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EVALUATION OF CARDIOPROTECTIVE ACTIVITY OFAQUEOUS EXTRACT OF Garcinia indica Linn FRUIT RIND.

MASTER OF PHARMACY DISSERTATION PROTOCOL

SUBMITTED TO THE

RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES KARNATAKA,BANGALORE

BYPATEL DHRUV KAMLESHKUMAR

Under The Guid n!e "# Mr$ SUNIL KOSHY, M$PHARM

DEPARTMENT OF PHARMACOLOGY,SRINIVAS COLLEGE OF PHARMACY, MANGALORE % &'()(*

+ )+ % + )*-MID STREAM BATCH.

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RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES

BANGALORE, KARNATAKA

ANNE/URE0II

PROFORMA FOR REGISTRATION OF SUBJECT FOR DISSERTATION

)$ NAME AND ADDRESS OF

THE CANDIDATE

PATEL DHRUV KAMLESHKUMAR 62,HARIOM SOC,BAVLA-382220DI-AHMEDABADGUJARAT

+$ NAME OF THE

INSTITUTION

SRINIVAS COLLEGE OF PHARMACYVALACHIL,MANGALORE-5 !"!3

*$ COURSE OF STUDY AND

SUBJECT

MASTER OF PHARMACY INPHARMACOLOGY

($ DATE OF ADMISSION TO

COURSE

"0#0"#20"3

&$ TITLE OF THE TOPIC

EVALUATION OF CARDIOPROTECTIVEACTIVITY OF AQUEOUS EXTRACT OFGarcinia indica Linn FRUIT RIND.

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1$ BRIEF RESUME OF THE INTENDED 2ORK 3

1$)NEED FOR THE STUDY 3

A$$%&'()* +% + .()'()*/ %. + N +(%) 1 V(+ 1 S+ +(/+($/ R %&+ 20084

)' + M%& ('(+ )' M%&+ 1(+ 7 1 R %&+ 200 4 %. + C )+ &/ .%&D(/ / C%)+&%1 )' P& 9 )+(%) CDC4, $ &'(%9 /$:1 & '(/ / / ()$1:'()*

; %$ &'( 1 (). &$+(%) MI4 )' + & /:1+ )+ $%; 1($ +(%) () $ &'( $

.:)$+(%) & & / )+ + 1 '()* $ :/ %. ;%& ('(+ )' ;%&+ 1(+ ()

' 9 1% ' $%:)+&( /",2 < M%& %9 &, =(+ '9 )$ ' 1(. /+ 1 () ' 9 1% ()*

$%:)+&( /, /:$ / I)'( , &+($:1 &1 () ; +&% %1(+ ) $(+( /, MI (/ ; ()*

()$& /()*1 (; %&+ )+ $%)+&( :+(%) +% ;%&+ 1(+ /+ +(/+($/ %. /:$$%:)+&( /3 * ) / $( / /:$

/ /: &%>(' )(%) 1 & '($ 1/ (' /, ' ; * %. $ 11

; ; & ) , )' ' /+&:$+(%) %. )+(%>(' +(9 ' . )/ / /+ ; 5,6(' , $ ) $ :/ %>(' +(9 ' ; * +% $ 11 1( ('/, &%+ ()/, )' ):$1 ($

$('/< A $%)/ )/:/ /+(11 >(/+/ + + & $+(9 %> * ) / $( / 1 )

(; %&+ )+ &%1 () + + %* ) /(/ %. $ &'( $ & &.:/(%) ()?:&

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'9%$ + ' .%& + $%)+&%1 %. CVS '(/ / / &(; )+ 1 ;%' 1/ () )(; 1/ ;() ' .%& (/+% + %1%*($ 1 ()9 /+(* +(%)/ ;() ' &

*&()' &< T $% &/ 1 %=' & ' .%&; %. / ' '&( ' .&:(+ &()'/ = /

1 $ ' () $%)($ 1 .1 / $%)+ ()()* '(/+(11 ' = + & )' $1%/ ' =(+ $%++%)

1:* .%& ' / + &%%; + ; & +:& < T ) (+ = / .(1+ & ' :/()* ( $ %.

$1 ), /+ &(1 , = (+ $%++%) $1%+ )' 9 %& + ' +% '& ) // +% ( 1'

: %:/ >+& $+< T / ;(/%1(' >+& $+ % + () ' = / /+%& ' () ) (&+(* +

$%)+ () & () & .&(* & +%& .%& .:&+ & :/ < T /%1:+(%) %. : %:/ >+& $+

= / & & ' :/()* )%&; 1 / 1() / /%19 )+ .%& > &(; )++& $+ 1%= '%/ 250;*# *4

o G&%: -V-Garcinia indica .&:(+/ >+& $+ (* '%/ 500;*# *4

C &9 '(1%1 =(11 ';()(/+ & ' +% *&%: III )(; 1/ %) = .%&

';()(/+& +(%) %. I/% &%+ & )%1< A11 + )(; 1/ () *&%: IV V =(11

+& + ' %)$ ' (1 %/+ %& 11 .%& ! = /< O) 2+ )' 30 + ' .+ & ++& +; )+, ; %$ &'( 1 (). &$+(%) =(11 ()':$ ' () *&%: II *&%: V

)(; 1/ /: $:+ ) %:/ ()? $+(%) %. I/% &%+ & )%1

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EVALUATION3

S ; +%;/ )' ;%&+ 1(+ () $ *&%: =(11 & $%&' ' )' $%; & '

=(+ )(; 1/ *(9 ) =(+ I/% &%+ & )%1 1%) < F%&+ - (* + %:&/ .+ & +

.(&/+ I/% &%+ & )%1 ';()(/+& +(%), + & +/ =(11 / $&(.($ ' )'

:+% /( '< T &+/ =(11 & ;%9 ' )' = (* ' )' + .&%)+ 1/ $+(%)/ =(11 ; '' ' .%& (/+% + %1%*($ 1 > ;() +(%)(' '(/;:+ / )' C + 1 / + )+ %.

$ &'(% &%+ $+(%) ': +% Garcinia indica >+& $+ =(11 9 1: + '

; /:&()* + ' 9 1% ' + )/(%)('

'(/;:+ / )' C + 1 /