laporan indapamide fix.docx

8/16/2019 laporan indapamide fix.docx

1/15

LAPORAN PRAKTIKUM

KIMIA FARMASI II

HUBUNGAN STRUKTUR AKTIVITAS (SAR) DARI DERIVATOBAT INDAPAMIDE

Nama kelompok :

1. Le!a"# H$!ao#! (P%.&'.&.1.1.&1*)

%. +#ka,a!# Ra-maa/# (P%.&&'.&.1.1.&*)

PROGRAM STUDI D III FARMASI

JURUSAN FARMASI

POLITEKKES KEMENKES TASIKMALAYA

2016


2/15

No P"ak!#k$m : &1

0$$l P"ak!#k$m : T$"$/a/ a"#

Ha"#!a/22al P"ak!#k$m : kam#3 1* Ma"e! %&1'

I. Tujuan

1. U/!$k me/2e!a-$# -$4$/2a/ k$a/!#!a!#5 !"$k!$" a/ ak!#6#!a 4#olo2# o4a!

(HKSA)

%. U/!$k me/2e!a-$# e"#6a!7e"#6a! a"# I/apam#e

. U/!$k me/2e!a-a$# pa"ama!e"7pa"ame!e" #5a! 5##ka a/ k#m#a alam HKSA

II. Dasar Ter!

"u#un$an S%ru&%ur A&%!'!%as ("SA) *an "u#un$an Kuan%!%a%!+ S%ru&%ur A&%!'!%as("KSA)

I/!# a"# $a!$ pe/el#!#a/ e/,a8a o4a! me/$"$! S9-$/a9k e! al.3 (1&) aala-

pe/2em4a/2a/ ;a! ak!#5 4a"$ $/!$k me/,em4$-ka/ pe/,ak#! ,a/2 e/2a/ !e"ap# o4a! ampa#

aa! #/# !#ak a!a$ 4el$m 4e"


3/15

H$4$/2a/ k$a/!#!a!#5 a/!a"a ak!#6#!a 4#olo2# a/ pa"ame!e" ,a/2 me/22am4a"ka/

pe"$4a-a/ #5a! k#m#a 5##ka3 ,a#!$ -arae%er /!*r+#!& 3 ee&%rn!& a/ s%er!& 3 paa $a!$

e"# molek$l3 m$la# #kem4a/2ka/ e9a"a le4#- #/!e/#5. H$4$/2a/ a!a$ ko"ela# ,a/2 4a#k

#2$/aka/ $/!$k me/$/ER) $/!$k moel pe"amaa/ $m$m

HKSA alam ko/!ek 4#olo2# (Topl#3 1?). Le4#-


4/15

Me!oe >"ee7+#lo/ #2$/aka/ #el A/al,# (@oM>A). @oM>A #kem4a/2ka/ e4a2a# pe/eka!a/ la#/ ,a/2

mema$kka/ 4e/!$k ek"#p!o" alam HKSA. Me!oe #/# 4e"$a-a me/,$$/ $a!$

-$4$/2a/ a/!a"a ak!#6#!a 4#olo2# a/ #5a! !e"#k a/ a!a$ elek!"o!a!#k a"# $a!$ e"#

e/,a8a.

Me!oe @oM>A 4e"aa"ka/ paa 9o/2e/e"#9 $a!$ e"# molek$l. Molek$l7molek$l

!e"e4$! !e"-ampa" e-#/22a !"$k!$"/,a !$mpa/2 !#/#- a/ 4e"aa paa ko/5o"ma# e/2a/

ak!#6#!a op!#m$m. Mea/ molek$la" ma#/27ma#/2 molek$l kem$#a/ #-#!$/2 e/2a/

me/empa!ka/ molek$l ,a/2 !$mpa/2 !#/#- alam 4e/!$k !#2a #me/#.

2.1.2 Parae%er S!+a% K!!a *an F!s!&a Daa "KSA

a. Parae%er /!*r+#!&

Koe5##e/ pa"!## ok!a/ola#" ,a/2 #/,a!aka/ alam lo2 P me"$paka/ !a/a"

k$a/!#!a $/!$k me/e/!$ka/ #5a! -#"o5o4#k-#"o5#l#k $a!$ molek$l. Pa"ame!e"

-#"o5o4#k-#"o5#l#k aala- #5a! ,a/2 a/2a! pe/!#/2 alam apl#ka# 4#ome#. Se4a2a#

9o/!o- apl#ka#/,a aala- $/!$k mempe"k#"aka/ #!"#4$# o4a! alam !$4$-. O4a!7o4a! ,a/2

4e"#5a! -#"o5o4#k e/2a/ koe5##e/ pa"!## !#/22# aka/ !e"#!"#4$# paa kompa"!eme/ ,a/2

4e"#5a! -#"o5o4#k p$la3 m#al/,a lap#a/ lemak3 ea/2ka/ o4a!7o4a! ,a/2 4e"#5a! -#"o5#l#k

e/2a/ koe5##e/ pa"!## "e/a- aka/ !e"#!"#4$# paa kompa"!eme/ -#"o5#l#k3 m#al/,a


5/15

e"$m a"a-. N#la# lo2 P alam ok!a/ola#" me"$paka/ "a#o lo2a"#!ma ko/e/!"a# ;a! !e"la"$!

alam ok!a/ol e/2a/ ko/e/!"a# ;a! !e"la"$! alam a#".

#. Parae%er ee&%rn!&

Pe/22$/aa/ !"$k!$" elek!"o/#k e4a2a# p"e#k!o" alam !$# HKSA 9e/e"$/2

#$ka# ka"e/a apa! #!e/!$ka/ e9a"a !eo"#!#k a/ -a#l ,a/2 #pe"ole- 9$k$p mem$aka/.Dalam -al #/#3 me!oe k#m#a k$a!$m apa! #2$/aka/ $/!$k mem#/#malka/ e/e"2# po!e/#al

alam !"$k!$" molek$l e"!a mempe"k#"aka/ m$a!a/ a!om3 e/e"2# molek$la" o"4#!al3 a/

ek"#p!o" elek!"o/#k la#//,a ,a/2 apa! me/$/


6/15

S$a!$ 2"a5#k G = G(V,E), ole- I6a/9#$9 a/ Bala4a/ (1?) #


7/15

#/"om /e5"#!#3 a/ !okem#a 2a2al 2#/$/2# $!ama a"# D#$"e!#k aala- $/!$k memo4#l#a# 9a#"a/ $em3 ,a/2 4e"a"!#

me/2$4a- kee#m4a/2a/ 9a#"a/ eem#k#a/ "$pa e-#/22a 6ol$me 9a#"a/ ek!"a el kem4al#

me/. U/!$k me/9apa# -al #/#3 o$!p$! Na@l -a"$ #/p$!/,a.

7 D#$"e!#k !e"$!ama me/9e2a- ma$k/,a Na ke alam el !$4$l$

7 Sem$a #$"e!#k ke9$al# p#"o/olak!o/ 4eke"


8/15

II.1.5 Gn$an T!a!*

D#$"e!#9 !$"$/a/ T#a;# aala- al$"e!#k3 ,a/2 apa! me/eka/ a4o"4# kem4al# #o/7#o/

Na3 @l7 a/ a#". T$"$/a/ #/#


9/15

. Ge


10/15

H#/a"# paa pa#e/ ,a/2 mem#l#k# ke!#ake#m4a/2a/ 9a#"a/ elek!"ol#! a!a$

paa me"eka ,a/2 4e"##ko me/2alam# ke!#ake#m4a/2a/ 9a#"a/ elek!"ol#!

(m#al/,a o"a/2!$a)3 pa#e/ e/2a/ cirrhosis -a!# le4#- m$/2k#/ me/2em4a/2ka/

-#pokalem#a a/ pa#e/ e/2a/ 2a2al o"m$la : @1'H1'@lNOS

• A6e"a2e ma : '.? Da

• Mo/o#o!op#9 ma : '.&'&&? Da

• @-emSp#e" ID : *

S!nn!

1,(5,/r,4,su+a8#ena!*),2,e%/8!n*!ne

259,012,: E-NE.S/

2690:,67,9 RN/

5,;/r,N,(2,e%/8,2


11/15

5,;/r,N,(2,e%/8,2


12/15

O

H2N

O

S

O

O

NH2

Cl

Cl

7DI@HLORO77SUL>AMOL BENTOL BENTAMIDE

Bo#l#/2 Po#/!: 1&3 WKX

Lo2 P: %3&1

MR: ??3'' W9mmolX

He/",Y La8: 113

!PSA: 1%&.%

@Lo2P: 1.%&*1

@MR: ?.*1

O

HN

O

S

O

O

H2N

Cl

)7@HLORO7(7SUL>AMOLBENTOL BENTAMIDE

Bo#l#/2 Po#/!: 1113*1 WKXLo2 P: %3&

MR: ?13*' W9mmolXHe/",Y La8: 1131

!PSA: 1&'.@Lo2P: %.?*&1

@MR: ?.&&1


13/15

Ta4el 1. A/al## Pe"4a/#/2a/ I/apam#e e/2a/ De"#6a!/,a

No Pa"ame!e" I/$k T$"$/a/ T$"$/a/

1. Bo#l#/2 Po#/! 1&'3WKX 1&3WKX 1113*1WKX%. Lo2 P 13 %.&1 %3&

. MR ??3''W9mmolX ?13*'W9mmol

X

. He/",Z La8 3 113 1131

. Tpa %. 1%&.% 1&'3

'. @ Lo2 P %.*&1 1.%&*1 %.?*&1

*. @MR .? ?.*1 ?.&&1

V. Pe#a/asan

Be"aa"ka/ a/al## komp$!a# ,a/2 # lak$ka/3 A/al## H$4$/2a/ K$a/!#!a!#5 S!"$k!$"7

Ak!#6#!a (HKSA) me"$paka/ ala- a!$ apl#ka# a"# k#m#a komp$!a# a/


14/15

Se4a2a# pa"ame!e" pem4a/#/2/,a epe"!# Lo2 P3 MR3 He/",Z La83 Tpa3 @ Lo2 P3

@MR ,a/2 # -a#lka/ a"# a!a komp$!a# !e"e4$!. Hal #/# apa! # ke!a-$# a"# !a4le 1

epe"!# Lo2 P3 4o#l#/2 po#/!3 MR3 He/",Z La8 a/ Tpa. Lo2 P aala- #/e

l#po5#l##!a-#"o5o4##!a3 a/ #/,a!aka/ e4a2a# lo2 P (Wkela"$!a/ alam ok!a/olX

Wkela"$!a/ alam a#" m$"/#X). Se-#/22a emak#/ !#/22# /#la# lo2P3 l#po5#l##!a emak#/ !#/22#.O4a!7o4a! ,a/2 4e"#5a! -#"o5o4#k e/2a/ koe5##e/ pa"!## !#/22# aka/ !e"#!"#4$# paa

kompa"!eme/ ,a/2 4e"#5a! -#"o5o4#k p$la3 m#al/,a lap#a/ lemak. Ka"e/a el$"$- !$4$-

ma/$#a !e"#"# a"# mem4"a/ ,a/2 4e"#5a! l#po5#l3 e-#/22a o4a! le4#- la"$! alam ko/##

l#po5#l.

Bo#l#/2 po#/! (!#!#k ##-) aala- keaaa/ #ma/a 9a#"a/ aka/ me/##- ke!#ka

!eka/a/ $ap 9a#"a//,a ama e/2a/ !eka/a/ #a!a pe"m$kaa/ 9a#"a/ !e"e4$!. Ka"e/a

!eka/a/ $ap 9a#"a/ 4e"$4a- me/$"$! pe"$4a-a/ !empe"a!$"/,a3 maka 9a#"a/ memp$/,a#

4a/,ak !#!#k ##- ,a/2 4e"4ea3 ,a#!$ !e"2a/!$/2 paa !eka/a/ #a!a pe"m$kaa//,a. Hal #/#

T#!#k ##- apa! #2$/aka/ $/!$k mempe"k#"aka/ e9a"a !ak la/2$/2 4e"apa k$a!/,a 2a,a!a"#k a/!a"a molek$l 9a#"a/. Se/,a8a ,a/2 2a,a !a"#k a/!a" molek$l/,a k$a!3 !#!#k ##-/,a

!#/22# a/ e4al#k/,a 4#la 2a,a !a"#k/,a lema- maka !#!#k ##-/,a "e/a-.

T#!#k ##- apa! #2$/aka/ $/!$k mempe"k#"aka/ e9a"a !ak la/2$/2 4e"apa k$a!/,a 2a,a

!a"#k a/!a"a molek$l 9a#"a/. Se/,a8a ,a/2 2a,a !a"#k a/!a" molek$l/,a k$a!3 !#!#k ##-/,a

!#/22# a/ e4al#k/,a 4#la 2a,a !a"#k/,a lema- maka !#!#k ##-/,a "e/a-. Aa/,a #ka!a/

-#"o2e/ a/!a"molek$l me/,e4a4ka/ !#!#k e/,a8a "ela!#5 le4#- !#/22# #4a/#/2ka/ e/2a/

e/,a8a la#/ ,a/2 mem#lk# 4e"a! molek$l e4a/#/2. D# !$/


15/15

e/2a/ e5ek a/!#-#pe"!e/# ,a/2 k$a!3 ,a/2 # 2$/aka/ $/!$k pe/2o4a!a/

-#pe"!e/# ee/#al ,a/2 "#/2a/ a/ moe"a!.

D#"e!#ka !$"$/a/ !#a;#a me/2a/$/2 $u$us su+a! e-#/22a meka/#me

ke"

laporan indapamide fix.docx

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