l test results hgb 77 g/l mcv 66 f/l rbc 3.2 x10 12 /l wbc 5.6 x10 6 /l plat 525 x10 9 /l l...

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Test results Hgb 77 g/L MCV 66 f/L RBC 3.2 x10 12 /L WBC 5.6 x10 6 /L Plat 525 x10 9 /L Blood film is a 55 year old woman who has fatigue. Her only r symptom is a craving for chewing ice cubes. Apa being pale her examination is normal.

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Page 1: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

Test results Hgb 77 g/L MCV 66f/L RBC 3.2 x1012/L WBC 5.6 x106/L Plat 525 x109/L

Blood film

This is a 55 year old woman who has fatigue. Her only other symptom is a craving for chewing ice cubes. Apartfrom being pale her examination is normal.

Page 2: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has
Page 3: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

Which one of the following tests would best define the type of anemia she has ?

A. Hgb electropheresis

B. Serum iron and iron-binding capacity

C. Serum ferritin

D. Serum transferrin

E. Bone marrow iron

Page 4: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

Test results Hgb 77 g/L MCV 66fL RBC 3.2 x1012/L WBC 5.6 x106/L Plat 525 x109/L

Blood film microcytosis hypochromia ovals pencil thrombocytosis

This is a 55 year old woman who has fatigue. Her only other symptom is a craving for chewing ice cubes. Apartfrom being pale her examination is normal.

Page 5: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

Test results Hgb 135 g/L MCV 65 fL RBC 5.4 x1012/L WBC 6.5 x106/L Plat 355 x109/L

Blood film

A 44 year old executive is sent to you for an insuranceexamination. He is fit, but on examination he has mild hypertension.

Page 6: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has
Page 7: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

Which test is likely to give a diagnosis in this case ?

A. Serum ferritin

B. Serum transferrin

C. Sickle Cell screen

D. Hgb electropheresis

E. Liver function tests

Page 8: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

Test results Hgb 135 g/L MCV 65 fL RBC 5.4 x1012/L WBC 6.5 x106/L Plat 355 x109/L

Blood film microcytosis hypochromia target teardrop basophilic stippling

A 44 year old executive is sent to you for an insuranceexamination. He is fit, but on examination he has mild hypertension.

Page 9: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

What would you tell this executive ?

A. You have Beta thalassemia minor

B. You have alpha thalasemia minor

C. You have Sickle cell trait

D. You have hemoglobin C trait

E. More tests are needed

Page 10: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

Test results Hgb 99 g/L MCV 100 fL RBC 3.7 x1012/L WBC 3.4 x106/L Plat 117 x109/L

bili 35 mol/L blood film

This is an 18 year old boy who you are investigating forJaundice. He has this intermittently for some time. Hisfamily are Christian Scientists. Physical exam shows jaundice and splenomegaly

Page 11: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has
Page 12: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

Which of the following would be most helpful in identifying this young man’s problem ?

A. Reticulocyte count

B. Osmotic fragility test

C. DAT (Coomb’s test)

D. Bone marrow test

E. Family studies

Page 13: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

Test results Hgb 99 g/L MCV 100 fL RBC 3.7 x1012/L WBC 3.4 x106/L Plat 117 x109/L

bili 35 mol/L blood film polychromasia spherocytes

This is an 18 year old boy who you are investigating forJaundice. He has this intermittently for some time. Hisfamily are Christian Scientists. Physical exam shows jaundice and splenomegaly

Page 14: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

Test results Hgb 142 g/L MCV 105 fL RBC 4.9 x1012/L WBC 6.7 x106/L Plat 105 x109/L

Blood Film

A 46 year old diplomat is referred to you because of abnormal blood results. On review of these you suspect the cause and order appropriate blood tests.

Page 15: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has
Page 16: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

What tests would you order on receiving these results ?

A. Serum B12 and folate

B. Bone marrow aspirate

C. Serum lipid studies

D. Liver function tests

E. Thyroid function tests

Page 17: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

Test results Hgb 142 g/L MCV 105 fL RBC 4.9 x1012/L WBC 6.7 x106/L Plat 105 x109/L

Blood Film

Macrocytosis

Target cells

stomatocytes

A 46 year old diplomat is referred to you because of abnormal blood results. On review of these you suspect the cause and order appropriate blood tests.

Page 18: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

Test results Hgb 85 g/L MCV 110 fL RBC 3.9 x1012/L WBC 2.4 x106/L Plat 89 x109/L

Blood Film

A 65 year old woman is referred to you because of memoryloss. Her family physician had received tests which included bilirubin of 28 mol/L and an LDH of 1560 U/L. He waspuzzled by these results.

Page 19: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has
Page 20: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

Which one of the following tests is most appropriate ?

A. Liver function

B. Thyroid function

C. RBC folate

D. Serum B12

E. Bone marrow aspirate

Page 21: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

Test results Hgb 85 g/L MCV 110 fL RBC 3.9 x1012/L WBC 2.4 x106/L Plat 89 x109/L

Blood Film

Macrocytosis

oval macroytes

hypersegmented

neutrophils

A 65 year old woman is referred to you because of memoryloss. Her family physician had received tests which included bilirubin of 28 mol/L and an LDH of 1560 U/L. He waspuzzled by these results.

Page 22: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

Test results Hgb 103 g/L MCV 99 fL RBC 3.8 x1012/L WBC 3.4 x106/L Plat 125 x109/L

Blood Film

A 65 year old woman complains of back pain. Her X-raysshow diffuse osteoporosis. She also complains of increasedthirst and drowsiness.

Page 23: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has
Page 24: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

Which one of these tests would most likely lead to the diagnosis ?

A. Serum osmolarity

B. Serum viscosity

C. Serum protein electrophersis

D. Serum TSH

E. Serum PTH

Page 25: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

Test results Hgb 103 g/L MCV 99 fL RBC 3.8 x1012/L WBC 3.4 x106/L Plat 125 x109/L

Blood Filmrouleauxbackground

staining

A 65 year old woman complains of back pain. Her X-raysshow diffuse osteoporosis. She also complains of increasedthirst and drowsiness.

Page 26: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

Test results Hgb 115 g/L MCV 115 fL RBC 2.2 x1012/L WBC 8.4 x106/L Plat 246 x109/L

Blood Film

You admit a 36 year old woman with pneumonia. She hasfever, shortness of breath and requires oxygen. She is also noted to be anemic.

Page 27: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has
Page 28: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

These test results would help you choose which one of these antibiotics ?

A. Cephalexin

B. Penicillin G

C. Erythromycin

D. Sulfamethoxazole

E. Ciprofloxacin

Page 29: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

Test results Hgb 115 g/L MCV 115 fL RBC 2.2 x1012/L WBC 8.4 x106/L Plat 246 x109/L

Blood Film

RBC agglutination

You admit a 36 year old woman with pneumonia. She hasfever, shortness of breath and requires oxygen. She is also noted to be anemic.

Page 30: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

Test results Hgb 75 g/L MCV 107fL RBC 2.8 x1012/L WBC 8.9 x106/L Plat 377 x109/L

Blood Film

An 18 year old woman has symptoms of cystitis. After urinecultures are taken she is given Sulfamethoxazole. Her urinarysymptoms improve but she becomes short of breath. A weeklater on follow-up her investigation shows.

Page 31: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has
Page 32: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

What type of anemia is causing this problem ?

A. An idiosyncratic drug reaction

B. An allergic drug reaction

C. Marrow suppressive effect

D. Immune hemolysis

E. Oxidative hemolysis

Page 33: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

Test results Hgb 75 g/L MCV 107fL RBC 2.8 x1012/L WBC 8.9 x106/L Plat 377 x109/L

Blood Filmploychromasiablisterbite cells

An 18 year old woman has symptoms of cystitis. After urinecultures are taken she is given Sulfamethoxazole. Her urinarysymptoms improve but she becomes short of breath. A weeklater on follow-up her investigation shows.

Page 34: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

Test results Hgb 115 g/L MCV 91 fL RBC 4.1 x1012/L WBC 14.5 x106/L Plat 52 x109/L

Blood Film

You are called to see this 29 year old primip in the case room. The obstetrician is concerned about her platelet count. She is well but a bit hypertensive.

Page 35: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has
Page 36: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

What diagnosis is most likely ?

A. ITP ( immune thrombocytopenia )

B. TTP ( thrombotic thrombocytopenic purpura)

C. PIH (pre-eclampsia)

D. Benign thrombocytopenia of pregnancy

E. DIC (disseminated intravascular coagopathy)

Page 37: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

Test results Hgb 115 g/L MCV 91 fL RBC 4.1 x1012/L WBC 14.5 x106/L Plat 52 x109/L

Blood Film

polychromasia

rbc fragments

thrombocytopenia

You are called to see this 29 year old primip in the case room. The obstetrician is concerned about her platelet count. She is well but a bit hypertensive.

Page 38: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

Test results Hgb 115 g/L MCV 105 fL RBC 3.8 x1012/L WBC 9.2 x106/L Plat 420 x109/L

Blood Film

This 35 year old man is sent to you because of unusual blood results. His complaints are of fatigue and an episodicitchy rash.

Page 39: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has
Page 40: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

What condition do you think is responsible for these results ?

A. Pernicious anemia

B. Sickle cell anemia

C. Hyposplenism

D. Leaky prosthetic valve

E. Liver cirrhosis

Page 41: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

Test results Hgb 115 g/L MCV 105 fL RBC 3.8 x1012/L WBC 9.2 x106/L Plat 420 x109/L

Blood Film

targets

acanthocytes

fragments

howell jolly bodies

This 35 year old man is sent to you because of unusual blood results. His complaints are of fatigue and an episodicitchy rash.

Page 42: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

What is the most likely cause ?

A. Blind loop syndrome

B. Coeliac disease

C. Ulcerative colitis

D. Crohn’s disease

E. Wilson’s disease

Page 43: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

Test results Hgb 99 g/L MCV 96 fl RBC 3.4 x1012/L WBC 3.65 x106/L Plat 560 x109/L

Blood Film

You are asked to asses a 72 year old woman for anemiaand splenomegaly. She has been losing weight for 1 year.She has had 2 episodes of gout.

Page 44: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has
Page 45: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

What test would give a definitive diagnosis ?

A. LAP score

B. Osmotic fragility

C. Hgb electropheresis

D. Bone scan

E. Bone marrow biopsy

Page 46: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

Test results Hgb 99 g/L MCV 96 fl RBC 3.4 x1012/L WBC 3.65 x106/L Plat 560 x109/L

Blood Film

thromboytosis

tear drop cells

leukoerythroblstic

You are asked to asses a 72 year old woman for anemiaand splenomegaly. She has been losing weight for 1 year.She has had 2 episodes of gout.

Page 47: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

Test results Hgb 136 g/L MCV 88 fL RBC 4.9 x1012/L WBC 17.3 x106/L Plat 110 x109/L

Blood Film

This 24 year old man has acute abdominal pain. He has notbeen feeling well for 5 days. After a baseball game he hadacute upper abdominal pain and was quite tender in the upper abdomen. The surgeon asks you to see the patient.

Page 48: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

What is the disorder most likely responsible for his condition ?

A. Acute leukemia

B. Pancreatitis

C. Malaria

D. Infectious mononucleosis

E. Liver abcess

Page 49: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has
Page 50: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

Test results Hgb 136 g/L MCV 88 fL RBC 4.9 x1012/L WBC 17.3 x106/L Plat 110 x109/L

Blood Film

variant lymphocytes

atypical

reactive

This 24 year old man has acute abdominal pain. He has notbeen feeling well for 5 days. After a baseball game he hadacute upper abdominal pain and was quite tender in the upper abdomen. The surgeon asks you to see the patient.

Page 51: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

Test results Hgb 139 g/L MCV 93 fL RBC 5.1 x1012/L WBC 29 x106/L Plat 178 x109/L

Blood Film

This 55 year old man is referred for unexplained elevatedWhite cell count. He feels well. Examination is normal.

Page 52: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has
Page 53: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

What test would confirm your diagnosis ?

A. Mono spot test

B. LAP score

C. Bone marrow biopsy

D. Immunophenotyping

E. Skeletal survey

Page 54: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

Test results Hgb 139 g/L MCV 93 fL RBC 5.1 x1012/L WBC 29 x106/L Plat 178 x109/L

Blood Film

Lymphocytosis

Smudge cells

This 55 year old man is referred for unexplained elevatedWhite cell count. He feels well. Examination is normal.

Page 55: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

Test results Hgb 92 g/L MCV 81 fL RBC 3.4 x1012/L WBC 5.2 x106/L Plat 13 x109/L

Blood Film

This 36 year old man is admitted to hospital with generalizedbruising and bleeding. He is febrile. There are many bruisesand petichia present.

Page 56: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has
Page 57: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

What disease is most responsible for his condition ?

A. Septicemia

B. Drug reaction

C. Infectious mononucleosis

D. Chronic leukemia

E. Acute leukemia

Page 58: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

Test results Hgb 92 g/L MCV 81 fL RBC 3.4 x1012/L WBC 5.2 x106/L Plat 13 x109/L

Blood Film

Cytopenias

Blasts

This 36 year old man is admitted to hospital with generalizedbruising and bleeding. He is febrile. There are many bruisesand petichia present.

Page 59: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

This is a 65 year old male who at retirement has his last regular work medical checkup. He is a bit fatigued but otherwise well. Test Results Hgb 11.0 g/L MCV 92 fL RBC 4.3x1012/L WBC 5.2x106/L Plat 565x109/L

Blood film

Page 60: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has
Page 61: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

What test would best establish the diagnosis ?

A. Serum iron and iron binding capacity

B. Serum B12

C. Urine hemosiderin

D. Bone marrow aspirate

E. Serum transferrin

Page 62: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

This is a 65 year old male who at retirement has his last regular work medical checkup. He is a bit fatigued but otherwise well. Test Results Hgb 11.0 g/L MCV 92 fL RBC 4.3x1012/L WBC 5.2x106/L Plat 565x109/L

Blood film Normocytic Normochromic Microcytic Hypochromic Dimorphic

population

Page 63: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

This is a 35 year old male who is found to have persistent leukocytosis. His family physician wants you to rule out a Chronic leukemia. Test Results HGB 146 g/L MCV 92 fL RBC 5.5x1012/L WBC 25X106/L Plat 465x109/L

Blood Film

Page 64: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has
Page 65: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

What test would be most cost effective in helping to establish a diagnosis ?

A. Immunophenotyping

B. Leukocyte alkaline phosphatase

C. Bone marrow aspirate

D. Cytogenetics

E. Blood cultures

Page 66: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

This is a 35 year old male who is found to have persistent leukocytosis. His family physician wants you to rule out a Chronic leukemia.

Test Results HGB 146 g/L MCV 92 fL RBC 5.5x1012/L WBC 25X106/L Plat 465x109/L

Blood Film Normocytic Normochromic Neutrophilia Metamyelocyte

Page 67: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

A 75 year old woman is admitted to hospital because of pneumonia. She has not been feeling well for some months.

Test Results HGB 96 g/L MCV 103 fL RBC 3.8x1012/L WBC 2.4x106/L Plat 74x109/L

Blood Film

Page 68: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has
Page 69: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

A 75 year old woman is admitted to hospital because of pneumonia. She has not been feeling well for some months.

Test Results HGB 96 g/L MCV 103 fL RBC 3.8x1012/L WBC 2.4x106/L Plat 74x109/L

Blood Film Macrocytes Mild pancytopenia

Page 70: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

Which test would you do next ?

A. Reticulocyte count

B. Serum B12 and Folate

C. Thyroid function tests

D. Liver function tests

E. Bone marrow aspirate and biopsy

Page 71: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

Which do you think is the most likely ?

A. RA - Refractory anemia

B. RARS - Refractory anemia , ring sideroblasts

C. RAEB - Refractory anemia excess blasts

D. RAEBt - RAEB in transformation to Acute

Page 72: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

A 25 year old female university student is found to have a very low hemoglobin. She in fact feels fairly well. Physical exam shows pallor only. Test Results HGB 7.1 g/L MCV 80 fL RBC 2.7x1012/L WBC 6.3x106/L Plat 345x109/L

Blood Film

Page 73: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has
Page 74: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

Which test do you think will give the diagnosis ?

A. Iron studies

B. Reticulocyte count

C. Endocrine studies

D. Liver function

E. Renal function

Page 75: L Test results  Hgb 77 g/L  MCV 66  f/L  RBC 3.2 x10 12 /L  WBC 5.6 x10 6 /L  Plat 525 x10 9 /L l Blood film This is a 55 year old woman who has

A 25 year old female university student is found to have a very low hemoglobin. She in fact feels fairly well. Physical exam shows pallor only. Test Results HGB 7.1 g/L MCV 80 fL RBC 2.7x1012/L WBC 6.3x106/L Plat 345x109/L

Blood Film Irreg contracted Burr cells