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CHM102A – General ChemistryCHM102A General Chemistry
Part 1: Inorganic and Organic ChemistryPart 1: Inorganic and Organic ChemistryRamesh Ramapanicker
Part 2: Physical ChemistryMadhav Ranganathan
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Inorganic/Organic – Section A
Lectures: MW 9:00-9:50 (L7); Tutorial: F 9:00-9:50 (L3, L4, L5 and L6)
Lectures: December 30January 1, 6, 8, 13, 15, 20, 22, 27, 29February 3, 5, 10, 12 Total 14
Tutorials: January 3, 10, 17, 24, 31February 7, 14 Total 7
Quiz will be conducted during the tutorial hour on 24th January.
Section TutorsA1 (L3)
A2 (L4)
Dr. M L N Rao and Dr. R Angamuthu
Dr M K Ghorai and Dr A K PatraA2 (L4)
A3 (L5)
A4 (L6)
Dr. M K Ghorai and Dr. A K Patra
Dr. R Gurunath and Dr. G Anantharaman
Dr. S Verma and Dr. J K Bera
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Inorganic/Organic – Section B
Lectures: MW 14:00-14:50 (L7); Tutorial: T 14:00-14:50 (L3, L4, L5 and L6)
Lectures: December – 30January 1, 6, 8, 13, 15, 20, 22, 27, 29February 3, 5, 10, 12 Total 14
Tutorials: December 31January 7, 21, 28February 4, 11 Total 6
Quiz will be conducted during the tutorial hour on 28th January.
Section TutorsB1 (L3) Dr. V K Yadav and Dr. B Sundararaju
B2 (L4)
B3 (L5)
Dr. J N Moorthy and Dr. S K Kundu
Dr. D H Dethe and Mr. Subrata Kundu
B4 (L6) Dr. S P Rath and Dr. A Singh
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Contents
Inorganic ChemistryCrystal Field Theory and Structure of Coordination ComplexesOxidative Addition, Reductive Elimination, Insertion ReactionsHydrogenation Hydroformylation Monsanto Acetic acid ProcessHydrogenation, Hydroformylation, Monsanto Acetic acid Processand Ziegler-Natta PolymerizationMetallaenzymes
Organic ChemistryConformational Analysis of Alkanes and CycloalkanesChiralitySubstitution and Elimination ReactionsSubstitution and Elimination ReactionsProteins, Nucleic Acids and Lipids
Booksi h i b h i d kiInorganic Chemistry by Shriver and Atkins
Inorganic Chemistry: Principles of Structure and Reactivity byJ E Huheey, E A Keiter and R L Keiter
Organic Chemistry by J Clayden, N Greeves, S WarrenFundamentals of Organic Chemistry by T W G Solomons
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Periodic table
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Tooth Paste
abrasives (calcium phosphates, alumina, calcium carbonate, silica) fluoride (sodium monofluorophosphate, stannous fluoride, sodium fluoride)antibacterial agents ‐ Triclosandesensitizing agents ‐ strontium chloride detergents sodium lauryl sulfatedetergents ‐ sodium lauryl sulfate sweetener ‐ xylitolhumectants ‐ sorbitol, glycerolanti‐tartar agents sodium bicarbonate (baking soda) enzymes thickener coloring agents Triclosancoloring agents Triclosanpreservatives
http://www.gwinnett.k12.ga.us/LilburnES/PromoteGA/beauty/toothpaste_intro.html
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Tea and Coffee
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Aroma Compounds in Coffee
Over 800 compounds are responsible for the aroma of coffee
http://www.coffeeresearch.org/science/aromamain.htm
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Sweet Compounds
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Artificial Sweeteners
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Spicy Hot Compounds
Capsaicin
16,000,000
Pepper spray 2 000 000
Capsaicin
Scoville scale
Pepper spray 2,000,000
3,500Tabasco sauce
Resiniferatoxin 16,000,000,000, , ,
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Bitter Compounds
Antipyretic, analgesic and antimalarial The most bitter compound known to date
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Cooling Compounds
Mint Leaves
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Compounds that Smell
cis-jasmone beta-Damascenone
tert-butylthiol 4-methyl-4-sulfanylpentan-2-one
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Synthetic Dyes
Fluorescein(ocular, muscular angiogram)
Chicago River: fluorescein is used to dye the rivergreen on St. Patrick’s Day
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Indigo the color of blue jeans
The Indigo Revolt of 1858 1861 in BengalIndigo
B 1865The Indigo Revolt of 1858 –1861 in Bengal Baeyer 1865
1897: 19,000 tons of indigo were produced from plant sources.1914: Production by natural sources dropped to 1000 tons1914: Production by natural sources dropped to 1000 tons2002: 17,000 tons of synthetic indigo were produced worldwide.
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Adhesives
C lCyanoacrylateEastman 910
Eastman Kodak lab in New York by H W l C JHarry Wesley Coover, Jr.
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Precious Stones - Gems
Alumina (Al O )Alumina (Al2O3)
Blue SapphireFe and Ti as Impurities
RubyRuby<1% of Cr(III)
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Organic Drugs
Ranitidinepeptic ulcer
Amoxycillinantibioticpeptic ulcer antibiotic
HN
O
Metformintype 2 diabetes
Diazepamsedative
HOO
Paracetamolanalgesictype d abetes sedativeanalgesic
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Chiral Drugs
(S)-NaproxenAnti-inflammatory (S)-Fluoxetine
A ti d ty
Anti-depressent
CaptoprilAnti-hypertensive
TIMOLOLAnti-hypertensive
ChloramphenicolAntibiotic
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Importance of Chirality
(S)-CarvoneC S d
(R)-CarvoneS i tCaraway Seeds Spearmint
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Inorganic Drugs
OH3N
O
O
Pt
H3N
O
Carboplatin (Ovarian Cancer)
A ranofin Pepto-BismolAuranofin Antirheumatic agent
Pepto Bismol
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Imaging
Fluorodeoxyglucose P it E i i T hPositron Emission Tomography
Gadodiamide MRI Contrast Agent
Technetium (99mTc) sestamibiSingle photon emission computed tomography
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Polymers and Conjugated Compounds
β‐carotene
Polyvinyl Chloride (PVC)
PolystyrenePolystyrene
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1,2,3,4,5,6- Hexachlorocyclohexane (HCH)
Substituted cyclohexanes
Insecticide, lice removal
Voluntary recall of Lindane owing to y genvironmental pollution
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DDT
ClClCl
Paul Hermann Müller: Nobel Prize in
ClCl
Physiology or Medicine in 1948 “for hisdiscovery of the high efficiency of DDT as acontact poison against several arthropods.”
ClCl
dichlorodiphenyltrichloroethane
DDT is banned in the US from 1972.DDT is banned in the US from 1972.
India is the only country stillmanufacturing DDT, with Chinahaving ceased production in 2007.
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The Bad Ones
CocaineCocaineAn addictive alkaloid 2,3,7,8-tetrachlorodibenzo-p-dioxin
Viktor YushchenkoBefore and after having ChloranceStrychnine
Toxic Alkaloid