases classified elsewhere (Code first underlying disease such as: - Hypothyroidism - Tuberculosis)

Anemia in

CHRONIC DISEASES CLASSIFIED ELSEWHERE

D63.

0 - Hereditary sideroblastic anemia 1 - Secondary sideroblastic anemia due to disease 2 - Secondary sideroblastic anemia due to drugs and toxins 3 - Other sideroblastic anemias 4 - Congenital dyserythropoietic anemia 9 - Unspecified

OTHER ANEMIAS

8 –Other specified anemias

1- Anemia due to anti-neoplastic chemotherapy 9 -Other specified anemias

STOP

D64.

HEMATOLOGY 5

© Copyright 2015; Revised 9/24/15

NEUTROPENIA & OTHER WBC DISORDERS

Functional Disorders of

POLYMORPHONUCLEAR NEUTROPHILS

D71

MYELOFIBROSIS, HLH, HIT, 2° POLYCYTHEMIA

0 – Congenital agranulocytosis 1 - Agranulocytosis secondary to cancer chemotherapy (Code also underlying neoplasm. Use additional code for adverse effect, if applicable, to identify drug.) 2 - Other drug-induced agranulocytosis (Use additional code for adverse effect, if applicable, to identify drug) 3 - Neutropenia due to infection 4 - Cyclic neutropenia 8 - Other 9 - Unspecified

NEUTROPENIA

Use additional code for any associated fever & mucositis

D70.

0 - Familial erythrocytosis 1 - Secondary polycythemia 9 - Unspecified

Other & Unspecified Diseases of

BLOOD & BLOOD-FORMING ORGANS (MYELOFIBROSIS)

8 - Other specified diseases of blood and blood- forming organs

1- MYELOFIBROSIS (Code first underlying disorder such as neoplasm. If applicable, code for associated therapy-related MDS and for adverse effects to identify drug) 2 - Heparin induced thrombocytopenia (HIT) 9 - Other specified diseases of blood and blood-forming organs

STOP

D75. Other Specified Diseases

W/Participation of

LYMPHORETICULAR & RETICULOHISTIOCYTIC TISSUE 1 - Hemophagocytic lymphohistiocytosis 2 - Hemophagocytic syndrome, infection-associated (Use additional code to identify infectious agent or disease) 3 - Other histiocytosis syndromes

D76.

0 - Lymphocytopenia 8 - Other 9 - unspecified

0 - Lymphocytosis (symptomatic)

1 - Monocytosis (symptomatic)

2 - Plasmacytosis 3 - Leukemoid reaction 4 - Basophilia 5 - Bandemia 8 - Other 9 - Unspecified

Other Disorders of

WHITE BLOOD CELLS

8 - Other

specified disorders

of white blood cells

0 - Genetic anomalies of leukocytes 1 - Eosinophilia 9 - Unspecified

1 - Decreased white blood cell count

2 - Elevated white blood cell count

9 - Other specified disorders

STOP

STOP

D72.

HEMATOLOGY 6

© Copyright 2015; Revised 9/24/15

HEPATIC THROMBOSIS

I81: PORTAL VEIN THROMBOSIS

I82.0: BUDD-CHIARI SYNDROME

NONPYOGENIC THROMBOSIS OF INTRACRANIAL VENOUS SYSTEM

I67.6

ACUTE EMBOLISM & THROMBOSIS OF DEEP VEINS OF LOWER EXTREMITY 0 - Unspecified deep veins/ lower extremity 1 - Femoral vein 2 - Iliac vein 3 - Popliteal vein 4 - Tibial vein 9 - Other specified Y - Proximal lower extremity Z - Distal lower extremity

1 - Right 2 - Left 3 - Bilateral 9 - Unspecified

I82.4

POSTTHROMBOTIC SYNDROME 0 - Without complications 1 - With ulcer 2 - With inflammation 3 - With ulcer & inflammation 9 - With other complications

1 - Right lower extremity 2 - Left lower extremity 3 - Bilateral lower extremity 9 - Unspecified lower extremity

I87.0

PULMONARY EMBOLISM W/O ACUTE COR PULMONALE

0 - Septic pulmonary embolism 2 - Saddle embolus of pulmonary artery 9 - Other

I26.9

Other

COAGULATION DEFECTS 0 - Von Willebrand's disease 1- Hereditary factor XI deficiency 2 -Hereditary deficiency of other clotting factors 4 - Acquired coagulation factor deficiency 8 - Other specified coagulation defects 9 - Unspecified

D68.

Hemorrhagic Disorders due to

CIRCULATING ANTI-COAGULANTS 3 - Hemorrhagic

disorder due to circulating anticoagulants

1- Hemorrhagic disorder due to intrinsic circulating anticoagulants, antibodies, or inhibitors

2 - Hemorrhagic disorder due to extrinsic

circulating anticoagulants

1 - Acquired hemophilia 2 - Antiphospholipid

antibody with hem-orrhagic disorder

8 - Other Hemorrhagic disorder due to intrinsic circulat- ing anticoagulants, antibodies, or inhibitors

STOP

D68.

1- Activated protein C resistance 2 - Prothrombin gene mutation 9 - Other primary thrombophilia

5 - Primary thrombophilia

6 - Other thrombophilia

1- Antiphospholipid syndrome 2 - Lupus anticoagulant syndrome 9 - Other thrombophilia

D68. Other Coagulation Defects,

THROMBOPHILIA

D75.82 HEPARIN INDUCED THROMBOCYTOPENIA

HEMATOLOGY 8

© Copyright 2015; Revised 9/24/15

0 - Wiskott-Aldrich syndrome 1 - Di George's syndrome 2 -Immunodeficiency with short-limbed stature 3 -Immunodeficiency following hereditary defective response to Epstein-Barr virus 4 -Hyperimmunoglobulin E [IgE] syndrome 8 - Other specified major defects 9 - Unspecified

D82. Immunodeficiency associated with

OTHER MAJOR DEFECTS

COMMON VARIABLE IMMUNODEFICIENCY

0 - With predominant abnormalities of B-cell numbers and function 1 - With predominant immunoregulatory T-cell disorders 2 -With autoantibodies to B- or T-cells 8 - Other common variable immunodeficiency 9 -Unspecified

D83.

STOP

9 - Other combined immuno- deficiencies

8 - Other combined immuno-

deficiencies

1 - Biotin-dependent carboxylase deficiency

0 - Biotinidase deficiency 8 - Other biotin- dependent carboxylase Deficiency 9 - Unspecified

COMBINED IMMUNODEFICIENCIES

0 - Severe combined immunodeficiency [SCID] with reticular dysgenesis 1 - SCID with low T- and B-cell numbers 2 - SCID with low or normal B-cell numbers 3 - Adenosine deaminase [ADA] deficiency 4 - Nezelof's syndrome 5 - Purine nucleoside phosphorylase [PNP] deficiency 6 - Major histocompatibility complex class I deficiency 7 - Major histocompatibility complex class II deficiency 9 - Unspecified

STOP

D81.

0 - Acute 1 - Chronic 2 -Acute on chronic graft- versus-host disease 3 - Unspecified

2 - Autoimmune lymphoproliferative syndrome [ALPS] 9 - Other specified disorders

Other Disorders Involving the

IMMUNE MECHANISM, NOT ELSEWHERE CLASSIFIED

8 - Other specified disorders involving the immune

mechanism, not elsewhere classified

0 - Polyclonal hypergammaglobulinemia 1 - Cryoglobulinemia 2 - Hypergammaglobulinemia, unspecified 3 - Immune reconstitution syndrome 9 - Unspecified

1 - Graft-versus-host disease

D89.

STOP

STOP

GRAFT-VERSUS-HOST DISEASE

0 - Acute 1 - Chronic 2 - Acute on chronic 3 - Unspecified

D89.81

1 - Right lacrimal gland 2– Left lacrimal gland 3 - Bilateral lacrimal glands 9 - Unspecified lacrimal gland

DRY EYE SYNDROME HO4.12

0 - Localized 1 - Generalized

ENLARGED LYMPH NODES

R59.

9

© Copyright 2015; Revised 9/24/15

DRUG-INDUCED PHENOMENON

D70.1 AGRANULOCYTOSIS SECONDARY TO CANCER CHEMOTHERAPY

OTHER SECONDARY THROMBOCYTOPENIA

D69.59

* Due to drugs, EtOH, alloimmunization; NOT ITP

DRUG (OPIATE) INDUCED CONSTIPATION

K59.09

ANEMIA DUE TO ANTINEOPLASTIC CHEMOTHERAPY

D64.81

DRUG-INDUCED CUSHING'S SYNDROME

E24.2 DRUG-INDUCED ADRENOCORTICAL INSUFFICIENCY

E27.3

STOP 0 - With cholestasis 2 - With acute hepatitis

TOXIC LIVER DISEASE

0 - Without coma 1 -With coma

1 - With hepatic necrosis

This is for toxic effects due to drug; Does Not include ETOH

K71.

0 - Drug-induced 1 - Alcoholic 2 - Due to other toxic agents 9 - Unspecified (as used for AIDS)

Other & Unspecified POLYNEUROPATHIES

1 -Critical illness 2 - Radiation-induced 9 - Other

8 - Other specified

STOP

G62.

ORAL MUCOSITIS, ULCERATIVE

0 -Unspecified 1 - Due to antineoplastic therapy 2 - Due to other drugs 3 - Due to radiation 9 - Other

K12.3

POLYNEUROPATHY IN DISEASES CLASSIFIED ELSEWHERE (Includes myeloma induced neuropathy)

G63

DRUG-INDUCED PHENOMENON

DRUG (OPIATE) INDUCED CONSTIPATION

K59.09

AGRANULOCYTOSIS DUE TO NON-CHEMOTHERAPY DRUG

D70.2