lecture vii. cns patterning bio 3411 wednesday september 22, 2010 1lecture vii. cns patterning
DESCRIPTION
Lecture VII. CNS Patterning3 Selected References: † Benito-Gutierrez, E., & Arendt, D. (2009). CNS evolution: new insight from the mud. Curr Biol, 19(15), R Hamilton, W. J., Boyd, J. D., & Mossman, H. W. (1972). Hamilton, Boyd and Mossman's human embryology; prenatal development of form and function (4th ed.). Cambridge,: Heffer. † Hartenstein, V. (1993). Atlas of Drosophila Development. Kandel, E. R., Schwartz, J. H., & Jessell, T. M. (2000). Principles of neural science (4th ed.). New York: McGraw-Hill, Health Professions Division. Chapter 52, pp † Puelles, L. (2009). Forebrain Development: Prosomere Model. in: New Encyclopedia of Neuroscience. Amsterdam: Elsevier. Ranson, S. W., & Clark, S. L. (1959). The anatomy of the nervous system; its development and function (10 th ed.). Philadelphia,: Saunders. –––––––––––––– † (pdfs on course websites: [http://artsci.wustl.edu/~bio3411/] & [http://www.nslc.wustl.edu/courses/Bio3411/bio3411.html]TRANSCRIPT
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Lecture VII. CNS Patterning
Bio 3411 Wednesday
September 22, 2010
September 22, 2010 1Lecture VII. CNS Patterning
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Reading
THE BRAIN ATLAS: p 10
2Lecture VII. CNS PatterningSeptember 22, 2010
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September 22, 2010 Lecture VII. CNS Patterning 3
Selected References:
† Benito-Gutierrez, E., & Arendt, D. (2009). CNS evolution: new insight from the mud. Curr Biol, 19(15), R640-642.Hamilton, W. J., Boyd, J. D., & Mossman, H. W. (1972). Hamilton, Boyd and Mossman's human embryology; prenatal development of form and function (4th ed.). Cambridge,: Heffer.†Hartenstein, V. (1993). Atlas of Drosophila Development.Kandel, E. R., Schwartz, J. H., & Jessell, T. M. (2000). Principles of neural science (4th ed.). New York: McGraw-Hill, Health Professions Division.Chapter 52, pp 1019-1040.†Puelles, L. (2009). Forebrain Development: Prosomere Model. in: New Encyclopedia of Neuroscience. Amsterdam: Elsevier.Ranson, S. W., & Clark, S. L. (1959). The anatomy of the nervous system; its development and function (10th ed.). Philadelphia,: Saunders.––––––––––––––
†(pdfs on course websites: [http://artsci.wustl.edu/~bio3411/] & [http://www.nslc.wustl.edu/courses/Bio3411/bio3411.html]
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What the last Lecture was about
• General mechanisms for assembling neurons and groups of neurons
• Diffusion vs Contact
• Attraction vs Repulsion
• Examples of impacts of contact
• Examples of impacts of diffusion
• Specification by growth factors
• The chemoaffinity hypothesis
September 22, 2010 Lecture VII. CNS Patterning 4
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What this Lecture is about
September 22, 2010 Lecture VII. CNS Patterning 5
• The Initiation of the Central Nervous System
• CNS Growth and Pattern Development
• Bug Brains
• Several Mechanisms for Directing the Show (scripts conserved)
• How did vertebrate and invertebrate patterns arise?
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September 22, 2010 6Lecture VII. CNS Patterning
Recap of Early Embryogenesis
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September 22, 2010 7Lecture VII. CNS Patterning
Ranson & Clark (1959)
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September 22, 2010 8Lecture VII. CNS Patterning
Kandel, Schwartz, & Jessell (2000)
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September 22, 2010 9Lecture VII. CNS Patterning
Kandel, Schwartz, & Jessell (2000)
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September 22, 2010 10Lecture VII. CNS Patterning
From Tube to Brain
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September 22, 2010 11Lecture VII. CNS Patterning
Kandel, Schwartz, & Jessell (2000)
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September 22, 2010 Lecture VII. CNS Patterning 12
THE BRAIN ATLAS 3rded, p.10
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September 22, 2010 Lecture VII. CNS Patterning 13
Hamilton, Boyd, & Mossman (1972)
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September 22, 2010 Lecture VII. CNS Patterning 14
Hamilton, Boyd, & Mossman (1972)
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September 22, 2010 Lecture VII. CNS Patterning 15
Hamilton, Boyd, & Mossman (1972)
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September 22, 2010 Lecture VII. CNS Patterning 16
Hamilton, Boyd, & Mossman (1972)
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September 22, 2010 Lecture VII. CNS Patterning 17
Hamilton, Boyd, & Mossman (1972)
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September 22, 2010 Lecture VII. CNS Patterning 18
Hamilton, Boyd, & Mossman (1972)
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September 22, 2010 Lecture VII. CNS Patterning 19
From Fly Egg to Fly Brain
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September 22, 2010 20Lecture VII. CNS Patterning
Hartenstein (1993)
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September 22, 2010 21Lecture VII. CNS Patterning
Hartenstein (1993)
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September 22, 2010 22Lecture VII. CNS Patterning
Hartenstein (1993)
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September 22, 2010 23Lecture VII. CNS Patterning
Hartenstein (1993)
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September 22, 2010 Lecture VII. CNS Patterning 24
Segmentation and Signals
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September 22, 2010 25Lecture VII. CNS Patterning
Kandel, Schwartz, & Jessell (2000)
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September 22, 2010 26Lecture VII. CNS Patterning
Kandel, Schwartz, & Jessell (2000)
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September 22, 2010 27Lecture VII. CNS Patterning
Kandel, Schwartz, & Jessell (2000)
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September 22, 2010 28Lecture VII. CNS Patterning
Kandel, Schwartz, & Jessell (2000)
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29September 22, 2010 Lecture VII. CNS Patterning
Kandel, Schwartz, & Jessell (2000)
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September 22, 2010 Lecture VII. CNS Patterning 30
Kandel, Schwartz, & Jessell (2000)
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September 22, 2010 31Lecture VII. CNS Patterning
Ancient Choice?
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September 22, 2010 Lecture VII. CNS Patterning 32
Benito-Gutierrez & Arendt, (2009)
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September 22, 2010 33Lecture VII. CNS Patterning
Benito-Gutierrez & Arendt, (2009)
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What this Lecture was about
September 22, 2010 Lecture VII. CNS Patterning 34
• The Initiation of the Central Nervous System
• CNS Growth and Pattern Development
• Bug Brains
• Several Mechanisms for Directing the Show (scripts conserved)
• How did vertebrate and invertebrate patterns arise?
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Reflections
• Early events initiating the nervous system
• Beginning the sculpture – proliferation and death mechanisms
• Signals for functional and connectional specificity – contact, distance, for or against
• The pattern and organization emerges
• Generalizations made but questions unanswered
September 22, 2010 Lecture VII. CNS Patterning 35
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Sequential Restrictions (Refinements) are the Bases for Development (and plasticity)
September 22, 2010 36Lecture VII. CNS Patterning
pluripotent, stem cell
differentiated
genetic
environmental
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September 22, 2010 Lecture VII. CNS Patterning 37
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September 22, 2010 Lecture VII. CNS Patterning 38
http://embryo.soad.umich.edu/
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September 22, 2010 Lecture VII. CNS Patterning 39
Finis