kingdom of saudi arabia...l1 introduction to course and therapeutics, definitions, definitions,...

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Kingdom of Saudi Arabia

King Faisal University

College of Clinical Pharmacy

المملكة العربية السعودية

جامعة الملك فيصل

كلية الصيدلة اإلكلينيكية

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Table of Contents

Therapeutics-1 ................................................................................................................... 3

Biopharmaceutics ............................................................................................................ 12

Medicinal chemistry 3 ...................................................................................................... 19

Pharmaceutical Delivery Systems ..................................................................................... 27

Pharmaceutical Care 2 ...................................................................................................... 32

Pharmacology 4 ................................................................................................................ 40

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Kingdom of Saudi Arabia

Ministry of Higher Education

King Faisal University College of Clinical Pharmacy DEPARTMENT OF PHARMACY PRACTICE

Course Plan: Therapeutics-1 2013-2014

A: General Information

Course Coordinator/Instructor: Dr. Afzal Haq Asif

Course Instructors: 1. Dr. Maitham Alhawwaj

2. Dr Mays Hassan (Practical female)

3. Dr. Khaled Alhussain (Practical male)

Contacts: 1. Dr Afzal: [email protected], [email protected]

Office No. Room No. 1022 Phone: 035899790 (direct) Office hours: Sunday: 9:30-10:30 , Tuesday: 9:30-10:30

2. Dr. Maitham: [email protected] Office hours: Office No. Old Classroom No. 1 Phone No. N/A Office hours: Monday: 12:30 PM–01:30 PM, Tuesday: 08:30 AM–09:30 AM

3. Dr Mays: [email protected]

Office No with Phone: Office hours

4. Dr. Khaled: [email protected] Office No with Phone: Office hours

Department: Department of Pharmacy Practice, College of Clinical Pharmacy,

Course title and code: Therapeutics-1, P-4 (departmental Code),

3030311 (University Code)

Year and Semester: 3rd

year Semester 1

Credit hours: 4+1

mailto:[email protected]





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Pre-requisite: Pharmacology-2, 2010211

Schedule: Male: Lecture: 7:30 to 9:30 am on Wednesday and Thursday, Practical: 11:30-2:30 Sunday Female: Lecture: 7:30 to 9:20 am, on Sunday and Monday, Practical: 11:30—2:30 Thursday

B: Course Description & Objectives

1. Aims of the Course:

This course is designed to consolidate students’ knowledge and skill in therapeutic planning, rational selection and use of drugs prescribed in common cardiovascular disorders, based on underlying pathophysiologic mechanisms of the diseases and the best evidence available. Therapeutic management of critically ill patient like shock and management of dyslipidaemias, Anemias and sickle cell disease, which will provide students with a sound foundation for all the subsequent courses in therapeutics and also for Advanced Pharmacy Practice Experience. Clinical case discussions/presentation and maintaining of clinical case portfolio will improve communication, analytical and decision making skills of the students.

3. Course Objectives: After successful completion of the course, the student will be able to:

A. Describe and correlate pathophysiology of the diseases included in this course (cardiovascular and coagulation disorders including dyslipidaemia), with clinical presentation and pharmacotherapy.

B. Describe the Clinical (history symptoms and signs) and laboratory data to diagnose the disease. C. Constitute therapeutic objectives, treatment plan with best evidence available and follow up

evaluation plan for diseases included in the course. D. Write and present the case in SOAP format

B: Learning Resources

1. Required Textbook(s) : 2. Pharmacotherapy: Handbook. By BG well, JT Dipiro TL Schwinghammer and CW Hamilton Appleton and

Lange 8th

ed.(2011) 3. Applied Therapeutics: The Clinical Use of Drugs by Mary Anne Koda-Kimble,Lloyd Yee Young, Wayne A.

Kradjan, B. Joseph Guglielmo, Brian K. Alldredge Robin L. Corelli PharmDBradley R. Williams: Lippincott Williams & Wilkins; Ninth edition (August 20, 2010)

4. Pharmacotherapy Casebook, A Patient Focused Approach TL Schwinghammer , BG well, JT Dipiro and CW Hamilton: Appleton and Lange (8

th Edition)

2. Additional References :

Pharmacotherapy: A Pathophysiologic Approach, by Joseph DiPiro, Robert L. Talbert, Gary Yee, Gary Matzke, Barbara Wells, L. Michael Posey McGraw-Hill Medical; 8 edition (April 4, 2011)

3.Electronic Materials, Web Sites, etc. www.PubMed.com, www.medscape.com/pharmacist, www.guidelines.com

5- Other learning material such as computer-based programs/CD, professional standards/ regulations:

http://www.pubmed.com/

http://www.medscape.com/pharmacist

http://www.guidelines.com/

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Note: Each lecture (L) will consist of two 50 minutes sessions, with 10 minutes interval between both

Week Lecture

Topic (chapter/section) Lab Assignment Comments/Quizzes

W-1 Sept 1

L1 Introduction to course and therapeutics, definitions,

Definitions, Abbreviations, Patients Data/Components of Clinical Case History SOAP notes

Parts of prescriptions (review)

L2 Prescriptions and responsibilities of Prescriber(2)

W-2 Sept 8

L3 Factors affecting response and effects of drugs (2)

Patients Data/Components of Clinical Case History SOAP notes Clinical Case

List of drugs contraindicated in pregnancy, liver kidney and Heart disease

L4 Factors affecting response and effects of drugs (1)

Lab tests and their Interpretation (1)

W-3 Sept 15

L5 Lab tests and their Interpretation (2)

Clinical case for abnormal lab values, Calculation of IBW and Creatinine Clearance

Guidelines for treatment of Hyperkalemia

Quiz Lab Tests

L6 Lab tests and their Interpretation (2)

W-4 Sept 22

L7 Hypertension and its treatment (2) Clinical case of Hypertension, SOAP for the case, points for patient counselling

Assignment on Updates on antihypertensive drugs: BB. ACEI, ARB, CCB

L8 Hypertension and its treatment(2)

W-5 Sept 29

L9 Hypertension and its treatment (2)

Clinical case of Hypertension, SOAP for the case, points for patient counselling

Anti anginal Drugs

Quiz Hypertension

L10 Coronary Artery Disease (2)

W-6 Oct 6-9) (4 days)

L11 Coronary Artery Disease (2) Clinical Case for Angina, ACS, Acute MI

Opioid Analgesics and thrombolytic

Quiz on CAD

L12

Coronary Artery Disease (2)

W-7 Oct 13

W-8 Oct-20 (1 day)

HAJJ VACATIONS

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W-8 Oct 21

(4 days)

L14 Cardiac Arrhythmias & Treatment (2)

Clinical case for AF, V Tech, Torsade de pointes, AV Blocks

Classification and main Pharmacologic features of Antiarrhythmic agents

W-9 Oct 27

L15 Cardiac Arrhythmias & Treatment (2)

Clinical case on Acute LVF Main Pharmacologic features of Drugs used in HF

L16 Heart Failure: Acute and Chronic (2)

W-10 Nov 3


Clinical case on Chronic HF, with different Classes and disease combinations

Guidelines on Classification and T/m of HF

Tentative Mid Term


W-11 Nov 10

L19 Pharmacotherapy of shock: use of various IV fluids and inotropes (2)

Clinical case on various types of Shock and its management

Parenteral inotropes and IV fluids

Quiz Heart Failure

L20 Pharmacotherapy of shock: use of various IV fluids and inotropes (1) Venous Thromboembolism (1)

W-12 Nov 17

L21 Venous Thromboembolism (2) Clinical case studies on VTE

Pharmacologic features of Anticoagulants, anti-platelets and thrombolytics

L22 Venous thromboembolism (1) Stroke and its management (1)

W-13 Nov 24

L23 Stroke and its management (1) Dyslipidaemias and treatment (1)

Clinical case of thrombotic and hemmorrhagic stroke, TIA

Review of antidyslipedemic

Quiz on VTE

L24 Dyslipidaemias and treatment (2)

W-14 Dec 1

L25 Dyslipidaemia and its treatment (1) Peripheral Arterial Disease (1)

Clinical case on dyslipidemia

Pharmacology of Iron therapy

L26 Peripheral Arterial Disease (1) Anemias: Investigation and treatment (1)

W-15 Dec 15

L27 Anemias: Investigation and treatment (1) Sickle Cell Disease: Complications and their treatment (1)

Clinical case on Anemia, Calculation for parenteral Iron therapy

Articles related with Incidence of SCD

Quiz on SCD

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L28 Sickle Cell Disease: Complications and their treatment (2)

W-16 Dec 22

L29 Sickle Cell Disease: Complications and their treatment (1) Cardiovascular testing (1)

Clinical case study on SCD

L30 Revision/left over topics

W-17 Dec-29

L31 Revision/left over topics/Practical

W-18 Jan 5 Final Exams

Course for MidTerm: Upto/including cardiac Arrhythmias: cered upto lecture 15, week 9 above

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D. Class Format:

1. Class will consist of interactive lectures/discussions 2. Students are required to come prepared in the class for the topic to be discussed. 3. Students may have brief unannounced quiz, from the material discussed in the previous class 4. Student will be responsible for all material in reading assignments regardless of whether or not the

material is discussed in class. Exams and quizzes will cover all the material, PP presentations, assignment and book

5. Generally the lecture format when a disease will be discussed, will be as under: o Clinical vignette followed by questions o ILO o Introduction

Definitions, Epidemiology Pathophysiology, Clinical Presentations & Diagnosis Signs Symptoms Lab investigations for the disease state under discussion

o Therapeutic objectives o Treatment:

General: Non Pharmacological Pharmacological Therapeutic aspect of Main Drugs: Drug related problems: Drug interactions/adverse

effects and contraindications o Therapeutics Outcomes and Follow up evaluation

6. Practical Session will consist of

a. ILO for the sessions, constructed mutually by the instructor and the students b. Clinical case discussion in Small Groups, as per above schedule followed by answer to the

questions c. Writing and presenting the case in SOAP format by each group. Students are required to keep

the record d. Maintaining clinical case portfolio

E. Library Assignments Students will be assigned to collect material from web resources regarding updates on therapy of various diseases which will be announced with the lecture presentations F. Service learning: Students will be required to participate in one or two sessions of service learning activity already planned, like, patients education, patients’ counselling, applicable during. E. Examinations and Assessment:

1. Quizzes: In addition to unannounced quizzes (which may be on daily basis), there will be announced classroom quizzes, as shown in the schedule above, however minimum number of quizzes will be as shown below in assessment schedule. These quizzes include topics from the lectures that are covered before the quiz. The quizzes worth 10% of the final grade in the course. The quizzes may consist of MCQ’s, SEQ’s or clinical histories followed by questions.

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2. Mid Term and Final: For the theoretical section of this course, there will be 2 examinations, Midterm (25) , and Final exam (40). The total outcome of these exams will represent 65% of the final grade in the course. Exam will generally consist of MCQ’s with Single Best Response, however, SEQ may also be included.

3. Practical Exam will carry 25 marks distributed as under: a. Portfolio and class performance/assignments during practical sessions 10 marks b. Final Practical Exam with three clinical cases: 5 points for each: 15 marks

4. Schedules for Midterm and Final exams will be announced by the Committee for Academic affairs in consultation with relevant students’ committee

5. Schedule of Assessment:

Schedule of Assessment (tentative) Assessment

Assessment task (eg. essay, test, group project, examination etc.)

Week due Proportion of Final Assessment

1

Quiz #1 3rd

2.5 %

2

Quiz #2 5th

2.5 %

3

Quiz #3 11th

2.5 %

Quiz #4 13 2.5%

6

Library/Home Assignment/Portfolio Continuous 10 %

7

Mid Term Exam (Final Schedule will be issued by Academic Affairs committee)

8/9th

25 %

8

Practical Exam With the

final exam 15 %

9 Final Exam End of

semester 40 %

Total 100%

F. Attendance: I expect you to be at every class. I often give information in class that is not found in the textbook. Attendance is one of the most important work ethics in this profession. If you miss 25% of the total classes during the semester, you will be dropped from the final exam. COMING IN LATE While it is mandatory to come on time in every class, I do realize that some logical circumstances may prevent you from getting to class on time. Please show respect if you come in late. G. Academic Dishonesty and misconduct: It includes all of the following:

1. Cheating in exams, quizzes, lab/small group sessions, from any source, like fellow student, notes, electronic sources.

2. Plagiarism: presenting work, words, ideas, presentations, assignments of others, in whole or in part, in assignments, presentations or projects

3. Falsifying tempering records of attendance, false excuses for absence 4. Disrespect to instructors, administration and colleagues 5. Non adherence to instructions regarding class discipline, dress code etc,

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Students found to commit any of the above will be subject to disciplinary actions according to University Rules and Regulations, mentioned in COCP Students’ Handbook

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Kingdom of Saudi Arabia Ministry of Higher Education

King Faisal University College of Clinical Pharmacy

DEPARTMENT OF…………….

Course Plan


Course Coordinator/Instructor: Dr Tamer Shehata

Instructors:

Contacts:

1. Office No. 1059 2. Office hours: Sunday 10:30-11:20, Monday 8:30-10:20, Thursday 8:30-9:20. 3. Email and office contacts: [email protected], Tel: 035899904

College/Department: COCF/ Pharmaceutical Sciences

Course title and code: Biopharmaceutics / 2010314

Year and Semester: 3rd year 1st smester

Credit hours: 3 (2+1) hours

Pre-requisite: None

Schedule: Male: Lecture: Sunday 7:30-9:20 Practical: Thursday 11:30-1:35 Female: Lecture: Wednesday 7:30-9:20 Practical: : Wednesday 11:30-1:35


1. Aims of the Course

This course is aiming to introduces students to the concept and principles of biopharmaceutics.

Physicochemical and dosage form factors influencing bioavailability. During this course,

students will learn how to assess and measure key biopharmaceutical properties,

bioequivalence, biopharmaceutical classification scheme (BCS). Influence of dosage regimens

on the plasma concentration-time profile of a drug in the body, elementary compartmental

modeling design and the factors involved in steady-state plasma concentration of a drug..

2. Briefly describe any course development objectives that are being implemented.


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The expected development of the current course is the use of computer software to simulate and

calculate different cases parameter we are discussing during lectures or practical labs.

3. Course Objectives:

After successful completion of the course, the student will be able to: After successful completion of the course, the student will be able to:

A-Upon successful completion of this course, students will be able to explain the key concept of

biopharmaceutics and pharmacokinetics

B- Interpret the relationship between the drug, its dosage form, and route of administration,

C- Evaluate the biological, physiological and physicochemical factors influencing bioavailability of a

drug,

D- Predict the concept of bioavailability and bioequivalence and explain the relationship between drug

delivery optimization and therapeutic outcome. Topics to be covered till Mid Term

Basics of Pharmacokinetics


1. Required Textbook(s) : Basic Pharmacokinetics, Second Edition. Mohsen Hedaya, 2012, CRC Press.


Biopharmaceutics and Clinical Pharmacokinetics an introduction, Robert E Notari, Marcel Dekker

Inc, New York.

Biopharmaceutics and Drug Interactions, D.E. Cadwallader, U.S.A.,Rache.

Drug Interactions: A source Book of Adverse Interactions, their Mechanisms, Clinical Importance

and Management, Ivan H. Stockley, London: Pharmaceutical Press.

Therapeutic Drug Monitoring, G.E. Schumacher, Appleton and Lange

3.Electronic Materials, Web Sites, etc. Excel sheets

5- Other learning material such as computer-based programs/CD, professional standards/regulations: Kinetica Software

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C: Course Weekly Activities

Week Lecture

Topic (chapter/section) Intended Learning Outcomes

Lab Assignment/projects

W-1 Sept 1

L1 Introduction to biopharmaceutics and Pharmacokinetics, Pharmacokinetic models

1. Define biopharmaceutics and pharmacokinetics 2. Describe general approaches utilized in pharmacokinetic modelling

Problems on

reaction rates

L2

W-2 Sept 8

L3 One compartment I.V bolus administration

1. calculate the appropriate IV dose required to achieve a specific drug concentration 2. estimate VD after a single IV

Problems on

one

compartment

L4

W-3 Sept 15

L5 Multicompartment 1. calculate the appropriate IV dose required to achieve a specific drug concentration following two compartment 2. estimate VD after a single IV

Problems on

one

compartment

L6

W-4 Sept 22

L7 Drug pharmacokinetics following single oral dose

1. calculate drug absorption and drug elimination rates following oral absorption 2. recognise flip flop phenomena

Problems on

one

compartment

L8

W-5 Sept 29

L9 Quiz

Steady state principles

1. calculate drug concentration at steady state 2. describe factors affecting drug concentration at steady state

Problems on

two

compartments

L10

W-6 Oct 6-9) (4 days)

L11 Dose regimen design Multiple drug administration and loading dose

1. define CPmax ss, Cp min ss 2 define factors affecting time to achieve steady state during multidrug administration.

Problems on

two

compartments

Collect

information

about

pharmacoki

netics for

certain

drugs

L12

W-7 Oct 13 Hajj Vacations

W-8 Oct-20 (1 day)

15

W-8 Oct 21

(4 days)

L14 Drug Absorption

following oral

administration

1- Biological Factors

1. describe the basic structure of cell membrane 2. describe different anatomical barriers in GIT and biological factors affecting absorption.

Problems on

oral drug

absorption

W-9 Oct 27

L15 Drug Absorption

following oral

administration

2- Physiological Factors

1. describe different

Physiological Factors affecting drug absorption

2. differentiate between the general mechanisms of drug absorption

Problems on

oral drug

absorption

L16

W-10 Nov 3

L17 Drug Absorption

following oral

administration

3- Physicochemical Factors

1. describe different

Physicochemical Factors affecting drug absorption

Problems on

dose regimen

L18

W-11 Nov 10

L19 Drug distribution Quiz

1. Describe different factors affecting drug distribution

Problems on

loading dose

L20

W-12 Nov 17

L21 Biotransformation

Phase I

1. Describe different factors affecting drug biotransformation 2- describe different mechanisms of biotransformation

Case study on

drug

distribution

L22

W-13 Nov 24

L23

Biotransformation

Phase II

1. Describe different factors affecting drug biotransformation 2- describe different mechanisms of biotransformation

Case study on

Phase I

L24

W-14 Dec 1

L25 Elimination 1. Describe factors affecting drug elimination 2. describe the drug elimination through different body organs

Case study on

Phase II

L26

W-15 Dec 15

L27

Bioavailability

And

Bioequivalence

1. define bioavailability 1. define bioequivalence 2. discuss the situation when bioequivalence is required. 3. discuss the situation when bioequivalence can be waived.

Case study on

elemination Collect

information

about

bioavilabili

ty for

certain

drugs

L28

W-16 L29 Bioavailability 1-different method for Problems on

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Dec 22 L30 And

Bioequivalence

determining bioequivalence 2. discuss the situation when bioequivalence can be waived.

Bioequivelance

W-17 Dec-29

L31 Application on

Biopharmaceutics

1. review the pharmacokinetic parameters on certain selected drug products

Application on

Biopharmaceu

tics

W-18 Jan 5

Final Exams

Class Format: Class will consist of lectures and in some instances class discussion of problems or other assignments. In addition, student will be responsible for all material in reading assignments regardless of whether or not the material is discussed in class. Since these reading assignments are provided before class, it is expected that students will read assignments before coming to class. It should be anticipated that class discussion may require knowledge of the reading material and student who are not prepared may find class discussion difficult to follow. E. Library Assignments Collect information about pharmacokinetics and bioavilability for certain drugs

F. Service learning/Interprofessional Education:(if applicable) NO E. Examinations and Assessment: During the semester, there will be announced classroom quizzes in advance. These quizzes include topics from

the lectures that are covered before the quiz. The quizzes worth 10% of the final grade in the course.

For the theoretical section of this course, there will be 2 examinations, Midterm , and Final exam. The outcome

of these exams will represent 65% of the final grade in the course.

Overall, the course will be graded as follows:

Schedules for Midterm and Final exams will be announced by the Committee for Academic affairs in

consultation with relevant students’ committee

Grading Scheme Assessment



1

Quiz #1 5th

5 %

2

Quiz #2 7th

5 %

3

Mid Term Exam 8th

25 %

4

Lab Exam 15th 20 %

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5 assignment and attendance 14th 5%

6 Final Exam End of

semester 40 %

Total 100%

F. Attendance: I expect you to be at every class. I often give information in class that is not found in the textbook. Attendance

is one of the most important work ethics in this profession. If you miss 25% of the total classes during the

semester, you will be dropped from the final exam.

COMING IN LATE

While it is mandatory to come on time in every class, I do realize that some logical circumstances may prevent

you from getting to class on time. Please show respect if you come in late.

G. Academic Dishonesty and misconduct: It includes all of the following:





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AKingdom of Saudi Arabia Ministry of Higher Education


DEPARTMENT OF…………….

Course Plan


Course Coordinator/Instructor: Dr. Mohammed Abdou

Instructors: Dr. Mohammed Abdou

Contacts:

4. Office No. 5. Office hours: 10.30am- 11.30 am every day

6. Email and office contacts: [email protected]

College/Department: College of clinical pharmacy, department of pharmaceutical sciences

Course title and code: Medicinal chemistry 3. Course code: PS-15

Year and Semester: 1st Semester, 3

rd year

Credit hours: 2+0

Pre-requisite: 2010212

Schedule: Male: Lecture: Tuesday , Practical: No practical Female: Lecture: Monday and Wednesday Practical: No practical

B:Course Description &Objectives


This course enables the student to know the chemistry and mode of action of drugs acting as antibacterials, antivirals, antifungals, antiparasitics and antineoplastics. The following topics will be addressed: Chemistry of antibiotics (Bata lactams, tetracyclines, macrolides, rifamycins, chloramphenicol, aminoglycosides, antifungal and polypeptide), antibacterials, antimycobacterials, antivirals, antifungals, antimalarials, anthelmientics, antiscabious, antipedicular agents, antiprotozoal, antibilharazial agents and antineoplastics. Drug design for related drugs

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2. Briefly describe any course development objectives that are being implemented. (eg increased use of IT or web based reference material, changes in content as a result of new research in the field or feedback from peers and students)

The Active learning method will be used for teaching the course and the students will

be asked to summarize the lectures at the end of each lecture.

Some topics will be covered such as the recent drugs from each class in the syllabus.


After successful completion of the course, the student will be able to: A. Demonstrate an understanding of the concept of chemotherapy and selective toxicity. B. Identify the different classification schemes for antibiotics along with knowledge of the history,

chemical structures, and pharmacokinetic and pharmacodynamic properties of selected natural and synthetic antimicrobial agents belonging to various classes.

C. Relate the chemical structure of various classes of antimicrobial agents to their biological activity.

D. Classify anticancer agent and describe pharmacodynamic and pharmacokinetic properties of various classes of anticancer agents.

Topics to be covered till Mid Term: Introduction to medicinal chemistry, topical antibacterials, urinar tract antiseptics, sulfonamides, antibiotics, beta lactams, cephalosporins, tetracyclines, macrolides, aminoglycosides.


1.Required Textbook(s) : Principles of Medicinal Chemistry, T. L. Lemke, W.O. Foye, David A Williams, Victoria F Roche, S.

William Zito, Wolters Kluwer, Publisher; Lippincott Williams and Wilkins, Ed. 6th

2008

2. Additional References : An Introduction to Medicinal Chemistry, Graham L. Patrick, Publisher; Oxford University Press Inc,

New York, Ed. 4th

2009

3.Electronic Materials, Web Sites, etc. www.kfu.edu.sa/digitallibrary

5- Other learning material such as computer-based programs/CD, professional standards/regulations:

Some websites will be used for teaching them the mode of action of drugs

Some softwares will be used to learn them the structure activity relationship

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C:Course Weekly Activities

Week Lec

ture

Topic (chapter/section) Intended Learning Outcomes Lab Assignment/projects

W-1 Sept 1

L1 Introduction to Medicinal

Chemistry 3 Description of the medicinal chemistry 3 and its role

in drug discovery

List all the course contents with grading system

Identify biochemical differences between the human

cell and invading organisms such as bacteria, fungi,

viruses and parasites

There is no lab

Will be assigned at the end of each lecture

L2 Topical Antibacterial

(Antiseptics and disinfectants) Identify the concept of chemotherapy and selective

toxicity.

Identify the different classes for topical antibacterial

Relate the chemical structure of various classes of

antimicrobial agents to their biological activity

Discuss the Pharmacodynamic properties of

antibacterial drugs

W-2 Sept 8

L3 Urinary antiseptics List the main clinical uses of urinary antiseptics

Identify the different chemical classes of drugs used

as urinary antiseptics

Discuss the structure activity relationship of urinary

antiseptics

Explain the mode of action of different urinary

antiseptics

There is no lab


L4 Sulfonamides: mode of action and

different uses Demonstrate the importance of sulfonamides for

treatment of varieties of diseases Identify the chemistry of different examples of

sulfonamides with different uses Discuss the main structure features of sulfonamides Describe the mode of action of some sulfonamides

W-3 Sept 15

L5 Introduction to Antibiotics List all types of antibiotics

Define ‘’Antibiotic’’ Demonstrate an understanding of the biochemical

differences between the human cell and invading

organisms such as bacteria, fungi, viruses and

parasites

There is no lab


L6 Antibiotics: A-β lactams

Identify the chemical modification for getting broad

spectrum, stable long acting penicillins

Discuss the structure activity relationship of β

lactams

Describe the mechanism of action for β lactams in

bacteria

W-4 Sept 22

L7 Quiz 1

There is no lab


L8 Antibiotics: Cephalosporins List the main differences between β lactams and

Cephalosporins

Demonstrate the different generations of

Cephalosporins.

Discuss the structure activity relationship of

Cephalosporins

Describe the mode of action of cephalosporins

W-5 Sept 29

L9 Antibiotics: Aminoglycosides -Discuss the aminoglycosides structure features, and uses

=List different examples of Aminoglycoside

=Discuss the structure activity relationship of

Aminoglycosides

=Illustrate the Pharmacodynamic properties of

aminoglycosides

There is no lab


22

L10

Antibiotics: Tetracyclines =Explain the chemical features of tetracyclines,

nomenclature.

=Discuss the chemical classes of tetracyclines

=Discuss the structure activity relationship of

Tetracyclines

=Describe the mode of action of Tetracyclines

W-6 Oct 6-9) (4 days)

L11

Antibiotics: Macrolides =Discuss the chemistry of macrolides as a class of

antibiotics

=List different examples of macrolides

=Discuss the structure activity relationship of Macrolides

=Explain the pharmacokinetics and Pharmacodynamic

properties of macrolides

There is no lab


L12

Antibiotics: Chloramphenicol Discuss the stereochemistry of Chloramphenicol

List all uses and features of Chloramphenicol


Chloramphenicol

Explain the pharmacokinetics and Pharmacodynamic

properties of Chloramphenicol

W-7 Oct 13 Hajj Vacations

W-8 Oct-20 (1

day)

W-8 Oct 21

(4 days)

L14

Midterm exam

.

There is no lab

W-9 Oct 27

L15

Antimycobacterial drugs

Explain the meaning of ‘’Antimycobacterial drugs’’

Discuss different examples of Antimycobacterial

drugs; structure, name, synthesis


Antimycobacterial drugs

Illustrate the mode of action of Antimycobacterial

drugs

There is no lab


L16

Antifungal drugs Demonstrate the features of fungal infection and

antifungal drugs.

Discuss different examples of Antifungal Drugs

drugs; structure, name, synthesis


Antifungal Drugs

Explain the Pharmacodynamic properties of

antifungal drugs W-10 Nov 3

L17

Antiviral Drugs part 1 Identify the main differences between bacteria and

viruses.

Discuss different examples of Antiviral Drugs drugs;

structure, name, uses

There is no lab


L18

Case studies Case studies of some antiviral drugs and how it was discovered

W-11 Nov 10

L19

Antiviral Drugs part 2 Correlate the chemical structure of antiviral drugs to

their biological activities

Describe the different mechanisms by which antiviral

drugs could act

There is no lab


L20

Anticancer drugs part1 Discuss Cancer etiology, types, methods of design of

different anticancer drugs

W-12 L2 Quiz 2 Ther

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Nov 17 1 e is no lab

L22

Anticancer drugs part 2 Identify different classes of anticancer drugs;

structure, name, synthesis

Correlate the chemical structure of anticancer drugs

to their biological activities

W-13 Nov 24

L23

Anticancer drugs part 3 Describe the different mechanisms of anticancer drugs There is no lab


L24

Case studies Case studies of some anticancer drugs and how it was discovered

W-14 Dec 1

L25

Ant scabies drugs Explain scabies, etiology, main causes, and treatmet

Explain the medicinal chemistry of different

Antiscabious drug

Correlate the chemical structure of Antiscabious

drugs to their biological activities.

Discuss the mode of action of Antiscabious drugs

There is no lab


L26

discussion of assignments

W-15 Dec 15

L27

Antileprotic drugs =Discuss leprosy, its etiology, main symptoms, and

methods of treatment

=Discuss the medicinal chemistry of some examples of

antileprotic drug

=Correlate the chemical structure of Antileprotic drugs to

their biological activities.

There is no lab


L28

Quiz 3

W-16 Dec 22

L29

Antiparasitic drugs =Identify the classification of parasitic drugs and the

chemistry of these classes.

=Correlate the chemical structure of Antiparasitic drugs to

their biological activities.

=Discuss the mode of action of different ant parasitic

drugs

There is no lab


L30

Revision and discussion of assignments

W-17 Dec-29

L31

Revision and discussion of assignments

There is no lab


W-18 Jan 5

Final Exams

24

D. Class Format: Class will consist of lectures and in some instances class discussion of problems or other assignments. In addition, student will be responsible for all material in reading assignments regardless of whether or not the material is discussed in class. Since these reading assignments are provided before class, it is expected that students will read assignments before coming to class. It should be anticipated that class discussion may require knowledge of the reading material and student who are not prepared may find class discussion difficult to follow. E. Library Assignments

The students will be given some assignment about

‘’Difference between antibiotics drugs’’

‘’Viral diseases’’

‘’Anticancer drugs’’ F. Service learning/Interprofessional Education:(if applicable) E. Examinations and Assessment: During the semester, there will be announced classroom quizzes in advance. These quizzes include topics from the lectures that are covered before the quiz. The quizzes worth 10% of the final grade in the course. For the theoretical section of this course, there will be 2 examinations, Midterm , and Final exam. The outcome of these exams will represent 65% of the final grade in the course. Overall, the course will be graded as follows: Schedules for Midterm and Final exams will be announced by the Committee for Academic affairs in consultation with relevant students’ committee

Grading Scheme Assessment Assessment task (eg. essay, test, group project, examination

etc.) Week due Proportion

of Final Assessment

1

Quiz #1 Week 4 5%

2

Quiz #2 Week 12 5%

3

Quiz #3 Week 15 5%

4

Service Learning (if applicable).

5

Classactivities, participation, attendance 5%

6

Library/Home Assignment 10%

7

Mid Term Exam Week 8 30%

8

Lab Exam …

9 Final Exam End of

semester 40%

25

Total 100%

F.Attendance: I expect you to be at every class. I often give information in class that is not found in the textbook. Attendance is one of the most important work ethics in this profession. If you miss 25% of the total classes during the semester, you will be dropped from the final exam. COMING IN LATE While it is mandatory to come on time in every class, I do realize that some logical circumstances may prevent you from getting to class on time. Please show respect if you come in late. G. Academic Dishonesty and misconduct: It includes all of the following:





Course Coordinator Dr. Mohammed Abdou

27



College of Clinical Pharmacy DEPARTMENT OF PHARMACEUTICAL SCIENCES

Course Outline


Course Coordinator/Instructor: Dr. Anroop Nair/ Dr. Arshia Shariff

Contacts:

7. Office No. 1084

8. Office hours: 7.30 AM - 2.30 PM

9. Email and office contacts: [email protected] Tel: 035899825

College/Department: Clinical Pharmacy/Pharmaceutical Sciences

Course title and code: Pharmaceutical Delivery Systems, 2010312

Year and Semester: Third Year, Fifth semester

Credit hours: 2+0 per week (2 office hours per week)

Pre-requisite: Pharmaceutical Dosage Forms (2010223)



The aim of this course is to provide the student a comprehensive knowledge & basics of

pharmaceutical drug delivery systems for efficient drug delivery into human body that are

therapeutically effective, bioavailable, safe and elegant.

2. Briefly describe any course development objectives that are being implemented. (eg

increased use of IT or web based reference material, changes in content as a result of new

research in the field or feedback from peers and students)

Update the recent advances in drug delivery systems with the aid of web material

Teaching aid includes videos and other interactive learning materials.

Involve students in research projects and home assignments.


After successful completion of the course, the student will be able to:

A. Explain the concept of drug delivery systems

B. Understand the fundamentals of Sustain/Controlled/Targeted drug delivery systems

C. Describe drug carriers and their common applications

D. Appreciate the importance of drug carriers with respect to drug delivery

E. Discuss the rationale use of Novel carrier systems such as Liposomes, Niosomes,

Microspheres, Nanoparticles.

mailto:[email protected]%20%20%20Tel

28


1. Required Textbook(s) :

1. Targeted and Controlled Drug Delivery: Novel Carrier Systems: Vyas S.P, Khar RK,

Publisher; CBS Publishers & Distributors. 2010

2. Drug Delivery Systems, Vasant VR and Mannfred AH, Publisher; CRS press, Ed. 2nd

2003.


1. Pharmaceutics: the Science of Dosage Form Design, Michael E. Aulton, Publisher;

Churchill Livingstone, Ed. 2nd

2002.

2. The Science and Practice of Pharmacy. Pharmaceutical Sciences, Gennaro A.R,

Remington, Publisher; Lippincott Williams & Wilkins, Ed. 21st 2005.

3. Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems, Ansel H.C. Allen,

L.V, Popovich N, Publisher; Williams and Wilkins, Ed. 9th

2010

3. Electronic Materials, Web Sites, etc.

1. www.emedicine.com

2. www.sciencedirect.com

3. www.pubmed.com

4. Other learning material such as computer-based programs/CD, professional

standards/regulations:

CD for British Pharmacopeia (B.P.), and United States Pharmacopeia (U.S.P). British

Pharmaceutical Codex (B.P.C). Martindale (extra pharmacopeia).


Week Topic (chapter/section) Lab Assignment Notes

1

Sept 1

L1

L2

Fundamentals of sustained release dosage

forms

- √

2

Sept 8

L3

L4

Physiological and biological factors

influencing design and performance of

controlled release products

- √

3

Sept

15

L5

L6

Liposomes - - √

4

Sept

22

L7 Liposomes - 1 √

L8 Niosomes

5

Sept

29

L9 Niosomes - 2 √

L10 Microspheres

6

Oct 6

7

Oct 13

8

Oct 20

L11 Microspheres - 3 √

L12 Nanoparticles

Hajj Vacation

Hajj Vacation

7

Oct 27

L13 Nanoparticles - 4 √

L14 Parenteral or Sterile Preparation

http://www.pubmed.com/

29

10

Nov 3

L15 Parenteral or Sterile Preparations -

L16 Parenteral or Sterile Preparations

11

Nov

10

L17 Parenteral or Sterile Preparations - 5 √

L18 Calculation related to Osmolarity &

Isotonicity

12

Nov

17

L19 Calculation related to Osmolarity &

Isotonicity

- 6 √

L20 Ocular drug delivery

13

Nov

24

L21 Ocular drug delivery - √

L22 Ocular drug delivery

14

Dec 1

L23 Ocular drug delivery - 7 √

L24 Pulmonary drug delivery

15

Dec 8

L25 Pulmonary drug delivery - 8 √

L26 Pulmonary drug delivery

16

Dec

15

L27 Radiopharmaceuticals - 9 √

L28 Radiopharmaceuticals

17

Dec

22

L29 Radiopharmaceuticals - √

L30 Radiopharmaceuticals

18

Dec29

19

Jan 5

L31

L32

Revision

Revision

Final Exam

D. Class Format:

Class will consist of lectures and in some instances class discussion of problems or other assignments. In addition,

student will be responsible for all material in reading assignments regardless of whether or not the material is discussed in

class. Since these reading assignments are provided before class, it is expected that students will read assignments before

coming to class. It should be anticipated that class discussion may require knowledge of the reading material and student

who are not prepared may find class discussion difficult to follow.

E. Library Assignments

Assignments on Liposomes, Niosomes, Microspheres, Nanoparticles, Parenteral or Sterile Preparations, Ocular

drug delivery systems, calculation related to Osmolarity & Isotonicity, pulmonary drug delivery and

Radiopharmaceuticals.

F. Service learning: (if applicable)

E. Examinations and Assessment:

30

During the semester, there will be announced classroom quizzes in advance. These quizzes include topics from the

lectures that are covered before the quiz. The quizzes worth 10% of the final grade in the course.

For the theoretical section of this course, there will be 2 examinations, Midterm , and Final exam. The outcome of these

exams will represent 65% of the final grade in the course.

Overall, the course will be graded as follows:

Schedules for Midterm and Final exams will be announced by the Committee for Academic affairs in consultation with

relevant students’ committee

F.

Attendance:

I expect you to be at every class. I often give information in class that is not found in the textbook. Attendance is one of

the most important work ethics in this profession. If you miss 25% of the total classes during the semester, you will be

dropped from the final exam.

COMING IN LATE

While it is mandatory to come on time in every class, I do realize that some logical circumstances may prevent you from

getting to class on time. Please show respect if you come in late.

G. Academic Dishonesty and misconduct:

It includes all of the following:

16. Cheating in exams, quizzes, lab/small group sessions, from any source, like fellow student, notes,

electronic sources.

17. Plagiarism: presenting work, words, ideas, presentations, assignments of others, in whole or in part, in

assignments, presentations or projects

18. Falsifying tempering records of attendance, false excuses for absence

19. Disrespect to instructors, administration and colleagues

20. Non adherence to instructions regarding class discipline, dress code etc,

Students found to commit any of the above will be subject to disciplinary actions according to University Rules and

Regulations, mentioned in COCP Students’ Handbook

Grading Scheme Assessment Assessment task (eg. essay, test, group project,

examination etc.) Week due Proportion

of Final Assessment

1

First quiz exam 5th 05%

2

Midterm exam 8th 30%

3

Second quiz exam 11th 05%

4

Library/Home Assignment 12th 10%

Final exam End of semester

50%

Total 100%

32



College of Clinical Pharmacy DEPARTMENT OF PHARMACEUTICAL SCIENCES

Course Outline


1. Course title and code: Pharmaceutical Care 2, 2030312

2. Credit hours 3 (2+1)

3. Program(s) in which the course is offered.

Pharm D Program

4. Name of faculty member responsible for the course Dr Sabah Akrawi

5. Level/year at which this course is offered 1st level, 3

rd year

6. Pre-requisites for this course (if any) Pharmaceutical Care 1, 2030221

7. Co-requisites for this course (if any) None

8. Location if not on main campus Main Campus

Objectives

1. Summary of the main learning outcomes for students enrolled in the course.

Upon successful completion of the course students will be able to:

(a) Have a clear understanding of the concept of the pharmaceutical care and medication

therapy management.

(b) Brief review of patient data collection, history taking, important lab. data

interpretation, communication skills in patient counseling.

(c) Perform basic physical patient assessments of human organ systems.

(d) Describe, Interpret and record positive findings in physical assessment required for

proper pharmaceutical care plan.

(e) Interpret the lab reports of the patient for Individualized Therapeutics plan and

follow up evaluation.

2. Briefly describe any plans for developing and improving the course that are being implemented. (eg increased use

33

of IT or web based reference material, changes in content as a result of new research in the field)

1) Constructive and focused review of the course content to ensure alignment with )

current development in the study areas

(2) Extensive use of problem-based assignments to deepen students’ critical thinking skills

(3) Increased learners’ interactions with the university library, recommended textbooks and

internet-based resources through regular assignment of guided readings

(4) Fast-track the democratization of the learning space for students during lecture periods to

facilitate constructive, deep and transformative learning

C. Course Description (Note: General description in the form to be used for the Bulletin or Handbook should be attached)

1 Topics to be Covered

List of Topics No of

Weeks

Contact hours

Introduction to Pharmaceutical care 0.5 1

Pharmacotherapy planning 1 2

Patient interview and history taking 1.5 3

Patient counselling 0.5 1

Barriers to effective communication 1 2

Ethical considerations in Pharmaceutical Care Practice 1 2

Interpreting laboratory values 2.5 5

Vital signs assessment and their interpretation 1 2

Medication therapy management 1.5 3

Inventory clinical examination of individual organ system 1 2

Interpretation of findings in diagnosis and prognosis during pharmacotherapy 0.5 1

Total 14 28

Exams 2 3.5 hours Final:2 hrs, MidTerm:1 hr, Quizes:30 minutes

2 Course components (total contact hours per semester):

Lecture: 31 Tutorial: SGS

During

lectures

Laboratory: 42 Practical/Field

work/Internship Other: None

2. Additional private study/learning hours expected for students per week. (This should be an average

:for the semester not a specific requirement in each week):

34

Students are expected to devote at least 3 hours /week for self study at home

Students will be motivated to apply the principles of Pharmaceutical care and physical assessment during clinical clerkship and practical sessions

4. Development of Learning Outcomes in Domains of Learning

For each of the domains of learning shown below indicate:

A brief summary of the knowledge or skill the course is intended to develop;

A description of the teaching strategies to be used in the course to develop that knowledge or skill;

The methods of student assessment to be used in the course to evaluate learning outcomes in the

domain concerned.

a. Knowledge

(i) Description of the knowledge to be acquired:

On successful completion of this course, students shall be able to: 1. Describe the roles of Pharmacists within the context of pharmaceutical care practice 2. Define various terms used in pharmaceutical Care Practice 3. Describe and identify various drug Therapy problems 4. Describe the various components of Pharmaceutical Care Practice 5. Demonstrate knowledge and skills required for an effective pharmaceutical care practice 6. Demonstrate the knowledge of ethical principles necessary for pharmaceutical care practitioner

(ii) Teaching strategies to be used to develop that knowledge:

Interactive Lectures where students act as central partner in learning.

Effective use of audiovisual equipment and PowerPoint presentations for class discussions

Encouraging independent study among students using books and relevant websites

Motivate the students to apply the knowledge during Clinical Rotations and Therapeutic practical

(iii) Methods of assessment of knowledge acquired:

Question and answer sessions in the class room (formative)

Written Short essay questions in Quizzes, Midterm exams and final semester exam

b. Cognitive Skills

(i) Description of cognitive skills to be developed:

On successful completion of this course, the students shall be able to: i. Identify the drug therapy problems in clinical cases (actual and potential) ii. Organize the data retrieved from patient and hospital record in a professional manner iii. Develop, implement and monitor pharmaceutical care plan with a view to resolving drug therapy

problems

(ii) Teaching strategies to be used to develop these cognitive skills:

Regular attendance and active participation of students during the grand rounds in hospital to understand the therapeutic approaches of disease management

35

Interactive discussion on the pharmaceutical care aspects of selected case in the hospital

Completion of therapeutic Log book with identifying patients problem

(iv) Methods of assessment of students cognitive skills :

Written SEQ, problem identifying and problem solving, questions in MidTerm and Final Exams

c. Interpersonal Skills and Responsibility

(i) Description of the interpersonal skills and capacity to carry responsibility to be developed :

Regularity and punctuality in academic schedules

Demonstrate of professional honesty, compassion and respect for patients and colleagues, while working as a team

Obtain, organize and analyze necessary information from the patients’ file/hospital data base

Observing all the ethics of Pharmaceutical Care Practice

Maintain patients confidentiality and trust all the time

Communication with the health care staff, like, Physicians, nurses, and the patients

(ii) Teaching strategies to be used to develop these skills and abilities:

Motivation and Encouragement of students to participate in class room and Clinical case discussions

Instruction and role modeling on ethics of team work, patient-pharmacist relationship, selflessness, during clinical activities

Clinical case discussions, followed by presentations by the students

Problem based learning

Each student has to maintain a log book of 4 therapeutic case histories in the semester

(iii) Methods of assessment of students interpersonal skills and capacity to carry responsibility:

Direct observation by the faculty

Written ( (problem solving), short essay questions in Quizzes, Midterm exams and final semester exam

d. Communication, Information Technology and Numerical Skills

(i) Description of the skills to be developed in this domain.

(ii) Teaching strategies to be used to develop these skills

(iii) Methods of assessment of students numerical and communication skills

e. Psychomotor Skills (if applicable) NA

5. Schedule of Assessment Tasks for Students During the Semester Assessment Assessment task (eg. essay, test, group project, examination Week due Proportion of

36

etc.) Final Assessment

Quiz 1

Written: SEQ's 5 5%

Quiz 2

Written: SEQ's 9 5%

Mid-Term Exam

Written: MCQ's, SEQ's 7 25%

Practical

Participation and Attendance Throughout the semester

25%

Final Exam

Written: SEQ's 16 40%

Total

100%

D. Student Support

1. Arrangements for availability of teaching staff for individual student consultations and academic advice.

(include amount of time teaching staff are expected to be available each week)

Office Hours: 3 hrs

Available on email, University Students' Forum

E Learning Resources

1. Required Text(s):

1. A Practical Guide to Pharmaceutical Care, John P. Rovers, Jay D. Currie, Harry P. Hagel,

Randy P. McDonough, Jenelle L. Sobotka

2. Pharmaceutical Care Practice., 2nd Ed. 2004, Robert J. Cipolle, Linda M. Strand, Peter C. Morley.

McGraw-Hill's.

2. Essential References

3- Recommended Books and Reference Material (Journals, Reports, etc) (Attach List)

4-.Electronic Materials, Web Sites etc:

www.medscape.com/pharmacist

5- Other learning material such as computer-based programs/CD, professional standards/regulations:

- Other learning material such as computer-based programs/CD, professional standards/regulations

F. Facilities Required

Indicate requirements for the course including size of classrooms and laboratories (ie number of seats in

classrooms and laboratories, extent of computer access etc.)

1. Accommodation (Lecture rooms, laboratories, etc.)

2. Lecture hall for 60 students (for future)

http://www.medscape.com/

37

3. Computing resources: Well equipped computer lab, connected to internet

4. Other resources (specify --eg. If specific laboratory equipment is required, list requirements or attach

list) :

1. College Library with all the texts and reference materials mentioned

2. University Hospital for planned clinical training of the students with clinical pharmacist in each unit

G Course Evaluation and Improvement Processes

1 Strategies for Obtaining Student Feedback on Effectiveness of Teaching:

Students anonymous evaluation in each semester

Feedbacks during class discussions with students

Students’ reflection through e-mails 2 Other Strategies for Evaluation of Teaching by the Instructor or by the Department:

Self evaluation

Individual feedback from students

3 Processes for Improvement of Teaching: Studying reports

Lectures and Workshops on various aspects of academic development including teaching methodology and learning techniques are conducted frequently by national and international experts throughout the academic year.

Regular reflection on teaching and assessment practices based students' feedback, students’

results and personal self-assessment with a view to identifying points intervention for improvement.

Sponsored grants for research and innovation in teaching and learning are frequently offered. Instructions by the Departmental Coordinators and the Dean on areas requiring

improvement.

3. Processes for Verifying Standards of Student Achievement (eg. check marking by an independent

member teaching staff of a sample of student work, periodic exchange and remarking of tests or a

sample of assignments with staff at another institution):

Evaluation by external reviewers

5 Describe the planning arrangements for periodically reviewing course effectiveness and planning for

improvement.:

Collecting all reports and evaluations at the end of the semester for a reviewing purpose

Curriculum review by the Curriculum Committee based on the recommendations of the Departments

Attendance:

I expect you to be at every class. I often give information in class that is not found in the textbook. Attendance is one of

the most important work ethics in this profession. If you miss 25% of the total classes during the semester, you will be

dropped from the final exam.

COMING IN LATE

While it is mandatory to come on time in every class, I do realize that some logical circumstances may prevent you from

getting to class on time. Please show respect if you come in late.

G. Academic Dishonesty and misconduct:


38

1. Cheating in exams, quizzes, lab/small group sessions, from any source, like fellow student, notes, electronic

sources.

2. Plagiarism: presenting work, words, ideas, presentations, assignments of others, in whole or in part, in

assignments, presentations or projects




Students found to commit any of the above will be subject to disciplinary actions according to University Rules and

Regulations, mentioned in COCP Students’ Handbook

40



DEPARTMENT OF Pharmaceutical Sciences

Course Plan


Course Coordinator/Instructor: Dr. Ibrahim Alhaider and Dr. Promise Emeka

Instructors: Dr. Promise Emeka

Contacts: 10. Office No. 1003 11. Office hours: 4-6 hours

12. Email and office contacts: [email protected], [email protected]

College/Department: Pharmaceutical Sciences, College of Clinical Pharmacy

Course title and code: Pharmacology 4 P-S13

Year and Semester: 2013/2014, 1st

semester

Credit hours: 6 credit hours

Pre-requisite: 2020121

Schedule: Male: Lecture: Tuesday and Thursday. Practical: days & time: NA Female: Lecture: Monday and Thursday Practical: NA


Aims of the Course: To equip the students with the knowledge of chemotherapy, their use and application in pharmacy practice and patient care. To identify adverse drug reactions and resistance that might accompany the use of chemotherapeutic agents. Also for them to be able to advice patients and their relatives for better treatment outcome and report side effects and misuse.

2. Briefly describe any course development objectives that are being implemented. (eg increased use of IT or web based reference material, changes in content as a result of new research in the field or feedback from peers and students).

The use of Blackboard for the lectures and supportive material will be undertaken.


41

Students will also be encouraged to ask questions and initiate discussions during the lecture to carry out interactive learning, where student's interest in the subject can be enhanced.

Case study scenarios will be used to bring out the clinical aspects and applications.

Students will be given assignments to take away in order to improve their reading habits and use of library in other to encourage self-study/learning.


After successful completion of the course, the student will be able to: A. Describe the pharmacodynamics and pharmacokinetics of a) antimicrobial drugs, b) anticancer drugs c) drugs acting on immune system. B. Apply this knowledge in the specific clinical situations in identifying the problem C. The students will be able to analyse a related clinical problem and suggest a solution for it. D. Describe the genetic basis of individualized response to drugs. Topics to be covered till Mid Term


Required Textbook(s) : Basic and Clinical Pharmacology, Bertram Katzung, Susan Masters, Anthony Trevor, Publisher; Lange

Basic Science, Ed. 12th 2012.

Additional References : 1. Rang & Dale's Pharmacology, Humphrey P. Rang, Maureen M. Dale, Publisher; Churchill

Livingstone, Revised Ed. 7th 2011.

2. Clinical Pharmacology, P. N. Bennett, Morris J. Brown, Publisher; Churchill

Livingstone/Elsevier, Ed.10th 2008. 3. Goodman and Gilman's: The Pharmacological Basis of Therapeutics, Laurence Brunton, Bruce

Chabner, Bjorn Knollman, Publisher; McGraw-Hill, Ed. 12th 2010.

3.Electronic Materials, Web Sites, etc.: http://aac.asm.org/cgi/content/abstract/43/6/1379

http://www.mayoclinicproceedings.com/content/86/3/250.full

http://aac.asm.org/cgi/reprint/10/4/736

http://www.cancer.org/Treatment/TreatmentsandSideEffects/

http://www.chemotherapytreatments.org/articles/types-of-chemotherapy-drugs.htm

http://www.ema.europa.eu/docs/en_GB/document_library/Other/2009/11/WC500015452.pdf

http://www.nice.org.uk/cg069

5- Other learning material such as computer-based programs/CD, professional standards/regulations: On-line text books, multimedia associated reference materials and the relevant websites learning

addresses on chemotherapy will be provided.

http://aac.asm.org/cgi/content/abstract/43/6/1379

http://www.mayoclinicproceedings.com/content/86/3/250.full

http://aac.asm.org/cgi/reprint/10/4/736

http://www.cancer.org/Treatment/TreatmentsandSideEffects/

http://www.chemotherapytreatments.org/articles/types-of-chemotherapy-drugs.htm

http://www.ema.europa.eu/docs/en_GB/document_library/Other/2009/11/WC500015452.pdf

http://www.nice.org.uk/cg069

42


Week Topic (chapter/section) Intended Learning

OUTCOMES

Lab Assignment/

projects

Remark

1

Sept 1

L1 Introduction to the course

and expectations.

1. Define course objectives. Outline

course outcome, assessment, and

mode of course delivery, and

student’s responsibilities.

NA Comments on

Course Plan

study.

L2 Basic principles of

chemotherapy

1. Cognize the concept of selective

toxicity, what it is and how it may

be achieved and how these

mechanisms relate to selective

toxicity.

2. Be acquainted with the

definitions of chemotherapeutic

spectrum and chemotherapeutic index and

how they relate to selective toxicity

3. Understand the role of the host in

chemotherapy.

4. Identify the multiple sites of

inhibition by antibacterial agents.

NA 1. Spectrum of

Activity of

Antimicrobial

agents

Library

search

L3 Mode of Action of

antibacterial drugs.

Microbial resistance, drug

combinations rationale

,Principles of clinical use of

antibacterial drugs

1. Define and describe the general

and specific pharmacokinetic

barriers to effective chemotherapy.

2. Understand the difference

between bacteriostatic and

bactericidal, and how this relates

to drug choice and dosage intervals.

3. Comprehend the general

mechanisms of actions of

antibacterial agents and resistance

to chemotherapeutic drugs, and

cognize how the use of these drugs

selects for resistant populations.

4. Pinpoint the indications for

combination chemotherapy.

5 Discern the rationale behind

chemoprophylaxis.

6. Comprehend the appropriate and

inappropriate uses of

chemotherapeutic drugs.

NA 2. . Bactreiostic vs

bacteriocidal Library

search

43

2

Sept 8

L4 Sulphonimides and

Trimethoprim

1. Describe the mechanism of

action of sulfonamides.

2. Cognize the concept of

"antimetabolite".

3. Appreciate the role of

pharmacokinetics in the action and

uses of sulfonamides.

4. Identify the pharmacokinetic and

pharmacodynamic differences

among various sulfonamides.

5. To know the adverse effects of

sulfonamides 6. 6. 6. Understand

the rationale of combined

sulfonamide-trimethoprim

chemotherapy.

7. Know the clinical uses and

adverse effects associated with

trimethoprim.

NA 3. Drug allergies

in chemotherapy. Library

search

L5 Penicillins. 1. Define the significance of the

beta-lactam ring.

2. Explain the role of penicillin

binding proteins (PBP) in their

MOA.

3. Enumerate the chemotherapeutic

spectrum of penicillins.

4. Classify and identify different

types of penicillins.

5. Describe the mechanisms of

resistance — beta-lactamases and

cross-resistance.

6. Describe fully their adverse

reactions — hypersensitivity

NA 4.Hypersensitivity

reactions with the

use of antibiotics

Library

search

L6 Cephalosporins and Case

study Discussion

1. Identify the similarities to and

differences from penicillins.

2. Describe the changes in

pharmacokinetics and

chemotherapeutic spectrum of first-,

second-, and third-generation

cephalosporins

3. Undertake the classification of

cephalosporins and their clinical

uses.

NA 5. Relationship

btw

Cephalosporins

and penicillins

Library

search

3

Sept

15

L7 Tetracyclines 1. Describe their mechanisms of

action.

2. Understand and describe their

spectrum of activity and clinical

uses.

3. Understand the dependency of

therapeutic and toxic effects on

pharmacokinetics.

4. Understand why their use is

relatively limited (i.e. specific

indications for use).

NA 6. Drug

interaction with

antibiotics.

Library

search

L8 Chloramphenicol 1. Describe their mechanisms of

action.



uses.



pharmacokinetics.




NA 7. Safe use of

antibiotics in

pregnancy

Library

search

44

L9 Aminoglycosides and Case

study Discussion

1. Understand the mechanisms of

action for aminoglycosides.

2. Identify spectrum of activity and

clinical uses.

3. Be acquainted with

pharmacokinetics — routes of

administration, excretion.

4. Know the classic adverse effects

of aminoglycosides.



pharmacokinetics.

6. Understand development of

resistance to aminoglycosides.

7. Role in combination

chemotherapy.

NA 8.Toxicity of

aminoglycosides Library

search

4

Sept

22

L10 Quiz 1 Anti-mycobacterial

Drugs: Tuberculosis

1. Describe and understand the

consequences of the mycobacterial

life cycle in regard to

chemotherapy.

2. Understand the mechanisms of

action for antimycobacterial drugs.

3. Distinguish between "first-line"

and "second-line" anti-TB drugs.

4. Know the pharmacogenetics of

isoniazid metabolism.

5. Understand and identify the

appropriate use of drug

combinations in antimycobacterial

chemotherapy.

NA 9. Rational for

combination

therapy

Library

search

L11 Anti-mycobacterial Drugs:

Leprosy

L12 Macrolides 1. Describe their mechanisms of

action.



uses.



pharmacokinetics.




NA 10. Drug

interactions with

Microlides

Library

search

5

Sept

29

L13 Quinolones and

Fluoroquinolones

1. Understand the function of DNA

gyrases, and the effects of their

inhibition.

2. Identify the clinical uses of

quinolones and fluoroquinolones.

3. Describe and enumerate their

classes.

4. Know the adverse effects and

potential drug-drug interaction for

quinolones.

NA

11. Safety of

Quinolones in

children

Library

search

L14 Clindamycin, Linezolid and

Case study Discussion

1. Describe their mechanisms of

action.



uses.



pharmacokinetics.




Library

search

45

L15 Streptogramins and

Cycloserine

. Describe their mechanisms of

action.



uses.



pharmacokinetics.




12. Synergistic

action in

chemotherapy

Library

search

6

Oct 6

L16 Vancomycin and other Beta

lactam agents

. Describe their mechanisms of

action.



uses.



pharmacokinetics.




NA

13. Treatment of

acquired

infections

Library

search

L17 Anti-viral Drugs 1. Understand the viral life cycle

and its' implications for

chemotherapy.

2. Explain and describe the

mechanisms of action antiviral

drugs.

3. Classify antiviral agents.

NA 14. Rationale for

drug

combinations in

viral infections

Library

search

L18 Anti-viral Drugs

7

Oct 13 Hajji Holiday

8

Oct 20

L 19

NA

Library search

L20 Anti-viral Drugs 4. Enumerate their clinical uses and

adverse reactions.

5. Identify resistance development

in their use and the rational for

combination therapy.

L21 Anti-fungal Drugs 1. Understand why selective

toxicity against fungal pathogens is

more difficult to achieve than is

antibacterial.

2. Know the mechanisms of action,

pharmacokinetics, and clinical uses

of the antifungal drugs.

3. Know the adverse effects of

antifungal drugs.

4. Describe different classes of

antifungal agents.

5. Drug interactions associated their

use.

NA

15. Drug- drug

interactions in the

use of antifungal

agents

Library

search 9

Oct 27

L22 Anti-fungal Drugs

L23 Anti-fungal Drugs

L24 Anti-protozoal Drugs 1. Understand the general

approaches to antiparasitic

NA

10 L25 Anti-protozoal Drugs

46

Nov 3 L26 OVERVIEWS chemotherapy

2. Descibe and enumerate the

general strategies and relevant

drugs used to treat the following

protozoal infections: a) Malaria, b)

Amebiasis, c) trypanosomiasis, d)

Cryptosporidiosis, e) Leshmaniasis

and f) Toxoplasmosis

3. Understand the principal

indications, mechanism of action,

adverse effects and

contraindications for the major

drugs used in the treatment of

protozoal infections.

L27 Anthelmintics 1. Know the distinction between

protozoal and helminth infections

2. Understand the general strategies

and relevant drugs used to treat the

major Helminth Infections.

3. Know the principal indications,

mechanism of action, adverse

effects and contraindications for the

major drugs used in the treatment of

helminth infections.

16. Broad

spectrum agents

in helmintic

therapy.

Library

search 11

Nov 10

L28 Anthelmintics

L29 Anthelmintics

L30 Quiz-2 Case study

Discussion

12

Nov 17

L31 Anticancer Drugs 1. Define the characteristics of

cancer cells and the principles of

cell kill and tumour growth

characteristics, and their relevance

to chemotherapy.

2. Describe the terms “cell cycle

specific” & “cell cycle nonspecific”

as it applies to anticancer drugs.

3. Understand the acute and chronic

toxic/ side-effects of the anticancer

drugs.

4. Understand the problems of drug

resistance and possible mechanisms

in cancer chemotherapy.

5. Enumerate and identify the major

classes of anticancer drugs

according to their mechanism of

action and their clinical uses.

6. Understand the rationale for

selecting combinations of

anticancer drugs.

NA

17. Selective

toxicity in cancer

chemotherapy

Library

search

L32 Anticancer Drugs


13

Nov 24



L36 Anticancer Drugs and Case

study Discussion

14

Dec 1

L37 Immunopharmacology 1. Understand the concept that

interference with immune responses

has the potential to increase the risk

of disease.

2. Understand the rationales for

diagnosis and treatment of

opportunistic pathogens in patients

treated with immunomodulators.

3. Understand the indications,

mechanism of action and potential

adverse effects of the major classes

of immunomodulatory drugs.

NA

Library

search L38 Immunopharmacology

L39 Immunopharmacology

15

Dec 8

L40 Pharmacogenetics 1. Define pharmacogenetic and

enumerate the concept of variability

NA

18. Genetic

induced drug Library

search L41 Pharmacogenetics

47

L42 Pharmacogenetics in drug responses among the

general population.

2. Describe the role of phase I and

II isozymes associated with adverse

drug reactions.

3. Identify the role of

polymorphisms in drug

metabolizing enzymes and their

relationship in drug actions and the

patient response to drugs.

4. The application of

Pharmacogenetics in clinical

practice as it applies to

individualized therapy.

reactions

16

Dec 15

L43 Case study Discussion Immunopharmacology and

Pharmacogenetics

NA

-

L44 Overview NA

L45 Class Assignment Assigned Research topics NA

17

Dec 22

L46 Revisions

NA

11 Submission of

research topics

L47 Review of class assignment NA Submission of

research topics Library

search

L48 Examinations NA

D: Class Format: (You can modify it according to your course)

Class will consist of lectures and in some instances class discussion of problems or other assignments. In

addition, student will be responsible for all material in reading assignments regardless of whether or not the

material is discussed in class. Since these reading assignments are provided before class, it is expected that

students will read assignments before coming to class. It should be anticipated that class discussion may require

knowledge of the reading material and student who are not prepared may find class discussion difficult to

follow. Students are required to have a course portfolio; this should consist of explanations of lectures

during class discussion and will be taken into account when considering border-line cases.

E: Library Assignments

Please add topics and description for library assignments: Topics:-

Mechanism of Drug resistance in chemotherapy

Adverse drug reactions in cancer treatment

Chemotherapy of immuno-compromised patients

Rationale for drug combination in chemotherapy

Contraindications of chemotherapeutic agents in pregnancy

Safe use of antibiotics in children

F: Service learning/ Interprofessional Education :(if applicable)

Please add the topics and strategy for service learning module of your course, if applicable

This semester, students will go on education campaign on the rational use of antibiotics at Al Ahsa mall/Al

Othaim Mall. Hand bills will be distributed in both Arabic and English explaining the proper use of antibiotics

to avoid drug resistance within the community.

G: Examinations and Assessment:

48

During the semester, there will be an announced classroom quizzes in advance. These quizzes include topics

from the lectures that are covered before the quiz. The quizzes are worth 10% of the final grade in the

course. For the theoretical section of this course, there will be 2 examinations, Mid-term, and Final exam. The

outcome of these exams will represent 80 % of the final grade in the course.

Overall, the course will be graded as follows: (Please see grade distribution of your course and arrange

accordingly)

Schedules for Midterm and Final exams will be announced by the Committee for Academic affairs in

consultation with relevant students’ committee

Grading Scheme (Please refer to grade distribution of your course and adjust the grading accordingly) Assessment



1

Quiz #1 4th

5 %

2

Quiz #2 12th

5 %

3

Quiz #3 ( if applicable) - -

4

Service Learning (if applicable). 13th

-

5

Class activities ( to assist border-line cases) 6th

-

6

Library/Home Assignment 12th

10%

7

Mid Term Exam (Final Schedule will be issued by Academic Affairs committee)

8th

30 %

8

Lab Exam - -

9 Final Exam End of

semester 50 %

Total 100%

H: Attendance:

I expect you to be at every class. I often give information in class that is not in the presentation or found in the

textbook. Attendance is one of the most important work ethics in this profession. If you miss 25% of the total

classes during the semester, you will be dropped from the final exam.

COMING IN LATE

While it is mandatory to come on time in every class, I do realize that some logical circumstances may prevent

you from getting to class on time. Chronic late comers will not be allowed into the class during lecture. Please

show respect if you come in late, stay outside.

I: Academic Dishonesty and misconduct:

49


21. Cheating in exams, quizzes, small group sessions, from any source like fellow student, notes,

electronic sources.

22. Plagiarism: presenting work, words, ideas, presentations, assignments of others in whole or in

part, in assignments, presentations or projects




Students found to commit any of the above will be subject to disciplinary actions according to University Rules

and Regulations, mentioned in COCP Students’ Handbook

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