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Please see Approved Use and Important Safety Information on slide 2 1

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Please see Approved Use and Important Safety Information on slide 2

Request full KYBELLA™ (deoxycholic acid) injection Prescribing Information or visit mykybella.com

1

Common Causes of Submental Fullness

Causes may include:

AGING: It may naturally develop as you age

GENETICS: Simply said, it may be part of your DNA

WEIGHT GAIN: It may be a result of gaining weight

SOMETIMES, no matter how much you diet or exercise, the condition may not go away, and can make you look older and heavier than you actually are

Please see Approved Use and Impo4 rtant Safety Information on slide 2

Request full KYBELLA™ (deoxycholic acid) injection Prescribing Information or visit mykybella.com

Faces of Submental Fullness

Please see Approved Use and Important Safety Information on slide 2

Request full KYBELLA™ (deoxycholic acid) injection Prescribing Information or visit mykybella.com

3

“I recently saw a photo of myself in profile and was really frustrated with the area under my chin.I work out, eat well, amin relatively good shape, but I can’t seem to losethe fat under my chin.”

David, 48

“I’ve always taken good care of myself – making sure to stay in shape – but the fullness under

my chin was something I was born with. My whole

family has it andmakes me feel less

attractive and overweight.”

Blanchard, 48

“My double chin is an issue, especially as I’ve gotten older. I work on

Wall Street, and while I have a successful career, I think my

double chin keeps me from looking confident at

meetings and with clients.”

Andy, 49

“For as long as I can remember, I’ve had a

double chin. It’s always bothered me. Having a double chin impacted

my self-confidence, especially when I look at photos of

myself.”

Jennifer, 45

An Innovative Treatment for Submental Fullness

Please see Approved Use and Important Safety Information on slide 2

Request full KYBELLA™ (deoxycholic acid) injection Prescribing Information or visit mykybella.com

4

• Is a nonsurgical, 15- to 20-minute in-office treatment session

• Is customized to help you achieve your treatment goals

• Destroys fat cells when injected into the fat beneath your chin.Once the aesthetic goal is achieved, retreatment is not expected

• The most common side effects of KYBELLA™ include swelling, bruising, pain, numbness, redness, and areas of hardness in the treatment area.

Unretouched photos of KYBELLA™ clinical trial patient taken before and after 4 treatment sessions with KYBELLA™

Actual Results withKYBELLA™ (deoxycholic acid) Injection

5

IMPORTANT SAFETY INFORMATION ABOUT KYBELLA™

Before receiving KYBELLA™, tell your healthcare provider about all of your medical conditions, including if you: Have had or plan to have surgery on your face, neck, or chin; have had cosmetic treatments on your face, neck, or chin; have had or have medical conditions in or near the neck area; have had or have trouble swallowing; have bleeding problems; are pregnant or plan to become pregnant (it is not known if KYBELLA™ will harm your unborn baby); are breastfeeding or plan to breastfeed (it is not known if KYBELLA™ passes into your breast milk; talk to your healthcare provider about the best way to feed your baby if you receive KYBELLA™).

1. KYTHERA Biopharmaceuticals, Data on File

Please see Approved Use and Important Safety Information on slide 2

Request full KYBELLA™ (deoxycholic acid) injection Prescribing Information or visit mykybella.com

Individual results may vary.

Sex: Female | Age: 35 | Weight (before): 115.5 lbs. | Weight (after): 113.2 lbs.

Actual Results withKYBELLA™ (deoxycholic acid) Injection

6

Individual results may vary.

Unretouched photos of KYBELLA™ clinical trial patient taken before and after 3 treatment sessions with KYBELLA™

IMPORTANT SAFETY INFORMATION ABOUT KYBELLA™

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your healthcare provider if you take a medicine that prevents the clotting of your blood (antiplatelet or anticoagulant medicine).

KYBELLA™ can cause serious side effects, including nerve injury in the jaw that can cause an uneven smile or facial muscle weakness and trouble swallowing.

1. KYTHERA Biopharmaceuticals, Data on File

Please see Approved Use and Important Safety Information on slide 2

Request full KYBELLA™ (deoxycholic acid) injection Prescribing Information or visit mykybella.com

Sex: Female | Age: 39 | Weight (before): 125.0 lbs. | Weight (after): 130.0 lbs.

Actual Results withKYBELLA™ (deoxycholic acid) Injection

7

IMPORTANT SAFETY INFORMATION ABOUT KYBELLA™

KYBELLA can cause serious side effects, including trouble swallowing and nerve injury in the jaw that can cause an uneven smile or facial muscle weakness.

The most common side effects of KYBELLA include swelling, bruising, pain, numbness, redness, and areas of hardness in the treatment area.

These are not all of the possible side effects of KYBELLA. Call your healthcare provider for medical advice about side effects.

Unretouched photos of KYBELLA™ clinical trial patient taken before and after 5 treatment sessions with KYBELLA™

Sex: Male | Age: 34 | Weight(before): 170 lbs.| Weight (after): 179.5 lbs.

Individual results may vary.

1. KYTHERA Biopharmaceuticals, Data on File

Please see Approved Use and Important Safety Information on slide 2

Request full KYBELLA™ (deoxycholic acid) injection Prescribing Information or visit mykybella.com

Actual Results withKYBELLA™ (deoxycholic acid) Injection

8

IMPORTANT SAFETY INFORMATION ABOUT KYBELLA™

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your healthcare provider if you take a medicine that prevents the clotting of your blood (antiplatelet or anticoagulant medicine).

Unretouched photos of KYBELLA™ clinical trial patient taken before and after 5 treatment sessions with KYBELLA™

Sex: Female | Age: 55 | Weight (before)150.3 lbs. | Weight (after):150.3 lbs. Individual results may vary.

1. KYTHERA Biopharmaceuticals, Data on File

Please see Approved Use and Important Safety Information on slide 2

Request full KYBELLA™ (deoxycholic acid) injection Prescribing Information or visit mykybella.com

Unretouched photos of KYBELLA™ clinical trial patient taken before and after 4 treatment sessions with KYBELLA™

Sex: Female | Age: 39 | Weight(before): 209.8 lbs.| BMI (after): 214.6 lbs. Individual results may vary.

Actual Results withKYBELLA™ (deoxycholic acid) Injection

9

IMPORTANT SAFETY INFORMATION ABOUT KYBELLA™

Before receiving KYBELLA™, tell your healthcare provider about all of your medical conditions, including if you: Have had or plan to have surgery on your face, neck, or chin; have had cosmetic treatments on your face, neck, or chin; have had or have medical conditions in or near the neck area; have had or have trouble swallowing; have bleeding problems; are pregnant or plan to become pregnant (it is not known if KYBELLA™ will harm your unborn baby); are breastfeeding or plan to breastfeed (it is not known if KYBELLA™ passes into your breast milk; talk to your healthcare provider about the best way to feed your baby if you receive KYBELLA™).

1. KYTHERA Biopharmaceuticals, Data on File

Please see Approved Use and Important Safety Information on slide 2

Request full KYBELLA™ (deoxycholic acid) injection Prescribing Information or visit mykybella.com

KYBELLA™ (deoxycholic acid) Injection Patient Results

10

“For as long as I can remember, I’ve had a

double chin—even when I was much younger. Having a double chin impacted my self- confidence. I’ve always taken good care of myself—

making sure to stay in shape—but the fullness under my chin made me feel less attractive and

overweight.”– Amy

Treated with KYBELLA™ (deoxycholic acid)injection in clinical trials

1. KYTHERA Biopharmaceuticals, Data on File

Please see Approved Use and Important Safety Information on slide 2

Request full KYBELLA™ (deoxycholic acid) injection Prescribing Information or visit mykybella.com

KYBELLA™ (deoxycholic acid) injection

• Is a nonsurgical, 15-to 20-minute in-office treatment session• Is customized to help you achieve your treatment goals• Destroys fat cells when injected into the fat beneath your chin. Once

the aesthetic goal is achieved, retreatment is not expected• The most common side effects of KYBELLA™ include swelling,

bruising, pain, numbness, redness, and areas of hardness in the treatment area.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch or

call 1-800-FDA-1088Please see Approved Use and Important Safety Information

on slide 2Request full KYBELLA™ (deoxycholic acid) injection Prescribing Information or visit mykybella.com

29

© 2015 KYTHERA Biopharmaceuticals, Inc. All rights reserved. P-DCA-US-0146 June 2015

Please see Approved Use and Important Safety Information on slide 2

Request full KYBELLA™ (deoxycholic acid) injection Prescribing Information or visit mykybella.com

29

© 2015 KYTHERA Biopharmaceuticals, Inc. All rights reserved. P-DCA-US-0146 June 2015

Los Angeles Board Certified Dermatologist Dr. Rebecca Fitzgerald was selected as a principal trainer for Kybella. The RFMD practice is a Kybella training site.

Training physicians are selected for their skill and knowledge. Kybella’s training physicians represent an elite core of Dermatologists and Plastic Surgeons who are recognized in the industry as having top skills and expertise in their field.