II[/' CALIFORNIA TUMOR TISSUE REGISTRY

"L YMPHOPROLIFERA TIVE DISORDERS"

Study Cases, Subscription A

January 2002

California Tumor Tissue Registry c/o: Department of Pathology and Human Anatomy

Lorna Linda University School of Medicine 11021 Campus Avenue, AH 335 Lorna Linda, CAlifornia 92350

(909) 558-4788 FAX: (909) 558-0188

E-mail: cttr@lin kline. com Web page: www.cttr.org

Target audience: Practicing pathologists and pathology residents.

Gila!: To acquaint the participant with the histologic features of a variety ofbenign and

malignant neoplasms and tumor-like conditions.

Objectives: The participant will be able to recognize morphologic features of a variety of benign

and malignant neoplasms and tumor-like conditions and relate those processes to pertinent. references in the medical literature.

Educational methods and media: Review of representative glass slides with associated histories. Feedback on consensus diagnoses from participating pathoiogists. Listing of selected references from the medical literature.

Principal faculty: Weldon K_ Bullock, MD Donald R. Chase, MD

CME Crejlit; .Lorna Linda University School of Medicine designates this continuing medical

education activity for up to 2 hours of Category l ofthePhysician's Recognitiori Award of the American Medical Association.

CME credit is offered for the subscription year only.

Accreditation: Lorna Linda University School of Medicine is accredited by the Accreditation

Council for Continuing Medical Education (ACCME) to sponsor continuing medical education for physicians.

Contributor: Philip G. Robinson, M.D. Case No. l - January 2002 Boynton Beach, FL

Tissue from: Left cervical lymph node Accession #29271

Clinical Abstract: On physical examination this 68-year-old male was found to have a left cervical mass.

Gross Pathology: The specimen consisted of irregular fragments of tan tissue measuring 4.2 x .18 x 1.6 em.

SPECIAL STUD rES (Outside facility): CD30 CDI5 CD45 CD20 CD3

Contributor : Boward Otto, M.D. Cheboygan, MI

Tissue from: Right groin

Clinical Abstract:

positive. positive negative negative negative

Case No. 2 - January 2002

Accession #28673

A non-tender groin mass was noticed by this 40-year-old male, gradually enlarging over two months. He denied night sweats, fever, chills, weight loss or fatigue.

Gross Patho logy: The fusiform gray lymph node measured 5.8 x 3.0 em.

SPECIAL STUDIES (Outside facility): CD30 CD20 CD3 CD43 CD 57 CDI5 EMA Kappa Lambda

positive positive positive positive negative negative negative negative negative

Contributor: K. Greg Peterson, M.D. Case No.3 - January 2002 Sioux Falls, SD

Tissue from: Right thyroid Accession #29039

Clinical Abstract: This 71-year-old male noticed a swelling in the right side of his neck. Work-up showed a mass

in the right thyroid lobe.

Gross Pathology: The 8.0 x 5.8 x 3.3 em right thyroid lobe showed homogeneous replacement of the gland by

firm gray-tan parenchyma.

SPECIAL STUDIES (Outside facility): positive positive positive scattered positivity scattered positivity negative

LCA CD20 CD29A CD3 CD5 Kappa Lambda punctate staining within the plasmacytoid cells

Contributor: Philip C. Gordon, M.D. Case No. 4 - January 2002 Winter Raven, FL

Tissue from: Retroper itoneal mass Accession #29004

Clinical Abstract: A 52-year-old male presented with fever, polyclonal gammopathy, anemia and a retroperitoneal

mass.

Gross Pathology: The 137 gram pale brown, solid, somewhat fleshy-appearing mass measured 7.0 x 6.0 x 4.3 em.

SPECIAL STUD1ES (Outside facility): CD20 follicles positive CD43 interfollicular areas and scattered c-ells in follicles positive Bcl-2 follicles negative Kappa & Lambda polyclonal staining

Contributor: Gordon H onda, M.D. Case No. 5 - Ja nuary 2002 F resno, CA

Tissue from: Cecum Accession #28487

Clinical Abstract : ACT scan done during work-up for acute bowel obstruction in this 78-year-old female showed

a complex mass in the area of the cecum. A large mass was found adherent to the cecum and a portion of small bowel, with exudates and adhesions suggestive of prior perforation.

Gross Pathology: Within the cecum was a I 0 x 9 x 9 em fungating mass that had eroded through the cecal wall

and into the mesenteric root.

SPECIAL STUDIES: CD30 CD43 CD3 CD15 CD45ro

Contributor: Pete r Morris, M.D. Santa Ba rbara, CA

Tissue from: Right ovary

Clinical Abstract:

positive positive negative negative negative

Case No. 6 - January 2002

Accession 1#28352

During a workup for lower abdominal pain, this 39-year-old female was found to have a lirm, tender, palpable mass in the right lower quadrant. A total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed.

Gross Pathology: The 453 gram ovarian mass measured 13.0 x 9.0 x 8.0 em. The cut surface was tan-white and

fleshy with a central 2 em diameter degenerative cyst.

SPECIAL STUDIES (Outside facility): CD20 CD3 Keratin cocktail Placental alka.line phosphastase S-100 Smooth Muscle Actin

positive negative negative negative negative negative

Contributor: LLUM:C Pathology Group (rc) Lorna Linda, CA

Tissue from: Left testicle

Clinical Abstract:

Case No. 7 - January 2002

Accession #28653

This 55-year-old male noticed an enlarging left testicular mass.

Gross Pathology: The 168 gram left testicle measured 8.0 x 6.0 x 4.0 em and was replaced by a tan, fleshy

lobulated tumor.

SPECIAL STUD1ES: CD20 LCA CD3 CD30

positive positive negative negative

Contributor: Rebecca L. Christensen, M.D. San Diego, CA

Tissue from: Left testis

Clinical Abstract:

Case No.8 - January 2002

Accession #29205

Following a two week history of a non-tender enlarged left testicle, an orchiectomy was performed oil this 62-year-old male.

Gross Pathology: The 5.0 x 3.5 x 3.0 em testis had a homogenous tan, fish-flesh cut surface.

SPECIAL STUDIES (Outside facility): CD20 CD45 CD3 CD43 CD45RO

positive positive negative negative negative

Contributor : LLUMC Pathology Group (rod) Lorna Linda, CA

Tissue from: Cecum & right scrotum

Clinical Abstract:

Case No. 9 - January 2002

Accession #29241

Two months after colonoscopic removal of a villous adenoma, this 76-year-old male developed a mass in the right scrotum" A CT scan of the abdomen showed a 10 em diameter cecal mass.

Gross Pathology: The cecal mass measured 15.0 x 10.5 x 8.5 em and completely encased the ileocecal junction.

There were numerous tumor nodules within the pericolic fat. The 171 gram scrotal mass was 12 x 6 x 5 em and bad a light tan cut surface with scattered degenerative cysts, an appearance similar to that seen in the cecal mass.

SPECIALS STUDIES: CD20 BCL-2 Kappa Lambda CD3 CD43 CD68

Contributor: Philip Robinson, M.D. Boynton Beach, FL

Tissue from: Left neck & right aJ:iJia

Clinical Abstract:

positive positive positive negative negative negative negative

Case No. 10 - January 2002

Accession #29148

A 35-year-old female developed axillary and left neck lymphadenopathy.

Gross J'athology: The left neck lymph node was 1.8 x 1.5 x 0.9 em. The two pale tan right axillary lymph nodes

were 2.5 x 1.8 x 1.2 em and 1.5 x 1.0 x 1.0 em.

SPECiALS STUDIES (Outside Facility): Flow cytometry showed polyclonal mature BandT cells with no overt phenotypic

abnormalities of the lymphoid populations.

CALIFORNIA TUMO R TISSUE REGISTRY

LYMPHOPROLIFERATIYE DISORDERS

Minutes - Subscription A

January 2002

SUGGESTED READING (General Topics from Rtuot Literature):

Preimplantation·Stage Stem Cells Induce Long· Term Allogeneic Graft Acceptance without Supplementary Host Conditioning. Fandrich 1', Lin X, Chaig, ct al. Nature M(!d 2002; 8(2): 171- 188.

Distinct Types of Diffuse Large B-Celll.ymphoma Identified by Gene Expression Profilin&- Alizadeh AA, Eisen MB, DavisRE, ct al. Nature 2000; 403(6769):503-511.

Tumors of the l.ympb Nodes and Spleen. Warnke RA, Weiss LM, Chan JK, et al. Atlas o/Tumor Pathology, 3,. Series, Fascicle 14, Washington D.C., Am1ed forces Institute of Pathology 1995.

lntraabdominal Follicular Dendritic Cell Tumour. A Rare Tumour in Need of Recognition. Shek TW, Uu CL. Peh we, et al. Nistopatho/1998; 33:465-470.

California Tumor Tissue Registry c/o: Department of Pathology and Human Anatomy

Lorna Linda University School of Medicine 11021 Campus Avenue, AH 335 Lorna Linda, California 92350

(909) 558-4788 FAX: (909) 558-0188

E-mail: cttr@linklinc.com Web site & Case of the Month: www.crtr.org

Case 1:

ClUe 2:

C~Ue3:

Ca.~e 4:

Case 5:

ca.,c 6:

ca.,e 7:

Ca.•e 8:

Ca.•e 9:

FILE DIAGNOSES

CITR Subscription A January 2002

Hodgkin's lymphoma, lymphocyte depleted, cervical lymph node T-08200, M-96503

Hodgkin's lymphoma, lymphocyt~predominant, groin lymph node T-Y9100, M-96503

Low grade B-cell lymphoma, MALT type with plasmacytoid differentiation, thyroid T-96000, M-95903

Castleman 's disease, plasma cell variant, retroperitoneum T-08580, M-72260

Anaplastic large T -cell lymphoma, cecum and small bowel T-50500, M-95903

Diffuse large B-cell lymphoma, ovary T-87000, M-95903

Diffuse small non-cleaved B-celllympboma (Burkitt's-like), testis T-78000, M-95903

Diffuse large B-cell lymphoma, immunoblastic type, testis T-78000, M-95903

Diffuse large B-cclllymphoma with plasmaC)1 ic differentiation, scrotum and cecum T-79400ff-67 100. M-95903

Ca.•e 10: Hodgkin's lymphoma, nodular sclerosing. neck and axilla

T-Y0600ffY8100, M-96563

Cast No. I, Accession No. 29271

BakcrsJictd - Hodgkin's lymphoma Baldwjn Pari<O<Wser PcnnQOCntcl - Hodgkin's (mixed cell)(!); Hodgkin's discasc(3) Bqy Ma - Hodgkin'sdiscasc:, mixed cell I)JlC (4) Fon!liJ1a (Kaiser PermMCD!ol • Hodgkin's, disease, clussic Haywurdlfsemoot - Hodgkin's disease, mixed cellularity Lons Beach (l.akcwoocj Regional Medical Center) - Hodgkin's disease, mixed oellulority (7) Monterey (Communily llmpita! of Mooterev Peninsula\ - Hodgkin's disease, lymph<>e)1c depl.,ioo type MoyntWn V'tCW rEI Camino Pa!hofoo Group) • Hodgkin's disease. mixed cellularity On!slood !Kaiser Pertn:!J1Cnlcl - Hodgkin's disea<e. mixed cellularity (4) O!nni<IUCI Medical Cc;ntq RL.,.ideniS) - Hodg)dn's lymphoma, mixed cellularity Sacmmcnto CUC Davis Mcdjeal Center\ - Hodgkin's disea'IC lymphocyte depleted vs. classic S!l!! !)iego /Naval Medical Ccmql - Classical l·lodsJ<in's disease, favor mixed cellularity

JanWlry l002

SMI!! Rosa (Santa Rosa Mcmoriu! Hospital\ - Hodg\in's disease, lymph depleted type (2); Hodgkin's disease (1) 5ei!A!t0001 (Pathology ServiC!CSl - Hodgkin's lymphoma, mixed ocllularity Alabs!ma CBMC Priooetonl - Hodgkin's disease. mixed cellularity Ark!I!JSA< CUAMSl - Mixed cellularity Hodgkin's lymphoma C&lgrndo !Lutheran Medical Center\ - Hodgkin· s diseuse. mixed cellularity Dclnwarc (Christiano tloonil.ol) • Hodgkin's disease, mixed cellulority E!nrlda !Baptist Hosni\!Jl) • ~lodgkin's lymphoma, mixcd collularity ( I); Hodgkin's disease(? LO vs. ccllulur phase NS) ( I);

llodgkin's disease, mixed cellularity (2); Hodgkin's vs. Ollllplastic CDJO +large cell lymphoma {Ki-1) ( I) Flori!lafMunroe Regional Mcdisasl Ccntql - Hodgkin's disease flnrjda {Pathology Asmja!cs) - Hodgkin's disease florida <Winter Ha""" Hosoi!A!l - Hodgkin's disease (I); Hodgkin's disease, mixed cellularity (I) Illinois CQu!'age Parhology Al50Ciutcsl - Hodgkin's lymphoma (I); Hodgkin'slymphoma, classical type (mixed cellularity) (I) !!Hnois <Evanson !losnitall -Hodgkin's l)mphomo Jlljnojs (Northwe.c;tcm Memorial Hospitall - ltodgkin's disea..~ Indiana (Fort Wamel - Hodgkin's lymphoma, lymphocyte-rich, c!a«ic, left cervical urea Murvl;wd (Jolms Honkio.<l lpspitol Resident) • Hod!lkin's lymphoma, favor mixed cellularity suhtypc Maryland CNJH Pathology Rcsidcnl<l - Mixed ocllularity Hodgkin's disea1e Maryland (National Noyal MediC!! Center! • Oassical Hodgkin lymphoma (fo•w mixed cellularity suhl}pe) Morvli!!!d CUnivcrsitv of M!!!ylandl - Mixed cellularity Hodgkin· s Ma'SH!cltu,.,tts @qkshire MediC!I Center) • Hod!lkin's disease. mixed cellularity Ma.~:rnchusens CBrioham 1Wd Women's Residents/Fellows\ - Classical Hodgkin's lymphoma, mixed cellulurity subtype MnssuchuscttsiNew Englund Medical Center Rcsjdcntsl - Cl!lSsical Hodgkin's lymphoma. cellular pha1c nodular sclerosis type Mjchi!:lli! ID-dkwood HosllilnJ.) • Hodgkin's lymphom!l. mixed cellularity Mjchi&J!!l fSl Joseph Mgcy !iospita!) - Hodgkin's disease. classical type Mjssi<siooi, Gulfuon • Mixed cellularity Hodgkin's l)mphoma Mis!OJuj !Truman Medical Ccp!sr) - Elodgkin's disease:, mixed cdlularily (2) Nelnaska ICrei!!lnon Universilv Sd!9o! of Medicine Residents) - Hodgkin's lymphoma. mixed cell type New Jcacv !Overlook Ho:mituD - Hodgkin's disease. mixed cellularity (2) New York fBC!h Israel MIX!icul Ccnlc'l') - Hodgkin's lymphoma. mixed cellul~rity

New York (Long Island Jewish Medical. Cen]er) - Mixed ccllulurityclassical llodgkin's l)mphomn New York !Nassau County Medical Centerl - HodsJ<in's l)mphoma. mixed cellularity, cervical New York IStonv Brook Uniysrsity Hospital Residcn!sl - liodgkln's disease. mixed ccllulority type ( II) Nonb CaroJjnafMoonmin Am! Pmhologyl - liodgkin'sl)mphoma, mixed cellularity(4) Qklohoma Es!mond - Mixed e~:Uularity classical tlodgkin's l}mphoma Pcpnsvlyunia (Allegheny (jenera! Hospital) - Hod!lkin's disease, mixed cellularity Pcnnsvlyonja Cl &high Vqllcy Hospital) . Hodgkin's disease. mixed c-ellularity l)"Pe Pcnnnlv!Ulia CMernoriol Medjcnl Center Rc>idcntsl • l lodgkin's lymphoma, L tmd H variant (2) Pupno Rico <tJnjyersjtvoC Pucno Rico) · Mixed cdluiCU'ity classka1 Hodgkin's lymphoma

TcXllS IProPath A•sociates) - Uodgkin's disease, S)DC}tial variant of nodular sclerosis-type (I); Malig)lant lymphoma, Hodgkin's syncytial cell variant of nodular sclerosing type (I)

Te<as (Scott & White Memorial Hospj!a!l - Hodgkin's l)mphoma, mixed cellularity (3) Vennont CF'Ictcher Allen Hc31thcare Centerl - Hodgkin's l)mphoma, lymphOC}1ic depletion Washington. Steilaoom - Hodgkin's lymphoma, mixed cellularity West Virginia (Greenbrier Valley Medical Cert!cr) • Hodgkin's disease, mixed cellularity Wisconsin CMeriter Health Services) - Hodgkin's lymphoma, mixed cellularity Wisconsin (St. Marv's Hosoitall - Hodgkin's di·sease Australia !North Queensland Pathology Group) • Hodgkin's disease with abundant histincytes Australia CRoval Prince Alfred Hospital) • Mixed cellularity Hodgkin's lymphoma Canada (Foothills Meilical Center) • Mixed cellularity, classical Hodgkin's lympho{lla Chile <Univcrsidad de Chile) . Mixed cellularity, Hodgkin's disea~e Japan CYnmana.•hi Medical Universirv) • Hodgkin's lymphoma, mixed type (2); Lymphocyte prcdominantrypc (I); Anapla'itic large

cell lymphoma (I)

Netherlands, Amsterdn..m - HodgJdn's l)mphoma (with histiocytes)

Case 1 - Diagnosis: Hodgkin's lymphoma, lymphocyte depleted, cervical lymph node

T-08200, M-96503

Consultation: Milton Drachenberg MD., Ph.D., "Hodgkin's lymphoma, lymphocyte depleted."

Case I -References: Cossman 1. Gene Expression Analysis of Single Neoplastic Cells and the PathogenesisofHodgkin's Lymphoma. J Hi.rtochem

Gytochem.2001; 49(6}:799-800. Grosso LE, CUllins B'l~ Dunphy CH, et al. Lymphoo;ct<>'Dcplcted Hodgin's .Disease. Diagnostic Challenges by Fine-Needle

Aspinllion. Diagn CytopaJ!ic/ 1998: 19(1):66-69. Mizoguchi Y, Okamoto M, S\IZllki H. ctal. Hodgkin's Disease Expressing Follicular Dendritic Cell Marker C.D21 Without any

Other 0 -Cell Mari<er. A Clinicopathologic Study of Nine cases. Am J Srug Pmho/1999; 23(4):363-376. Kuppers R Md Rnjewsky K. The Origin of Hodgkin and Reed/Stcmlx.Tg Cells in Hodgkin's .Disease. Annu Rev lmmunol 1998;

16:411-493.

Case No. 2, Accession No. 28673

Bakersfield • Peripheral T~lll)'lllphoma Baldwin Park (Kaiser Permanent~) - Follicular l)mphoma (2); Follicular 1)11tp.homa, mixed (2) Bav Area . . Hodgkin's disease, l)mphoc)to predominant (2); T -cell rich, B-cell lymphomo (2) Fontana IKai.er Permanemel - Hodgkin's disease, nodular lymphocyte predominant Uavward/fremont - Nodular lymphncyte·prcdominant Hodgkin's l)mphoma Long t}each Ci.altewood Regional Medical Center) - Lymphocyte-r.ich Hodgkin's disca.e(7) Montercv (Community Hospital ofMomerev Peninsula) · Lymphoma, favor low grade 13-cell Mountain View CEI Camino Pathology Group> · Lymphocyte prcdomi.nant Hodgkin•·, disea.­Oakland (Kaiser 'Permanente) - Lymphocyte rich classic Hodgkin's (4) Oranec IUC! Medical Center Besjs!ents) · HOdgkin's lymphoma, lymphoc}te predominant Sacrdl11cnto CUCDavis Medical Center) · Lymphocyte predominant nodular Hodgkin's disease San Diego !Naval Medical Cemer) - Lymphocyte predominant Hodgkin's disease

January 2002

Santll Rosa (Santa Rosa Memorjal Hospirull • Hodgkin's disease, lymph predominant (2); Nodular l~tphocyte·prcdominant Hodgkin's disease(!)

Sebastoooi/Patht>logy Services) - Follicular lymphoma Alabrunn iBMC Princeton) • Hodgkin's disease, nodular lympho(.yte predominant Arkansas CUAMS) • Nodular lymphocyte predominance Hodgkin's lymphoma Coloradp C!.u1hmm Medical Center) • Hodgkin's disease, nodular lymphocyte predominant Delaware (Christiana Hospital) . Reactive l)mph node

4 CTTR, January 2002 '"Minute.<>'' (Subsc-riplion A}

Florida ffiap!j:g Hosni!AD • 8-o:U lymphoma, follicular l)'pC w-ith mixed small and lll!ll" oells, g,:ndc U (I); Malignant lymphoma. fullicular mixed (!); ~lodgkin's disease (I); Hodgkin'sdisea<e, lymphoc)tc prcdominant(l); tlodgJ<in'sl)mphocy1e p«dominant vs. T ~~~rich B-cciii)1Dphonta (favor latter if the COS7 is negative) {I)

florida <Munroe Regional Medical Centerl - Lymphocyte predominant Hodgkin 's disease Flori<la CPathology Associates\ - Hodgkin's disco.s., T -;;ell rich B~lllymphomn Florida (Winter Haven Uoopitall • Hodglr.in's disease ( 1); Uodgkin's disease. lyrnpbocyte predominunt ( l) O!jnojs (Dyl'age l'athology Associates) · T -<ell ric:h, H-celll)mphoma (I); Fo!Ucular l)mpboma, nodul.,, grade 2 vs. other B-ccll

lymphoma (possible """Sinal zone l)mpboma?) vs. 1)1Dphocyte predominant Hodgkin's di=sc ( 1) ll!jn<Hs<Evanston Hosnilal) ·Nodular l)mpbocytc pn::domi.oMl Hodgkin's D!jnoisfNonhwCS!cm Mernorinl Hosoimll • Lymphocyte predominant HodaJc,in's disease

Indiana (fort Wa,11c\ • ALCL (8-<:elll)'pC), right groin Mnrylund (Johns Hookjns Ho;;pjta! Resident) • l'rogrc.o;sive uansformotion of germinal centers. rule out nodular l)mphocyte

predominant disease Mwxland (NIH Patllolnsy Residents) · Progressive <runs formation of gcnni1 .. 1 centers MarvJand !Natjona! Navel Medical Center) · Nodular l)mpboc}te prcdomillJlllt llodgkin's l>mphoma Marytand CUnhmiiYofMPQ1and\ · Nodular lymphocyte predominant Hodgkin's MassaehusettsC!lerlsshire Medical Center) • Hodpin's disease, lymphocyte predominant Mu.<.,achusctts CBrioluun and Women's ResidcnlYfclb>w.;) - Nodular l)mphoc)tc predominant tlodpin's l)mphoma MassachuscttsCNew llnalnnd Medical Center Rysjdemsl -Nodular l)1Dphcx:ytc predominant Hodgkin'slymphoma Michigan (Qak·woqd Npsni~1ll • liodgkin's lymphoma, lymphoc~tic predomlonnt Michigan 1St. Joseph Mcr~y Hospjtall • Hodgkin's disease. nodular sclerosis vs. nodular lymphoc)te, prcdomiOUJU type Mj.sissiooi. Oulli>on • Nodular l)mphocytc predominant liodgkin'sl)mphoma MjW!!!ri <Truman Medical Cen!e.) - Hodgkin's disease, OO!Kiassificd (2)

N!;bra:ska (Crei!!hton Uniymjtv Scl!qgl ofMedjcinc ResidentS) - Uodgkin's l)mphoma, l)mpboc)te predominant Nw Jersy (Overlook I !Mpitall • Progressive trunsfonnation of genninnl centm (2); ? nodular l)mpboc)te predominant HodaJc.in's

di:ICl!Se (I) New York CQeth lsQJcl Medical Center) · NoduiRr lymphoc)tic prcdominantl lodgkio's l)mphomn New York (Loog Js lnu~ Jewish Medical Ccntgl - Favor nodular lymphocyte predominant Hodgkin's lymphoma New York (Nassou CouJl!y Medical Center) • Hodgkin's lymphoma. nodular l)mpbocyte prcdominwu New York fStonv Broo!s Unjyroilv Hosniinl ROi!jden!sl - Hodgkin' s disease, lymphoc)1c predominance l)'pC (II) Nonh Carolina !Moumajn An;a Pathology) • T -cell rich. B-«11 1)1Dpboma ( 4)

Okloboma Edmond • Nodulor l)mpbocyte predominant Hodgj<in'slymphoma l'ennsylvaniaiAllcehcny Go'!!Cra! H!ll!pjtaD - Lymphnc)tc predominant i'lodpin's l'cnnsylvonia <Lchioh Vul!cy Hospital) • Hodgkin's disease l)mpbocytc prcdominanl type

Pennsylvania IMcmorjal Medical Center gcsjdcmsl • Hodgkin's lymphoma, L & H variant (2) Puerto Rico C!Jnivcrsity o!'Pys:no Rjcol - Nodular 1)1Dphocyte predominruu Uodgkin's lymphoma vs. diffuse B-oell lymphoma T-

oe II rich Tli!Sas CPro!'!l!h A£i'XiaJesl • Malignant lymphoma. Iorge oel! (T -cell iype) (2) TCI!as !Soo!l<l Wbite M!;morinl HC>Soitall · Hod!JI<in's l)mpboma. l)mphoqte predominant (3) Vs:nuont {Flqchq Allen He;,lthcan: Center) • l'rugrcssh'e transfOrtnntion of &"rtninal center W"shington, S!cilacom • Nodular l)mphocyte predominant Hodgkin's 1)1Dphoma West Virginia (Greenbrier Valley Medical CCnt<a:) • Follicular 1)1Dphoma Wisconsin <Meri)Cr llcQ!lh Services) • Hodgkin's lymphoma, 1)1Dphocytc prcdomiOWJt Wj:;consin (St. Mary's llospj)ol) . Nodular lymphoc)1c-rich classical Hodgkin's l>mphoma 1\u.<tralia (North OucenSIMd f!J!hologv Orouol • B«<llymphoma wi1h rcao'tivc T -«lis Australia <Ro''BI Prinoc Nfm! liospiml\ • L)mpboc)te-rich classical Hodgkin'sl)mphoma (DDx: Nodular l)mpboc.')tC

predominant Hodgkin's lymphoma) Cana4a(foothills Medical Cento-l - Nodular l)mpboc)tc predominantllodpin's lymphoma Chile f\lniversidad de Cbjlcl • Nodular lymphocyte predO<!Jinant Hodgkin's dist11S< l!ollli'• (Yarnanashi Mcdjgd l/nivcrsi!Vl - Hodgkin's lytnphoma, nodulnr lymphocyte predominan! type (3): Mnmlccclll)11lphonw

(I)

Ncthcnands. Amsterdam • Lymphoc)1C rich cla..,ica! liodgkin's lymphoma

C'rrR. January 2002 .. Minu1n'" (Subscription A)

Casel- Diagnosis: Hodgkin's lymphoma, lymphocytic-predominant, groin lymph node

T-Y9100, M-96503

Consultation: Milton Drachenberg, M.D., Ph.D., "Lymphocyte-predominant Hodgkin's lymphoma with co-existent follicular lymphoma.»

Consultation: William G. Finn, M.D., University of Michigan, "Hodgkin 's disease, nodular lymphocyte predominance type.

Case 2 - References: Harris NL, JaOe ES, Sie.in It ct aL A Rc,>ised European-American Cla~sification of lymphoid Neoplasms. A Proposal from me

ln.ternational L)mpnoma Study Group. Blood 1994; 84(5):361-392. Regula DP, Weiss L.M, Warnke RA, et al. Lymphocyte Predomillllnec Hodgkin's Disease. R<.'llppraisal B""cd on Histological and

lmmllllOhcnotypical Findings in Relapsing Cases. Histopatho/1981; II(II):IJ07-1120: . Poppema $. L~mphocyte-Ptedominance Hodgkin's Disease. Semin Diag Patho/1992; 9(4):257-264.

Case No. 3, Accession No. 29039

Ba1cersfield - Plasmat)10ma Baldwin Plltk<Kaiscrl'crmanc:ntc) - L}mphoplasmacy1ic lymphoma (3); Plasmacytic lymphoma (I) flay Area - B-cell lymphoma, plasmaC)1oid type (4) Fontana CKajser Permanentel • P1asmac..-ytoma

Hayward/Fremont - Lymphoplasmacytoid lymphoma l&ng Beacl! !La!;ewood Regional Medical Center) - Plasmacytoma (7) Monterey ICommunitv Hosnital ·ofMonierev Penjn<ulq) - MALToma with plasmacytoid features Mountain View CEI Ounino Pathology Group) - Lymphopla~macy1oid lymphoma Oakland (Kaiser Permaneme) - Plasmacytoma (4) Orange IUCI Medical Center n e,<ident<l - Plasmacyrio.lymphoma Sacramento ffiC Davjs Medjeal Cemerl - MALToma with plasmac)10id lcatures San Dieoo !Naval Medical Center) - Extranodai matgi!lal rone 8-celllymphoma

January 2002

Santa Rosa CSan!a Rosa Memorial Hospilllll - Low-grade B-oelll)mphoma, MALf or l}mphoplasmacytoid type (3) Seba<toool (Pathologv Services\ - Plasmacyloma Alabama CBMC Prince!Qnl - Malignant lymphoma, plasrnQC)1ic Arkansa.< llJAMS) - Extrunodal marginal zone B-eell l}mpMma (Mo\L n, thyroid Colorado CLuthernn Medical Center\ - MALT vs. ext111llledullary plasmacytoma Delaware IChriS1iana Hosoitall - Plasmacytoid l)mphoma F!orjda IBamist Hosoita!) - Extramedullary plasmacytoma {I); Plasmacy1oma (2); Malignant J~mphoma, small lymphocytes,

plasmacytoid {I); Plasmacytoma {also cooside~·cd, pla<mac)<oid B..:ell lymphoma in view of LCA and CD20) (I) Florida CMunroe Regional Medical Cenrerl - Myeloma/plasmacytoma Florida !Pamology A.sociate.<) - Ma!ignam lymphoma with plasmacytoid features. MALT Florida !Winter Haven Hospjtall - Plasmac)1oma (2) Illinois (Oul'agc Patho!osv A<.<ocimes) - Plasmacytoma/multiple myeloma ( I); Plasmacytoma with residual reactive l)mpltoid

rissue(gennbJal centers)(!) lltjnois fl>vanston Hospital) - Lymphoplasmac)<ic lymphoma llljoojs !Northwestern Memorial Hospital) - Lymphoplasmacytic lymphoma Indiana !Fort Wavncl • Plasmacytoma, tl1yroid gland (plasmacytoid immunoeytoma) Maryland Oohns ~opkin'i Hospital Resideml - Extranodal roatgioal zorje l)'mphoma witll extensive plasmacytOid teaturcs Marvland fN1H Pad1ology Residents) - Lymphopla.smoc.:ytic lymphoma , .•. marginal rone lymphoma Marvland !National Naval Medical Center) - Ex{I'Qnodai marginal ronc B-colllymphoma of mucosa associated l~mphoid tissue

(MALT lymphoma) Marvland IUnj,.crsitvofMarvlandl - Extramedullary plasmaL')'IOma Ma..sac!Juseus <Berkshire Medical Center) - PlasmaC)1oma

6 CTTR, January 2002 MMfnutes" (Sub$Cription A)

Ma..sachusotts CBrj!!ham !lJ)d Women's Residents/Fellows) • Extrllnodal margimd zone 8-<:elllymphomo (MALT lymphoma) apporently arising in a backgrowld of Hashimoto tb)TOiditis

M•ssarbmttslNew Enoland Medical Ccnta Residents\ • MALT lymphomo with pro!lOIIIlo:d plasma ccll oomponent (cxtrnnodal omrgjnai2100C 8-<elllymphoma, MALT type)

Michil!l!!! COokwoocl UwitaD • Noo-Hodglcin"s lymphoma. fl..celllymphoplasmacytic Mjchjl!l!!! <St. JO!!sob Mqcy Hospjtall - L>mphopla<macytoid lymphoma ML<.<issiwi. C'111llj!ort • MALT lymphoma Miwwi CJruman Medical Ccoter> - MALT l)mphoma with pla.smacytic di1Terentiotioo (2) Nebra.<!ca CCrcjgbton Univ<~ity School of Medicine Residents\ • MlV!Iinal :rone lymphoma with plasmacytoid dilli:rcoti!llion New Jec!QY !Oycr(ook. Hoopita!l - 8-<eU lymphoma with plasmacytoid features (2) N•w York !Beth Ll[aol Medical Center) - MALT New York l!,ono Island Jewish Medical Cemql - Lymphoplo..macytic lymphoma New Ymk !No.<.<An County Medical Center) - Lymphoplusmuc)'lic lymphomu, thyroid New Y<>rk ISwny Brpok Uniycrsitv HospjJ!!I Residents\ - Plasmacytoma ( II ) North Qvolina (Mountain Area Pathology) • Plasmacytoid smallll~ll l)mphoma (2): Plasma0)10rna (I); MAI; r lymphoma with

plasmac)10ld dlfl'erentiation (I) · Oklahoma. Edmond • MALT l)mphoma Pennsvl\1!Jlja!A!Iegbcoy Geoera] Hosoitall • Lymphoplasmacytic lymphoma Pennsylvania CLebjgb valley HospitaD • DiJfusc Iorge 8-lllymphoma ofplo.scnac>1oid type

PeMS>jvanjo/Msrporjal Medica! Ccnter Residents\ • Th)roid, MAl.Toma (2) I'Ue!lo Rim 1\Jnjymity of !'IJe!!9 Rjg>) • l..ymphoplasmacytie lymphoma Texa.< CPmPmh AMgciatcsl - Plasmacytoid lymphocytic l}mphoma (2) Texas ISM!l & White Memorial Hospi!all - Plasmac)toma (3) Vermont lfletcbcr Allen Hcalthcarc Center\ - PlasmaC)1oma ~ston Steil!lCQm • Plasm~U.'}10ma Wes1 yjr11joia COrccnbricr Valley Medica! Cemerl - Maligmmt lymphoma. MALT \Visoonsjn (Meriter llealth Services) • Lymphoplasma<.')'lic lymphoma \Visconsjo !SL. Mnry's Hoopitall - Low gnlde 8-celllymphoma of MALT vs. lyrnphoplasmac)1ic lymphoma Australia CNorth Ouc:eusland l'arhology Grounl • Myeloma; DIITcrcnlilll Dx: Diffuse plu:;macytoid 0-celllymphoma Australia ! Royal l'rinee AI fred Hospital\ • Extrd!lodal marginal 7.0nc lymphoma (MAL n of th}TOid Ca.nad!! (fOOJbjl!s Mcdjcal Center! • El.'tl'al1odal marginlll zone 8-cell lymphoma ofmuC!!Sal associated l)mphoid tissue Chile CIJnivqsjda!l de Chile) - Pla.<macytoid lymphoma Japan IXADJ(l!U(I;hj Mc<lical Uoi\'g'Sjtvl - Non-Hodgkin's lymphomL MALT type (2); Diffuse large 8-<ell (I):

Lymphoplasmacytoid (I) Nctbqlaruk, Amsrn!am - L)mphoplasrnac)1ic immunoc)'loma

Case 3- Diagn05is: Low grade B-ee!! lymphoma, MALT type, with plasmacytoid differenliatioo. thyroid

T-96000, M-95903

Coosultatjon: Paul Kurt in, M.D., Mayo Clinic, "Low grade B·celllyrnphoma, MALT type, with plasma cell differentiation."

Case 3 • Rcfcr~n\i!:S: Matsuzuku F, Miyttuchi A, Katayama S. clal. Clinical Aspco1s ofPrimW"y llJyroid LYJnphoma. Diag11osis and 1'rcatrncnt nosed on

Our Expcricnoc of 119 Cases. 17o,.oid 1993; 3(2):93-99. Wi117fcld OA, Winston JS. Hicks WL. et al. Oinical Presentation and Trcatmc111 ofNon·Hodgkin's Lymphomo of the Thyroid

Gland. AturSwg Onco/2001; 8(4):338-341. Oelal AA, Alla.m A. K311dil A. et ill. Primary Th)TOid L)mphoma. A Rctrospecth·e Anal}-sis of Prognostic FllOOli'S and Trcauno:nt

Ou1oome for Localized Intermediate aod High Grade Lymphoma. Am J Clin Onc41200J; 24(3):299-305. Ogawa X. Klllo X, ll:eda K. ct al. The ValucofUitn!SOUOd.<Juidcd f'inc-Nccdic Aspiration C)1ology for Th)Toid Nodules. An

Asscssrncttl oflts Diagnostic Potential and Pi•fulls. Surg T~2001; 31(2):97-101. Takalcuwa T, DoogZ. Taka)11mll H, et al. Frequent MuiBiions of FilS Gene in Th)roid Lyrnphomo. Cancer Res 2001:

15;61(4): 1382-1385. Satabc GO. P!llhogt'OI!llis ofTh)Toid Nodulc:s. Histological Cl3.'1$ificotion? Biomed PhormtlC()Iher 2001; 55(1):39·53.

C'rfR. lonuory 2002 "Minules" (Subscriplion A) 7

Case No. 4, Accession No. 29004 January 2002

Balqmfield - Plasma cell type of giant lymph node, Baldwin Park/Kaiser Pennanente\ - Castleman's diS<:aSe (I); Castleman's, plasma c:.:ll variant (3) Bay Area - Nodular lymphoma, incipient (l); Plasma cell variant of Castleman's disease with incipient lymphomatous

transformation (3) Fontana (Kaiser Permanente\ - Castleman's disease, plasma cell type Hayward/Fremont - A!LD (what is CD43?) Long Beach flakcwood Regional Medical Center) - Castleman's disease, plasmac}1oid variant (7)

Monterey <Communitv Hospital of MOnterey Peninsula\ - C&1lcman's disease, plasma cell type Mountain View CEI Camino Pathology Group) - Castleman's disease, plasma cell variant Oakland (Kaiser Pcnnanenle) - Castleman's disease (4) Orange CUCI Medical Center ResidenJS\ - Angioimmuncblastie lymphadenopathy Sncrnmento IUC Davis Medica1 Center\ - Castleman's disoose San Diego (Naval Medical Center) - Plasma cell Castleman's disease Santa Rosa (Santa Rosa Memorial Hosoitall - Castleman's disea.1e, plasma c:.:lltypc (2) vs. plasma cell dyscrasia (I) Sebastoool <Pathology Service.<) - 1l-<:ell follicular lymphoma Alabama CBMG J>rjnceton\ - Castleman's disease, plasma cell type Arkansas CUAMS\ • Castleman's disease, plasma cell variant (multicentricisyst<-mic Castleman's disease) Colorado O.utheran Medical Center\ - Plasma cell Castleman's disease Delaware CChri§!jana Hospital\ - Plastnac}1oma Florida ffiap!ist Hospitall - Hyaline vasculwtype Castleman's disease(!); Ca'>tleman's disease, plasma cell type (I); C&1leman's

disease, plasmaeytie variant (3) Florjda (Munroe Regional Medical C-enter) - Plasma oeiJ Castleman's disease F lorida CP31hology Associates) - Castlemun's disease ·Florida <Winter Haven Hospital) - Castleman's disea.e (2)

l llinois (DuPage Pathology Msoclmes\ - Casileman's (I); Plasma cell varirutt of Castleman's disease vs. marginal zone lymphoma extranodal MALToma (I)

Illinois !Evanson Hoopital\ - Gas! Ieman's pla.<ma ceiJ type lllinojs (Northwestern Memorial Hospital) - Plasma cell variant of Castleman's lpdjana (Fort Wavnel • Multicentric Ca'>tleman's, <etroperitooeal Marvland (Johns Hopkins Hospital Resident) - C1Stleman' s disease. plasma ceiJ type Marvland (NIFI Patltology Residents) - Castleman's disease, plasma cell variant Maryland <National Naval Medical Center) - Plasma cell CasUeman's disease Marvland CUniver5ityofMarvland) - Cas~emao's di~e

Massachusetts CBerkshire Medical <'&nter} - Castleman's disease, plasma cell variant Massachusetts <Brigham and Women's Rcsidc'llts/Fellows) • Castleman's disease. plasma cell type lvtassachusetts(Ncw l;ngland MedlcaJ Center Resid<.."Tlts) • Castleman's disea.:oe. plasma ceiJ varinnl Midtigao fOak\vOO<J Hospital) - c;,.tleman's disease, plasma cell variant Michigan CSL Joseph Mqcy Hospital\ - Castleman's disease, plasma cell type Mississippi. GuUDort - Castleman disease, plasma cell type Missouri !Truman Medical Center} - Castleman's dc<~<e (2) Nehra<>ka(Creighton Uni\·ersitv School ofMedjcine Resjdemsl - Castleman's disease, plasmacytoid varion1 New Jetse>' (Overlocl< Hospital) • Castleman's disease. plasma cell type (2) New York CBeth Israel Medical Center\ - Castleman's disease New York fl..on•lsland Jewish Medical Ceoterl - Castleman's disease, pla~macell variant New York (Nassau Countv Medical Center) - Casllemao's disease, rd icperitooeal mass New York (Stony Brook Uoi\•ersilv Hospital Rcsidenis\ - Castleman's disease plasma cell type (I I) North Carolina CMountain Area Pathology\ - Cas1leman's disease, plasma cell variant (4) Oklahoma, Edmond - Ca~tleman's disease Pennsylvania {AIIeghenv t".ener.il f·lospjta!l - Castlcman·.s disca'i~ plasma celt varianl Pcnnsvlvania <Lehigh Vallev !·!ospjtall - Plasma cell variant of Castleman's discaw

8 CrfR. January 2002 "'Minutes•· (Subscriplioo A)

Peonsy!vanialMcmorja! Medical Center Residency) • Mulricmtric Castleman's disease, plasma cxll variant (2) 1'\icrto Rico <University of Puerto Rioo\ · Castleman's discesc. plasma ex II variant Texas CProPath A"'oci•uru · Plasmacytoid tonn ofCa.tleman's disea~e (2) Texas CSoott & White Memorial tfospiJaD • Costlemun • s disease (3) Ycnnont (Fietcbet Allen Hg!lthcare Center) · Cn.tlem1111' s disease Washington. Stejlarom • Ca.Ucman's disease, plasma cxll variunt West Virginia <Greenbrier Y!!llcy Medical Ceruer> • Rcacri,·e hyperplasia WisoonsinfMeriter Hshh Scryicxs) • Cas! Ieman's discosc WiSOO!lSin 1St. M81V'S llo!!Pita!l • Castleman's disease. plasma cxll variant t\11.\trolia !North Oueensli!Od Pothology Gn1Uol • Myeloma; Differential Ox: Diffuse plasmacytoid B-ee!! l}tuphoma Australia (Royal Prinoe Alfred Hospital) • Ca.tlemw>'s disease (plasma cell variW11) Cnnqda (Foothills Medlcttl Center) • Ca<tlcman's <Jiscasc, plosma cell variant ChilciUniversidad de Chile\ . Ca.tlemnn's disease, plasma cell t)llC

Janan Cvamana<hi Medico! Unjversitvl . Castleman's disease(J); Peripheral T-<:elllymphoma associatod with hemophugocytMis (I)

NL1halands. Amsterdam • Casllcman 's, plasma cxllular type

Case 4- Diagnosis: Castleman's disease, plasma cell variant, retropcritoneum

T ·08580, M-12260

Consultation: Milton Drachenberg, M.D., Ph.D., ''Castleman's disease (angiofollicular lymph node hyperplasia), plasma oell variant"

Case 4 • References; Menke OM and OeW•Id GW. Laek.oi'Cytogenctic Abnormulities in Castleman'$ Disease. Scurh Met/ J 2001: 94(5):472-474. O.ma U, Curcoglu S, Yaldiz M, et al. Castlemru1's Disca.o;c (Giant Lymph Node l~ypcrplasia) oft he Neck. A Case Report. Eur

Arch Otorhino/aryngo/2001 ; 258(1 ):42-44. Hsiao CJ. f<lsu MM. l,.cc JY, a at P.araueopla~ric (>cmphigus in Association with a Retroperitoneal Castleman's OiSct~Sc. Presenting

witb a Lichen Planw; Pcmphigiodcs-Lik.e l)ruption. A Case Report and Review ofLitcralure. Br.l /.krmalo/ 2001: 144(2):372· 376.

Tch US. Un MB, Tan AS. c1 al. Retroperitoneal Casllcman's Disease in the Perincpltric Space-lmagjn& Appcar.lllCC and a Rcvic~• of the Litcr81\rt. Ant• lkad Med Signopore 2000; 29(6):773-776.

Riccio A, Natale D, Peninato G. cl al. Castleman· s Oisea'IC. Ami Rheum DU 2001; 60(2): 176.

Cnse No. 5, Accession No. 28487

llakmfield - Annplaslic Iorge relll)mphoma Boldwjp Park (K•igr Pmn8!JC!)te\ - Diffuse large cclll)mphoma. anaplastic (3): Anaplastic l)mphoma (I) !Jay Area - AnaplilStic lnrge celll)mphoma (4) Fontana (Kal<e< Pcrrnancll]C) • Anaplastic IW"ge cclli)Tnphoma Huywa«Vfremont ~ Anuplustic Jacge cell lymphoma 1 ,on• lleacl1 (Lakewood llcllional Medical C'.<!mcr) • Anapla"t ic large cell lymphoma (7) M<mtcrey!Commuojty Hospital oi'Momerev Penln•ulal - T-cclllymphomu. pMsible E.A.T.L. Mountrun View (El Camjoo l'a!hology Group) • Large cell !)mphoma Oakland (Kai:;qJ'qmansotc\ - Anaplastic large oclll)mphoma (4) OnwSS IUC! Medical Crncr ResidentS) • Ki- I anapl11$1ic l)mphoma Socrd!Tlcnto IUC Davis Mcslical Center) • llodl)kin's disease Sun Diego rNa val Mecllca! Center) · Anaplastic large ccll lympbomo Santa Rosa<Santa Rosa Memorial Rospitan • AntlJ>Ia,tic large ccll lyrnphomn, Ki· l positivG (3) Sc)r.~Stoool (1'\ithology Seryiccsl • Hodgkin's lymphoma. lymph depleted Alai>ama !BMC Prinoc!QO) • M!!lignantlymphon>o, large cell anaplastic Maruas IUAMSl • AnapiOSlic lwgc cclll)mphoma Colorodo (Lutheran Mcs!jcul Cmerl • Hodgkin's discasc,l)mphoc}1e dcpiCic-d

January 2002

9

!)elawnre fGhdstjana Hospital\ - Aoi!J'Iastic large cell lymphoma Florida (Baptist Hoooimll - Ani!J'IasticJG-IIymphoma (!);Malignant l}mphoma, anaplastic Ki-1 0); Malignanllymphoma, diffuse

large B-cell (l); Malignant l)mphoma. high grade prob Ki-1 + T-cell (I); Anaplastic large cell lymphoma CD30 + \'llriant (Ki-1) (l)

flori<fa (Munroe Regiopal Medical Center\ - Ani!J'Iastic large celllympboma Florida (pathology ASsociates\ - Anaplastic large celllymphQma Floritm (Wjnter Haven Hospital) - Mi<ed smrul cell, large cell lymphoma (1); Anaplastic IIITge ceil lymphoma (I) Dlinois (DuPllgc Pathology Assoeiatcsl - B and T-cclllymphoma (I); Cecum CD20? LCA?, other T -cell markers?, diffuse large

cell B-cell lymphoma vs. anaplastic large celll)mphorna vs. peripheral T-ocll lymphoma·(l) Illinois (llvanston Ho.spicill -Anaplastic large celll}mphbma llljnojs CNQf1hwestern Memorial Hospital) - Anaplastic large disease cell lymphoma lndjana Cfort Wayne\ - Anaplastic large cell lymphoma, cecum Marvland (Johns Hopkins Hosoital Resident) - Anapl.,1ic large cell lymphoma (would perform (ALK) immunostain) Maryland <NIH Pathology Residents) - Anaplastic large cell lymphoma Marvland (National Naval Medical Center) - Anaplastic large cell l}mphoma Maryland IUnivefl!ily pfMarylandl - Anaplastic large cell-lymphoma Massachusetts CBeri<shire Medical Center\ - Anaplastic lwge cell l}mphoma Massachusetts (Brigh!IJ'O and Women's Rcsident'II'Fellows) • Anapla.stic large cell lymphoma Ma,ssachusens !New England Medical Ceni<.T Residents) • Anaplastic lymphoma, T-ccll type Michigan {Oakwood Hospital) • Non-Rodgkin's l)mphoma, T -<:ell, anaplastic large cell type

Michil?llll {St. Joseph Mercv Hospital\ • Anaplastic large cell lymphoma Mississipni Gulfuori • Anaplastic large eelllymphQma Missouri <Truman Medical Center) • Anaplastic large cell l)mphoma (2) Nebraska <Greighlon !lnjyersjty School of Medicine Resjdents) - Malignant l)mphoma, anapl.,'tic large cell type New Jersey (Overlook Hospital) • Diffuse large cell lymphoma (2); \\;th immunoblastie tearures (1) New York rileth Israel Medical Center\ • Anaplastic lymphoma New York (Long Island Jewish Medical \.enter\ - Anaplastic large cell l)mpboma (I) New York CNassau County Medical Center\ • Ani!J'Iastic T -cell lymphoma, cecum New York CStony fll'll9k Univenhx Hoooj!al Residents\ - Difiuse large (1-celllymphoroa (I t )

Nortb Carolina IMountajo Area Pathology) - Anaplaslic large cell lymphoma ( 4) Okhlhoma. Edmond - Anaplastic large cell lymphoma Pennsylvania (Allegheny General Hospital\ - Anaplastic large cell lymphoma Pennsylvania (Lehigh Vallcv Hospital) • Ani!J'Iastic large cell l)mphoma l'<."DnSylvania (Memorial Medical Center Residents) - Anaplastic large cell lymphoma (2) l'l1eno Rico flJni\'crsity of Puerto Rico) • Anaplastic large T -celll}mphoma Texas CProPath Associates\ • Ki-1 l}mphoma ( I); Anaplastic large B-eell lymphoma ( I) Te.as I Scott & White Memorial Hospi!all • Anaplastic large cell lymphoma (3) Vermont <Fletcher Allen Hcalthc:ire Center) • Anaplastic large cell lymphoma, B-ceU lypc Wa<ihington Steilacom • Anaplastic large cell lymphoma West Virginia (Greenbrier Valley Medical Center) - Large T <ell intestinal lymphoma Wisconsin IMeriter Health Services) • Anaplastic large cell lymphoma Wisconsjn !S1. Mary's Uospilal) - Large cell lymphoma AUSI!jllia <NooJl Queensland Pruho!ogy Groun> - Diffuse large cell U-cell l)•mphoma Australia <Royal Prince Alfred Hospital) - Anapla:.1ic large cell lymphoma Canada CFoothills Medical Ccnlcrl • Anaplastic large ccll l)mphoma Chile IUnivcrsidad de Chile) - Lwsc cell anaplaslic l)mphoma "T'' cell type

Japan (Yarnanashi Medical University) • Non-Hodgkin' s lymphoma, anapl.,1ic large type (3); Adult T -eelll)mphoma (I) Netherlands. Amsterdam - L!JJ'ge cell anaplastic lymphoma

Case 5 .. Diagnosis:

10

Anaplastic large T-cell lymphoma, cecum and small bowel

T-.50500, M-95903

CTTR.. Jam1:uy 2002 ··Minutes" (Sul)sc.ription A)

Consullatjon: Milton Drachenberg, M.D., Ph.D., "Anaplastic large cell lympboma, T-cell type."

Case 5 - References: Chan JC. Oasuointcstinel Lympbomos. An Overview \\ith Emphasis on New Findings and DiagJIOSrlc Problems. Scnln /)jag

Pmhc/1996; 13(4):260--296. Lewin KJ. R8nthod M and Oorfinan RF. Lymphomas of the Goslrointestinal Tract. ASrudy of 117 Cases Presenting wilh

Ga•trointcstinal Disease. Cancer 1918; 42(2):693-707. Orody WW, Mnsidson JG, Weiss LM. et al. Gastrointestinal Lymphorn ... Immunohistochemical Srudicson the Cell of Origin. Am

J S urg Patho/ 198S; 9(5) :328-337.

Case No. 6, Accession No. 28352 Janunry 2002

Bakersfield • 8-<>CII large cell lymphoma, intcrmedintc &rodo Baldwin Pgrk fKulssr Pq mancntel - Diffilsc large 1}-ccll lymphomll. anaplastic (2); large B-ee II lymphoma (2) Bay AI'Sll • Oi Ausclargc U«ll lymphoma (4) l'on!Ma O<aiscr Pcgp!l!]cntcl · Diffuse large B-ccll l)mphoma Havwardlf!l3!l9!lt . Uigh grade U-<:elllymphoma !.mg flcach O.aJscwooc! Rcgjooa! Medical Cen!er) • Large tell l)mplloma (7)

Monterey <Communi!)' Hospital afMO!l!erey peninsula) • B-cclli)1Dphoma. diffitse large ocll Mountain View CEI Camino Palhology Groo!!l · Large tell lymphoma Oakl!l!]d CKaiser Ppmancntc) · High grade B-<:<11 lymphoma (4)

Oranoe CUC! Mcdjc-•1 Center Residents) • Diffuse large ll·cell lymphoma Saqnmonto fUC Dnyis Medical Center) • large U-<:elllymphomu San Diego CNavnl Medical Center) • Difli"" I urge fl..:ell lymphoma Santa Rosu ISun!U RosQ Memorial Hospital) • B-<:<11 diAusc hu-ge cell lymphoma (3) Scba1tnpo! (J)mhology Services) · Sarcoma \'S, lyrnphonHl involving f811opian tube Alabama fBMC Ptincc1on) • Mal ignant l}mphoma, large cell Arkaosus !Ui\MSI • Diflusc large B-<:ell lymphoma. ov:u-y (follicular ocntcr B..:cll lymphoma. large cleaved cell type. dlil'use, with

associated sclerosis) Colorado lkullun n Medical Ccnta-\ - Diffuse large B-ce!llymphoma Dcla"'ll'll ICbrisiaoa l lospitall • MetaStatic smail-<:lca•·od oclllympboma Florida @aJlliSI Uosphall • Diffuse large cell lymphoma (I); Malignant lymphoma. di!fuse large clea•'Cd wilh sclerosis (I);

Malignant lymphomll. U-<:<11, mixed large and small (I); Diflilse large cclll)mpltoma faey large clca,,ed cell ( I); large ocll lymphomo, diffuse; clea•-ed (I)

flnrida IMtJI!!l!S Rcgjonal Medical Center) • Diffuse large U-<:elll)mphoma Florida !Pnlh91ogy 1\.<sociatcs) · large B-<:ell lymphoma Florida !Wimer Haven Hospital) · Anaplastic lymph9ma {I); L.ar~~t ccll l)mphoma, diffitse (l) Illinois !DuPngel'nthology Associates) . B-cclll)mphomallcukcmiu ( I); Diftitse large cell B--<.-ell l)mphoma, ovary (I ) Illinois !EV!LnS]!HJ Hl>Spitttl) -large ceU lymphoma Illinois <Northwe<tero Memorial Hospital! • B-<>:11 oon-l lodgkin 's lymphoma Indiana (Fort Wume\ • Large B--cc:JIIympboma, spindle tell type, right <wary Mnryland (Johns l lqnkins Hospital Resident) · Diffuse Iorge B-ccll lymphorno Maryl!l!]d CNIIjl'!I~JOlogy Residents\ · DiffiiSe large ll-tell lymphoma Maryland 1Nu1ional Naval Medical Center) • Diffuse large 0 -<:ell l)mphoma Maryland !University of Maryland) • Diffuse large B-et !I l)mphoma Ma.'!SJ!chUS£!!SIIlerbhire Medical Ccotcr) • Diffuse large ll-<:ell l)mpboma M"Wdl!•gn•(Qrigbam and Women's Rcsidcnts!FeJtow$) · l)iffusc large B~11 1ymphoma

MllSSJic:busctt< INc!!· F.n2land Medical Center Resident<) • Diffuse JW1" B-<>elllymphoma Michi!!liJl !Oakwos•J HOI!!!j!all . Non-Hodg)cin' s l)mphoma. o .... u. diftitsc large a:ll. anapl851ic variant Michi!!M ISJ. Josg>h Mqcy Hospital\ • Diffitse large B-<:elllymphoma Mi.si1.~noL Gulfuort - Diffuse large U-<:<11 l)mphoma Missnurt ITrum;UJ Medical Center) • Non-Hodg!dn's lymphoma. diffuse large U-<:<11 type (possible anapi3Stic larf:c cell l)mphoma,

O..:cll type) (2)

CrrR, J•nu•ry 2002 "Mutut.,•· (Subscription A) I I

NehraskaCCreiohton Univcr.;itv School ofMe<Jicinc Resident<\ - Diffuse B-celll~mphoma New Jer.;ey (Overlook Hospital) - Diffuse large cell lymphoma (2); B-cellcype, cleaved (I ) New York (Beth Israel Medical Center) - Large B-celllymphoma New Y<!tk (Lon•l<land Jewish Me<lical Center) - Follicular dendritic cell sarcoma New York <Nassau County Medical Cenrer) - Large ~II lymphoma, ovary Now YorkCStony Bril<>k UniverSity tlospiral Residents\ - Diffuse large B-cell lymphoma (1 I) North Carolina <Mountain Area Pathology) - Large cell B-cx:lllymphoma (3); Diffuse large B-ee! I lymphoma (I) Oklahoma. Edmond - Spindly large B-oclllymphomll Pennsylvania (AIIegj]eny General Hospital) - Large cell an.1plastic lymphoma Pennsylvania (Lehigh Valley HnspitaD - Anaplastic large cell lymphoma Pennsvlvania (Memorial Me<lical (',enter Re,<idenl<) - f·Ugn grade 1,!-cell lymphoma (2) Puerto Rjoo OJojverojw ofPue!!O Rjco) - Diffuse large B-celllymphoma Texas CProPath Associates) - Malignant lymphoma, large B-ccll type (2) Texas (Scott & Vihjte Memorial Hospital\ - Large B-cclllymphoma (3} Vermgnt <Fletcher Allen Heal!hcary Center) - Malignant lymphoma, B-cc:II type Washington. Steilaoom - Hodgkin's lymphoma West VirginiA (Qreepbrier VAl lev Medicai 'Center) - Stromal sarcoma Wisconsin IMeritcr Health Services) - I..:Jrge B-ceU lymphoma Wiseonsin CSr. Marx's Hospirall - I..:Jrge ceU lymphoina Australia <North Queensland Pathology Group) - Diffuse large cell B-cell lymphoma Australia CRoV'.!l Prince Alfred Hospital\ - Difl'u<e lar1,oe B-ee! I lymphoma Canada !Foothills Medical Center) - Diffuse large B-cell lymphoma Chile 1\Jniversidad de Chile) - I..:Jrge cell "B" cell lymphoma Japan 1Yam!l!\!l$hi MedicaiiJojversjty) - Non-Hodgkin's lymphoma, diffuse and large (2); Endometrial stromal sarcoma. bign grade

(I ) Netherlands. Amsteroam - Diffuse large B-eell lyrophorna

Case 6- Diagnosis: Uilfuse large B-celllymphoma, ovary

T-87000, M-95903

Case 6 -References: l' reeroan C, 13er'g JW and Cutler SJ. Occurrence and Prognosis of Extranodal Lymphomas. Cancer 1972; 29( 1):252--260. Rotmansch J and Woodrulf JD. Lymphoma of the Ovary, Reprirt of1'wenty New Cases and Update of Previous Series. Am./

Obstet Gyneco/ 1982; 143(8):870:875.

Casc..No. 7, Accession No. 28653 January 2002

Bakersfield - Burkitt) lymphoma Baldwin ·rark (Kaiser Pcrmancotc) - Burkiu's l)mphoma (I ); Burkiu's vs. noo-Burl<itt's lymphoma (l);? Burkitt's vs. non-

Burkitt' s small non-cleaved (2) Bay Area - Diffuse B-cell l)mphorna, higll grade (Burkitt's-like) ( 4) fontana<Kaiser Permrulemel - 8urkin's lymphoma Hayward/Fremont - 1·6gh grade ll-celllymphoma (Burkitt's like) Lon~ Beach /Lakewood Regional Medjgll O:merl - Large eell lympboma (Burkitt's like) (7) Monterey/Camrnunitv HOSpital ofMoOferey Peojn:;ula) - l:l-celllymphoma, possible Burkitt's Mountain View lEI Cami!JQ Pruholo&y Group) - Small non-cleaved cell lymphoma (llur~;n's-cypc)

Oakland (Kaiser Pcrmancntc\ - B-ccll l)mphoma, large cell type (4) Orange CUCI Medical Center Residents\ - Burkitt's lymphoma Sacramento /UC Davis Modieal Center) - Burl<itt's lymphoma San Diego (Naval Medical Center) - Burkitt's l)mphoma Santa Rosa (Santa Rosa Memorial Hospitall - High-grade ditfusesmall non-cleaved cell lymphoma (2): B-cell lymphoma (I) Sehastoool (pathologv Services) - Lurge B-cell lymphoma

t2 CTTR, January 2002 "'Minules"' (Subscriplioo A)

AlAbama ([!MC Prin9e1onl • MalignMt lymphoma. l}mphoblastic Arkansas CUAMS) • Bwkitt's l)mphoma, testis Cn!orado <Lutheran MediCI!! Center) • OUii<in's!ymphO<na Delaware (Christiana t losnitall • B..:cl! lyntph01n.c marginal :woe type florida @ap!iS! Hnsoitall • Small OO<H:Ieaved lymphocytic lymphoma (I); Malili'I8J'll)mphoma, diffuse large non.<>JCP,·ed ( I):

Malignant lyrnphomasma!J !nlllsitiooal 8-c:el! (Burkitt's?) (I); Small celll).mpltoma, diffuse ooo-deaved (Burkitt' s type)( I) Florida !Munroe Re•ioonl MediC!)! C'.entcrl - Burkitt's !)mphoma Florjda <Pml!olooy A<.o;gcjateol - Burldtt's lymph011111. diffuse large ee!l!yrnphoma Florida (Wimq Hayen HoooitaJl - Burkitt's !yrnpltoma (I): Malignmtt lyrnpltoma. small eel~ ooo-deaved. non· Burkitt's (I) Illinois !DuPugc Patho!oay Associa)cs\ • I..argt cell anapla.1tic lyrnphoma, 8-c:ell ( !);Testis, diffuse large cell, 8-cclll)mphoma

(small non-cleaved n<Ht-Ourkin's type) ( I) llliQOis lE)'Wion Hospital> • Burkitt's l)nlphoma Illinois rNonhwgtcm Memorial ~lmnita!) · Burkiu's l)nlphoma lndhma (fon Wavncl • Burkitt's-liko B-ce!ll)nlphomn. testi< MoryJand (Johns llonkins Ho:>pj)al Resident) · f.avor Burkin 's·like l)mpboma, would oonfirm with Ki67 prolifenuion marker Morvland CN!H Pathology Residerul · Burkitt's ~mpltoma Moryland (NaJjonal Naval Medical Center! - ~ligh grode B-<:ell lyrnphoma, favor Burkin's·like Maryland CUniyecsirv ofM!l!Ylandl • Burkin's·like lymphoma Manesi!USC!!.1 CBer!§hirc Medical C'-AAterl - Diffuse large 8-c:el! l)mphoma Massachuseu• CBrigh;un Md Women's RcsidenWFcllows) • Atypical l.lurkin's/Butlcill's·like lymphoma Massachuse!t$ fNew Englund Medical Center Rcsjdeot•l • Burkin's lymphoma Michigan COakwooc! H<><nitall - Non-Hodgkin'sl)mphO!Oa, 8-c:el~ Burkitt'S·t)'pe Michiil!!! 1St Jogph Mercy Hosoi!AII • Small non-cleaved eelll}mplt(Jma. uncertain type MississiPPi. Cru!fix>rt - llurkittts lymphoma Missoori <Tmmao Medjcal Center) • Burkitt's l)mpboma (2)

Nebraska <Crciohtoo Uniymirv Scl!ool of Medicine Residcnql - Diffuse 8-c:eU lyrnphoma (Burkitt's-likc) New Jersey <Overlook Hosoi!all • !..urge oelllyrnphomn (I); Dill\Lse. B<cll l)nlphoma, small non-cleaved oel!, non-Durkin's type

( I)

Npw York Olab Israel Mtdi~ Cenrer> - Large lkclllyrnphoma New York <Long Island Jc"ish Medical Ccn!erl • Favor Burkitt's l)nlphoma New York (NB.<iiau Coumy Medical Center) • Lorge B..:cll!ymphoma, !tstis New York l$tonv Brook University l!osoital Residents) • MaJignantlympbonta, Burkiu's-likc(ll) Noah Carolion (Mountain Area Pathology\ • Burkill's (Ourkitt's·like), ll-«lll)mphoma(2): Owl-itt's '"· Burkitt's·like large cell

lymphoma (I); Large cell B-ee!! l)mpboma ( I) Oklahoma. Edmond • Burldtt's l)nlphorna Pcnp:w!vania (Allegheny Genera! li!!!!pi!l!l) - Burkitt's lymphoma Ps;nnsylvanja (!.chigh Vgl!cy Hospif!!!l - Small non-cleaved eell lyrnphorna of Burkitt's type Pennsylvania rMwodal Medical Center Rc'Sidentsl • High grade B·oelllymphomu (2) Puq1o Rim CUni,'erSi•Y of Puerto KiM) · Burkitt's 1)-mphocna Texas fProl'a!h A:ssoeiaJesJ • Mali8J1atU l)mphoma, INgc B-cell type (2) Tcxus IScnn & White Mcmorialliospitall • Burkitt's lymphoma {3) Vcnnom (Fle!cbcr All Oil Ncalthcao: C'.cntorl · Undifferentiated l)mphoma, non·Ourkitt's·type Woshin!!!on. S!cilaeom • Burkiu's l~mpboma Wes! yirninjo (Greenbrjcr Valley Medical Cemerl • Di nuse large B·col! !ymphomo Wisconsin IMcritcr Hcal!h Services) • Bur!Uu's lymphoma Wi'!CO!!Sjn IS!, Mary's !10<oitall • Malignaru lynlphoma, Btwldtt's·likc Amu-alia !North Queens! nod f'athology Group) • Ditf= snwll cell. tl-ccll l)ntphoma 1\ustrdlia!Royu!l'rinoe Allied liospjlllll • Burkiu's lymphoma (at)'l'ical varirutl) Cpnada CFO!l!hills Medical Ceoterl • Burkitt's l)mphoma Chile fUniversidad de Chj!el • lar&e cell ·B" cell lymphoma Janan (Yamann<hi MediCI!! Uojversjtyl - Non-l!odgkin's lymphomn. Hurki~'s·likc !ype (3): Di ffi~<e (I) Ntsherlands, Amsterdam • flurkitt's !ype, non·Hodgkin's l}mpltoma

cnR.Jarm.ry2002 '"Millutcs"' (Substr'ipdon A)

Case 7 - Diagnosis: Ditfuse small non-cleaved B-celllymphomo (Burkitt's-like), testis

T-78000, M-95903

Case 7 • References: ferry JA, Harris NL. Young RH, e1 Bl. Malignant Lymphoma of the Testis, Epididymis and Spermatic Cord AmJ Surg P01hol

1994: 18(4):376-390. Root M, Wang TV, Nesoook H, ct Bl. Burkitt's Lymphoma of the Testicle, Repor1 of2 ea,.., Occ:wring in Elderly PatientS. J Urol

1990; 144(5):1239-1241. Fonseca R, Hubcrmann TM, Colgan JP, ct al. Testiculnr Lymphoma is Associated with a High Incidence ofExtranodal Recurrence.

Ca11Cer2000; 88(1):154-161. Niit<u Nand Umeda M. Clinical Features of Testicular Non-Hodgl<in's L)mphomu-Foeus on Treatment SCnltegy. Acta Ollco/1998;

37(7-3):677~80. Romics ~Fekete S. llely M, <:181. A Case of8ilmeml Testicular Lymphoma. Pmhol Onccl RQ 1999; 5(2):152-154.

Case No. 8, Accession No. 29205 January 2002

Balsorsfield - ~Hell. large cell lymphoma Baldwin Park !Kaiser Pqmanems> • Diffuse smaii~Hclll)mpboma (I); B-celllymphoma ( I); Diffuse ~Hclll)mphoma, mixed or

large cell ( I); Diffuse mi,ed IJ-celllymphoma (I) Bay Area - OlftUsc B-<:ell lymphomu. high ll"'•de ('I immunobla.o;tic) (4) Fontana (Kaiser l'crmjl!!entcl • Dilluse Iorge fkcll lymphoma Hayward/Fremont • High grade B-<:<:lllymphoma (Burkiu's-like) Long Beach ry,kcwosx! Regional Mcs!ia!l Center) - l..arge cell immunoblastic lymphoma (7) Monterev <Community Hospital ofMoo!en:v Peninsul!!) • !l-ee II lymphoma. immWlOblastic Mountain View lEI Camino Pathology Grpuol - Large cell lymphoma Onklnnd CKni:;er Psrmnnente) • B-cclllymphoma, large <'CII typ¢ (4) Orjl!!ge <IJCI Medical Center Residc11[sl • Large B-cell lymphomn Sogamento fUC Qgvis MedicaiC<:ntql - lkell immunoblastlc lymphoma San [)iero !Naval Mcdjca! Center) • Diffuse large B-<:elll)mphoma. immWlOblt~>'!ic type Santa Rosa !Santa Rooa Mcmqri!ll tlmpitall - B-cell diffuse large cell lymphoma (3) Sebastopol (Pa!hology Services) • Large B-<:elllymphorna Alabama rBMC l'rjnootonl • Mlllignant lymphoma. immunoblnstic Arkansa< !!JAMS! - Diffuse large U-ooll lymphomn, testis Col acado (LuthCf!ln Medical Ccntg) • Diffuse large B-ee !I lymphoma Dclawan: (Chris lana Hospital) • Diffuse large odll)mphoma Florida ffi•"'iSI t lq mil;!!} • !.argt cell immWlOblastic l)mphoma {I); MaliKJICIIU l)mphoma, lqc immWlOblaslic (I); Mnlignaot

lymphoma. diffuse large lkell with intmtubular cells (I); Malignant l)mphoma, WS (I); Largecclll}mphoma, immunoblastic type ( I )

Florida ( Muproc Regional Medjg\1 Center) - Diffuse large B-oell lymphoma.. Burkitt's-likc Florida CPatholoo• A<sociatcsl • Burkitt's-likc lymphoma with plasmacytoid features, immunoblastic B-celll)mphomu Florida I Wimer Hu,en Hosoitall • Mixed small cell· I""''" cell lymphoma (I); Large cclll}mphnma (I) !llioosffiul'llge P!!!ho!ogy AW!fiatW • Large cell lymphoma. 8-<:ell (I): Testis. diffuse large cell. B..:elll}mphoma vs.

l}mphoblaslic (Burkitt's) lymphoma ( I) lllinnis!EvanS(on tlospjtall ·Large ccll lympboma llljnojs (Northwestern Memorial l·lrumitnll - Non HodsJ<in'> l)mphoma. tnrse B-ccl l t)-pc

Indiana (Fort W•yru;l - lkell lymphomu. testis Maryland (Johns Hopkins Hosoi)a! Resident) • Testicular lnrge B-celllymphoma M!l!y!and (NIH Pathology Residcms\ - Diffuse large 0-<:elll)mp/loma Marvland (Nl!tjonu! Na>-.1 Mcdigl Crntql - Diffuse larJIC B-<:elll)mphoma Marvljl!!d llloiyer<itvofMarvlandl • Diffuse large B-cel l Ma.S!!lchuseUs fficrkshirc Modj(;j)l C.entcr) • Diffuse lnrgo ll..:ell lymphomu (imtnunoblastic) MassachuseJ!SI!lrighrun and Women's ResidenL<If'cllowsl • l)ilfu.<e largo ll-ccll lymphoma Massachugu.• !New England Me<llml Centa Residents) • Dilfu.<e large B-<:<:lllymphoma with immunol>lastic fea1un:s

14 CJTR. Janual')' 2002 "'Minutes .. (Su""npOon A)

•

Micbioao (Qdkwoos! Hospilall - Non-Hodgkin' s lymphoma, B-cell, diffuse large cell. immunohlasdc variant MichiJ!l!o 1St Joseph Mercy Hospital) - l)iffusc large B-oelllymphomu M"wissimj. Gulfoort - Diffuse larg,: B«IJ l)mphoma. immunoblastic >'8rianl M"!SSOI!ri ITruman Mc:diQ!I Center) - Small DOD<Ic:avc:d cell. BurkiU's-like (2)

Nebra•ka (Creishton UnlyeJ11ity School of Me!licinc Residents) - Diffw<: lllr!,>e BoQllllymphomn New Jcryey {()yerJook Hospital) - OUl'use large <>!II lymphoma (2); Non-cleaved, probably B-ccll type (I ) New York (!}elh tvael Mccliel Ceruq) - Large B-<:elll}mpboma New Yorlc CLans Island Jcwjsb MedigU Ceruq) - Diffuse large 8-<:elll)mphoma. immunoblastic variant New Ymk CNa<..<au Coumy Medical Ccmcr) - Low grode B-cell lymphoma, testis New York !Stony Brook !Joiversiw li()spitnl Resident•> - Oilluse !urge B-celllymphoma Nortb Cam! ina !Moumain Area Pruholo<:yl - Large cell, B<ell lymphoma (4) Ol:laboma. Edmond - Diffw<: l~~rge 0-<:elll)mphoma Pennsylvania <Allegheny General Hospjcnll .. lmmunoblastic lymphoma PennsvlyJl!!iu t'Lebjoh Ynllcy Hospimll - Small non·clenved cell lymphoma PC!!!\Sylvania (Memorial Medical Cent<r Rcsidc:niS) .- High grade 8-<Clllymphoma (2)

Puerto Rico CUoiversiw of Puerto RiCO) - Diffuse lqc B-oell l)mphoma T cxas CJ>m!'a!h Associau:sl - Immunoblastic lymphoma (2) Texus <Soon & White Memorial Hosllim!J - lmmunoblustic lymphoma (3) Vcrmonl (fletcher All!ffi li calthcan; Center) - Large cclllymphomu \Vashini!!<MJ. Stei!aoom • DiJfuse large B-«lllymphoma \Vest Virojnja CC.recnbrier Valley Mcc!i<'u! Centql - SpcrmatOC)1ic Kminoma Wjsoonsjo fMcrilcr Hcallh S=ices> - Large B-ee II lymphoma Wisconsin (SJ. Marv's H()(lpimll , Malignant lymphoma, Burkill's Ausln!li• CNorth OueeoSIWJd Pathology Grouol - Diffuse large B-<>elllymphoma Ausr]1!ljo CRoya! Prjoee Al&c:d HosniJAil - Diffuse Iorge lkclllymphoma (immunoblastic varian!) Canada (foothills MedjQ!I Cooter) - Diffuse large ll-<:elll)mphoma Chile l!lniycrsidad de Chilel - lmmunoblaslic "B" cell lymphoma Jup!!O fYamana.<hi MediQ!l UnivectiiV> - Non·Bodgkin's lymphoma. diffusc lar~;c 0-celllypc ( I); IJnmunoblastic type (2); Medlum­

si21:d l)l>C (I} Netherlands, Amtterdam - Diffuse large B-oell lymphoma

Case 8 - Diagnosis: Diffuse large 0-celllymphoma, immunoblastic lype, testis

T-78000,~·95903

Case 8 - References: Rojo J Snles V, Paredes A. et al. Non·l·lodgkin's Lymphoma CNHL) of tlle Testicle. A Clinicopmhologic S1udy of 19 Patients. In

l'ivo 1991:5(3)297-300. Jackson SM and Montessori GA. Malignan1 Lymphoma oflbe Tes1is. Review or 17 Cllse5 in British Columbia with Survival

Rclutcd to Patholosical SubclassifiCtllion. J Uro/ 1980; 123(6):881-883. Fellboum C. Straler J nod 1-lrutsmann M J~ Folliculnr Dendritic Cells in Extranodal Non-Hodgkin l .. ymphomas ofMAl.T and Non

MAI.'J' Type. Vicho•cr Arcft A l'arlwl A nat m,tO{XJJho/ 1993; 423(5):335-341 .

Case No. 9, Acc~-ssion No. 29241 January 2002

Bakersfield - lkcllljmphoma Baldwin Pwk <Kaiser Pcnnanente) - L)mphoma, follicular ( I); B-c.:lll)mphorna ( 1): Diffuse B....U lymphoma(l); 11wanodal

diiTusc B..:ell lymphomu ( I) Rav Area • DiffilSC 8-<:cll i)1Dphoma (2); MALToma (2) FQQU!!!a(J<aiscr PerroMentc) - Dill\Jsc large B-«lllymphoma Havwardlfremrol - High grade 8-«lll}mphoma. NOC Lono Elcach {Lakewood Reoional Medical Center) • Noo-Hodgkin's lymphoma (MALT'!) (7) Molltersy <CommunjlY 1-fnomital of Mpntcrcy Pcninsulu) .. 8--ccll lymphoma, di,fusc large cell

Mountain Vic\v CEI Camino Pathology Group) - Large cell lymphoma Oa!slandfKaiser Permanentel - B-celllymphoma, Jorge ceU type (4) Orange QJCI Medical Center Resident<) - Burkitt's lymphoma Sacramento aJC Davis Mediall Center) - Follicular lymphoma

·San ()!ego Waypl Me<ljgJI Ceoterl - OUl'use large Ll-«11 lymphoma Santa Rosa !Santa Rosa Memorial lioopjmll - Intermediate grade diffuse ~U lymphoma (2);1Hlell diffuse large ccll l}mphoma

(1); B-celllymphoma (I) Sehastonoltpruhology Services) - B-celllymphoma Alabama CBMC Prioceron) - Malignant lymphoma, mantle cell Arkansas ClJAMS) - Mantle cell lymphoma Colorado (Lutheran Medical Center) - Low grade 0-<>elllympboma, NOS Delaware (Christiana HoSpital) - MAL Tlymphoma !'lorida ffiaQljst I rosoilal) - follicle center lymphoma, diffuse (l); Malignarulymphoma, large cell, follicular center oelltypc ( l);

Malignant lymphoma, diffuse small cleaved cell (!);Diffuse large cleaved (I); Large cell lymphoma, diffuse cleaved (1) Florida <Munroe Regional Medical Center) - Diffuse large B-ee II lymphoma Florida !Pathology Associates) • Large B-celllymphorna, rollicular center origin (I) Florida (Winter Haven Aospiral) - Small cleaved cell lymphoma (1 ); Follicular center cell lymphoma, gtade 1, small cell cleaved ( 1) lllinnis IDuPaoc Pathology Associates) - Diffuse large 1l-celllymphoma (I); ('.ecum/scrotum, diffuse large cell Ll-celllymphorna

(l) lllinois (Evanston HospiU!l) - Large cell lymphoma Illinois (Northwestern Memoriallfospitall - B..:ell non-Hodgkin's lymphoma (MALToma) Indiana !Fort Wavncl - ()!ffuse large B-<JCIIIymphoma (folli<-ular center cell lymphoma), cecum and right scrotum MI!D'Iand Oohn<'Hopkirn Hospiral Resident) - Diffuse large B-oell l)mphoma Marvlanil (N1H Pathology Residents) - Diffuse large B-cell lymphoma Maryland (National Naval Medical Center) - Malignant Bo<:clllymphoma, diffuse large B-cdllymphoma vs. blastic mantle cell

lymphoma M!I01and (Uojyer;;jiY ofMazylan<l) - Diffi•se Iorge ~II Ma$<achusetts (Berkshire Medical Center) - Diffuse large B-celllymphoma Massaehusens !Brigham and Women's Residents/Fellows\ - Diffuse large ~II lymphoma MClSSaehusetts (New England Medical Center Residents\ - Muse Jbltieular lymphoma Michigan ({)al<wood Hospjtal) - Non-Hodgkin's l)'lllphoma, B-cell, NOS 1\oftchigan 1St. Joseph Mercy Hospital) - Sclerosing large Ll-«ll lymphoma Mississippi, Gulfoi>rt - DiJluse Jl>llicle center lymphoma Missouri !Truman Medical Center) - Malignant l)mphoma (2) Nebraska !Crcieluon University School or Medicine Resjde11Js) - Dilluse large ~l l l}mpboma

New Jersev !Overlook Hospital) - Diffuse large cell lymphoma ( l); DiJfusc intenncdiotc oclllymphocytic type probably mantle rell type (I)

New York ffieth Israel Medical Center) • Follicular lymphoma New York (Long Island Jewish Medical Ceoter> - f'avor mantle celll)'lllphoma New Yo[k CNns&W County Medical Cente.r) - Follicu]ar l)mphoma. cecum New York IStonv Brook UniversitY Hospital Residents) - DiffuSe large 13-oell lymphoma North Carolina (Mountain Arc• Palbo!ogyl - B-eelllymphoma, tollicular center cell type (1); Follicle centered cell lymphoma,

mixed (I); B-<:ell lymphoma (I); B-cel! lymphoma, ]'ojOS (l) Oklahoma, lldmond - Diffuse large B-cell lymphoma Pennsylvania (AIIeghenyJleneral Hospital) • Large cell lymphoma, B-ccll type PennsylvaniaiLehigh Valley Ho.<pitall - Diffuse mixed small and large cell type· follicular l)mphoma Pennsylvania !Memorial Medical Cemer ResidenL<) - B-cell, MAL Toma (2) Puerto Rico !Uni,•ersity of Puerto Rioo) - l'ollicular lymphoma, grade 2 vs. marginal mne lymphoma Texas CProl'ath Associates\ - Malignantl)mphoma, follicular cente-red type.( I); Diffiasc large D-oell lymphoma (I) T "-'as !Soou & Wliite Memorial l·lospital) - L.a.-ge cell lymphoma (J) Vcr:mont !Fletcher Allen Healthcare Center) - Malignant lymphoma, large cleaved, B-oelltype \VashjnOIO!l. Stcilaoom - B-celllymphoma West Virginia !Greenbrier Vaflcy Medical Center) - Diffuse small Ll-ce!llymphoma Wisconsin (Meriter Hcalth Services) - Large B-ceU lymphoma

16 CTTR, January 2!102 "'Mjnuics" (Subscription A)

•

Wjsooosin<St. M!vy's Hoooitall - L.ow BJUdo B-o:lll)mphoma of MALT Australia CNorth Oui>ms!Wld Pnthology Group) - Small 13,..,.11 l)mphoma. alveolar pottcrn Au..rralia (Ro'llll l'rincc Airred Hospi!al) - Oiffusc Jarg~ 0 -cell lymphoma Canada <FOO!hills Medjoal Cerner> - F.xtranoda! margill!ll zone B-ee!! l>mph9111o of mucosal associated t)mphoid tissue Chile <Uni-;asidad de Chile) - large celt "0" cell lymphoma Japan <Yamanasbi Medical Uni-;asiM - Non·Hodgltin's l)mplloma. diffuse huae B-cell t}J>C (3); Mixed type (I) NetheriWJds Amstqdnm - Diffuse Jarae 0-«lt l)mphoma

Case 9- Dlllgnosls: Diffuse large 8-cell lymphoma with plasmacyric differentiation, saotum nnd cecum

T-79400/T-67100, M-95903

Consultation: Milton Drachenberg, M.D., Ph.D., "Diffuse large 8-celllymphoma with plasmacyric differentiation."

Case 9 - References: Armitage JQ and Coiffier 0. Activity of Interferon-Alpha in Relapsed Paticms with Diffuse Large B-ee!! und Periphcrn! T..Ccll Non­

Hodgltin's L)mphoma. AnnOnoo/ 2000: I 1(3):359-361. Skinnidcr BF, Homnan DE, Dupuis B. ct al. Bcl-6 and Bc!-2 Protein f-"Jl"'5Sion in Diffuse Large B..CC!t L)mphoma and follicular

l..)mphoma. Com:!ation with 3q27 and 18q21 Chromosomal Aboonnalities. llum Pmho/1999; 30(7):803-808. Donoghue S. Baden liS, Lauder I, et Ill. lmmunobistoehemical Localization ofCasposc-3 Com:lates with Clinical Outoomc in B­

Cc!t Diffuse Lor&<>-Celt L)mphorna. Cancer Res 1999; 59(20):5386-5391. Chung CC, Liu YC. C!eveiWld RP, L1 at. £xprCS$ion of c·Myc and p53 Com:lates with Clinical Outcome in Diffuse Large 0-cell

L)mphomas. Am J Clin l'atho/2000; 11 3(4):512-518. Alizadch AA, Eisen MB, Davis RE, et al. Distinct Types ofl)iffuse Large B..CCII L)mphoma Identified by Gene Expression

Profiling. Na111n 2000; 403(6769):503-Sll.

Case No. 10, Accession No. 29148 January 2002

llakcrsfield - Acute l)mpbadeoitis

Baldwin P!!rk O<njgr Pcrmwenle) - Nodular scJerosjng Hod&kin's disease(4) lby Area - Hodg)dn'~ disease, nodular sclerosing type (4) Fontana {Kaiser J'e-nnnncnt¢) - Hodgkin':> disease~ nodulnr ~clcrooing

l laxward!Frcmom - Nodular sclerosing Hodgkin's disease J.oog Beach CLakewtlO!! Rceional McdjC!\1 Center) · Nodular sclerosing Hodgkin's disease (7) Montcrcv (C9111munjtv Hoopital ofM011ercy Peninsula> - Nodular sclerosing llod&kin's disea,;e Mountain View lEI Camino Pathology Orouo> - Nodular sclerosing lfodgkin's di$<-'liSC

Oakland O<aiscr Pcrmanente) - Hodg)dn's disca,c, noduhlr sclerosing (4) Qrw1ge C!JCI Mcdicul Center Rcsido'llt~) - llodgkin's lymphoma. nodular sclerosing type SMrarnemoiUC Dnyjs Medical Ccntql - Hodgkin's disease. nodular sclerosis San pjeoo CNava! M>vical Center) - Nodular sclemsiog liodgkin's disease Santa Rosa (Santa ROS!! Memorial Hosoito!l - Nodular sclerosing Hodgkin's disease ~I (Pathology Services) - Nodular Hodgltio's l)mphomu Alliliama (BMC Prinoc)on) - Hodgkin's disease, nodular sclerosing Arkansas (lJAMS) - Nodular sclcrosb llod&kin's lymphomo, grade I Colorado <Lutheran Medical Center) - Hodgkin's disease. nodular sclerosis Delaware <ChriSliana Hosoitall - Nodular sclerosing Hodgkin's disease Florida l!lan!is! Uomjtall - Hodgkin ·s l)mphoma. nodul>r sclerosis (5)

Florida !Munroe Rcgjom•l Medical Cenrer> - Nodular sclerosing Hodgkin's disease florida (P!!Jholosy t\ssociatcsl - Hod&kin's disease Jllorjda (Winter Hayen Hospital) - Hodgkin's diseose (t); Follicular c~nter cclll)mphoma. grade II, rniKcd (I) Illinois <Pu!>ase Pmhnlogy Associmes) - Bodgltio's l)mphorno (I); Nodular sclerosis Hod!l)Un's lyn1phoma ( I) llljoojs !Ewwtnn HrnDitall - Nodular sclerosing Hodgkin's l)mphoma

CITR. Januasy 2002 .. MinuceS"" (Subsc:ri·puon A) t7

Illinois (Northwestern Memorial t lospjulll - Nodular·sclerosing Hodgkin's disease Indiana (fort Wayne) - NOdular sclerosing Hodgkin's l)'lllphoma, left neck, tight axilla Marvland (Johns Hopkins Hospital Resident) - Hodgkin's l)'lllphoma, nooulllf sclerosis subtype Marvland INIH Palllology Residents) -Nodular sclerooing Hodgkin's disease Marvland !'National Naval Medica! Center) - Nodular sclerosis Hodgkin's l)'lllphoma Marvland (\lniversitv ofMarvlandl - Nodular sclerosing Hodgkin's Massachusetts <Bcrl<shireMedjcaJ Center) - Hodgkin's disease, nodular sclerosis Massachusells (Bri@ant and Women's Re.<ident.!Fellows) - Clas.sica! Hodgkin' s l)'lllphoma, oodular sclerosis subtype Massachusetts (New England Medical Center Residents! - Nodular sclerosing Hodgkin's l)'lllphoma Michiean {Oakwood Hospil!ll) - Hodgkin's l)'lllphoma. nodular selerosiog type Michi@M 1St. Joseph Mercy Hospital) - Nodular sclerosis Hodgkin's disease, S}T1Cytial variant Mississipni Gulfuort - Nodular sclerosis Hodgkin's l)'tnphoma Missouri <Truman Medical Center) - HOdgkin's disease, nodular sclerosing (2) Nebraska {Creighton University School of Medicine Residents) • Hodgkin's l}mphoma, nodular sclerosis New Jersev {Overlock.Hosoital) - Nodular sclerosing HOdgkin's disea<~c (2)

New York <Beth Israel Medical Center) • Nodt~ar sclerosis Hodgkin's lymphoma New York O:.Ong Island Jewish Medical Center) - Nodular sclerosis Hodgkin's l)'tnphoma New York (Nassau County Medical Centerl - .Nodular sclerosing Hodgkin's lymphoma, neck New Yorl.:fStonv Brook University Hn.~pital Residents) • Hodgkin's disease, nodular sclerosis t)pe

North Carolina (Mounl!lin Area Pathol0&1l - HOdgkin's lymphoma. ·nOdular sclerosing ( 4)

Oklahoma. Edmond - NOdular sclerosis Hodgkin's l)'lllpboma Pennsylvania (AII¢eny General Hoopititl) • Hodgkin's disease Pennsylvania (Lehigh Valley Hospital) - Hodgkin's disease, nodular s.:lerosing type Pcnnsvlvania,(Mernorial Medical Center Residents\ - Hodgkin's l~mphoma, nodular sclerosing Puerto Rico !Univegity ofPuerto Rico\ - Nodular sclerosis classical Hodgkin's l)'lllphoma Texas fProPath Associates! - HOdgkin's disease, nOdular sclerosis type (2) Texas <Soon & White Memorial Hospital\ - Hodgkin's l)mphoma, nodular sclerosing (3) Vermont CFic:tchcr Allen Hca!thcarc Center) • Hodgkin's lymphoma, nOdular s.:lcrosis

Wa.qhinmon Steilaoom - Hodgkin's lymphoma, nodular sclerosing West Virginia {Greenhrier Valley Medical Center) • NOdular sclerosis Hodgkin's disease WiSCOJ]sjn fMcriter Health Seryig:sl • Rodg)dn's lymphoma, nodular sclerosing Wi~OOJtSin <St. Marv's Hospital) - Hodgkin's disease. nodular sclerosing Australia <North Ouoensland Pathology Group\ - NOdular sclerosing Hodgkin's disea'" Aumalia (Ro\!lll Prince Alfred Hn<pital) - Nodular sclerosis HOdgkin's lymphoma Canada <Foothills Medical Center) - NOdular sclerosis classical tlodgkin' s l)'lllphoma Chile IIJniversidad de Chile! - WOdular sclerosis lymphocyte depleted Hodgldn's disease Lapan CYamanQI!hi Medical Universitv) - Hodgkin' s l)'lllphoma, nodular sclerosis type (3); Eosinophiliclympborna (1) Netherlands. Amsterdam - Hodgkin' s Jymphomll, 110dular sclerosing

Case 10 - .Diagnosis: Hodgkin's lymphoma, nodul.ar sclerosing, neck and axilla

T-Y0600/T·Y8100, M-96563

Case I 0 - References: Lukes RJ Craver LF, Hall TC, et al. The .Pathology and Nomenclature of Hodgkin' s Disease. Cance~· Res 1966; 26(6):1063-1083. Moccia F. Tognoni E and Boocaccio P. ALK-Negative Anaplastic Large Cell Lymphoma and Hodgkin's Disease of Nodular

Selcmsiog T}Pe in 2 Siblings. Acl<l lfaemalo/2000; 103(4):214-219. Ohno T, Treon G, Wu G, c1 al. The Clonal Relatiort•hip Between Nodular Sclerosis Hodgkin's Disease with a Clonnl Reed­

Sternberg Cell Population and a Subsequent 8-Cell Small Noncl.eaved Cell Lymphoma. Mod Pat hoi 1998; II (5):485-490. S1lll11ey MW rutd Powers CN. Syncytial Variant of Nodular Sclerosing Hodgkin's Disc-..,c. Fine-Needle Aspiration Findings in Two

Cases. Diagn Cytl)p(J1hol l997; 17(6):477-479. von Wasielewski R, Seth S, Franklin 1, Fischer R, ctal. Tissue Eosinophilia Corrclares Strorlgly with Poor Prognosis in Nodular

Sclerosing Hodgkin's Disease, Allowing for Known Prognostic Fac1ors. Blood 2000; 95(4): 1207-1213.

18 ClTR, Jaomuy 2002- "Mioulcs'• {Subscription A)