kuliah endokrin 2006 [compatibility mode]
TRANSCRIPT
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SISTEM ENDOKRIN
BATASANSINYAL SELULER
MEKANISME KERJA
PS Poli/endokrin/2005 1
Batasan :
• Kumpulan kelenjar
dgn sekresi kurir
kimia disebut
HORMON
• Hormon membawa
sinyal lewat darah,
tiba di organ sasaran,
diproses oleh
reseptor yang tepat
PS Poli/endokrin/2005 2
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PS Poli/endokrin/2005 3
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PS Poli/endokrin/2005 5
PS Poli/endokrin/2005 6
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• RESPONS dr SISTEM ENDOKRIN(SE) sifatnya LAMBAT :LAMBAT : menit, jam,bulan, atau tahun.
• Komunikasi SE melalui media yiHORMONHORMON
• Hormon menjadi molekul sinyal,dilepaskan oleh jaringan, organ, menujuke sel sasaran utk menghasilkan
respons.
PS Poli/endokrin/2005 7
KLASIFIKASI :
1. Molekul sinyal
dihasilkan oleh sel
organ endokrin, asal
tempat jauh, lewat
pembuluh darh ke
sel sasaran, disebut
ENDOKRINENDOKRIN
PS Poli/endokrin/2005 8
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2. Sinyal molekul asal
dari sel/organ dekat
pada sel sasaran
disebut PARAKRINPARAKRIN
3.Sinyal molekul berasal
dari sel sendiri
disebut AUTOKRIN AUTOKRIN
PS Poli/endokrin/2005 9
PS Poli/endokrin/2005 10
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1. MOLEKUL SINYAL : -
HORMON
-NEUROTRANSMIT
- GROWTH
FACTORS
Disebut LIGANDLIGAND
2.RESEPTOR : molekul
protein, terletak pada
permukaan sel,
sitoplasma, inti.
Disebut RESEPTORRESEPTOR
PROTEINPROTEIN
PS Poli/endokrin/2005 11
KARATERISTIK RESEPTOR :
1.Spesifisitas
2.Afinitas
3.Jenuh
PS Poli/endokrin/2005 12
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KATEGORI HORMON :1.1. HIDROFILIK HIDROFILIK :
Larut dalam air: -peptida
-asam amino
2.2.LIPOFILIK LIPOFILIK :
Larut dalam lemak :
-terikat reseptor
permukaan sel
-terikat reseptor inti sel
PS Poli/endokrin/2005 13
PS Poli/endokrin/2005 14
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ANALOG HORMON :
1.1. AGONIS :AGONIS :
fungsi sama dengan hormon, ikat pd reseptor
dan memberi respons.
2. ANTAGONIS:ANTAGONIS:
terikat reseptor, tidak mengaktifkan hormon,
tidak ada respons
PS Poli/endokrin/2005 15
KARATERISTIK HORMON :
- Hormon normal ada dalam plasma, jar
interstitial
- Konsentrasi hormon 10 M s/d 10 ºM
- Terikat plasma protein utk diangkut,
mencegah kerusakan hormon &filtrasi ginjal, me↑ half life.
PS Poli/endokrin/2005 16
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PS Poli/endokrin/2005 17
MEKANISME KERJA1. Klasifikasi & Karateristik Hormon :
2. Jenis Reseptor :
a. Reseptor permukaan membran sel
aktifkan ensim → second messenger →fosforilase oleh protein kinase (PK ?) →respons biologis.
b. Reseptor sitoplasma / inti : hormonreseptor kompleks → DNA → hormonreseptor elemen → transkripsi → translasi →respons biologis
PS Poli/endokrin/2005 18
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JARINGAN :
1. Mempunyai reseptor, afinitas thd hormon.Reseptor pd membran plasma : peptida &asam amino (first messenger), mengaktifkansecond messenger. 2nd messenger :-cAMP
-Ca++
-IP3 (inositol triphosphate)
-DAG (diacylglycerol)
PS Poli/endokrin/2005 19
2.Sinyal transduksi :
a. reseptor + ligand → protein-G → adenylate
cyclase →cAMP →fosforilase protein : Protein
kinase A (PKA) & PKC
b. reseptor + ligand → protein G → fosfolipase
C → hidrolisa fosfatidylinositol bifosfat → IP3→ RE →Ca++
DAG :aktifkan PKC & Ca++
PS Poli/endokrin/2005 20
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HIPOTHALAMUS & HIPOPHYSE
PS Poli/endokrin/2005 31
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HIPOFISE = pituitary gland-Master gland :kontrol produksi hormon
dari kelenjar endokrin lainnya.
-Hormon lob post dihasilkan oleh
hipotalamus → akson
-Hormon lob ant diproduksi & simpan,
releasing factor dari hipotalamus → p.
darah-Releasing & trophic hormones
PS Poli/endokrin/2005 33
HIPOFISE ANTERIOR :
1. Thyrotropin
2. Adrenocorticotropin
3. Luteinizing hormone
4. Follicle stimulatinghormone
5. Growth hormone
6. Prolactin
7. Melanocytestimulating hormone
8. Endorphine
9. Enkephalin
HIPOFISE POSTERIOR :1. Oxytocin
2. vasopressin
PS Poli/endokrin/2005 34
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PS Poli/endokrin/2005 47
HORMON GASTER & USUS:Hormon lokasi kerja
Gastrin gaster/duod as lambg & pepsin
Cck duod/jeju amylase
Gip usus hls insulin↑ /as lbg
Vip pankreas rlks usus/hco3↑
Motilin usus hls motilitas usus
Panc polypept pankreas hco3 & prot
Enkepalin lmbg, duod, empd aksi opiat
Subs p seluruh usus ?Bombesin lmbg duod gastrin cck ↑
Neurotensin ileum ?
Enteroglukagon usus hls, pankr ?
PS Poli/endokrin/2005 48
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KELENJAR TIROID
1. Sekresi hormon utk mengatur proses
metabolisme, pertumbuhan dan enersi
2. Ada 2 hormon utama, thyroxine (T4) & tri-
iodothyronine (T3)
3. Kebutuhan Iod manusia 150g / hr
4. Iod terutama dari makanan laut
PS Poli/endokrin/2005 49
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4.Makin besar T3 & T4 dalam darah, makincepat metabolisme tubuh.
5.Dikontrol, monitor dan regulasi oleh hipofise &hipotalamus melalui TSH.
6.Pembesaran kel tiroid (goitre), tu oleh asupaniod (negative-feedback)
7.Hipertiroid, T3&T4 ↑, tu oleh peny Grave
(otoimun, TSH sbg ab)
PS Poli/endokrin/2005 51
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8.Gejala hipertiroid : nadi cepat, tremor,
keringat, BB, nervous, fatigue, diare,
exopthalmus, goitre.
9.Hipotiroid : fatigue, dingin, depresi,
konsentrasi, pucat, hair loss, konstipasi,
goitre.
PS Poli/endokrin/2005 53
KELENJAR ADRENAL
PS Poli/endokrin/2005 54
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• Kel adrenal duaorgan jadi satu, tdkorteks & medulla.
• Korteks adrenal,sintesis & sekresikortikosteroid tucortisol,aldosteron dantetosteron.
• Ada 3 zona :1. Glomerulosa :
aldosteron
2. Fasciculata
:glukokortikoid
3. Reticularis :
Ada beda dan tumpang
tindih bioaktivitas
ke-3 hormon tsb.
PS Poli/endokrin/2005 55
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• Glukokortikoid : CRH → ACTH →
glukokortikoid & androgen
• ACTH ↑ → kortisol ↑, mis Cushing’ssyndrome
• Adrenacortical :adrenal crisis, kortisol
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• Cushing’ syndr :
- Hiperglikemia - moonface
- Nitrogen - Vit D3
- Lipogenesis - osteoporosis
- Hiperlipidemia - kulit kasar & lepas
- BB↑ - imun
PS Poli/endokrin/2005 59
• Adrenocrisis :
-stres -vomiting
-sakit kepala - diare
-hipotensi
• Addison’s disease : adrenocortical insuff
chronis-malas, lemah, anorexia, nausea
PS Poli/endokrin/2005 60
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• Aldosteron :
- Na+ reab ↑, K+ ekskresi tub distalis
- pe↑ aldosteron, edema & hipertensi
- respons renin-angiotensin-system
- bebas pengaruh ACTH
- aldosteron ↑: hipernatremia, dehidrasi,
hemorrhage, hipokalemia
PS Poli/endokrin/2005 61
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• ANDROGEN :
- androgen↑, disbt androgenital synd, virilisasi pd ♀, amenorea.
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PS Poli/endokrin/2005 75
Terima kasih !
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HORMON GINJAL
1. ERYTHROPOIETIN (EPO).
2. CALCITRIOL (VIT D3).
3. RENIN
• EPO :
- Glycoprotein, kerja pd bone marrow, dipicu olehperdarahan, daerah tinggi (O2)
- dihasilkan juga di otak bila O2, mis pd stroke
PS Poli/endokrin/2005 77
• CALCITRIOL :
- asal calciferol, kulit, bantuan UV
- calciferol → D3 di hati, ginjal dgn
bantuan PTH
- bantu absorbsi usus
- kekurangan: anak→ rickets
dewasa → osteomalacia
PS Poli/endokrin/2005 78
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• RENIN :
- monitor tek darah (ginjal)
- kerja pd angiotensinogen →
angiotensin I →ACE → angiotensin II
- terjadi : konstriksi arteriole, reabs
Na+, pelepasan aldosteron,
kontraksi jantung ↑, stimulus hipofise lepas
ADH, → tek darah ↑
PS Poli/endokrin/2005 79
KULIT
• Paparan UV → dehydrocholesterol →
calciferol → sirkulasi → hati → vit D3
→ ginjal → calcitriolcalcitriol ( bantuan PTH).
• Disebut hormon :
- dibuat pd sel tertentu
- masuk aliran darah
- transkripsi gen pd sel sasaran
PS Poli/endokrin/2005 80
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JANTUNG
1. Atrial Natriuretic Peptide (ANP) :
dilepas oleh atrium, pd kondisi?
2. Brain Natriuretic Peptide (BNP) :
dilepas oleh ventrikel
Ke2nya berfungsi :
- relaksasi arteriole
- inhibisi renin & aldosteron- inhibisi reabs Na+ pd ginjal
PS Poli/endokrin/2005 81
TESTIS
PS Poli/endokrin/2005 82
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PS Poli/endokrin/2005 83
PS Poli/endokrin/2005 84
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PS Poli/endokrin/2005 85
PS Poli/endokrin/2005 86
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PS Poli/endokrin/2005 87
PS Poli/endokrin/2005 88
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PS Poli/endokrin/2005 89
PS Poli/endokrin/2005 90
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PS Poli/endokrin/2005 91
PS Poli/endokrin/2005 92
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OVARIUM
PS Poli/endokrin/2005 93
PS Poli/endokrin/2005 94
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• Kelenjar hormon kerja
1.Pineal melatonin terang/gelap,
BB, reproduksi
2.Hipotala releasing :
mus GnRH FSH & LH (hipof)
TRH TSH & PRL
CRH ACTH
GRH GH
PS Poli/endokrin/2005 95
inhibitingPIF inhibit PRL
HIPOFISE gonadotroph
ant FSH folikel & spermto
LH estr & proges & testos
trophik
TSH tiroid
ACTH adrenal
GH somatomed
PS Poli/endokrin/2005 96
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intermed MSH pigmentasi
post oxytocin susu, uterus
vasopres ↑ air & garam
tiroid T3 & T4 pert, metab, enersi
paratir pth, calcit metab ca
pankreas insulin gula , msk sel
glucagon gula↑, gluconeo
adrenal kortisol dst
aldosteron
testost
PS Poli/endokrin/2005 97
ovarium folikelestrogen sex II, reprod tr,
umpan balik
inhibin inhibt FSH
korpus luteum
progest jaga kehamilan,
mama, umpan
balik
relaxin dilatasi serviks
PS Poli/endokrin/2005 98
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testis leydig
testosteron reprod ♂, spermt
sertoli
estrogen umpan blk (-) Gondt
inhibin inhibt FSH
plasenta
progest, estr, relaxin
HCG seperti LH
PS Poli/endokrin/2005 99
SISTEM REPRODUKSI• SEKSUAL
• ASEKSUAL
PS Poli/endokrin/2005 100
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PS Poli/endokrin/2005 109
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