le prosta tik

7/25/2019 Le Prosta Tik

1/15

LEPROSTATIKLEPROSTATIK

dr. Yora Ninditadr. Yora Nindita20092009


2/15

SULFONSULFON

Derivat 4.4 diamino difeni !"fonDerivat 4.4 diamino difeni !"fon

DDS# Da$!on# S"fo%!onDDS# Da$!on# S"fo%!on &a%terio!tati%&a%terio!tati%

Kom$etitif in'i(itor PA&AKom$etitif in'i(itor PA&A


3/15

SULFONSULFON

FarmakokinetikFarmakokinetik

) A(!or$!i *A(!or$!i * Lam(at di tr. +ILam(at di tr. +I

&an,a% ter("an- eat fe!e!&an,a% ter("an- eat fe!e! Kadar $"n/a% 1 3am# 01Kadar $"n/a% 1 3am# 0155-6m-6m


4/15

SULFONSULFON


) Di!tri("!i *Di!tri("!i * !e"r"' 3arin-an 7 /airan t"("'!e"r"' 3arin-an 7 /airan t"("'

0180 teri%at $ada $rotein $a!ma0180 teri%at $ada $rotein $a!ma


5/15

SULFONSULFON


) :eta(oi!me *:eta(oi!me * daam 'e$ardaam 'e$ar

%e/e$atan a!etia!i ditent"%an oe'%e/e$atan a!etia!i ditent"%an oe'fa%tor -eneti%fa%tor -eneti%


6/15

SULFONSULFON


) E%!%re!i *E%!%re!i * 801;0 eat "rine daam (ent"%801;0 eat "rine daam (ent"%

meta(oitn,ameta(oitn,a


7/15

SULFONSULFON

Efek SampingEfek Samping

)


8/15

SULFONSULFON

Efek SampingEfek Samping

) Sindroma S"fonSindroma S"fon 1= m--1= m-- fe(ri!# maai!e# dermatiti!fe(ri!# maai!e# dermatiti!

e%!foiatif# i%ter"!# ne%ro!i! 'e$ar#e%!foiatif# i%ter"!# ne%ro!i! 'e$ar#imfadeno$ati# met'emo-o(inemia#imfadeno$ati# met'emo-o(inemia#

anemiaanemia


9/15


10/15

SULFONSULFONTerapi DAPSONTerapi DAPSON

) 2 m-6m-- !eama 2 m--2 m-6m-- !eama 2 m--

) Tia$ 2 m-- dinai%%an @ !m$Tia$ 2 m-- dinai%%an @ !m$@6m--@6m--

) 0 m-# @6m-- (nB0 m-# @6m-- (nB) 0 m-# 4@6m-- (nB0 m-# 4@6m-- (nB

) 0 m-# @6m-- (nB0 m-# @6m-- (nB


11/15

SULFONSULFON

Terapi DAPSONTerapi DAPSON) 00 m-# @6m-- (nB00 m-# @6m-- (nB) 00 m-# 4@6m-- ta% ter(ata!B00 m-# 4@6m-- ta% ter(ata!B


12/15

RIFAMPISINRIFAMPISIN

Kom(ina!i den-an Da$!onKom(ina!i den-an Da$!on Do!i! =00 m-6'ariDo!i! =00 m-6'ari


13/15

LOFA!IMINLOFA!IMIN

Kom(ina!i den-an Rifam$i!inKom(ina!i den-an Rifam$i!in(ia re!i!ten den-an Da$!on(ia re!i!ten den-an Da$!on

Efe% anti radan-Efe% anti radan-

&a%teri!id !etea' 0 'ari&a%teri!id !etea' 0 'aritera$itera$i

00 m-6'r /a$!"B00 m-6'r /a$!"B


14/15

AMITIO!ONAMITIO!ON

T"r"nan tio!emi%ar(aConT"r"nan tio!emi%ar(aCon

Le$ra 3eni! t"(er/"oidLe$ra 3eni! t"(er/"oid Re!i!ten!iRe!i!ten!i

) t'n %e 2 $er(ai%an meam(at#t'n %e 2 $er(ai%an meam(at#) t'n %e $en,a%it %am("'t'n %e $en,a%it %am("'

&ia Da$!on td% d$t diterima&ia Da$!on td% d$t diterima


15/15

AMITIO!ONAMITIO!ON

Efe% !am$in- * anore%!ia#Efe% !am$in- * anore%!ia#na"!ea# vomit"!# anemiana"!ea# vomit"!# anemia'emoiti%# e"%o$enia#'emoiti%# e"%o$enia#a-rano"!ito!i!a-rano"!ito!i!

Do!i! * 0 m-6'r 12 m--# d$tDo!i! * 0 m-6'r 12 m--# d$tdinai%%an !m$ 200 m-dinai%%an !m$ 200 m-

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