lampiran a data skrining farmakologi data skrining

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LAMPIRAN A DATA SKRINING FARMAKOLOGI Data Skrining Farmakologi Kelompok Kontrol Mencit Betina No Uji Skrining Hewan 1 Hewan 2 Hewan 3 0 30 60 120 240 0 30 60 120 240 0 30 60 120 240 1 Platform 48 36 19 12 48 15 5 7 7 7 11 5 18 2 7 2 Akt. Motorik 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3 Straub 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 Piloereksi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 Ptosis 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 R. Pineal 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 7 R. Kornea 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 8 R. Fleksi 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 9 Haffner 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 Lakrimasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 11 Salivasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 12 Katalepsi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 13 Sikap Tubuh 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 14 Menggelantung 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 15 Retablisemen 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 16 Kolik Ach 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 17 Mortalitas 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 18 Grooming 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 19 Urinasi 0 0 0 1 0 0 0 0 1 0 0 0 1 0 1 20 Defekasi 0 0 0 1 0 0 0 0 1 0 0 0 0 0 0 58

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  • LAMPIRAN A

    DATA SKRINING FARMAKOLOGI

    Data Skrining Farmakologi Kelompok Kontrol Mencit Betina

    No Uji Skrining Hewan 1 Hewan 2 Hewan 3

    0 30 60 120 240 0 30 60 120 240 0 30 60 120 240

    1 Platform 48 36 19 12 48 15 5 7 7 7 11 5 18 2 7

    2 Akt. Motorik 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    3 Straub 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    4 Piloereksi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    5 Ptosis 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    6 R. Pineal 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    7 R. Kornea 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    8 R. Fleksi 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    9 Haffner 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    10 Lakrimasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    11 Salivasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    12 Katalepsi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    13 Sikap Tubuh 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    14 Menggelantung 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    15 Retablisemen 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    16 Kolik Ach 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    17 Mortalitas 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    18 Grooming 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    19 Urinasi 0 0 0 1 0 0 0 0 1 0 0 0 1 0 1

    20 Defekasi 0 0 0 1 0 0 0 0 1 0 0 0 0 0 0

    58

    55

  • Data Skrining Farmakologi Kelompok Kontrol Mencit Jantan

    No Uji Skrining Hewan 1 Hewan 2 Hewan 3

    0 30 60 120 240 0 30 60 120 240 0 30 60 120 240

    1 Platform 7 18 19 13 20 0 6 14 28 16 1 6 0 4 6

    2 Akt. Motorik 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    3 Straub 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    4 Piloereksi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    5 Ptosis 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    6 R. Pineal 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    7 R. Kornea 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    8 R. Fleksi 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    9 Haffner 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    10 Lakrimasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    11 Salivasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    12 Katalepsi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    13 Sikap Tubuh 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    14 Menggelantung 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    15 Retablisemen 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    16 Kolik Ach 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    17 Mortalitas 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    18 Grooming 0 0 0 0 0 1 0 0 0 0 1 0 1 1 1

    19 Urinasi 0 0 0 1 1 1 0 0 1 0 0 1 0 0 0

    20 Defekasi 0 2 1 1 0 1 0 0 0 1 1 1 0 1 0

    59

    55

  • Data Skrining Farmakologi Kelompok Asam-(3-klorometil)benzoil salisilat Mencit Betina

    No Uji Skrining Hewan 1 Hewan 2 Hewan 3

    0 30 60 120 240 0 30 60 120 240 0 30 60 120 240

    1 Platform 11 1 18 7 3 8 1 9 32 19 28 2 0 0 0

    2 Akt. Motorik 1 1 1 1 1 1 1 1 1 1 1 1 0 0 0

    3 Straub 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    4 Piloereksi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    5 Ptosis 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    6 R. Pineal 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    7 R. Kornea 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    8 R. Fleksi 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    9 Haffner 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    10 Lakrimasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    11 Salivasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    12 Katalepsi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    13 Sikap Tubuh 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    14 Menggelantung 1 1 1 1 1 1 1 1 1 1 1 1 1 0 1

    15 Retablisemen 1 1 1 1 1 1 1 1 1 1 1 1 1 0 1

    16 Kolik Ach 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    17 Mortalitas 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    18 Grooming 1 1 0 0 0 1 1 1 0 0 0 0 0 0 1

    19 Urinasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    20 Defekasi 0 0 0 0 0 1 0 0 0 0 0 0 0 0 1

    60

  • Data Skrining Farmakologi Kelompok Asam-(3-klorometil)benzoilsalisilat Mencit Jantan

    No Uji Skrining Hewan 1 Hewan 2 Hewan 3

    0 30 60 120 240 0 30 60 120 240 0 30 60 120 240

    1 Platform 7 12 3 0 0 8 2 4 0 8 1 1 3 2 0

    2 Akt. Motorik 1 1 1 1 0 1 1 1 1 0 1 1 1 1 1

    3 Straub 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    4 Piloereksi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    5 Ptosis 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    6 R. Pineal 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    7 R. Kornea 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    8 R. Fleksi 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    9 Haffner 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0

    10 Lakrimasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    11 Salivasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    12 Katalepsi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    13 Sikap Tubuh 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    14 Menggelantung 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    15 Retablisemen 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    16 Kolik Ach 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    17 Mortalitas 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    18 Grooming 0 1 1 0 0 0 0 1 0 0 1 1 0 1 1

    19 Urinasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    20 Defekasi 0 0 1 0 0 0 0 0 0 0 1 0 2 0 3

    61

  • Data Skrining Farmakologi Kelompok Asam-(4-klorometil)benzoil salisilat Mencit Betina

    No Uji Skrining Hewan 1 Hewan 2 Hewan 3

    0 30 60 120 240 0 30 60 120 240 0 30 60 120 240

    1 Platform 36 5 3 1 0 28 1 2 0 0 19 6 3 2 0

    2 Akt. Motorik 1 1 1 1 1 1 0 0 0 0 1 0 0 0 1

    3 Straub 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    4 Piloereksi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    5 Ptosis 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    6 R. Pineal 1 1 1 1 1 1 0 0 0 1 1 1 1 1 1

    7 R. Kornea 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    8 R. Fleksi 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    9 Haffner 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    10 Lakrimasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    11 Salivasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    12 Katalepsi 0 0 0 0 0 0 0 1 1 0 0 0 0 0 0

    13 Sikap Tubuh 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    14 Menggelantung 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    15 Retablisemen 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    16 Kolik Ach 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    17 Mortalitas 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    18 Grooming 0 0 0 0 0 1 0 0 0 1 0 0 0 0 0

    19 Urinasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    20 Defekasi 0 0 0 0 0 0 0 0 0 0 0 0 0 1 2

    62

  • Data Skrining Farmakologi Kelompok Asam-(4-klorometil)benzoil salisilat Mencit Jantan

    No Uji Skrining Hewan 1 Hewan 2 Hewan 3

    0 30 60 120 240 0 30 60 120 240 0 30 60 120 240

    1 Platform 23 4 0 0 4 2 2 1 0 2 6 7 0 2 2

    2 Akt. Motorik 1 1 0 0 0 1 0 1 0 0 1 1 0 0 0

    3 Straub 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    4 Piloereksi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    5 Ptosis 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    6 R. Pineal 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    7 R. Kornea 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    8 R. Fleksi 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    9 Haffner 1 1 1 1 1 1 0 0 0 0 1 1 1 1 1

    10 Lakrimasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    11 Salivasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    12 Katalepsi 0 0 0 0 0 0 0 1 1 1 0 0 0 0 0

    13 Sikap Tubuh 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    14 Menggelantung 1 1 1 1 1 1 0 0 0 0 1 1 1 1 1

    15 Retablisemen 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    16 Kolik Ach 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    17 Mortalitas 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    18 Grooming 2 0 0 0 0 0 0 0 0 0 1 0 0 0 0

    19 Urinasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    20 Defekasi 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0

    63

  • Data Skrining Farmakologi Kelompok Asetosal Mencit Betina

    No Uji Skrining Hewan 1 Hewan 2 Hewan 3

    0 30 60 120 240 0 30 60 120 240 0 30 60 120 240

    1 Platform 12 9 0 3 0 5 0 2 1 0 25 4 7 16 4

    2 Akt. Motorik 1 1 0 0 0 1 1 1 1 1 1 1 1 1 1

    3 Straub 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    4 Piloereksi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    5 Ptosis 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    6 R. Pineal 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    7 R. Kornea 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    8 R. Fleksi 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    9 Haffner 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    10 Lakrimasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    11 Salivasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    12 Katalepsi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    13 Sikap Tubuh 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    14 Menggelantung 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    15 Retablisemen 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    16 Kolik Ach 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    17 Mortalitas 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    18 Grooming 1 1 0 0 0 0 1 0 0 1 0 0 0 0 0

    19 Urinasi 0 0 0 0 0 1 0 0 1 1 1 2 0 0 1

    20 Defekasi 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0

    64

  • Data Skrining Farmakologi Kelompok Asetosal Mencit Jantan

    No Uji Skrining Hewan 1 Hewan 2 Hewan 3

    0 30 60 120 240 0 30 60 120 240 0 30 60 120 240

    1 Platform 13 1 3 0 0 9 20 9 0 0 9 9 11 9 6

    2 Akt. Motorik 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1

    3 Straub 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    4 Piloereksi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    5 Ptosis 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    6 R. Pineal 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    7 R. Kornea 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    8 R. Fleksi 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    9 Haffner 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    10 Lakrimasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    11 Salivasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    12 Katalepsi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    13 Sikap Tubuh 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    14 Menggelantung 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    15 Retablisemen 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

    16 Kolik Ach 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    17 Mortalitas 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

    18 Grooming 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0

    19 Urinasi 0 1 0 0 1 1 0 0 0 0 2 0 0 1 1

    20 Defekasi 1 2 0 0 0 1 0 0 0 0 0 0 0 1 0

    65

  • LAMPIRAN B

    DATA PENIMBANGAN BOBOT HEWAN COBA PASCA PERLAKUAN

    1. Kontrol

    a. Mencit Betina

    Hewan

    Coba

    Hari ke-

    0 1 2 3 4 5 6 7 8 9 10 11 12 13 14

    1 18 20 20 21 22 21 22 22 22 21 21 22 22 24 23

    2 20 20 21 23 23 22 24 23 23 23 24 25 25 25 24

    3 19 20 21 22 23 23 24 22 22 22 24 25 25 24 25

    57 60 62 66 68 66 70 67 67 66 69 72 72 73 72

    Rata2 19,0 20,0 20,7 22,0 22,7 22,0 23,3 22,3 22,3 22,0 23,0 24,0 24,0 24,3 24,0

    SD 1,00 0,00 0,58 1,00 0,58 1,00 1,15 0,58 0,58 1,00 1,73 1,73 1,73 0,58 1,00

    b. Mencit Jantan

    Hewan

    Coba

    Hari ke-

    0 1 2 3 4 5 6 7 8 9 10 11 12 13 14

    1 18 22 19 21 22 22 22 19 20 23 22 24 24 24 21

    2 19 20 23 24 24 25 24 24 24 26 25 25 26 25 24

    3 21 22 22 22 23 24 24 23 24 25 26 26 27 25 25

    58 64 64 67 69 71 70 66 68 74 73 75 77 74 70

    Rata2 19,3 21,3 21,3 22,3 23,0 23,7 23,3 22,0 22,7 24,7 24,3 25,0 25,7 24,7 23,3

    SD 1,53 1,15 2,08 1,53 1,00 1,53 1,15 2,65 2,31 1,53 2,08 1,00 1,53 0,58 2,08

    66

  • 2. Asam-(3-klorometil)benzoilsalisilat

    a. Mencit Betina

    Hewan

    Coba

    Hari ke-

    0 1 2 3 4 5 6 7 8 9 10 11 12 13 14

    1 17 18 18 19 21 21 22 22 23 21 21 22 24 24 23

    2 17 18 18 19 19 20 22 20 18 17 19 19 19 20 20

    3 17 17 17 17 17 17 19 17 16 15 16 16 18 18 17

    51 53 53 55 57 58 63 59 57 53 56 57 61 62 60

    Rata2 17,0 17,7 17,7 18,3 19,0 19,3 21,0 19,7 19,0 17,7 18,7 19,0 20,3 20,7 20,0

    SD 0,00 0,58 0,58 1,15 2,00 2,08 1,73 2,52 3,61 3,06 2,52 3,00 3,21 3,06 3,00

    b. Mencit Jantan

    Hewan

    Coba

    Hari ke-

    0 1 2 3 4 5 6 7 8 9 10 11 12 13 14

    1 22 24 25 25 27 28 31 31 32 31 32 32 32 32 33

    2 21 20 21 22 22 25 23 25 25 27 27 26 27 27 28

    3 24 24 24 25 25 24 26 26 27 26 27 27 25 27 27

    67 68 70 72 74 77 80 82 84 84 86 85 84 86 88

    Rata2 22,3 22,7 23,3 24,0 24,7 25,7 26,7 27,3 28,0 28,0 28,7 28,3 28,0 28,7 29,3

    SD 1,53 2,31 2,08 1,73 2,52 2,08 4,04 3,21 3,61 2,65 2,89 3,21 3,61 2,89 3,21

    67

  • 3. Asam-(4-klorometil)benzoilsalisilat

    a. Mencit Betina

    Hewan

    Coba

    Hari ke-

    0 1 2 3 4 5 6 7 8 9 10 11 12 13 14

    1 16 14 13 13 16 16 15 16 17 16 16 19 20 21 21

    2 19 18 18 19 20 21 20 19 19 19 22 22 21 22 21

    3 20 20 21 22 22 23 23 22 22 23 24 24 25 25 26

    55 52 52 54 58 60 58 57 58 58 62 65 66 68 68

    Rata2 18,3 17,3 17,3 18,0 19,3 20,0 19,3 19,0 19,3 19,3 20,7 21,7 22,0 22,7 22,7

    SD 2,08 3,06 4,04 4,58 3,06 3,61 4,04 3,00 2,52 3,51 4,16 2,52 2,65 2,08 2,89

    b. Mencit Jantan

    Hewan

    Coba

    Hari ke-

    0 1 2 3 4 5 6 7 8 9 10 11 12 13 14

    1 27 29 29 29 32 32 34 34 36 34 34 34 34 34 34

    2 24 24 23 23 25 26 28 29 32 31 29 30 29 29 28

    3 26 24 24 28 29 29 29 29 28 27 28 26 25 26 28

    77 77 76 80 86 87 91 92 96 92 91 90 88 89 90

    Rata2 25,7 25,7 25,3 26,7 28,7 29,0 30,3 30,7 32,0 30,7 30,3 30,0 29,3 29,7 30,0

    SD 1,53 2,89 3,21 3,21 3,51 3,00 3,21 2,89 4,00 3,51 3,21 4,00 4,51 4,04 3,46

    68

  • 4. Asetosal

    a. Mencit Betina

    Hewan

    Coba

    Hari ke-

    0 1 2 3 4 5 6 7 8 9 10 11 12 13 14

    1 26 26 25 25 26 27 30 30 29 29 29 30 30 29 32

    2 24 24 24 25 25 24 24 24 24 24 25 25 26 26 27

    3 18 21 18 18 28 29 20 21 21 21 23 22 23 25 26

    68 71 67 68 79 80 74 75 74 74 77 77 79 80 85

    Rata2 22,7 23,7 22,3 22,7 26,3 26,7 24,7 25,0 24,7 24,7 25,7 25,7 26,3 26,7 28,3

    SD 4,16 2,52 3,79 4,04 1,53 2,52 5,03 4,58 4,04 4,04 3,06 4,04 3,51 2,08 3,21

    b. Mencit Jantan

    Hewan

    Coba

    Hari ke-

    0 1 2 3 4 5 6 7 8 9 10 11 12 13 14

    1 22 23 25 24 24 22 22 22 23 23 23 25 24 24 25

    2 22 23 25 24 24 23 23 23 22 22 23 25 26 26 28

    3 22 22 23 23 23 21 19 19 20 21 21 22 23 23 23

    66 68 73 71 71 66 64 64 65 66 67 72 73 73 76

    Rata2 22,0 22,7 24,3 23,7 23,7 22,0 21,3 21,3 21,7 22,0 22,3 24,0 24,3 24,3 25,3

    SD 0,00 0,58 1,15 0,58 0,58 1,00 2,08 2,08 1,53 1,00 1,15 1,73 1,53 1,53 2,52

    69

  • 70

    LAMPIRAN C

    PENGAMATAN MAKROSKOPIS DAN PENIMBANGAN BOBOT

    ORGAN HEWAN COBA

    Keterangan : Hasil pengamatan makroskopis organ mencit betina kelompok

    kontrol : (1) jantung (2) paru-paru (3) hati (4) lambung (5)

    pankreas (6) ginjal (7) anak ginjal (8) ovarium

    Keterangan : Hasil pengamatan makroskopis lambung mencit betina

    kelompok kontrol

    Hewan

    Coba

    Berat Organ (mg)

    Jantung Paru2 Hati Lambung Ginjal Anak

    Ginjal Pankreas Ovarium

    1 120,4 220,2 1423,6 249,9 336,1 7,3 151,0 184,8

    2 117,4 176,4 1231,5 406,6 287,2 5,5 104,5 150,1

    3 124,0 155,9 1335,9 406,6 287,2 6,5 104,5 150,1

    Rata2 120,6 184,2 1330,3 354,4 303,5 6,4 120,0 161,7

    SD 3,30 32,85 96,17 90,47 28,23 0,90 26,85 20,03

    Keterangan : Hasil penimbangan bobot organ mencit betina kelompok

    kontrol

    1 1 1

    2

    2

    2 3

    3

    3

    4

    4

    4

    5

    5

    5

    8

    8

    8

    6

    6 6

    7

    7

    7

  • 71

    Keterangan : Hasil pengamatan makroskopis organ mencit jantan kelompok

    kontrol : (1) jantung (2) paru-paru (3) hati (4) lambung (5)

    pankreas (6) ginjal (7) anak ginjal (8) testis (9) vas deferens

    Keterangan : Hasil pengamatan makroskopis lambung mencit jantan

    kelompok kontrol

    Hewan

    Coba

    Berat Organ (mg)

    Jantung Paru2 Hati Lambung Ginjal Anak

    Ginjal Pankreas Testis

    Vas

    Deferens

    1 90,1 169,9 1185,8 327,6 310,5 0,8 36,2 126,5 22,6

    2 101,0 185,8 1462,0 239,8 398,0 1,7 90,2 163,7 70,3

    3 113,8 177,7 1145,5 395,3 337,3 1,6 46,8 170,4 39,5

    Rata2 101,6 177,8 1264,4 320,9 348,6 1,4 57,7 153,5 44,1

    SD 11,86 7,95 172,28 77,97 44,83 0,49 28,61 23,65 24,19

    Keterangan : Hasil penimbangan bobot organ mencit jantan kelompok

    kontrol

    1

    1

    1

    2

    2 2 3

    3 3 4

    4

    4 5

    5 5 6

    6

    6

    7 7 7

    8 8 8 9 9

    9

  • 72

    Keterangan : Hasil pengamatan makroskopis organ mencit betina kelompok

    Asam-(3-klorometil)benzoil salisilat : (1) jantung (2) paru-

    paru (3) hati (4) lambung (5) pankreas (6) ginjal (7) anak

    ginjal (8) ovarium

    Keterangan : Hasil pengamatan makroskopis lambung mencit kelompok

    Asam-(3-klorometil)benzoil salisilat

    Hewan

    Coba

    Berat Organ (g/10g BB)

    Jantung Paru2 Hati Lambung Ginjal Anak Ginjal Pankreas Ovarium

    1 108,4 177,9 1273,8 282,3 323,5 9,3 119,6 54,9

    2 75,5 192,9 1198,3 381,0 364,8 6,5 106,5 306,2

    3 76,2 144,2 1054,8 516,7 226,5 3,0 146,1 77,0

    Rata2 86,7 171,7 1175,6 393,3 304,9 6,3 124,1 146,0

    SD 18,80 24,94 111,25 117,69 70,99 3,16 20,17 139,15

    Keterangan : Hasil penimbangan bobot organ mencit betina kelompok

    Asam-(3-klorometil)benzoil salisilat

    1

    1

    1

    2

    2 2

    3

    3 3

    4

    4

    4

    5 5 5

    6 6

    6

    7

    7 7

    8

    8 8

  • 73

    Keterangan : Hasil pengamatan makroskopis organ mencit jantan kelompok

    Asam-(3-klorometil)benzoil salisilat : (1) jantung (2) paru-

    paru (3) hati (4) lambung (5) pankreas (6) ginjal (7) anak

    ginjal (8) testis (9) vas deferens

    Keterangan : Hasil pengamatan makroskopis lambung mencit jantan

    kelompok Asam-(3-klorometil)benzoil salisilat

    Hewan

    Coba

    Berat Organ (mg)

    Jantung Paru2 Hati Lambung Ginjal Anak

    Ginjal Pankreas Testis

    Vas

    Deferens

    1 121,2 174,2 1530,0 321,3 436,1 5,0 137,0 172,9 84,3

    2 128,9 198,4 1982,5 389,1 419,7 5,0 147,7 172,8 104,4

    3 135,6 224,3 2256,7 541,1 473,8 4,9 317,8 167,5 108,6

    Rata2 128,6 199,0 1923,1 417,2 443,2 5,0 200,8 171,1 99,1

    SD 7.21 25.05 366.98 112.56 27.74 0.06 101.44 3.09 12.99

    Keterangan : Hasil penimbangan bobot organ mencit jantan kelompok

    Asam-(3-klorometil)benzoil salisilat

    1 1

    1 2 2

    2

    3

    3 3

    4

    4

    4

    5

    5

    5 6

    6

    6

    7

    7

    7

    8

    8

    8 9

    9

    9

  • 74

    Keterangan : Hasil pengamatan makroskopis organ mencit betina kelompok

    Asam-(4-klorometil)benzoil salisilat : (1) jantung (2) paru-

    paru (3) hati (4) lambung (5) pankreas (6) ginjal (7) anak

    ginjal (8) ovarium

    Keterangan : Hasil pengamatan makroskopis lambung mencit betina

    kelompok Asam-(4-klorometil)benzoil salisilat

    Hewan

    Coba

    Berat Organ (mg)

    Jantung Paru2 Hati Lambung Ginjal Anak

    Ginjal Pankreas Ovarium

    1 95,7 183,9 1448,4 246,2 278,6 12,4 148,3 37,7

    2 122,9 158,0 1179,9 461,6 302,6 8,4 109,4 166,7

    3 127,3 185,9 1323,4 303,8 307,8 9,8 129,9 163,5

    Rata2 115,3 175,9 1317,2 337,2 296,3 10,2 129,2 122,6

    SD 17.,12 15,56 134,36 111,52 15,58 2,03 19,46 73,57

    Keterangan : Hasil penimbangan bobot organ mencit betina kelompok

    Asam-(4-klorometil)benzoil salisilat

    1

    1 1

    2 2

    2

    3

    3

    3

    4 4 4

    5

    5

    5

    6

    6

    6

    7 7

    7

    8

    8

    8

  • 75

    Keterangan : Hasil pengamatan makroskopis organ mencit jantan kelompok

    Asam-(4-klorometil)benzoil salisilat : (1) jantung (2) paru-

    paru (3) hati (4) lambung (5) pankreas (6) ginjal (7) anak

    ginjal (8) testis (9) vas deferens

    Keterangan : Hasil pengamatan makroskopis lambung mencit jantan

    kelompok Asam-(4-klorometil)benzoil salisilat

    Hewan

    Coba

    Berat Organ (mg)

    Jantung Paru2 Hati Lambung Ginjal Anak

    Ginjal Pankreas Testis

    Vas

    Deferens

    1 155,5 253,9 1855,2 333,6 593,8 7,1 94,7 321,2 116,5

    2 110,2 187,1 1567,5 600,0 520,0 5,5 143,9 259,2 142,8

    3 134,7 215,6 1478,6 379,8 428,9 5,7 71,3 168,7 125,7

    Rata2 133,5 218,9 1633,8 437,8 514,2 6,1 103,3 249,7 128,3

    SD 22,68 33,52 196,85 142,36 82,60 0,87 37,06 76,69 13,35

    Keterangan : Hasil penimbangan bobot organ mencit jantan kelompok

    Asam-(4-klorometil)benzoil salisilat

    1

    1 2

    2 3

    3

    4 4

    5 5

    6

    6 7

    7

    8 8

    9 9

  • 76

    Keterangan : Hasil pengamatan makroskopis organ mencit betina kelompok

    Asetosal : (1) jantung (2) paru-paru (3) hati (4) lambung (5)

    pankreas (6) ginjal (7) anak ginjal (8) ovarium

    Keterangan : Hasil pengamatan makroskopis lambung mencit betina

    kelompok Asetosal

    Keterangan : Hasil penimbangan bobot organ mencit betina kelompok

    Asetosal

    Hewan

    Coba

    Berat Organ (g/10g BB)

    Jantung Paru2 Hati Lambung Ginjal Anak

    Ginjal Pankreas Ovarium

    1 128,6 296,4 1190,8 298,6 315,7 4,7 126,0 97,6

    2 135,7 195,4 1138,7 239,8 268,7 5,3 117,8 108,8

    3 139,8 218,7 1209,6 196,7 297,7 6,5 106,7 87,5

    Rata2 134,7 236,8 1179,7 245,0 294,0 5,5 116,8 98,0

    SD 5,67 52,89 36,73 51,15 23,71 0,92 9,69 10,65

    1

    1

    1

    2 2

    2 3 3 3

    4

    4

    4 5

    5 5

    6 6

    6

    7

    7

    7

    8

    8

    8

  • 77

    Keterangan : Hasil pengamatan makroskopis organ mencit jantan kelompok

    Asetosal : (1) jantung (2) paru-paru (3) hati (4) lambung (5)

    pankreas (6) ginjal (7) anak ginjal (8) testis (9) vas deferens

    Keterangan : Hasil pengamatan makroskopis lambung mencit jantan

    kelompok Asetosal

    Hewan

    Coba

    Berat Organ (mg)

    Jantung Paru2 Hati Lambung Ginjal Anak

    Ginjal Pankreas Testis

    Vas

    Deferens

    1 97,5 156,2 1434,3 408,5 345,4 2,5 60,9 219,0 47,8

    2 121,6 194,6 1440,3 383,1 370,8 1,6 50,8 165,1 94,1

    3 113,3 174,7 1388,9 557,0 347,6 5,5 54,9 164,5 53,6

    Rata2 110,8 175,2 1421,2 449,5 354,6 3,2 55,5 182,9 65,2

    SD 12,24 19,20 28,10 93,93 14,07 2,04 5,08 31,29 25,22

    Keterangan : Hasil penimbangan bobot organ mencit jantan kelompok

    Asetosal

    1 1 1 2

    2

    2 3 3

    3

    4

    4

    4 5

    5

    5

    6

    6 6 7

    7

    7 8 8

    8 9 9

    9

  • 78

    LAMPIRAN D

    HASIL STATISTIK PENINGKATAN BERAT BADAN HEWAN COBA

    Mencit Betina Descriptives

    Peningkatan_Berat_Badan

    N Mean Std.

    Deviation Std. Error

    95% Confidence Interval for Mean

    Minimum Maximum Lower Bound Upper Bound

    Kontrol 3 24.0000 1.00000 .57735 21.5159 26.4841 23.00 25.00

    3-klorometil 3 20.0000 3.00000 1.73205 12.5476 27.4524 17.00 23.00

    4-klorometil 3 22.6667 2.88675 1.66667 15.4956 29.8378 21.00 26.00

    Asetosal 3 28.3333 3.21455 1.85592 20.3479 36.3187 26.00 32.00

    Total 12 23.7500 3.88763 1.12226 21.2799 26.2201 17.00 32.00

    Test of Homogeneity of Variances

    Peningkatan_Berat_Badan

    Levene Statistic df1 df2 Sig.

    1.360 3 8 .323

    ANOVA

    Peningkatan_Berat_Badan

    Sum of Squares df Mean Square F Sig.

    Between Groups 108.917 3 36.306 5.066 .030

    Within Groups 57.333 8 7.167

    Total 166.250 11

  • 79

    Multiple Comparisons

    Peningkatan_Berat_Badan LSD

    (I) Kelompok (J) Kelompok Mean

    Difference (I-J) Std. Error Sig.

    95% Confidence Interval

    Lower Bound Upper Bound

    kontrol 3-klorometil 4.00000 2.18581 .105 -1.0405 9.0405

    4-klorometil 1.33333 2.18581 .559 -3.7072 6.3738

    Asetosal -4.33333 2.18581 .083 -9.3738 .7072

    3-klorometil Kontrol -4.00000 2.18581 .105 -9.0405 1.0405

    4-klorometil -2.66667 2.18581 .257 -7.7072 2.3738

    Asetosal -8.33333* 2.18581 .005 -13.3738 -3.2928

    4-klorometil Kontrol -1.33333 2.18581 .559 -6.3738 3.7072

    3-klorometil 2.66667 2.18581 .257 -2.3738 7.7072

    Asetosal -5.66667* 2.18581 .032 -10.7072 -.6262

    asetosal Kontrol 4.33333 2.18581 .083 -.7072 9.3738

    3-klorometil 8.33333* 2.18581 .005 3.2928 13.3738

    4-klorometil 5.66667* 2.18581 .032 .6262 10.7072

    *. The mean difference is significant at the 0.05 level.

    Mencit Jantan

    Descriptives

    Peningkatan_Berat_Badan

    N Mean Std.

    Deviation Std. Error

    95% Confidence Interval for Mean

    Minimum Maximum Lower Bound Upper Bound

    kontrol 3 23.3333 2.08167 1.20185 18.1622 28.5045 21.00 25.00

    3-klorometil 3 29.3333 3.21455 1.85592 21.3479 37.3187 27.00 33.00

    4-klorometil 3 30.0000 3.46410 2.00000 21.3947 38.6053 28.00 34.00

    asetosal 3 25.3333 2.51661 1.45297 19.0817 31.5849 23.00 28.00

    Total 12 27.0000 3.78994 1.09406 24.5920 29.4080 21.00 34.00

    Test of Homogeneity of Variances

    Peningkatan_Berat_Badan

    Levene Statistic df1 df2 Sig.

    .672 3 8 .593

  • 80

    ANOVA

    Peningkatan_Berat_Badan

    Sum of Squares df Mean Square F Sig.

    Between Groups 92.000 3 30.667 3.717 .061

    Within Groups 66.000 8 8.250

    Total 158.000 11

    Multiple Comparisons

    Peningkatan_Berat_Badan LSD

    (I) Kelompok (J) Kelompok Mean

    Difference (I-J) Std. Error Sig.

    95% Confidence Interval

    Lower Bound Upper Bound

    Kontrol 3-klorometil -6.00000* 2.34521 .034 -11.4081 -.5919

    4-klorometil -6.66667* 2.34521 .022 -12.0747 -1.2586

    Asetosal -2.00000 2.34521 .419 -7.4081 3.4081

    3-klorometil Kontrol 6.00000* 2.34521 .034 .5919 11.4081

    4-klorometil -.66667 2.34521 .783 -6.0747 4.7414

    Asetosal 4.00000 2.34521 .126 -1.4081 9.4081

    4-klorometil Kontrol 6.66667* 2.34521 .022 1.2586 12.0747

    3-klorometil .66667 2.34521 .783 -4.7414 6.0747

    Asetosal 4.66667 2.34521 .082 -.7414 10.0747

    Asetosal Kontrol 2.00000 2.34521 .419 -3.4081 7.4081

    3-klorometil -4.00000 2.34521 .126 -9.4081 1.4081

    4-klorometil -4.66667 2.34521 .082 -10.0747 .7414

    *. The mean difference is significant at the 0.05 level.

  • 81

    LAMPIRAN E

    HASIL STATISTIK PENIMBANGAN BOBOT ORGAN HEWAN COBA

    Mencit Betina

    Descriptives

    N Mean Std.

    Deviation Std. Error

    95% Confidence Interval for Mean

    Minimum Maximum Lower

    Bound Upper Bound

    Jantung Kontrol 3 12.0600 .33045 .19079 11.2391 12.8809 11.74 12.40

    3-klorometil 3 8.6700 1.87960 1.08519 4.0008 13.3392 7.55 10.84

    4-klorometil 3 11.5300 1.71161 .98820 7.2781 15.7819 9.57 12.73

    Asetosal 3 13.4700 .56666 .32716 12.0623 14.8777 12.86 13.98

    Total 12 11.4325 2.13932 .61757 10.0732 12.7918 7.55 13.98

    Paru Kontrol 3 18.4167 3.28461 1.89637 10.2573 26.5761 15.59 22.02

    3-klorometil 3 17.1667 2.49412 1.43998 10.9709 23.3624 14.42 19.29

    4-klorometil 3 17.5933 1.55629 .89852 13.7273 21.4594 15.80 18.59

    Asetosal 3 23.6833 5.28854 3.05334 10.5459 36.8208 19.54 29.64

    Total 12 19.2150 4.01233 1.15826 16.6657 21.7643 14.42 29.64

    Hati Kontrol 3 1.3303E2 9.61709 5.55243 109.1432 156.9235 123.15 142.36

    3-klorometil 3 1.1756E2 11.12456 6.42277 89.9284 145.1983 105.48 127.38

    4-klorometil 3 1.3172E2 13.43562 7.75706 98.3474 165.0993 117.99 144.84

    asetosal 3 1.1797E2 3.67302 2.12062 108.8457 127.0943 113.87 120.96

    Total 12 1.2507E2 11.53582 3.33010 117.7430 132.4020 105.48 144.84

    Lambung Kontrol 3 35.4367 9.04708 5.22333 12.9625 57.9109 24.99 40.66

    3-klorometil 3 39.3633 11.72615 6.77010 10.2340 68.4927 28.32 51.67

    4-klorometil 3 33.7200 11.15166 6.43842 6.0177 61.4223 24.62 46.16

    asetosal 3 24.5033 5.11512 2.95321 11.7967 37.2100 19.67 29.86

    Total 12 33.2558 9.98358 2.88201 26.9126 39.5991 19.67 51.67

    Ginjal Kontrol 3 30.3500 2.82324 1.63000 23.3367 37.3633 28.72 33.61

    3-klorometil 3 30.4933 7.09948 4.09889 12.8572 48.1294 22.65 36.48

    4-klorometil 3 29.6333 1.55760 .89928 25.7640 33.5026 27.86 30.78

    asetosal 3 29.4033 2.37136 1.36910 23.5126 35.2941 26.87 31.57

    Total 12 29.9700 3.50848 1.01281 27.7408 32.1992 22.65 36.48

    Anak_Ginjal Kontrol 3 .6433 .09018 .05207 .4193 .8674 .55 .73

    3-klorometil 3 .6267 .31565 .18224 -.1574 1.4108 .30 .93

    4-klorometil 3 1.0200 .20298 .11719 .5158 1.5242 .84 1.24

    asetosal 3 .5500 .09165 .05292 .3223 .7777 .47 .65

  • 82

    Total 12 .7100 .25477 .07355 .5481 .8719 .30 1.24

    Pankreas Kontrol 3 12.0000 2.68468 1.55000 5.3309 18.6691 10.45 15.10

    3-klorometil 3 12.4067 2.01743 1.16477 7.3951 17.4182 10.65 14.61

    4-klorometil 3 12.9200 1.94594 1.12349 8.0860 17.7540 10.94 14.83

    asetosal 3 11.6833 .96862 .55924 9.2771 14.0895 10.67 12.60

    Total 12 12.2525 1.77293 .51180 11.1260 13.3790 10.45 15.10

    Ovarium Kontrol 3 16.1667 2.00341 1.15667 11.1899 21.1434 15.01 18.48

    3-klorometil 3 14.6033 13.91478 8.03370 -19.9629 49.1696 5.49 30.62

    4-klorometil 3 12.2633 7.35718 4.24767 -6.0129 30.5396 3.77 16.67

    asetosal 3 9.7967 1.06547 .61515 7.1499 12.4434 8.75 10.88

    Total 12 13.2075 7.23305 2.08800 8.6118 17.8032 3.77 30.62

    Test of Homogeneity of Variances

    Levene Statistic df1 df2 Sig.

    Jantung 5.302 3 8 .026

    Paru 2.139 3 8 .173

    Hati .851 3 8 .504

    Lambung .793 3 8 .531

    Ginjal 3.323 3 8 .077

    Anak_Ginjal 1.582 3 8 .268

    Pankreas 1.280 3 8 .346

    Ovarium 8.486 3 8 .007

  • 83

    ANOVA

    Sum of Squares Df

    Mean Square F Sig.

    Jantung Between Groups 36.558 3 12.186 7.072 .012

    Within Groups 13.786 8 1.723

    Total 50.344 11

    Paru Between Groups 82.286 3 27.429 2.315 .152

    Within Groups 94.800 8 11.850

    Total 177.086 11

    Hati Between Groups 643.325 3 214.442 2.091 .180

    Within Groups 820.502 8 102.563

    Total 1463.827 11

    Lambung Between Groups 356.638 3 118.879 1.286 .344

    Within Groups 739.753 8 92.469

    Total 1096.390 11

    Ginjal Between Groups 2.558 3 .853 .051 .984

    Within Groups 132.846 8 16.606

    Total 135.404 11

    Anak_Ginjal Between Groups .399 3 .133 3.383 .075

    Within Groups .315 8 .039

    Total .714 11

    Pankreas Between Groups 2.571 3 .857 .214 .884

    Within Groups 32.005 8 4.001

    Total 34.576 11

    Ovarium Between Groups 69.691 3 23.230 .367 .779

    Within Groups 505.796 8 63.225

    Total 575.487 11

  • 84

    Multiple Comparisons

    LSD

    Dependent Variable (I) Kelompok (J) Kelompok

    Mean Difference (I-J) Std. Error Sig.

    95% Confidence Interval

    Lower Bound

    Upper Bound

    Jantung Kontrol 3-klorometil 3.39000* 1.07182 .013 .9184 5.8616

    4-klorometil .53000 1.07182 .634 -1.9416 3.0016

    asetosal -1.41000 1.07182 .225 -3.8816 1.0616

    3-klorometil Kontrol -3.39000* 1.07182 .013 -5.8616 -.9184

    4-klorometil -2.86000* 1.07182 .028 -5.3316 -.3884

    asetosal -4.80000* 1.07182 .002 -7.2716 -2.3284

    4-klorometil Kontrol -.53000 1.07182 .634 -3.0016 1.9416

    3-klorometil 2.86000* 1.07182 .028 .3884 5.3316

    asetosal -1.94000 1.07182 .108 -4.4116 .5316

    asetosal Kontrol 1.41000 1.07182 .225 -1.0616 3.8816

    3-klorometil 4.80000* 1.07182 .002 2.3284 7.2716

    4-klorometil 1.94000 1.07182 .108 -.5316 4.4116

    Paru Kontrol 3-klorometil 1.25000 2.81069 .668 -5.2315 7.7315

    4-klorometil .82333 2.81069 .777 -5.6581 7.3048

    asetosal -5.26667 2.81069 .098 -11.7481 1.2148

    3-klorometil Kontrol -1.25000 2.81069 .668 -7.7315 5.2315

    4-klorometil -.42667 2.81069 .883 -6.9081 6.0548

    asetosal -6.51667* 2.81069 .049 -12.9981 -.0352

    4-klorometil Kontrol -.82333 2.81069 .777 -7.3048 5.6581

    3-klorometil .42667 2.81069 .883 -6.0548 6.9081

    asetosal -6.09000 2.81069 .062 -12.5715 .3915

    asetosal Kontrol 5.26667 2.81069 .098 -1.2148 11.7481

    3-klorometil 6.51667* 2.81069 .049 .0352 12.9981

    4-klorometil 6.09000 2.81069 .062 -.3915 12.5715

    Hati Kontrol 3-klorometil 15.47000 8.26893 .098 -3.5982 34.5382

    4-klorometil 1.31000 8.26893 .878 -17.7582 20.3782

    asetosal 15.06333 8.26893 .106 -4.0049 34.1315

    3-klorometil Kontrol -15.47000 8.26893 .098 -34.5382 3.5982

    4-klorometil -14.16000 8.26893 .125 -33.2282 4.9082

    asetosal -.40667 8.26893 .962 -19.4749 18.6615

    4-klorometil Kontrol -1.31000 8.26893 .878 -20.3782 17.7582

    3-klorometil 14.16000 8.26893 .125 -4.9082 33.2282

    asetosal 13.75333 8.26893 .135 -5.3149 32.8215

  • 85

    asetosal Kontrol -15.06333 8.26893 .106 -34.1315 4.0049

    3-klorometil .40667 8.26893 .962 -18.6615 19.4749

    4-klorometil -13.75333 8.26893 .135 -32.8215 5.3149

    Lambung Kontrol 3-klorometil -3.92667 7.85150 .630 -22.0323 14.1789

    4-klorometil 1.71667 7.85150 .832 -16.3889 19.8223

    asetosal 10.93333 7.85150 .201 -7.1723 29.0389

    3-klorometil Kontrol 3.92667 7.85150 .630 -14.1789 22.0323

    4-klorometil 5.64333 7.85150 .493 -12.4623 23.7489

    asetosal 14.86000 7.85150 .095 -3.2456 32.9656

    4-klorometil Kontrol -1.71667 7.85150 .832 -19.8223 16.3889

    3-klorometil -5.64333 7.85150 .493 -23.7489 12.4623

    asetosal 9.21667 7.85150 .274 -8.8889 27.3223

    asetosal Kontrol -10.93333 7.85150 .201 -29.0389 7.1723

    3-klorometil -14.86000 7.85150 .095 -32.9656 3.2456

    4-klorometil -9.21667 7.85150 .274 -27.3223 8.8889

    Ginjal Kontrol 3-klorometil -.14333 3.32723 .967 -7.8159 7.5293

    4-klorometil .71667 3.32723 .835 -6.9559 8.3893

    asetosal .94667 3.32723 .783 -6.7259 8.6193

    3-klorometil Kontrol .14333 3.32723 .967 -7.5293 7.8159

    4-klorometil .86000 3.32723 .803 -6.8126 8.5326

    asetosal 1.09000 3.32723 .752 -6.5826 8.7626

    4-klorometil Kontrol -.71667 3.32723 .835 -8.3893 6.9559

    3-klorometil -.86000 3.32723 .803 -8.5326 6.8126

    asetosal .23000 3.32723 .947 -7.4426 7.9026

    asetosal Kontrol -.94667 3.32723 .783 -8.6193 6.7259

    3-klorometil -1.09000 3.32723 .752 -8.7626 6.5826

    4-klorometil -.23000 3.32723 .947 -7.9026 7.4426

    Anak_Ginjal Kontrol 3-klorometil .01667 .16195 .921 -.3568 .3901

    4-klorometil -.37667* .16195 .048 -.7501 -.0032

    asetosal .09333 .16195 .580 -.2801 .4668

    3-klorometil Kontrol -.01667 .16195 .921 -.3901 .3568

    4-klorometil -.39333* .16195 .041 -.7668 -.0199

    asetosal .07667 .16195 .649 -.2968 .4501

    4-klorometil Kontrol .37667* .16195 .048 .0032 .7501

    3-klorometil .39333* .16195 .041 .0199 .7668

    asetosal .47000* .16195 .020 .0965 .8435

    asetosal Kontrol -.09333 .16195 .580 -.4668 .2801

    3-klorometil -.07667 .16195 .649 -.4501 .2968

    4-klorometil -.47000* .16195 .020 -.8435 -.0965

  • 86

    Pankreas Kontrol 3-klorometil -.40667 1.63312 .810 -4.1726 3.3593

    4-klorometil -.92000 1.63312 .589 -4.6860 2.8460

    asetosal .31667 1.63312 .851 -3.4493 4.0826

    3-klorometil Kontrol .40667 1.63312 .810 -3.3593 4.1726

    4-klorometil -.51333 1.63312 .761 -4.2793 3.2526

    asetosal .72333 1.63312 .670 -3.0426 4.4893

    4-klorometil Kontrol .92000 1.63312 .589 -2.8460 4.6860

    3-klorometil .51333 1.63312 .761 -3.2526 4.2793

    asetosal 1.23667 1.63312 .471 -2.5293 5.0026

    asetosal Kontrol -.31667 1.63312 .851 -4.0826 3.4493

    3-klorometil -.72333 1.63312 .670 -4.4893 3.0426

    4-klorometil -1.23667 1.63312 .471 -5.0026 2.5293

    Ovarium Kontrol 3-klorometil 1.56333 6.49228 .816 -13.4079 16.5346

    4-klorometil 3.90333 6.49228 .564 -11.0679 18.8746

    asetosal 6.37000 6.49228 .355 -8.6012 21.3412

    3-klorometil Kontrol -1.56333 6.49228 .816 -16.5346 13.4079

    4-klorometil 2.34000 6.49228 .728 -12.6312 17.3112

    asetosal 4.80667 6.49228 .480 -10.1646 19.7779

    4-klorometil Kontrol -3.90333 6.49228 .564 -18.8746 11.0679

    3-klorometil -2.34000 6.49228 .728 -17.3112 12.6312

    asetosal 2.46667 6.49228 .714 -12.5046 17.4379

    asetosal Kontrol -6.37000 6.49228 .355 -21.3412 8.6012

    3-klorometil -4.80667 6.49228 .480 -19.7779 10.1646

    4-klorometil -2.46667 6.49228 .714 -17.4379 12.5046

    *. The mean difference is significant at the 0.05 level.

  • 87

    Mencit Jantan Descriptives

    N Mean Std.

    Deviation Std. Error

    95% Confidence Interval for Mean

    Minimum Maximum Lower

    Bound Upper Bound

    Jantung kontrol 3 10.1633 1.18627 .68489 7.2165 13.1102 9.01 11.38

    3-klorometil 3 12.8567 .72058 .41603 11.0667 14.6467 12.12 13.56

    4-klorometil 3 13.3467 2.26752 1.30915 7.7138 18.9795 11.02 15.55

    asetosal 3 11.0800 1.22430 .70685 8.0387 14.1213 9.75 12.16

    Total 12 11.8617 1.83911 .53091 10.6931 13.0302 9.01 15.55

    Paru kontrol 3 17.7800 .79505 .45902 15.8050 19.7550 16.99 18.58

    3-klorometil 3 19.8967 2.50548 1.44654 13.6727 26.1206 17.42 22.43

    4-klorometil 3 21.8867 3.35196 1.93525 13.5599 30.2134 18.71 25.39

    asetosal 3 17.5167 1.92043 1.10876 12.7461 22.2873 15.62 19.46

    Total 12 19.2700 2.71809 .78465 17.5430 20.9970 15.62 25.39

    Hati kontrol 3 1.2678E2 16.88919 9.75098 84.8216 168.7317 115.55 146.20

    3-klorometil 3 1.9231E2 36.69775 21.18745 101.1444 283.4689 153.00 225.67

    4-klorometil 3 1.6338E2 19.68511 11.36520 114.4762 212.2772 147.86 185.52

    asetosal 3 1.4212E2 2.81043 1.62260 135.1352 149.0982 138.89 144.03

    Total 12 1.5614E2 32.06883 9.25747 135.7686 176.5197 115.55 225.67

    Lambung kontrol 3 32.0900 7.79662 4.50138 12.7221 51.4579 23.98 39.53

    3-klorometil 3 41.7167 11.25558 6.49841 13.7563 69.6771 32.13 54.11

    4-klorometil 3 43.7800 14.23560 8.21893 8.4168 79.1432 33.36 60.00

    asetosal 3 44.9533 9.39314 5.42313 21.6195 68.2872 38.31 55.70

    Total 12 40.6350 10.72336 3.09557 33.8217 47.4483 23.98 60.00

    Ginjal kontrol 3 34.8600 4.48311 2.58833 23.7233 45.9967 31.05 39.80

    3-klorometil 3 44.3200 2.77400 1.60157 37.4290 51.2110 41.97 47.38

    4-klorometil 3 51.4233 8.26011 4.76898 30.9041 71.9426 42.89 59.38

    asetosal 3 35.4600 1.40727 .81249 31.9642 38.9558 34.54 37.08

    Total 12 41.5158 8.29563 2.39474 36.2450 46.7866 31.05 59.38

    Anak_Ginjal kontrol 3 .1367 .04933 .02848 .0141 .2592 .08 .17

    3-klorometil 3 .4967 .00577 .00333 .4823 .5110 .49 .50

    4-klorometil 3 .6100 .08718 .05033 .3934 .8266 .55 .71

    asetosal 3 .3200 .20421 .11790 -.1873 .8273 .16 .55

    Total 12 .3908 .21108 .06093 .2567 .5249 .08 .71

    Pankreas kontrol 3 5.7733 2.86121 1.65192 -1.3343 12.8810 3.62 9.02

    3-klorometil 3 20.0867 10.14949 5.85981 -5.1261 45.2994 13.70 31.79

  • 88

    4-klorometil 3 10.2967 3.65088 2.10784 1.2274 19.3660 7.13 14.29

    asetosal 3 5.5533 .50797 .29328 4.2915 6.8152 5.08 6.09

    Total 12 10.4275 7.77980 2.24583 5.4845 15.3705 3.62 31.79

    Testis kontrol 3 15.3533 2.36500 1.36543 9.4783 21.2283 12.65 17.04

    3-klorometil 3 17.1067 .30892 .17836 16.3393 17.8741 16.75 17.29

    4-klorometil 3 24.9700 7.66926 4.42785 5.9185 44.0215 16.87 32.12

    asetosal 3 18.2867 3.12938 1.80675 10.5129 26.0605 16.45 21.90

    Total 12 18.9292 5.28838 1.52662 15.5691 22.2892 12.65 32.12

    Vas_Deferens

    kontrol 3 4.4133 2.41852 1.39633 -1.5946 10.4213 2.26 7.03

    3-klorometil 3 9.9100 1.29881 .74987 6.6836 13.1364 8.43 10.86

    4-klorometil 3 12.8333 1.33463 .77055 9.5179 16.1487 11.65 14.28

    asetosal 3 6.5167 2.52243 1.45632 .2506 12.7827 4.78 9.41

    Total 12 8.4183 3.75961 1.08530 6.0296 10.8071 2.26 14.28

    Test of Homogeneity of Variances

    Levene Statistic df1 df2 Sig.

    Jantung .978 3 8 .450

    Paru 1.061 3 8 .418

    Hati 2.825 3 8 .107

    Lambung .771 3 8 .542

    Ginjal 1.893 3 8 .209

    Anak_Ginjal 6.375 3 8 .016

    Pankreas 7.837 3 8 .009

    Testis 3.318 3 8 .078

    Vas_Deferens 1.133 3 8 .392

  • 89

    ANOVA

    Sum of Squares df

    Mean Square F Sig.

    Jantung Between Groups 20.072 3 6.691 3.124 .088

    Within Groups 17.134 8 2.142

    Total 37.206 11

    Paru Between Groups 37.602 3 12.534 2.296 .154

    Within Groups 43.666 8 5.458

    Total 81.268 11

    Hati Between Groups 7257.769 3 2419.256 4.773 .034

    Within Groups 4054.742 8 506.843

    Total 11312.511

    11

    Lambung Between Groups 308.178 3 102.726 .859 .500

    Within Groups 956.718 8 119.590

    Total 1264.896 11

    Ginjal Between Groups 560.985 3 186.995 7.632 .010

    Within Groups 196.006 8 24.501

    Total 756.992 11

    Anak_Ginjal Between Groups .387 3 .129 9.956 .004

    Within Groups .104 8 .013

    Total .490 11

    Pankreas Between Groups 416.206 3 138.735 4.447 .041

    Within Groups 249.571 8 31.196

    Total 665.778 11

    Testis Between Groups 159.038 3 53.013 2.854 .105

    Within Groups 148.598 8 18.575

    Total 307.636 11

    Vas_Deferens Between Groups 124.121 3 41.374 10.555 .004

    Within Groups 31.360 8 3.920

    Total 155.481 11

  • 90

    Multiple Comparisons

    LSD

    Dependent Variable (I) Kelompok (J) Kelompok

    Mean Difference (I-J) Std. Error Sig.

    95% Confidence Interval

    Lower Bound

    Upper Bound

    Jantung kontrol 3-klorometil -2.69333 1.19492 .054 -5.4488 .0622

    4-klorometil -3.18333* 1.19492 .029 -5.9388 -.4278

    asetosal -.91667 1.19492 .465 -3.6722 1.8388

    3-klorometil kontrol 2.69333 1.19492 .054 -.0622 5.4488

    4-klorometil -.49000 1.19492 .693 -3.2455 2.2655

    asetosal 1.77667 1.19492 .175 -.9788 4.5322

    4-klorometil kontrol 3.18333* 1.19492 .029 .4278 5.9388

    3-klorometil .49000 1.19492 .693 -2.2655 3.2455

    asetosal 2.26667 1.19492 .094 -.4888 5.0222

    asetosal kontrol .91667 1.19492 .465 -1.8388 3.6722

    3-klorometil -1.77667 1.19492 .175 -4.5322 .9788

    4-klorometil -2.26667 1.19492 .094 -5.0222 .4888

    Paru kontrol 3-klorometil -2.11667 1.90758 .299 -6.5156 2.2822

    4-klorometil -4.10667 1.90758 .063 -8.5056 .2922

    asetosal .26333 1.90758 .894 -4.1356 4.6622

    3-klorometil kontrol 2.11667 1.90758 .299 -2.2822 6.5156

    4-klorometil -1.99000 1.90758 .327 -6.3889 2.4089

    asetosal 2.38000 1.90758 .247 -2.0189 6.7789

    4-klorometil kontrol 4.10667 1.90758 .063 -.2922 8.5056

    3-klorometil 1.99000 1.90758 .327 -2.4089 6.3889

    asetosal 4.37000 1.90758 .051 -.0289 8.7689

    asetosal kontrol -.26333 1.90758 .894 -4.6622 4.1356

    3-klorometil -2.38000 1.90758 .247 -6.7789 2.0189

    4-klorometil -4.37000 1.90758 .051 -8.7689 .0289

    Hati kontrol 3-klorometil -65.53000* 18.38193 .007 -107.9188 -23.1412

    4-klorometil -36.60000 18.38193 .082 -78.9888 5.7888

    asetosal -15.34000 18.38193 .428 -57.7288 27.0488

    3-klorometil kontrol 65.53000* 18.38193 .007 23.1412 107.9188

    4-klorometil 28.93000 18.38193 .154 -13.4588 71.3188

    asetosal 50.19000* 18.38193 .026 7.8012 92.5788

    4-klorometil kontrol 36.60000 18.38193 .082 -5.7888 78.9888

    3-klorometil -28.93000 18.38193 .154 -71.3188 13.4588

    asetosal 21.26000 18.38193 .281 -21.1288 63.6488

  • 91

    asetosal kontrol 15.34000 18.38193 .428 -27.0488 57.7288

    3-klorometil -50.19000* 18.38193 .026 -92.5788 -7.8012

    4-klorometil -21.26000 18.38193 .281 -63.6488 21.1288

    Lambung kontrol 3-klorometil -9.62667 8.92897 .312 -30.2169 10.9636

    4-klorometil -11.69000 8.92897 .227 -32.2802 8.9002

    asetosal -12.86333 8.92897 .188 -33.4536 7.7269

    3-klorometil kontrol 9.62667 8.92897 .312 -10.9636 30.2169

    4-klorometil -2.06333 8.92897 .823 -22.6536 18.5269

    asetosal -3.23667 8.92897 .726 -23.8269 17.3536

    4-klorometil kontrol 11.69000 8.92897 .227 -8.9002 32.2802

    3-klorometil 2.06333 8.92897 .823 -18.5269 22.6536

    asetosal -1.17333 8.92897 .899 -21.7636 19.4169

    asetosal kontrol 12.86333 8.92897 .188 -7.7269 33.4536

    3-klorometil 3.23667 8.92897 .726 -17.3536 23.8269

    4-klorometil 1.17333 8.92897 .899 -19.4169 21.7636

    Ginjal kontrol 3-klorometil -9.46000* 4.04152 .047 -18.7798 -.1402

    4-klorometil -16.56333* 4.04152 .003 -25.8831 -7.2436

    asetosal -.60000 4.04152 .886 -9.9198 8.7198

    3-klorometil kontrol 9.46000* 4.04152 .047 .1402 18.7798

    4-klorometil -7.10333 4.04152 .117 -16.4231 2.2164

    asetosal 8.86000 4.04152 .060 -.4598 18.1798

    4-klorometil kontrol 16.56333* 4.04152 .003 7.2436 25.8831

    3-klorometil 7.10333 4.04152 .117 -2.2164 16.4231

    asetosal 15.96333* 4.04152 .004 6.6436 25.2831

    asetosal kontrol .60000 4.04152 .886 -8.7198 9.9198

    3-klorometil -8.86000 4.04152 .060 -18.1798 .4598

    4-klorometil -15.96333* 4.04152 .004 -25.2831 -6.6436

    Anak_Ginjal kontrol 3-klorometil -.36000* .09289 .005 -.5742 -.1458

    4-klorometil -.47333* .09289 .001 -.6875 -.2591

    asetosal -.18333 .09289 .084 -.3975 .0309

    3-klorometil kontrol .36000* .09289 .005 .1458 .5742

    4-klorometil -.11333 .09289 .257 -.3275 .1009

    asetosal .17667 .09289 .094 -.0375 .3909

    4-klorometil kontrol .47333* .09289 .001 .2591 .6875

    3-klorometil .11333 .09289 .257 -.1009 .3275

    asetosal .29000* .09289 .014 .0758 .5042

    asetosal kontrol .18333 .09289 .084 -.0309 .3975

    3-klorometil -.17667 .09289 .094 -.3909 .0375

    4-klorometil -.29000* .09289 .014 -.5042 -.0758

  • 92

    Pankreas kontrol 3-klorometil -14.31333* 4.56044 .014 -24.8297 -3.7969

    4-klorometil -4.52333 4.56044 .350 -15.0397 5.9931

    asetosal .22000 4.56044 .963 -10.2964 10.7364

    3-klorometil kontrol 14.31333* 4.56044 .014 3.7969 24.8297

    4-klorometil 9.79000 4.56044 .064 -.7264 20.3064

    asetosal 14.53333* 4.56044 .013 4.0169 25.0497

    4-klorometil kontrol 4.52333 4.56044 .350 -5.9931 15.0397

    3-klorometil -9.79000 4.56044 .064 -20.3064 .7264

    asetosal 4.74333 4.56044 .329 -5.7731 15.2597

    asetosal kontrol -.22000 4.56044 .963 -10.7364 10.2964

    3-klorometil -14.53333* 4.56044 .013 -25.0497 -4.0169

    4-klorometil -4.74333 4.56044 .329 -15.2597 5.7731

    Testis kontrol 3-klorometil -1.75333 3.51898 .632 -9.8681 6.3614

    4-klorometil -9.61667* 3.51898 .026 -17.7314 -1.5019

    asetosal -2.93333 3.51898 .429 -11.0481 5.1814

    3-klorometil kontrol 1.75333 3.51898 .632 -6.3614 9.8681

    4-klorometil -7.86333 3.51898 .056 -15.9781 .2514

    asetosal -1.18000 3.51898 .746 -9.2948 6.9348

    4-klorometil kontrol 9.61667* 3.51898 .026 1.5019 17.7314

    3-klorometil 7.86333 3.51898 .056 -.2514 15.9781

    asetosal 6.68333 3.51898 .094 -1.4314 14.7981

    asetosal kontrol 2.93333 3.51898 .429 -5.1814 11.0481

    3-klorometil 1.18000 3.51898 .746 -6.9348 9.2948

    4-klorometil -6.68333 3.51898 .094 -14.7981 1.4314

    Vas_Deferens

    kontrol 3-klorometil -5.49667* 1.61658 .009 -9.2245 -1.7688

    4-klorometil -8.42000* 1.61658 .001 -12.1478 -4.6922

    asetosal -2.10333 1.61658 .229 -5.8312 1.6245

    3-klorometil kontrol 5.49667* 1.61658 .009 1.7688 9.2245

    4-klorometil -2.92333 1.61658 .108 -6.6512 .8045

    asetosal 3.39333 1.61658 .069 -.3345 7.1212

    4-klorometil kontrol 8.42000* 1.61658 .001 4.6922 12.1478

    3-klorometil 2.92333 1.61658 .108 -.8045 6.6512

    asetosal 6.31667* 1.61658 .004 2.5888 10.0445

    asetosal kontrol 2.10333 1.61658 .229 -1.6245 5.8312

    3-klorometil -3.39333 1.61658 .069 -7.1212 .3345

    4-klorometil -6.31667* 1.61658 .004 -10.0445 -2.5888

    *. The mean difference is significant at the 0.05 level.

  • 93

    LAMPIRAN F

    TABEL UJI R