LDC-CEVACevac IBird

April 2015

1. Presentation of LDC group

2. French Infectious Bronchitis epidemiology

3. Actions

4. Monitoring implementation

5. Results

CONTENT

A Group present in every poultry region in France

Brittany10 sites

1 700 employees500 farmers

Pays de Loire / Centre / Normandy35 sites

9 600 employees3 500 farmers

Aquitaine2 sites

250 employees100 fermers

South-East13 sites

2600 employees1000 farmers

Paris2 sites

250 employees

LDC - Overview

From its creation in 1970, LDC is today…

62 production sites in France and 5 platforms

5 100 commited farmers

More than 16 000 employes, 90% in France

Activities : 85% in poultry, 15% in convenience

3 billions € in turnover from which 15% in subsidiaries

abroad (Poland and Spain)

100 Millions Euros of investments in 2013 from which

95 % in France

Production sites in poultry production areas : Brittany, Loire Valley, Normandy, Burgundy, Aquitaine,…

Production sites in poultry production areas : Brittany, Loire Valley, Normandy, Burgundy, Aquitaine,…

LDC - The Group Organization

Poultry DivisionPoultry DivisionSlaughterhouses

France Upstream France

Convenience Division

Convenience Division

International DivisionInternational Division

POLAND SPAIN

International (group Export)

Direction : Gilles HUTTEPAIN

Upstream

DivisionLDC - Group Organization

EggsEggs

PoultryPoultry

Grain CollectGrain Collect

PoultryPoultry

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LDC – Group organization – The ProductsUpstream Division

Turnover 610 M€Turnover 610 M€Number of farmers 1 440

Surface 1 970 000 m²

Number of farmers 1 440

Surface 1 970 000 m²

Production of poultryIn front of the Group needs

70 % Chicken

15 % Label rouge chicken

60 % Turkey

50 % Duck

40 % Guinea fowl

Production of poultryIn front of the Group needs

70 % Chicken

15 % Label rouge chicken

60 % Turkey

50 % Duck

40 % Guinea fowl

Tons Feed /year

Poultry 780 000 T

From which processed

700 000 T

Tons Feed /year

Poultry 780 000 T

From which processed

700 000 T

Collect Cereals/year

178 000 T

Collect Cereals/year

178 000 T

Eggs/boxes/year

325 millions eggs Label Rouge, Free range, & Organic

150 millions eggs Standards

475 millions eggs

From which 50% under brands Loué & Le Gaulois

Eggs/boxes/year

325 millions eggs Label Rouge, Free range, & Organic

150 millions eggs Standards

475 millions eggs

From which 50% under brands Loué & Le Gaulois

Direction : Denis LAMBERT

LDC Sablé+ CEPA

Cavol

LDC - The Group Organization Poultry

Division

Turnover : 2,1 Bn €

Volume : 460 000 T

Turnover : 2,1 Bn €

Volume : 460 000 T

Mix customers Retail / HD 67 %

Prof & Indust 25 %

EXPORT 8 %

Mix customers Retail / HD 67 %

Prof & Indust 25 %

EXPORT 8 %

Mix Product Poultry /week

2 500 000 Standard chickens 150 000 Guinea fowls

1 000 000 Label chickens + Org 104 000 Rabbits

340 000 Certified chickens 300 000 Quails

390 000 Turkeys 40 000 Squabs

315 000 Ducks

Mix Product Poultry /week

2 500 000 Standard chickens 150 000 Guinea fowls

1 000 000 Label chickens + Org 104 000 Rabbits

340 000 Certified chickens 300 000 Quails

390 000 Turkeys 40 000 Squabs

315 000 Ducks

Further-processed products

1 500 T per week

Further-processed products

1 500 T per week

LDC - The group Organization – The Products

Poultry division France

Poultry

Red Label Poultry

Cut ups

Further processed

Convenience

LDC - Our Strategy : Innovations and Brands for a strong organic growth

Poultry and convenience : synergy and complementarity in offers

French Infectious bronchitis epidemiology

% of broiler production per department

830 million broilers43 million layers45 millions turkeys120 million ducks….Multi species production

Infectious bronchitis viruses are circulating.

Need for a good viral protection

French Infectious bronchitis epidemiology

IB Mass Strain

(Hatchery)

IB Variant Strain

(Field vaccination)793B/QX

GUMBORO

D0 D10-D14 D16-D20

Vaccination with Mass vaccine is done on 100 % of the birds, at the hatcheries.

Vaccination with Mass vaccine is done on 100 % of the birds, at the hatcheries.

Field boosting with either 793 B or QX are applied according to veterinarian, integration or farmer decision related to IB perceived pressure or type of broilers produced (big birds).

Field boosting with either 793 B or QX are applied according to veterinarian, integration or farmer decision related to IB perceived pressure or type of broilers produced (big birds).

=> Vaccination at the hatchery is not perceived as critical by the independant hatcheries

=> Field vaccination is usually applied by spray with no regular monitoring.

Need for LDC

-to get better control of vaccine & protection on the production.

-to get better evaluation of epidemiological situation in real time

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French Infectious bronchitis epidemiology

Actions : a new vaccination program

IB Mass Strain

+ IB Variant strain (Cevac IBird).

Hatchery

GUMBORO

D0 D16-D20

Big birds Certified birds

Big birds Certified birds

HATCHERY IB Vaccination.

Monitoring Implementation

HATCHERY IB Vaccination.

Monitoring Implementation

Actions

3 different slaughterhouses

Vaccination Mass & Cevac IBird spray day 1

230 different poultry housesIn 2 regions from nov 14.

Control of spray equipment & CHICK Program implementation7 different hatcheries

Monitoring of day 10 PVR & respiratory signs during growing period3 different organisations

Monitoring implementation

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Sampling & Sampling & Analysis for Analysis for

epidemiologicepidemiological monitoringal monitoring

10 Blood samples per flock : Biocheck ElisaCecal tonsils: frozen and PCR analysis according to Elisa & farm results

3 different slaughterhouses

Vaccination Mass & Cevac IBird spray day 1

230 different poultry housesIn 2 regions from nov 14.

Control of spray equipment & CHICK Program implementation7 different hatcheries

Monitoring of day 10 PVR & respiratory signs during growing period5 different organisations

Desvac In-Line sprayer

Desvac In-Line sprayer

Hatchery spray evaluation

Results :

Safety 1 out of 230 flocks with

mortality before 10 days, after veterinarian visit it was due to E coli infection

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Results : IB ELISA MEAN TITERS

Results : IBV mappingOctober-December 2014, 28% of the farms are challenged by a field virus (T> 3000)

No vaccination< 500 1000< « normal »< 3000

Doubtfull > 3000, high CVField infection > 3000, low CV

Results : IBV mapping

December 14 – February 15 , 38% of the farms are challenged by a field virus (T> 3000)

December 14 – February 15 , 38% of the farms are challenged by a field virus (T> 3000)

No vaccination< 500 1000< « normal »< 3000

Doubtfull > 3000, high CVField infection > 3000, low CV

Results :

Some respiratory signs after 10 days in 9 out of 230 flocks :

• 1 IB titers OK• 1 positive for ORT• 1 positive for MS• 2 IB PCR >0 no identification possible• 4 IB PCR >0 for IBird, no conclusion other cause ?

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Conclusion

Hatchery vaccination with Mass & Cevac IBird gave consistent seroconversion at slaughter

It can be used as hatchery vaccination monitoringHatchery spray application was improved with equipement setting

& control

Field virus circulation was detected between 28 % and 38% of the farms according to the period.

Reinforced the need of a complete and well applied vaccination program in our production area.

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