knee joint: a case report - cureus .pigmented villonodular synovitis of the knee joint: a case...

Download Knee Joint: A Case Report - Cureus .Pigmented Villonodular Synovitis of the Knee Joint: A Case Report

Post on 14-Sep-2018

214 views

Category:

Documents

0 download

Embed Size (px)

TRANSCRIPT

  • Received 09/26/2016 Review began 09/28/2016 Review ended 09/29/2016 Published 10/04/2016

    Copyright 2016Kapoor et al. This is an open accessarticle distributed under the terms ofthe Creative Commons AttributionLicense CC-BY 3.0., which permitsunrestricted use, distribution, andreproduction in any medium,provided the original author andsource are credited.

    Pigmented Villonodular Synovitis of theKnee Joint: A Case ReportChirag Kapoor , Maulik Jhaveri , Rishit Soni , Malkesh Shah , Parth Rathi , PareshGolwala

    1. Orthopaedics, Sumandeep Vidyapeeth, Vadodara, Gujarat

    Corresponding author: Chirag Kapoor, drchirag_kapoor@yahoo.com Disclosures can be found in Additional Information at the end of the article

    AbstractPigmented villonodular synovitis (PVNS) is a rare, benign, but potentially locally aggressiveand recurrent condition characterized by synovial proliferation and hemosiderin depositioninside the joints, tendon sheaths, and bursae. It usually affects the large joints such as hip,knee, and ankle. We report a case of PVNS of the knee joint in a young female which wastreated by subtotal synovectomy alone without the use of adjuvants. At the 14-month follow-up, the patient was pain free and had no signs of disease recurrence.

    Categories: Oncology, Orthopedics, PathologyKeywords: villonodular, synovitis, synovectomy, mri

    IntroductionPigmented villonodular synovitis (PVNS), coined by Jaffe, et al. [1] in 1941 is a rare, benign, butpotentially locally aggressive and recurrent condition. It is characterized by synovialproliferation and hemosiderin deposition inside the joints, tendon sheaths, and bursae. Itusually affects the large joints, i.e. hip, knee, and ankle, but few cases of PVNS involving smalljoints have been reported [1]. The most commonly involved joint has been the knee, followedby the hip and the ankle [2]. There are two types of PVNS: localized and diffuse. The diffuse typeis reportedly three times more common than the localized type [3].

    The etiology of PVNS is not certain but some researchers have debated whether it isinflammatory or neoplastic in origin while others have suggested trauma-induced hemorrhageas an etiology.

    Case PresentationA 28-year-old female presented to us with a six-month history of pain and swelling in the leftknee joint. The swelling gradually increased over a period of time and was associated withdifficulty in walking and standing. The swelling was diffuse and nodular in consistency,measuring 17 cm x 11 cm in size (Figure 1). The overlying skin was normal with no signs ofinflammation. There was no instability of the knee joint on physical examination. No otherjoint was involved.

    1 1 1 1 1

    1

    Open Access CaseReport DOI: 10.7759/cureus.816

    How to cite this articleKapoor C, Jhaveri M, Soni R, et al. (October 04, 2016) Pigmented Villonodular Synovitis of the Knee Joint:A Case Report. Cureus 8(10): e816. DOI 10.7759/cureus.816

    https://www.cureus.com/users/28562-chirag-kapoorhttps://www.cureus.com/users/28608-maulik-jhaverihttps://www.cureus.com/users/29286-rishit-sonihttps://www.cureus.com/users/29287-malkesh-shahhttps://www.cureus.com/users/31940-parth-rathihttps://www.cureus.com/users/28570-paresh-golwala

  • FIGURE 1: Clinical image showing the swelling around theknee joint

    Radiographs of the left knee were obtained which showed no bony abnormality (Figure 2). Amagnetic resonance imaging (MRI) scan revealed a large joint effusion seen predominantly inthe suprapatellar recess as well as in the lateral and medial femoral recesses appearinghyperintense on T2-weighted images. Diffuse synovial thickening was seen which appearedhypointense on T1 as well as hypo on T2-weighted and susceptibility images, and the synoviumappeared hypertrophied. A multilobulated lesion was seen in continuity with the synovium inthe anteromedial, anterolateral, and patella-femoral joint space. Few internal septae were seen.On postcontrast scan, thick enhancement was seen along the synovium (Figure 3). All thesefeatures were consistent with the diagnosis of pigmented villonodular synovitis.

    2016 Kapoor et al. Cureus 8(10): e816. DOI 10.7759/cureus.816 2 of 8

    https://assets.cureus.com/uploads/figure/file/7687/lightbox_d7c2d7a083c711e689ad51b917ae168b-Figure_1.pnghttps://assets.cureus.com/uploads/figure/file/7688/lightbox_fb1644d083c711e69ca6b7e288118a22-Figure_2.png

  • FIGURE 2: Pre-op radiograph of knee joint showing noabnormality

    FIGURE 3: MRI of the knee joint - coronal and axial viewsMulitlobulated lesions seen medially and laterally around the knee joint suggestive of PVNS.

    After obtaining written informed consent from the patient, she was submitted to surgery. Sub-total synovectomy was done using a medial parapatellar approach to the knee joint. Thesynovium was excised in toto as a pouch. Intraoperatively, a brownish nodular synovium wasfound which again was suggestive of PVNS (Figure 4).

    2016 Kapoor et al. Cureus 8(10): e816. DOI 10.7759/cureus.816 3 of 8

    https://assets.cureus.com/uploads/figure/file/7690/lightbox_43d21c8083c811e69e561f2dd553d7af-New_Microsoft_Office_PowerPoint_Presentation.pnghttps://assets.cureus.com/uploads/figure/file/7691/lightbox_91b5138083c811e6967f0ba2fb2fd289-Figure_4.png

  • FIGURE 4: Intra-operative imageImage shows multinodular brownish synovium around the knee joint.

    The excised synovium (Figure 5) was sent for histopathological examination which showedsynovial tissue with hyperplastic synovial lining forming papillary proliferation withoedematous stroma and presence of granulation tissue. The blood vessels were dilated andcongested, surrounded by dense inflammatory infiltrate of plasma cells, lymphocytes, andhistiocytes. Scattered hemosiderin granules along with hemosiderin-laden macrophages werealso seen (Figure 6). All these features confirmed the diagnosis of PVNS.

    2016 Kapoor et al. Cureus 8(10): e816. DOI 10.7759/cureus.816 4 of 8

  • FIGURE 5: The excised tissue after synovectomy

    2016 Kapoor et al. Cureus 8(10): e816. DOI 10.7759/cureus.816 5 of 8

    https://assets.cureus.com/uploads/figure/file/7692/lightbox_b96b178083c811e6ba006780549391d2-Figure_5.png

  • FIGURE 6: Histopathological slide showing hyperplasticsynovial lining with scattered hemosiderin deposits

    Postoperatively, the patient was started on passive knee flexion and extension exercises for 15days and made to walk after that. Follow-up was taken at regular intervals, and at the 14-month follow-up there were no signs of recurrence both clinically and radiologically, and thepatient had full knee range of movement.

    DiscussionIntra-articular PVNS is an uncommon disease. The prevalence has been estimated to be 1.8cases per million population [4]. It commonly affects individuals in the fourth and fifth decades[5]. Most cases that occur have been monoarticular but rarely, polyarticular PVNS has beenreported [6].

    The mechanism of bone erosion in PVNS is still unclear. Some believe that pressure within theinvolved joints increases because of the synovial overgrowth while others believe that thesynovium releases a substance that causes bone erosion which in turn results in jointdestruction [7].

    The reported rate of recurrence is varied. PVNS has been reported to have a high recurrencerate, but it rarely becomes malignant [5]. Surgical excision is the preferred management forboth localized and diffuse PVNS with success being dependent on complete resection with clearmargins. The best treatment for diffuse PVNS is controversial. Open surgical excision has beenthe primary method for treating diffuse PVNS [8]. Another method is arthroscopic synovectomywhich has the advantage of smaller incisions and reduced morbidity but has reportedrecurrence rates as high as 46%, so some authors recommend open synovectomy [5]. It is alsotheoretically possible that arthroscopy results in secondary seeding because of limited surgicalview and joint irrigation system which probably leads to recurrence [5].

    2016 Kapoor et al. Cureus 8(10): e816. DOI 10.7759/cureus.816 6 of 8

    https://assets.cureus.com/uploads/figure/file/7693/lightbox_d602467083c811e6b6505dc24cdb8d7b-Figure_6.png

  • In patients with diffuse PVNS, some authors have recommended staged anterior and posteriorsynovectomies. The recurrence rate associated with such treatment ranges from 14% to 56% [5].However, total synovectomy is difficult to perform and may injure the neurovascular structuresadjacent to the affected synovium. Furthermore, one report suggests that total synovectomymay increase the risk of osteoarthritis, so subtotal synovectomy is preferred [8]. Non-resectablePVNS tissue also may be controlled using adjuvant therapy, such as intra-articular instillationof radioactive isotopes, which was not necessary in our case [9]. However, adjuvantradiotherapy with agents such as yttrium-90 has been associated with side effects. We did notopt for adjuvant radiotherapy as it was possible to remove the affected synovium completely inour patient and because of the potential significant risks like radionecrosis of the soft tissueand infertility involved with radiotherapy in a young female [10]. Kotwal, et al. [9] reported norecurrence of PVNS after surgery followed by postoperative radiotherapy and sixpercent recurrence after surgery alone.

    ConclusionsPVNS is an unusual condition with a high potential for recurrence and requires excision. If it iseasily resectable, adjuvant radiotherapy is not required.

    Additional InformationDisclosuresHuman subjects: Consent was obtained by all participants in this study. Conflicts of interest:In compliance with the ICMJE uniform disclosure form, all authors declare the following:Payment/services info: All authors have declared that no financial support was recei

View more >