kirkman digestiveenzymesguide

8/3/2019 Kirkman DigestiveEnzymesGuide

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cover


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A Message from the Author


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By Jon B. Pangborn, PhD, CCN

When we eat carbohydrate oods, we consume comple sugars called

disaccharides (two connected simple sugars) and polysaccharides or oligosac-

charides (more than two connected together). Our digestive tract must break

these comple sugars down into single, simple sugars that our cells need to

generate energy, aid metabolism, and help build and repair tissue. The most

important o these simple sugars is glucose. The body stores energy by com-

bining phosphate and glucose molecules in long, chain-like structures (gly-

cogen), and it draws on these reserves by disassembling glycogen into single

molecules o glucose with attached phosphate. Glucose with its phosphate

then can provide chemical energy and hydrogen to orm the most important

nutrient or combating oidant stress, the orm o vitamin B-3 denoted asNADPH. Glucose can also be transormed into other simple sugars and can

participate in many other processes that cells need or health and unction.

The problem that some o our children have is that they are unable to di-

gest some o the comple sugars in oods. This was discovered and published

in the science literature by Horvath et al.,1 Horvath and Perman,2 Kushak and

Buie3 and Kushak et al.4

Failure to completely digest comple sugars not only handicaps cellular

energy and antioidant capabilities, it also provides a ood supply or unwant-

ed and possibly harmul gut ora (dysbiotic ora). That, in turn, may lead toinammation, leaky gut and uptake o toic substances.

Our intestines contain seven major enzymes that digest comple sugars.

These are sugars that eist mostly in ruits, vegetables, and grains.

Several clinical studies by Kushak, Buie and others (cited above) indi-

cate that one o these enzymes, isomaltase, may be defcient in digestive

activity or 40% to 64% o our children. Isomaltase, also called palatinase

or isomaltulose, digests isomaltose and palatinose sugars that are ound

in grains, potatoes, and other carbohydrate-containing oods, even honey.

Isomaltase defciency is not uncommon and oten is described in nutritiontetbooks. It may lead to abdominal pain, cramping, diarrhea and general un-

happiness ollowing meals o what are normally thought o as healthy oods.

In the human small intestine, isomaltase (palatinase) is combined with the

sucrose-digesting enzyme in a comple that grows rom the same crypt cells

as dipeptidyl peptidase IV (DPP-IV). Sucrase digests sucrose, a comple sugar

(glucose plus ructose) ound in ruit. DPP-IV, digests opiate-acting peptides

rom casein and gluten casomorphins and gluteomorphins.

Is Isogest theMissing Puzzle Piece

for Digestion?


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Tetbooks tell us that all o these enzymes are inhibited or inactivated by

certain toicants, including mercury, silver, amine chemicals and some organo

chlorines.5,6 So, defciency o isomaltase (and sucrase and DPP-IV) is not neces

sarily o genetic origin and may be acquired temporarily due to toicity in th

small intestine. Detoifcation therapy that releases heavy metals like mercur

may also lead to temporary impairment o these digestive enzymes.

Wt d It t d wit ti?

When we design digestive aids or use as nutritional supplements, we

do not have human enzymes to work with. What we do have and might use

are enzymes etracted rom animals, plants or microbes. O those, we pre-

er to use plant-sourced material or reasons o purity and human tolerance.

Unortunately, the arsenal o available etracted enzymes does not include

isomaltase/palatinase while it does include some other disaccharidases (lacta

maltase). These are also ound to be lacking in many o our children.1,2,3,4

So at Kirkman we set out to discover i some available, plant-sourced en

zyme possessed signifcant isomaltase and palatinase activities that is, could

we fnd a ood-grade enzyme material that digests isomaltose and palatinos

sugars without producing any problem by-products. Ater considerable searc

ing and laboratory testing, we ound a plant-based, single-protein enzyme

o plant source, highly purifed, that digests isomaltose and palatinose. We

named it Isogest. It is patent-applied-or and is eclusively available in

Kirkmans Isogest products such as EnZym-Complete/DPP-IV II with Isogest

ormula.

My son uses it.

Jon B. Pangborn, PhD, Ch.E., F.A.I.C.

Co-ounder, DAN!

Certifed Clinical Nutritionist

Consultant to KirkmanGroup, Inc.

References

1. Horvath K, JC Papadinitriou, et al.,J.Pediatrics 135 no.5 (Nov 1999) 559-5632. Horvath K. and JA Perman Curr Opinion

in Pediatrics 14 (2002) 583-873. Kushak RI and T Buie Disaccharidase De-ficiencies in Patients with Autistic SpectrumDisorders presented at Defeat AutismNow New Orleans Think Tank Jan 20044. Kushak RI, HS Winter et al. Gastroin-testinal Symptoms and Intestinal Disaccha-ridase Activities in Children with Autism,Poster Session. N.Am.Society of PediatricGastroenterology, Oct 20, 2005 (Drs.Kushak and Winter are at MassGeneralHospital, Boston)5. White and White, Source Book of En-zymes, CRC Press, 19976. Misumi and Ikehara, Chapt. 128 in Bar-rett et al. Eds, Handbook of ProteolyticEnzymes, Academic Press, 1998.


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IMPORTANT

The material in this guide is for informational

use only. It should not be used as a substitute

for advice from a health care professional.

Please consult with a health care professional

regarding the application of this material

to your own personal needs and situation.

Ti pbiation i not intntd to diano,

trat, r or prvnt any dia.

2009 Kirkman Group, Inc.


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A MessAge fROM The AuThOR

Is IsOgesT The MIssINg Puzzle PIece fOR DIgesTION?

IMPORTANT

WhAT ARe eNzYMes?

DIgesTIVe eNzYMes

WhY shOulD I TAKe A DIgesTIVe eNzYMe suPPleMeNT?

WhY MIghT I Be lAcKINg The eNzYMes I NeeD?

The PANcReATIc eNzYMes

fuNcTIONAlITY Of DIgesTIVe PANcReATIc eNzYMes

WhAT ARe sOMe Of The INDIcATORs Of suBOPTIMAleNzYMe BAlANce?

WhAT ARe The POTeNTIAl cONseQueNces Of NOT hAVINgThe PROPeR BAlANce Of DIgesTIVe eNzYMes?

PlANT BAseD VeRsus ANIMAl BAseD eNzYMes

WhAT Is uNIQue ABOuT KIRKMANs fAMIlY Of DIgesTIVe eNzYMes?

The IsOgesT fAcTOR IN KIRKMANs BROAD-sPecTRuM eNzYMes

WHY IS ISOGEST SUCH AN IMPORTANT DISCOVERY?

WHICH OF KIRKMANS ENZYME PRODUCTS CONTAIN ISOGEST?

HAS ISOGEST BEEN EVALUATED IN ANY CLINICAL STUDIES?

WhO shOulD cONsIDeR TRYINg eNzYMes cONTAININg IsOgesT?

effecT Of IsOgesT ON IsOMAlTOse AND PAlATINOse

The cOMPleTe fAMIlY Of KIRKMANs DIgesTIVe eNzYMes

ENZYME GUIDE COMPARISON CHART

ENZYM-COMPLETE/DPP-IV

ENZYM-COMPLETE/DPP-IV II WITH ISOGEST

CARB DIGEST WITH ISOGEST

MAxIMUM SPECTRUM ENZYM-COMPLETE/DPP-IV FRUIT FREE W/ISOGEST

ENZYMAID MULTI-ENZYME COMPLEx

DPP-IV FORTE

MULTI-ENZYME FORMULA

PEPTIDASE COMPLETE

PHENOL ASSIST

BIOCORE DAIRY

QuesTIONs AND ANsWeRs

NOTes

ABOuT The KIRKMAN fAMIlY

OuR cusTOMeR seRVIce sTAff

Table of conTenTs


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WhaT are enzymes?

Enzymes are protein-based constituents o living organisms, plant and

animal, that regulate the activities o all living cells. Without enzymes, there

would be no lie.

The human body contains in ecess o 3,000 dierent enzymes that unc-

tion in chemical reactions, metabolism, digestion, immune response and

many other body processes. Enzymes are considered catalysts o biochemi-

cal reactions. Each enzyme in the body has a very speciic job to accomplish

and rarely has multiple unctions. I the enzyme necessary to catalyze a given

reaction is deicient or not available, that reaction cant take place.

DIgesTIve enzymes

Digestive enzymes are those enzymes ound in the body

that unction as biological catalysts to begin the breakdown

o oods so that the important nutrients in the ood can be

properly absorbed and utilized.

All ood contains nutrients and potential nutritional

value; however, until enzymes start the digestive process, the

nutrients are locked up in the cellular structure and are not

yet available to be absorbed by the body. For eample, the

iber and vitamins in your breakast cereal provide no value

until your digestive enzymes start the digestion process and

unlock the nutrients. Similarly, the meat or ish you consume

does not deliver the protein necessary or growth and devel-

opment until protease enzymes digest the protein.

Why shoulD I Take a DIgesTIve

enzyme supplemenT?

Proper and complete digestion is essential in maintain-

ing good health because without digestion, the nutrients

you consume rom the ood you eat wont be adequately

absorbed. Digestive enzymes also play a key role in gastro-

intestinal health because they can eert a powerul eect in

addressing a ull range o commonly recognized gastrointes-

tinal disturbances, including intestinal irritation, maldigestion, malabsorption,

intestinal hyperpermeability, gut dysbiosis, and ood allergies and sensitivities.

Clinical eperience with the use o digestive enzymes has shown that these

conditions can be supported by the use o broad-spectrum enzyme ormula-

tions.

The body contains in excess of 3,000different enzymes.


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Why mIghT I be lackIng The enzymes I neeD?

The human body naturally produces digestive enzymes; however, the o

lowing situations can leave an individual lacking in necessary enzymes:

nutritional deficiency adversely impacts enzymes

enzyme production can decrease with age

cooking of foods destroys naturally occurring enzymes that workwith human digestive enzymes

stress can deplete enzymes

illness can inhibit enzyme production

injury can tax enzyme levels

The pancreaTIc enzymes

When we talk about supplementing with digestive enzymes, we meanthe pancreatic enzymes. These are the enzymes that have speciic jobs and

act only on speciic types o ood substrates.

When digestive enzyme supplementation is called or or recommended

by a health proessional, it is imperative that the proper combination o

enzymes is chosen in order to address the particular digestive issues pres-

ent. For eample, lipase only digests ats; it does not act on protein or suga

Sucrase only digests sugars; it has no eect on at or protein. Proteases and

peptidases act on protein, casein, and gluten. Other enzymes do not.

A speciic enzyme combination must be selected based on an individualspeciic needs. There are many dierent enzyme products in the market-

place including:

lipase - specifically addresses fat digestion

lactase - specifically aids lactose intolerance

peptidase/protease - digest proteins and peptides including caseinand gluten

DPP-IV (peptidase) - targets casein and gluten

multi- or broad-spectrum enzymes that digest all food groups

carbohydrate digesting enzymes

I you know speciically that a person needs a particular enzyme, such

as lipase or ats, you can look or that speciic enzyme in the product you

choose. Usually, however, individuals are not sure which enzymes are need

Many situations can cause enzyme deficiency.


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ed. In that case, a multi- or broad-spectrum enzyme product would be the

best choice. Broad-spectrum enzyme products help digest all ood groups

including proteins, ats, starches and other carbohydrates, sugars, celluloses,

and iber.

Kirkman has advanced digestive enzyme products containing Isogest,

a patent pending enzyme component with isomaltase activity. No other

commercially available enzymes contain the Isogest raction. Kirkmans

EnZym-Complete/DPP-IV II with Isogest and Maimum Spectrum Enzym-Complete/DPP-IV Fruit Free w/ Isogest are the two products o choice. The

latter product is ruit-ree, which is important or individuals who are sensitive

to pineapple or papaya ruit.

A chart describing all o the components o typical digestive enzyme prod-

ucts ollows along with what speciic unction they perorm in the digestive

process. This is a complete list o pancreatic

enzyme ingredients; all enzyme products

will not contain all o these because many

digestive enzyme products are ormulated to

carry out speciic unctions. Wide- or broad-spectrum enzyme products may contain

nearly all o the components eplained in the

chart with the eception o Isogest because

only Kirkmans enzyme products contain that

unique ingredient.


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fntionaity o Ditiv Panrati enym

Idit at fd g Ditd

pt Protein Meats, nuts, eggs, milk, cheese,

soy, some grains

ptid Peptides, amino acids Casein, gluten

proteins

Dpp-Iv Casein, gluten Dairy products and grains

bi Proteins Meats, ish, dairy, soy, some grains

pi Proteins Meats, ish, dairy, soy, some grains

li Fats Oils, at soluble vitamins, essential atty acids,

butter, margarine, at in meats, prepared oods,

nuts, and seeds

lt Milk sugar Lactose

c Cell membrane o plants Vegetables and ruit ibers, grains, cellulose,

cereal

x (also known Plant protein and iber Legumes and crucierous vegetables

as hemicellulase)

It (sucrase) Sucrose, sugar Beet and cane sugar

a Starches and Starches, potatoes, corn anda-a, carbohydrates polysaccharides

g-a

a-gtid Vegetable starch and Beans, legumes, and crucierous vegetables

pt Phytic Acid Present in plants such as wheat, corn, oats, and

soybeans (phytic acid adversely aects the

absorption o minerals)

mt Maltose Maltose

pti Proteins, ats, starches Pancreatin contains lipase, amylase, and

protease

It Isomaltose, Palatinose Select carbohydrates

legumes


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WhaT are some of The InDIcaTors of

subopTImal enzyme balance?

Many enzyme imbalances require laboratory testing or verifcation, but

there are some visual or sensory signs that may be useul to physicians or in-

dividuals in spotting a problem or suggesting an enzyme issue. The ollowing

chart summarizes some o these.

enzyme InDIcaTIons sympToms

Prota

DPP-IV/Pptida

lata

lipa

Amya/Diaarida

Invrta/sra

ca

incomplete breakdown of proteinscan result in the development offood allergies as molecules enterthe bloodstream and the body seesthese substances as foreign, result-ing in allergic/adverse reactions

opiate peptide excess resultingfrom incompletely broken downcasomorphin and gluteomorphinpeptides

deficiency of lactase to breakdownlactose (milk sugar)

long-term malabsorption of fat

caused by deficiency of the lipaseenzyme results in malabsorption offats, fat-soluble vitamins and es-sential fatty acid deficiencies

incomplete breakdown of carbohy-drate containing foods

high sugar intake resulting in notenough enzyme to optimally breakdown sugar

inability to break down fiber foods;only enzyme that is not naturallyproduced in the body and as aresult it must be supplementedorally

presence of ammonia smell can bedetected in urine, with incompletedigestion, meat fibers may be pres-ent in stool along with a foul odor

may present with a number ofphysical and/or behavioral issues

abdominal bloating, gas, cramp-ing, occasional diarrhea

oily (greasy) stools which can con-

tribute to a rancid and foul smellof the stool, tan or gray coloredstools are also an indication of fatmalabsorption problems as well asfoamy stools

intestinal gas (flatulence) andbloating

fermentation in the intestinal tractwith a potential for overgrowth ofbacteria or yeast

noticeable undigested food fiber inthe stools (e.g. undigested veg-etable parts)


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WhaT are The poTenTIal consequences of noT

havIng The proper balance of DIgesTIve

enzymes?

malabsorption o nutrients can lead to malnutrition, abnormalgrowth patterns, improper organ development and immune systemimpairment

malnutrition can result in vitamin and mineral defciencies, poor orimpaired wound healing, skin conditions, behavioral problems,intestinal ora imbalances, and lack o immune system supportleading to requent illness

eeling o ullness or bloating ater meals

gas, diarrhea, constipation, and/or oul smelling stools

poor health and conditions o the digestive system, colon, or rectum

planT-baseD versus anImal-baseD enzymes

Animal derived pancreatic enzymes rom cows and pigs have been used

successully to aid digestion or decades. Some drawbacks do eist, however,

in animal derived enzymes. O concern are:

1. Some individuals can be sensitive to the animal derived ingredients.

2. Animal derived enzymes are not stable in the pH o stomach acid,thereby requiring special coating or processing so they go through thestomach undamaged. This special processing adds to costs.

3. The source, health and environmental history o the animals is aconcern.

Kirkman uses only plant-based enzymes. Plant-based enzymes are deriv

rom cultivated plant sources, most oten the Aspergillus oryzae species o

plant mold, though other species o Aspergillus are used or certain enzymes

These enzymes go through etensive purifcation processes and oer sae an

eective alternatives to the animal products. An etensive fltering process

separates the pure enzyme rom its original substrate, which makes these

products suitable even or the etremely sensitive individual. Plant based en

zymes oer these advantages over the animal enzymes:

better tolerated by the sensitive individual

no concern o the animal source or environment

stable and eective at a ull range o pHs, so they are not inactivatedin the acid pH o the stomach

Kirkman uses only plant-based enzymes.


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no special coatings are needed, which makes plant enzymes armore economical than animal based enzymes

starts the digestive process in the stomach, which makes theintestinal digestive unctions easier and more efcient

WhaT Is unIque abouT kIrkmans famIly of

DIgesTIve enzymes?All o Kirkmans enzyme products are made rom plant derived enzymes

and are encapsulated in all vegetable capsules manuactured rom pine cel-

lulose. Our enzymes are:

casein ree

gluten ree

soy ree

sugar ree

preservative ree

color ree

ree o other common allergens

ree o sulftes

ree o fsh and tree nuts


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Enzymes that digest carbohydrates are a major component o broad-spectrum enzymes. The human digestive tract contains seven carbohydrase

enzymes that split dietary disaccharides into ree monosaccharides. Prior to

Kirkmans introduction o Isogest, commercially available digestive enzyme

products contained enzyme ingredients that had the activity o only some

o these disaccharidase enzymes. A very important enzyme called sucrose-

isomaltase was only partially represented in these commercial products. The

invertase or sucrase portion o the enzyme was present, but the isomaltase

raction was not - and or a good reason: there is no commercially available

orm o isomaltase available in the world.

Raail Kushak, Ph.D. and Timothy Buie, M.D. o MassGeneral Hospital orChildren in Boston confrmed the importance o this missing enzyme rac-

tion in January 2004. This was done by an intestinal biopsy study involving

100 special needs children. The study showed that 60% o these patients ha

weak lactase activity and 25-40% had weak isomaltase/palatinase activity.

Similar results were noted in an October 2005 paper in the Journal o Pediatr

Gastroenterology and Nutrition published by Kushak, Winter, Farber, and Bu

o MassGeneral Hospital or Children. This study indicated a need or addi-

tional carbohydrase enzymes in special needs situations. These studies were

evidence or the need o an enzyme providing isomaltase/palatinase activity

fll a void in commercially available digestive enzyme products.

These studies provided the impetus or Kirkman to begin searching or a

enzyme that had this isomaltase/palatinase activity. Kirkman, in conjunction

with the National Enzyme Company o Forsyth, MO, ound such an enzyme

that Kirkman registered as the trademark Isogest. Isogest has the ability

to split isomaltose into two molecules o glucose and to split palatinose into

one molecule o glucose and one molecule o ructose. This is a revolutionar

ingredient in the world o enzymology since commercially available enzyme

products never had this isomaltase enzyme capability. Only Kirkmans en-

zymes contain Isogest, or which Kirkman has a patent pending.

Why Is IsogesT such an ImporTanT

DIscovery?

When there is weak isomaltase/palatinase activity in the body as ound in

the studies cited, enzyme supplementation is called or. Prior to Isogest the

was no means through commercially available enzyme products to get that

The IsOgesT fAcTOR INKIRKMANs BROAD-sPecTRuM

eNzYMes


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supplementation. When insufcient isomaltase/palatinase activity is present,

isomaltose and palatinose, two comple sugars, remain partially undigested.

Isomaltose is ound in corn syrups, candies, and in comple starches. Palatino-

se is produced in the body primarily as a by-product o bacterial breakdown o

other sugars and starches. When isomaltose and palatinose remain partially

undigested, gas, bloating, constipation or diarrhea, and other intestinal distur-

bances can result that can contribute to gastrointestinal pain.

Kirkmans broad-spectrum enzyme products containing Isogest fnallyprovide a solution to the missing isomaltase enzyme raction.

WhIch of kIrkmans enzyme proDucTs

conTaIn IsogesT?

Kirkmans two most popular broad-spectrum multiple enzyme products

contain Isogest along with a specialty product specifcally ormulated to di-

gest carbohydrates. These products are:

EnZym-Complete/DPP-IV II with Isogest

Maimum Spectrum Enzym-Complete/DPP-IV Fruit Free with Isogest

Carb Digest with Isogest

has IsogesT been evaluaTeD In any

clInIcal sTuDIes?

Yes, prior to marketing enzymes containing Isogest, Kirkmanarranged

or twelve prominent health proessionals, who specialize in patients with

special dietary requirements and special needs, to use enzymes containing

Isogest

in their practices. This was done to veriy the efcacy o the productsand ensure the absence o undesirable side eects. The ollowing doctors and

clinics participated in the study:

Dr. Lynne Mielke, East Bay Medical Clinic, Pleasanton, CA

Dr. David Berger, Wholistic Pediatrics, Tampa, FL

Dr. Andrew Levinson, Vitality Health and Wellness, Miami, FL

Dr. John Green, The Evergreen Center, Portland, OR

Dr. Miriam Jang, San Rafael, CA

Dr. James Neubrander, Edison, NJ

Dr. Phillip DeMio, Seven Hills, OH

Dr. Stephanie Cave, Baton Rouge, LA

Dr. Anju Usman, True Health Medical Center, Naperville, IL

Dr. Jaquelyn McCandless, Woodland Hills, CA (now in Honokaa, HI)

Dr. Brian Klepzig, Charleston, IL

Dr. Brian Jepson, Draper, UT (now at Thoughtful House, Austin, TX)


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Doctors and parents o the patients were polled as to the eectiveness o

the new products. Results were outstanding and side eects virtually none

tent. Kirkman immediately went to market with these eciting new produc

Below is a brie summary o the benefts that the doctors and parents

evaluations o the new products highlighted:

less bloating

more regular bowel habits less constipation

more normal stools

better overall digestion with less discomort

frmer stools

less gas

less diarrhea

less sensitivity to dairy and grains

ewer odorous bowel movements

Who shoulD consIDer TryIng enzymes

conTaInIng IsogesT

There are several situations that could make an Isogest containing enzy

very benefcial. In general, anyone having digestive issues could beneft. Se

eral special situations also may be supported by Isogest containing product

including:

I you are currently taking any other digestive enzyme product and arnot completely satisfed with results.

I you are specifcally having problems digesting carbohydrates, Carb

Digest with Isogest could help with the bloating, gas, and

discomort associated with poor carbohydrate digestion.

I you are on the Specifc Carbohydrate Diet (SCD) and are still having

discomort, this could be due to the incomplete digestion o isomaltos

and palatinose. The late Elaine Gottshall, author o the book titled

Breaking the Vicious Cycle, points out this act in her book.

I you are on the SCD and epect some minor inractions to occur

(the SCD allows the consumption o monosaccharides only and prohib

the ingestion o disaccharides and polysaccharideinractions are

difcult to avoid, especially when consuming prepared or starchy oo


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ouTlIne

Isomaltose and Palatinose are implicated in

xarbatin atrointtina ondition

Find an enzyme that converts the above sugars

to arm ompond (o and rto)

Target enzyme: Isogest

proposeD experImenTs anD resulTs

Test to determine if Isogest onvrt iomato to

o

Make sure Isogest does not convert glucose back

to iomato

Determine if Isogest onvrt mato to iomato(onntration dpndant)

Determine if Isogest breaks down palatinose

effecT Of IsOgesT

ON IsOMAlTOseAND PAlATINOse

A Joint Project with NEC and KIRKMAN GROUP


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resulTs

Isogest does not convert glucose back to isomaltose

Isogest, at onntration ttd, do not onvrt

mato to iomato

Isogest was also tested in combination with maltase

in mato a btrat

Conclusion: near 100% conversion of isomaltose

EFFECT OF ISOGEST ON ISOMALTOSE (0.56M)AT VARIOUS CONCENTRATIONS

Isogest ug/ml

Glucoserelea

sed(ug/ml)

0 20 40 60 80 100 120

100

90

80

70

60

50

This graph demonstrates

that Isogest converts isomaltose

to glucose at a rate eceeding

90%.


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effecT of IsogesT on palaTInose

Check to see if Isogest breaks down palatinose

Determine dose required

Various concentration of Isogest

Various concentration of palatinose

LIBERATION OF GLUCOSE FROM PALATINOSE(0.56mM) USING Isogest @ 100 ug/ml

Palatinose (mM)

%c

onversionto

glucose

0 50 100 150 200 250 300 350

80

70

60

50

40

30

20

10


that Isogest eectively converts

palatinose to glucose.


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LIBERATION OF GLUCOSE VS. TIME AT VARIOUSISOGEST CONCENTRATIONS USING PALATINOSE

AT 0.56 mM

Time Incubated (min)

%C

onversion

50 100 150 200 250

100

80

60

40

20

0


that the conversion o palatino-

se to glucose increases by raising

the concentration o Isogest.


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conclusIon

Isomaltosei an xnt btrat or Iot

(100% conversion to glucose)

Palatinose is not as good a substrate as isomaltose

or Iot

Need higher concentration of Isogest to break

down palatinose

Dose depends on palatinose concentration

LIBERATION OF GLUCOSE AT VARIOUSPALATINOSE CONCENTRATIONS USINGISOGEST AT 500 ug/ml FOR 90 MINUTES

Palatinose (mM)

%c

onversiont

oglucose

0 0.5 1 1.5 2 2.5 3

90

85

80

75

70

65

60

55

50

45


that Isogest is more eective

on isomaltose than palatinose,

but eective on both substrates.


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The cOMPleTe fAMIlYOf KIRKMANs

DIgesTIVe eNzYMes

EnZym-Complete/DPP-IV

EnZym-Complete/DPP-IV IIwith Isogest

Carb Digest with Isogest

Maximum Spectrum Enzym-Complete/DPP-IV Fruit Free with Isogest

EnZymAid Multi-Enzyme Complex

DPP-IV Forte

Multi-Enzyme Formula

Peptidase Complete

Phenol Assist

BioCore Dairy


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Protein

carb / uar

starhe

fat

caein / guten

fiber

latoe

Dairy

Phenoi food

ceuoe

Iomatae Ativity

fruit free

scD lea

gf / cf

enzym-comp

/DPP-IV

enzym-comp

lt/

DPP-IVI

IIogt

carbDigt

withIsogest

Maximumsp

trum

enym-comp

lt/

DPP-IVfruitfr

withIsogest

enzymAid

Multi-enymcomplx

DPP-IVfort

Multi-enym

formula

Pptidaco

mplt

PhnolAit

BiocorDairy

ome

ome

ome

aein

aein

ome

Aid dietion o/eature

eNzYMe guIDe cOMPARIsON chART


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ez-ct/Dpp-Iv

EnZym-Complete/DPP-IV is Kirkmans higheststrength, broad-spectrum digestive enzyme. This pro-prietary product is ormulated to support maximumdigestive activity or a ull range o oods.

EnZym-Complete/DPP-IV is a unique blend o 18pure, plant-based enzymes that are recognized asessential or the eective digestion o all ood groups,including proteins, carbohydrates, ats, sugars andber, under a wide range o pH conditions. The ad-dition o the dipeptidyl peptidase-IV (DPP-IV) enzymeanalog supports the ability o the body to degradepeptides ormed rom exposure to casein and gluten.EnZym-Complete/DPP-IV provides a comprehensiveoundation o supplemental enzymes to supportoptimal digestion.

Each enzyme works independently, but also in acomplementary role to optimally impact digestion oall dietary components. Kirkmans EnZym-Complete/DPP-IV provides a combination o proteases, amy-lases, lipases, disaccharides and cellulases that replace

the enzymes lost in cooking, thus lessening the burdenon the bodys digestive tract so that it can unctionoptimally, while also supporting optimal nutrient

absorption.

enzym-compt/DPP-IV avaiab in

60 ap Itm #234/60

120 ap Itm#234/120200 ap Itm#234/200

DPP-IV (activity) 50,000 HUT *

Protease (rom vegetable pancreatin

4X/NF) 38,000 DAPU *

Alkaline Protease 50 DAPU *

FP 31 Protease 100 HU *

AFP (acid ast protease) 100 SAPU *

Bromelain (Pineapple source/1,280,000 FCCPU) 100 BTU *

Papain (Sulfte-ree Papaya source) 2,000,000 FCCPU *

Amylase (rom vegetable pancreatin 4X/NF) 89,000 MWU *

Alpha Amylase 100 SKBU *

Glucoamylase 30 AGU *

Alpha-Galactosidase 125AGSU *

Lactase 1,000 LAU *

Maltase 200 MWU *

Invertase (sucrase) 400 SU *

Cellulase 200 CU *

Xylanase (Hemicellulase) 100 XU *

Phytase 10 PU *

Lipase (rom vegetable pancreatin 4X/NF) 15,000 LU *

* Daily Values Not Established.

st ftServing Size: 2 capsules

Each Serving Contains Amount % Dailyper Serving Value*


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ez-ct/Dpp-Iv II wit It

A revolutionary enzyme product from Kirkman

The human intestinal tract contains seven enzymesthat split dietary disaccharides into ree monosac-charides. Until now, commercially available enzyme

products contained enzyme ingredients that had theactivity o only some o these disaccharidase enzymes.One in particular, however, sucrase-isomaltase com-plex, was only partially represented in these products.Invertase is present in these products to hydrolyzesucrose to yield glucose and ructose, and to hydrolyzeother complex sugars that contain ructose, so it actsas a sucrase enzyme. The isomaltase raction o thathuman enzyme is not represented because there is nocommercially available orm o isomaltase in the world.

The importance o this missing enzyme raction wasconrmed in January 2004 by R. Kushak, PhD and T.

Buie, MD o MassGeneral Hospital or Children in anintestinal biopsy study involving 100 children with spe-cial requirements and sensitivities. The study showedthat 60% o these patients had weak lactase activityand 25-45% had weak isomaltase/palatinase activity,which substantiated their special dietary need or anenzyme providing isomaltase/palatinase activity.

This study provided the impetus or Kirkman to searchor an enzyme that had isomaltase/palatinase activ-ity. Kirkman ound that enzyme and trademarked itIsogest.

Isogest has the ability to split isomaltose into twomolecules o glucose and to split palatinose into onemolecule o glucose and one molecule o ructose.The result o including this new enzyme is better, morecomplete carbohydrate digestion. Currently, no other

enzyme product can oer this added activity.

EnZym-Complete/DPP-IV II with Isogest is Kirk-mans second generation version o Enzym-Complete/DPP-IV. It contains all the enzymes present inEnzym-Complete/DPPIV plus Isogest. The presenceo Isogest gives this product the equivalent activityo the isomaltase raction o the sucrase/isomaltaseenzyme ound in the human digestive system.

Individuals currently using Enzym-Complete/DPPIVwho are getting partial results and still need someimprovement or individuals using other enzymes who

are not completely satised with the results should tryEnZym-Complete/DPP-IV II with Isogest ormula.

enym-compt/DPP-IV

II with Isogest avaiab in

90 ap Itm #851/90

180 ap Itm #851/180

DPP-IV (activity) 50,000 HUT *Protease (rom vegetable pancreatin

4X/NF) 38,000 DAPU *

Alkaline Protease 50 DAPU *

FP 31 Protease 100 HU *

AFP (acid ast protease) 100 SAPU *

Bromelain (Pineapple source/1,280,000 FCCPU) 100 BTU *

Papain (Sulfte-ree Papaya source) 2,000,000 FCCPU *

Amylase (rom vegetable pancreatin 4X/NF) 89,000 MWU *

Alpha Amylase 100 SKBU *


Alpha-Galactosidase 50 Gal U *

Lactase 1,000 LAU *

Maltase 200 MWU *

Invertase (sucrase) 400 SU *

Cellulase 200 CU *


Phytase 10 PU *

Lipase (rom vegetable pancreatin 4X/NF) 15,000 LU *

Isogest 100 mg *


st ftServing Size: 2 capsules



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c Dit wit It

Carb Digest with Isogest is specially ormulatedor individuals who nd it dicult to digest carbohy-drates. It is a revolutionary product that contains onlydisaccharidases and Kirkmans proprietary Isogestenzyme.

Kirkman developed Isogest based on the work oR. Kushak, PhD and T. Buie, MD, o MassGeneralHospital or Children. They studied individuals withspecial requirements and sensitivities and ound thatin their test group, 25-45% o their subjects had weakisomaltase/palatinase activity.

Our Isogest ormulation has the ability to splitisomaltase into two molecules o glucose, and to splitpalatinose into one molecule o glucose and one mol-ecule o ructose. The result o the inclusion o thisnew enzyme is better, more complete carbohydrate

digestion. Currently, no other enzyme product canoer this added activity.

Carb Digest with Isogest may also be very use-ul to those on the Specic Carbohydrate Diet (SCD),because slight inractions o this diet may be counter-acted.

Physicians and parents who evaluated products con-taining Kirkmans Isogest reported the ollowing:

less bloatingmore regular bowel habits

less constipation

more normal stoolsbetter overall digestion with less discomortrmer stoolsless gasless diarrhealess odorous bowel movements

No adverse eects were reported.

Carb Digest with Isogest avaiab in

120 ap Itm #852/120

st ftServing Size: 1 capsule


n-zimes (a proprietary blend) 265 mg *

Amylase 200 DU *


Lactase 2000 ALU *

Invertase 1000 SU *

Maltase 800 DP *

Isogest 100 mg *


n-zimes is a trademark o National Enzyme Company


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mi st e-ct/Dpp-Iv fit f wit It

Kirkmans Maximum Spectrum Enzym-Complete/DPP-IV Fruit Free w/Isogest capsules are ree oruit derived enzymes, such as bromelain, kiwi, andpapaya, that can occasionally cause issues or somesensitive individuals.

This product diers rom Kirkmans EnZym-Com-plete/DPP-IV II with Isogest by including ad-ditional disaccharidase enzyme activity to morecompletely breakdown complex disaccharides andcarbohydrates, such as sugars and starches, to themonosaccharides glucose and ructose.

However, like EnZym-Complete/DPP-IV II withIsogest , it is a comprehensive multiple enzymeormulation that acts on all ood groups. In additionto the carbohydrase enzymes, it contains proteases,peptidases, lipase, cellulase, phytase, and amylases

or complete digestive support.

Disaccharidase enzymes in the product with in-creased concentrations include: lactase or additionallactose digestion; maltase or additional maltose di-gestion; glucoamylase or polysaccharide and starchdigestion; and Isogest, Kirkmans exclusive specialtyenzyme or addressing isomaltase insuciency.Kirkman products are the only commercially avail-able enzyme products that contain this isomaltaseactivity.

The importance o this missing enzyme raction was

conrmed in January 2004 by R. Kushak, PhD andT. Buie, MD o MassGeneral Hospital or Childrenin an intestinal biopsy study involving 100 specialneeds children. Thestudy showed that 60%o these patients hadweak lactase activityand 25-45% had weak

isomaltase/palatinase activity, which substantiatedtheir special dietary need or an enzyme providingisomaltase/palatinase activity.

This study provided the impetus or Kirkman to

search or an enzyme that had isomaltase/palatinaseactivity. Kirkman ound that enzyme and trade-marked it Isogest.

Isogest has the ability to split isomaltose into twomolecules o glucose and to split palatinose into onemolecule o glucose and one molecule o ructose.The result o including this new enzyme is better,more complete carbohydrate digestion. Currently, noother enzyme product can oer this added activity.

The presence o Isogest gives this product theequivalent activity o the isomaltase raction o the

sucrase/isomaltase enzyme ound in the human diges-tive system.

Peptidase (DPP-IV activity) 60,000 HUT *

Protease 50,000 HUT *

Protease 6.0 10,000 HUT *

Acid Fast Protease 30 SAPU *

Amylase 200 DU *


Alpha-Galactosidase 125 Gal U *

Lactase 2000 LAU *

Maltase 200 MWU *

Invertase (Sucrase) 1000 SU *

Cellulase 200 CU *


Phytase 10 PU *

Lipase 15,000 LU *

Isogest 150 mg *

*%Daily Values Not Established

st ft

Serving Size: 2 capsules


Maximm sptrm enym-compt/

DPP-IV Fruit Free with Isogest available in

120 ap Itm #869/120


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ezaid mti-e c

EnZymAid Multi-Enzyme Complex is a plant-basedenzyme ormulation designed to address severalimportant digestive unctions or individuals withspecial requirements and sensitivities. This ormula-tion comes in #1 plant cellulose capsules.

This exceptional enzyme complex:

specically targets the breakdown (cleaving)o casein, gluten and gliadin and acilitates thebreakdown o wheat (gluten) and milk (casein)proteins

enhances the absorption and utilization oimportant minerals (this is accomplished by theaddition o the enzyme phytase, which breaksdown phytic acid ound in grains, beans,soybean, etc., that is known to interere withthe absorption o crucial minerals including

calcium, magnesium and zinc)

increases the amount o the important dipepti-dyl peptidase-IV (DPP-IV) enzyme (this hap-pens when the peptidase enzymes exert DPP-IV activity, and by the inclusion o galactose)

About our formulation:

Ingredients include:

Caso-glutenase 10,000 AU*



Caso-glutenase (a proprietary blend) 10,000 AU *

Bromelain Concentrate 230 BTU *

Acid Fast Protease 100 SAPU *

Lactase 330 LACU *

Phytase 125 PU *

Galactose 100 mg *


enzymAid Mti-enym compx

avaiab in90 ap Itm #043/90

180 ap Itm #043/180

Bromelain concentrate 230 BTU(approximately equal to 4,500,000 FCCPU)

Acid Fast protease 100 SAPU

Lactase 330 LACU

Phytase 125 PU

Galactose 100 mg

*This proprietary blend is comprised o a combinationo many dierent proteases and peptidases, assayedwith activity units based on acceptable compendialmethods o assay. Since a wide variety o dierentpeptidases/proteases are utilized, the overall activity isnoted in special Activity Units (AU).


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Dpp-Iv ft

Kirkmans DPP-IV Forte capsules eature a dipeptidylpeptidase-IV (DPP-IV) analog or comprehensive diges-tion o protein peptides.

This proprietary enzyme rom Kirkman

works in aunique way to specically break apart proline-containingpeptides (casomorphin, gluteomorphin and gliadomor-phin), which are generally known to come rom dairyproducts and cereal grains. The DPP-IV enzyme assistsdigestion o these peptides, which are generally resistantto being completely broken down by other enzymes.

Wat i DPP-IV?

DPP-IV is a protein that has multiple unctions in thebody. It is known by dierent names depending onwhere it is ound. When DPP-IV is on the surace o the T-

cell (lymphocyte), it is called CD26 and supports immuneunction. When this enzyme is ound on and imbeddedon the epithelial brush border mucosal membrane o theintestinal tract lining, it is known as DPP-IV.



DPP-IV (activity) 60,000 HUT *

* Daily Value Not Established.

The importance o DPP-IV is that it has primary unctionin breaking down casein and side chain activity in break-ing down gluten. Thus, the use o a DPP-IV containingenzyme will support the digestion o casein-containing

milk products as well as the protein in gluten-containinggrains.

DPP-IV fort avaiab in

60 ap Itm #230/60


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mti-e f

Multi-Enzyme Formula is Kirkmans moderatepotency, multi-spectrum digestive enzyme designedto support digestion o a ull range o oods.

This product consists o a unique blend o 17 pure

plant-based enzymes that are recognized as impor-tant or the eective digestion o all ood groups,including proteins, carbohydrates, ats, sugars andber, under a wide range o pH conditions.

st ft

Serving Size: 1 capsule


Amylase (Pancreatin 4X) 67,320 MWU *

Alpha Amylase 68 DU *

Glucoamylase 13.7 AGU *

Protease (Pancreatin 4X) 23,562 DAPU *

Protease (Acid Stable) 68 SAPU *

Protease (Alkaline) 119 HUT *

Protease FP 31 68 HU *

Cellulase 137 CU *

Hemicellulase (Xylanase) 68 XU *

Alpha-Galactosidase 68 GaIU *

Lactase 226 ALU *

Lipase (Pancreatin 4X) 1500 FCCLU *

Papain (Sulte Free) 343,000 FCCPU *

Bromelain 870,000 FCCPU (68 BTU) *

Maltase 137 MWU *

Invertase (Sucrase) 274 SU *

Phytase 6.8 PU *


Multi-Enzyme Formula includes a combinationo proteases, amylases, lipases, disaccharides andcellulases that replace the enzymes lost in cooking,thus lessening the burden on the bodys diges-tive tract so that it can unction optimally, while

also supporting optimal nutrient absorption. Eachenzyme works independently, but synergisticallyto optimally impact digestion o all dietary compo-nents.

Mti-enym forma avaiab in

250 ap Itm #250/250


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ptid ct

Broad spectrum protease/peptidase enzyme for-mulation with dipeptidyl peptidase-IV activity

Kirkmans Peptidase Complete was ormulated toprovide more activity o the proteolytic/peptidase

enzymes than that supplied by EnZymAid. Thisspecialty ormulation oers a complete combina-tion o protease and peptidase enzymes or optimalbreakdown o animal proteins (meats, sh, poultry,eggs, dairy, gelatin, etc.), plant-based proteins (in-cluding soybean, legumes, etc.), as well as peptidesderived rom milk/casein and grains/gluten. Pepti-dase Complete is one o the most comprehensivedigestive enzyme ormulations in the marketplaceaddressing these dietary components.

This unique blend o pure plant-based and ruit-based enzymes provides digestive activity or a ull

range o proteins under the wide range o pH condi-

tions ound in the intestinal tract. Each enzyme in thisspecialty ormulation works independently, but also incombination with the other ingredients present.

Peptidase Complete contains a ull range o prote-

olytic/protein digesting enzymes. The use o prote-olytic enzymes should not be taken when there is theabsence o normal gastric mucosa, such as is ound inindividuals who have a peptic/duodenal ulcer. Consultwith your physician in such cases or specic recom-

mendations.



n-zimes (a proprietary blend) 355 mg *

Peptidase 63,000 HUT *

Protease (4,5 & 6.0) 25,000 HUT *

Protease (Other)** 2,000,000 FCCPU * **Papain (Sulte Free Papaya Source) - 1,000,000 FCCPU

** Bromelaise (Pineapple Source) - 1,000,000 FCCPU


Pptida compt avaiab in

250 ap Itm #248/250


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p ait

Phenol Assist is an enzyme designed to help digestpart o the cell wall structure o plant cells in ruits,vegetables and grains. Doing so opens the cell andallows the process o phenol digestion to occur.

When an apple or a pear is sliced open and is let outor a while, the tissue o the ruit turns brown. Thatbrowning process is the result o the natural enzymepresent in ruits, phenolase, oxidizing the ruittissue. This process cannot occur until the cell wallis broken and oxygen gets into the cells. Phenol As-sist gets this process going and thereore supportssulation by reducing the phenolic load on the bodyssulation capacity.

Phenols are compounds with a speciic chemicalstructure o an aromatic ring plus a hydroxyl group.They are ound in ruits, vegetables, some grains andnuts, favorings and spices. A salicylate is a type o

phenolic compound. Phenols and polyphenols haveantioxidant qualities and protective unctions, whichmake some o them benecial and desirable or mostindividuals.

An important chemical process that occurs in body tis-sues is called sulation. Sulation is the movement osulate (sulur plus oxygen) ions rom one body tissueto another. Sulating molecules change the molecules

character and behavior and how they act in the body.Connective tissue is sulated or structural reasons andneuron tissue is sulated to provide a protective sheath.Sulation also causes molecules to vary in activity, solubil-ity, and mobility. For the body to work properly, these

sulation processes must occur.

What is the relationship between phenolic compoundsand sulation? Phenols and salicylates use up a lot osulate in the body in order to be broken down. Inother words, the phenols and salicylates compete orthe bodys sulate stores. In certain individuals, break-ing down phenolic compounds can provide a benet bysupporting the sulation mechanism.

Phenol Assist contains a variety o enzymes to ac-complish cell wall digestion, and other enzymes to assistin the total digestion o ruits, vegetables, grains, and

spices.



Xylenase 32,000 XU *

CereCalase 1,600 MU *

Cellulase 200 CU *

Beta-Glucanase 20 BGU *

Phytase 60 PU *

Alpha-Amalase 70 SKBU *


Alpha-Galactosidase 80 AGSU *


Pno Ait avaiab in

90 ap Itm #835/90


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BioCore Dairy available in

100 capsules 843/100bic Di

NEC created BioCore Dairy to help dairy intolerantindividuals be able to enjoy dairy products again.

How Does BioCore Dairy dir rom lataid orimiar prodt?

The active ingredient in Lactaid is a lactase enzymethat acts on and digests lactose. Lactase supplementsalone, however, do not oer any help in the diges-tion o milk proteins. The normal symptoms o dairyintolerance, such as nausea, cramping, bloating, gas,or diarrhea, may be construed by individuals sel-diag-nosing themselves as lactose intolerance when, in act,dairy proteins are part o the problem. BioCore Dairycontains not only lactase to digest lactose, but alsospecic protease enzymes to target the whey proteinbeta-lactoglobulin. There is scientic data that indi-cates that this dairy protein is resistant to breakdownby pepsin and pancreatic enzymes in the body.

Wat ar t ontnt o Biocor Dairy?

The non-animal-based enzymes present in BioCoreDairy are obtained by the controlled ermentation oAspergillus niger and Aspergillus oryzae, which meansthat they are plant-based ungally-derived enzymes.

The amount o this proprietary enzyme blend presentin one capsule is specically ormulated to digest thelactose (12 grams) and the dairy proteins (8 grams)ound in one cup o milk. O the 8 grams o dairyprotein in a cup o milk, 6.4 grams are rom casein and1.6 grams are rom whey. The enzyme system in Bio-Core Dairy will eciently hydrolyze all milk proteins,including casein and beta-lactoglobulin.

*BioCore is a registered trademark o National Enzyme Company

**Lactaid is a registered trademark o McNeil PPC



Protease (Beta-lactoglobulin Units) 630 BLGU *

Lactase (Acid Lactase Units) 1000 ALU *

*Daily Value Not Established.

BioCore* Dairy addresses both lactose intoleranceand dairy intolerance, conditions that most healthcare practitioners agree are not necessarily inter-changeable. This product was developed by NationalEnzyme Company (NEC) to digest lactose, whey

proteins, beta-lactoglobulin and other complex dairyproteins.

This product was ormerly known as Dairyzimes.Although it was renamed, the ingredients remainedthe same, as did the ecacy in dealing with lactoseintolerance and digesting whey proteins.

According to NEC, 70% o the worlds populationcannot digest lactose properly. They estimate thatbetween 30 and 50 million Americans are lactoseintolerant. Many o these individuals begin avoidingdairy products or turn to lactase over-the-counterenzyme products such as Lactaid** to address theproblem. Though this type o product does help in

digesting lactose, the entire problem is not really ad-dressed. Dairy products not only contain lactose, butalso whey proteins, beta-lactoglobulin and other dairyproteins, which may contribute to sensitivity to dairyproducts, in general. So, lactose intolerance is onlypart o the problem, which probably more correctlyshould be known as dairy intolerance. For some, Bio-Core Dairy may provide the reedom to enjoy dairyproducts again.

Although milk and dairy products are the only naturalsources o lactose and dairy proteins, individualsmust be aware that they can be ound in many otherproducts made with dairy products. A ew exampleso hidden lactose and dairy proteins are:

various breads and baked goodsmargarinebreakast cerealslunch meatsprepared oodssalad dressingcandycoee creamersand whippedtoppings

Biocor Dairy avaiab in

100 ap Itm #843/100


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Q---Wat do nym do?

A---Enzymes act as catalysts in speeding up biochemical reactions. With

out enzymes, these reactions could not occur successully.

Q---Wat atay ar nym?

A---Enzymes are proteins which act as chemicals in body reactions.

Q---Do on nym av vra ntion in t body?

A---No, each enzyme has one speciic job to do. I that specialized enzym

is not present or available, that job does not get done in a timely manner.

Q---Why take supplemental digestive enzymes?

A---Good health depends on proper digestion and absorption o nutri-

ents. Enzymes support proper digestion and as a result, proper absorption.

Q---Ar nym prnt in ood?

A---Yes ood does contain enzymes, but cooking and processing destroy

much o that enzyme activity.

Q---When is the best time to take digestive enzymes?

A---The best times are at the very beginning o a meal or just beore a

meal.

Q---Are digestive enzymes destroyed by our bodies like they arin cooking or processing?

A---Animal enzymes are destroyed to some degree by stomach acids.

Plant based enzymes have been tested to show that they are resistant to

stomach acids and are eective throughout the digestive tract.

Q---Wi ditiv nym dit a t ood I at?

A---No, digestive enzymes support the overall digestive process and wor

in concert with the pancreatic enzymes produced in the body.

quesTIons & ansWers


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Q---How do I know what dosage of digestive enzymes to use?

A---The amount o the dose is dependent on how much ood one eats or

a meal. A small snack or small breakast may only require hal o the enzyme

dosage a big dinner may require. A child will eat less and thereore require

ewer enzymes than an adult. Usually small portions and childrens portions

can get by with one capsule at a meal, while large meals and adults will oten

require two capsules. One has to eperiment individually to determine what

the optimal level is or that person. How you eel is the best indicator. Bloat-ing, gas or intestinal discomort may indicate that a larger dose is required.

Q---sin nym dit ood, an ty b danro to ?

A---Enzymes are completely sae when ingested, but some precautions

need to be taken with the powder inside the capsules. The powder should

not be inhaled or rubbed onto the skin or into the eyes because protease

enzymes can attack mucous membranes and cause irritation. Enzyme powder

should also not remain on the lips or any signiicant time.

Q---If my child wont swallow capsules, can I open the capsulesand mix with food or beverages?

A---Yes, but you should eat the ood or drink the beverage immediately,

so that digestion doesnt begin. I that is not possible, reezing the mitures

will delay the process but even with reezing, the mitures should be used by

the end o the day.

Q---I I am on t gf/cf dit, do I ti nd nym?

A---Yes, enzymes still aid the breakdown o the ood. Though casein and

gluten may not be present, there are still other constituents o the ood thatneed digestion. Also, the enzymes guard against casein or gluten inractions

which can be common in prepared oods.

Q---I I am on t scD dit, do I ti nd nym?

A---Yes, inractions on the SCD diet can be numerous and unnoticed es-

pecially in prepared oods. Furthermore, bacteria in your body oten convert

certain sugars and starches to palatinose, which isnt digested without an

isomaltase (Isogest) type enzyme.

Q---Can enzymes take the place of the GF/CF or the SCD diet?

A---That is not a recommended practice by most physicians using these

diets. Because it is not possible to measure eactly how many enzymes would

be needed or a given amount o ood, it is advised that individuals stay on

the diets and use the enzymes or inractions and insurance.


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Q---Will I have side effects with digestive enzymes?

A---When you irst begin enzymes, there can be an adjustment period,

especially i you have sensitivities to casein, gluten, soy or other ingredients

Adjustment symptoms could be hyperactivity, digestive disturbances, stool

changes or sleep pattern changes. These usually subside in a ew days.

Q---Do I nd a prription or ditiv nym?

A---Animal based enzymes generally do require a prescription, but plan

based enzymes are sold as dietary supplements. You should, however, dis-

cuss using enzymes with your health care proessional irst.


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noTes


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Join Our Kirkman famiy

eXclusIVe BeNefITs!

It fRee to Join!

spia DIscOuNTs andotr pia or

spia Prodtedationa inormation andpia ommniation

Or Kirkman Family

Newsletterand mor . . .

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www.kirkmangroup.com800 245 8282503 694 1600


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Our Customer Service Staf

Amy Beth Carrie E.

Chris Karijane Kathy V.

Kathy E . Racheal Rhonda

Shirley Sonia

6400 SW Rosewood Street

Lake Oswego, Oregon 97035

Telephone: (800) 245-8282

(888) KIRKMAN(503) 694-1600

FAX: (503) 682-0838

e-Mai

Ordering:

[email protected]

Customer Service:

[email protected]

Technical Support:

[email protected]

Servicio al Cliente en Espanol:

[email protected]

Linea Directa en Espanol:

(503) 783-2714


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Weve Opened the Door . . .with a revolutionary discovery in enzymes

IsogestOnly from Kirkman the only commercially

available enzyme

with isomaltase

activity

the need for this

enzyme was

established by a

clinical study at

MassGeneral Hospital

or Children in 2004

Isogest has been

evaluated by 12 o the

countrys leading physicians

who specialize in

working with individuals

with special dietary

requirements

kirkman digestiveenzymesguide

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